Redesigned Face Mask Improves "Real Life" Aerosol Delivery for Nebuchamber

Pediatric Pulmonology

Volumn 37, Issue 2, 2004, Pages 172-177

  Amirav, Israel ^a   Mansour, Yasser ^b   Mandelberg, Avigdor ^c   Bar Ilan, Igal ^d   Newhouse, Michael T ^e,f  

^a Rebecca Sieff Government Hospital   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

^c WOLFSON MEDICAL CENTER   (Israel)

^d MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^e ST JOSEPH S HOSPITAL   (Canada)

^f NEKTAR THERAPEUTICS   (United States)

Author keywords

Aerosol; Electrostatics; Face mask; Inhalation therapy; Spacer devices

Indexed keywords

BUDESONIDE;

AEROSOL; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG DELIVERY SYSTEM; FACE MASK; FEMALE; FILTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; METERED DOSE INHALER; NEBUCHAMBER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL;

ASTHMA; BRONCHODILATOR AGENTS; BUDESONIDE; CHILD, PRESCHOOL; CROSS-OVER STUDIES; EQUIPMENT DESIGN; FEMALE; HUMANS; INFANT; MALE; MASKS; NEBULIZERS AND VAPORIZERS; PATIENT SATISFACTION;

EID: 1642515009     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/ppul.10418     Document Type: Article

References (16)

1. Amirav I, Newhouse MT. Aerosol therapy with valved holding chambers in young children: importance of the facemask seal. Pediarics 2001;108:389-394.
2. Janssens HM, Heijnen EM, de Jong VM, Hop WC, Holland WP, de Jongste JC, Tiddens HA. Aerosol delivery from spacers in wheezy infants: a daily life study. Eur Respir J 2000;16:850-856.
3. Fok TF, Monkman S, Dolovich M, et al. Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1996;21:301-309.
4. Tal A, Golan H, Grauer N, Aviram M, Albin D, Quastral MR. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction. J Pediatr 1996;128:479-484.
5. Bisgaard H, Anhoj J, Klug B, Berg E. A non-electrostatic spacer for aerosol delivery. Arch Dis Child 1995;73:226-230.
6. Berg E, Madsen J, Bisgaard H. In vitro performance of three combinations of spacers and pressurized metered dose inhalers for treatment in children. Eur Respir J 1998;12:472-476.
7. Wildhaber JH, Devadason SG, Hayden MJ, Eber E, Summers QA, LeSouef PN. Aerosol delivery to wheezy infants: a comparison between a nebulizer and two small volume spacers. Pediatr Pulmonol 1997;23:212-216.
8. Barry PW, O'Callaghan C. The output of budesonide from spacer devices assessed under simulated breathing conditions. J Allergy Clin Immunol 1999;104:1205-1210.
9. Mandelberg A, Tsehori S, Houri S, Gilad E, Morag B, Priel IE. Is nebulized aerosol treatment necessary in the pediatric emergency department? Chest 2000;117:1309-1313.
10. National Institutes of Health, National Heart Lung and Blood Institute, Global Initiative for Asthma. Global strategy for asthma management and prevention. NHLBI/WHO workshop report. Publication no. 96-3659. Bethesda. MD: National Institutes of Health; 1995.
11. Barry PW, O'Callaghan C. An in vitro analysis of the output of budesonide from different nebulizers. J Allergy Clin Immunol 1999;104:1168-1173.
12. Lodrup Carlsen KC, Nikander K, Carlsen KH. How much nebulized budesonide reaches infants and toddlers? Arch Dis Child 1992;67:1077-1079.
13. Janssens HM, Devadason SG, Hop WC, LeSouef PN, De Jongste JC, Tiddens HA. Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. Eur Respir J 1999;13:787-791.
14. Bisgaard H. A metal aerosol holding chamber devised for young children with asthma. Eur Respir J 1995;8:856-860.
15. Anhoj J, Bisgaard H, Lipworth BJ. Lung dose in children from plastic spacer varies by up to 2-fold depending on handling. Eur Respir J [Suppl] 2000;116:383.
16. Borgstrom L, Asking L, Beckman O, Bondesson E, Kallen A, Olsson B. Discrepancy between in vitro and in vivo dose variability for a pressurized metered dose inhaler and a dry powder inhaler. J Aerosol Med [Suppl] 1998;11:59-64.