Glomerular number and size in Milan hypertensive and normotensive rats: Their relationship to susceptibility and resistance to hypertension and renal disease

Journal of Hypertension

Volumn 22, Issue 11, 2004, Pages 2185-2192

  Menini, Stefano ^a   Ricci, Carlo ^b   Iacobini, Carla ^c   Bianchi, Giuseppe ^d   Pugliese, Giuseppe ^b   Pesce, Carlo ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Glomerular mass; Glomerular number; Glomerular volume; Glomerulosclerosis; Hypertension; Morphometry

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE RESISTANCE; DISSECTION; FRACTIONATION; GLOMERULOSCLEROSIS; GLOMERULUS; HYPERTENSION; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; KIDNEY MASS; MALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT; RAT STRAIN; RENAL ARTERY;

EID: 7744225401     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200411000-00022     Document Type: Article

References (32)

1. Ohshima T, Inaba S, Arai M, Sakai Y, Kurose K, Ishihara S, et al. A case of oligomeganephronia. Quantitative measurement of the glomerular surface area and the number of glomeruli with a colour image analyser Nippon Jinzo Gakkai Shi 1994; 36:271-276.
2. Nomura S, Osawa G. Focal glomerular sclerotic lesions in a patient with unilateral oligomeganephronia and agenesis of the contralateral kidney: a case report. Clin Nephrol 1990; 33:7-11.
3. Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1988; 1:335-347.
4. Pesce C. Glomerular number and size: facts and artefacts. Anat Rec 1998; 251:66-71.
5. Pesce CM, Schmidt K, Fogo A, Okoye ML, Striker LJ, Striker G. Glomerular size and the incidence of renal disease in African American and Caucasians. J Nephrol 1994; 7:355-358.
6. Schmidt K, Pesce C, Liu Q, Nelson RG, Bennett PH, Karnitschnig H, et al. Larger glomerular size in Pima Indians: lack of change with diabetic nephropathy. J Am Soc Nephrol 1993; 3:229-235.
7. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, et al. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1998; 96:857-881.
8. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 1988; 96:379-394.
9. Keller G, Zimmer G, Mall G, Ritz E, Amann K. Nephron number in patients with primary hypertension. N Engl J Med 2003; 348:101-108.
10. Skov K, Nyengaard JR, Korsgaard N, Mulvany MJ. Number and size of renal glomeruli in spontaneously hypertensive rats. J Hypertens 1994; 12:1373-1376.
11. Kett MM, Alcorn D, Bertram JF, Anderson WP. Glomerular dimensions in spontaneously hypertensive rats: effects of AT1 antagonism. J Hypertens 1996; 14:107-113.
12. Hellmann H, Davis JM, Thurau K. Glomerulus number and blood pressure in the Prague hypertensive rat. Kidney Int (Suppl) 1988; 67:S211-S212.
13. Cusi D, Bianchi G. Renal mechanisms of genetic hypertension: from the molecular level to the intact organism. Kidney Int 1996; 49:1754-1759.
14. Brandis A, Bianchi G, Reale E, Helmchen U, Kuhn K. Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normo-tensive strain and not in rats of the Milan hypertensive strain. Lab Invest 1986; 55:234-243.
15. Salvati P, Ferti C, Ferrario GR, Duzzi L, Bianchi G, Perico N, et al. Enhanced glomerular synthesis of thromboxane A2 is a major determinant of the progressive kidney disease of normotensive rats of Milan strain. Kidney Int 1990; 38:447-458.
16. Sterio DC. The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc 1984; 134:127-136.
17. Nyengaard JR, Bendtsen TF. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 1992; 232:194-201.
18. Moritz KM, Wintour EM. Functional development of the meso- and metanephros. Pediatr Nephrol 1999; 13:171-178.
19. Moritz KM, Wintour EM, Didic M. Fetal uninephrectomy leads to postnatal hypertension and compromised renal function. Hypertension 2002; 39:1071-1076.
20. Bianchi G, Baer Pg, Fox U, Pagetti D. Kidney function and blood pressure in a genetic type of hypertension. Proceedings of the Sixth International Congress of Nephrology, Florence 1975, Basel: Karger; 1976, pp. 274-283.
21. Hakim RM, Goldszer RC, Brenner BM. Hypertension and proteinuria: long-term sequelae of uninephrectomy in humans. Kidney Int 1984; 25:930-936.
22. Bianchi G, Tripodi G, Casari G, Salardi S, Barber BR, Garcia R, et al. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 1994; 91:3999-4003.
23. Tripodi G, Valtorta F, Torielli L, Chieregatti E, Salardi S, Trusolino L, et al. Hypertension-associated point mutations in the adducin alpha and beta subunits affect actin cytoskeleton and ion transport. J Clin Invest 1996; 97:2815-2822.
24. Ferrandi M, Tripodi G, Salardi S, Florio M, Modica R, Barassi P, et al. Renal Na, K-ATPase in genetic hypertension. Hypertension 1996; 28:1018-1025.
25. Feld LG, Van Liew JB, Brentjens JR, Boylan JW. Selectivity of renal injury and proteinuria in the spontaneously hypertensive rat. Kidney Int 1977; 12:332-338.
26. Raij L, Azar S, Keane W. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. Kidney Int 1984; 26:137-143.
27. Boberg U, Persson AEG. Increased tubuloglomerular feedback activity in Milan hypertensive rats. Am J Physiol 1986; 250:F967-F974.
28. Persson AEG, Bianchi G, Boberg U. Tubuloglomerular feedback in hypertensive rats of the Milan strain. Acta Physiol Scand 1985; 123:139-146.
29. Tolbert EM, Weisstuch J, Feiner HD, Dworkin LD. Onset of glomerular hypertension with ageing precedes injury in the spontaneously hypertensive rat. Am J Physiol 2000; 278:F839-F846.
30. Dworkin LD, Hostetter TH, Rennke HG, Brenner BM. Haemodynamic basis for glomerular injury in rats with desoxycorticosterone-salt hypertension. J Clin Invest 1984; 73:1448-1461.
31. Pugliese F, Ferrario RG, Ciavolella A, Tamburin M, Benatti L, Casini A, et al. Growth abnormalities in cultured mesangial cells from rats with spontaneous glomerulosclerosis. Kidney Int 1995; 47:106-113.
32. Pugliese G, Pricci F, Mene P, Romeo G, Nofroni I, Giannini S, et al. High glucose level unmasks a genetic predisposition to enhanced extracellular matrix production in mesangial cells from rats of the Milan normotensive strain. J Am Soc Nephrol 1997; 8:406-414.