Identification and characterization of oxidation and deamidation sites in monoclonal rat/mouse hybrid antibodies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 9-10, 2010, Pages 777-784

  Timm, Vera ^a   Gruber, Patrick ^a   Wasiliu, Michael ^a   Lindhofer, Horst ^a   Chelius, Dirk ^a  

^a TRION Pharma ^*  (Germany)

Author keywords

Antibody; Deamidation; Mass spectrometry; Mouse; Oxidation; Peptide mapping; Pharmaceutics; Rat

Indexed keywords

ASPARAGINE RESIDUE; CHEMICAL DEGRADATION; DEAMIDATION; FREE-FLOW ELECTROPHORESIS; HALF LIVES; HEAVY CHAIN; ISOFORMS; KINETIC CHARACTERIZATION; METHIONINE RESIDUES; NON-ENZYMATIC; OXIDATION RATES; PEPTIDE MAPPING; SAMPLE PREPARATION;

ELECTROPHORESIS; GRAFTING (CHEMICAL); MAPPING; MASS SPECTROMETERS; MASS SPECTROMETRY; OXIDATION; PEPTIDES; SYNTHESIS (CHEMICAL);

ANTIBODIES;

ASPARAGINE; METHIONINE; MONOCLONAL ANTIBODY;

ARTICLE; ARTIFACT REDUCTION; DEAMINATION; ELECTROPHORESIS; HALF LIFE TIME; HEAVY CHAIN; MOUSE; NONHUMAN; OXIDATION; PH; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CHEMICAL PROCESSES; MICE; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PEPTIDE MAPPING; RATS; RECOMBINANT FUSION PROTEINS;

RATTUS;

EID: 77449103392     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.01.036     Document Type: Article

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