Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis

BMC Developmental Biology

Volumn 10, Issue , 2010, Pages

  Coletta, Ricardo D ^a,c   McCoy, Erica L ^b   Burns, Valerie ^a   Kawakami, Kiyoshi ^d   McManaman, James L ^a,b   Wysolmerski, John J ^e   Ford, Heide L ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d JICHI MEDICAL UNIVERSITY   (Japan)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MUS; MUS MUSCULUS;

HOMEODOMAIN PROTEIN; SIX1 PROTEIN, MOUSE; SIX2 PROTEIN, MOUSE; SIX4 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; BREAST TUMOR; C57BL MOUSE; FEMALE; GROWTH, DEVELOPMENT AND AGING; HUMAN; LACTATION; METABOLISM; MOUSE; PREGNANCY; UDDER;

ANIMALS; BREAST NEOPLASMS; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED C57BL; PREGNANCY; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 77349122759     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-10-4     Document Type: Article

References (42)

1. Modulating Hox gene functions during animal body patterning. JC Pearson D Lemons W McGinnis, Nat Rev Genet 2005 6 893 904 10.1038/nrg1726 16341070
2. Deregulated homeobox gene expression in cancer: cause or consequence? C Abate-Shen, Nat Rev Cancer 2002 2 777 785 10.1038/nrc907 12360280
3. Homeobox gene expression in cancer: insights from developmental regulation and deregulation. S Samuel H Naora, Eur J Cancer 2005 41 2428 2437 10.1016/j.ejca.2005.08.014 16199152
4. Hox genes in hematopoiesis and leukemogenesis. B Argiropoulos RK Humphries, Oncogene 2007 26 6766 6776 10.1038/sj.onc.1210760 17934484
5. The six family of homeobox genes in development and cancer. KL Christensen AN Patrick EL McCoy HL Ford, Adv Cancer Res 2008 101 93 126 10.1016/S0065-230X(08)00405-3 19055944
6. Tissue-specific regulation of retinal and pituitary precursor cell proliferation. X Li V Perissi F Liu DW Rose MG Rosenfeld, Science 2002 297 1180 1183 12130660
7. Six1 is required for the early organogenesis of mammalian kidney. PX Xu W Zheng L Huang P Maire C Laclef D Silvius, Development 2003 130 3085 3094 10.1242/dev.00536 12783782
8. The role of Six1 in mammalian auditory system development. W Zheng L Huang ZB Wei D Silvius B Tang PX Xu, Development 2003 130 3989 4000 10.1242/dev.00628 12874121
9. Giant eyes in Xenopus laevis by overexpression of XOptx2. ME Zuber M Perron A Philpott A Bang WA Harris, Cell 1999 98 341 352 10.1016/S0092-8674(00) 81963-7 10458609
10. Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. K Behbakht L Qamar CS Aldridge RD Coletta SA Davidson A Thorburn HL Ford, Cancer Res 2007 67 3036 3042 10.1158/0008-5472.CAN-06-3755 17409410
11. Abrogation of the G2 cell cycle checkpoint associated with overexpression of HSIX1: a possible mechanism of breast carcinogenesis. HL Ford EN Kabingu EA Bump GL Mutter AB Pardee, Proc Natl Acad Sci USA 1998 95 12608 12613 10.1073/pnas.95.21.12608 9770533
12. Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Y Yu J Khan C Khanna L Helman PS Meltzer G Merlino, Nat Med 2004 10 175 181 10.1038/nm966 14704789
13. Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation. RD Coletta KL Christensen DS Micalizzi P Jedlicka M Varella-Garcia HL Ford, Cancer Res 2008 68 2204 2213 10.1158/0008-5472.CAN-07-3141 18381426
14. Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. C Laclef E Souil J Demignon P Maire, Mech Dev 2003 120 669 679 10.1016/S0925-4773(03)00065-0 12834866
15. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. X Li KA Oghi J Zhang A Krones KT Bush CK Glass SK Nigam AK Aggarwal R Maas DW Rose MG Rosenfeld, Nature 2003 426 247 254 10.1038/nature02083 14628042
16. Six1 controls patterning of the mouse otic vesicle. H Ozaki K Nakamura J Funahashi K Ikeda G Yamada H Tokano HO Okamura K Kitamura S Muto H Kotaki,, et al. Development 2004 131 551 562 10.1242/dev.00943 14695375
17. Altered myogenesis in Six1-deficient mice. C Laclef G Hamard J Demignon E Souil C Houbron P Maire, Development 2003 130 2239 2252 10.1242/dev.00440 12668636
18. Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis. Y Konishi K Ikeda Y Iwakura K Kawakami, Brain Res 2006 1116 93 102 10.1016/j.brainres.2006.07.103 16938278
19. Eya1 and Six1 are essential for early steps of sensory neurogenesis in mammalian cranial placodes. D Zou D Silvius B Fritzsch PX Xu, Development 2004 131 5561 5572 10.1242/dev.01437 15496442
20. Six1 is essential for early neurogenesis in the development of olfactory epithelium. K Ikeda S Ookawara S Sato Z Ando R Kageyama K Kawakami, Dev Biol 2007 311 53 68 10.1016/j.ydbio.2007.08.020 17880938
21. Homeobox genes and connective tissue patterning. G Oliver R Wehr NA Jenkins NG Copeland BN Cheyette V Hartenstein SL Zipursky P Gruss, Development 1995 121 693 705 7720577
22. Expression of Six1 homeobox gene during development of the mouse submandibular salivary gland. EL McCoy K Kawakami HL Ford R Coletta, Oral Dis 2009 15 6 407 413 10.1111/j.1601-0825.2009.01560.x 19371398
23. Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. R Grifone J Demignon C Houbron E Souil C Niro MJ Seller G Hamard P Maire, Development 2005 132 2235 2249 10.1242/dev.01773 15788460
24. Gene expression changes during HPV-mediated carcinogenesis: a comparison between an in vitro cell model and cervical cancer. F Wan X Miao I Quraishi V Kennedy KE Creek L Pirisi, Int J Cancer 2008 123 32 40 10.1002/ijc.23463 18398830
25. Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma. KT Ng K Man CK Sun TK Lee RT Poon CM Lo ST Fan, Br J Cancer 2006 95 1050 1055 10.1038/sj.bjc.6603399 17008870
26. The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. RD Coletta K Christensen KJ Reichenberger J Lamb D Micomonaco L Huang DM Wolf C Muller-Tidow TR Golub K Kawakami HL Ford, Proc Natl Acad Sci USA 2004 101 6478 6483 10.1073/pnas.0401139101 15123840
27. Gene amplification is a mechanism of Six1 overexpression in breast cancer. KJ Reichenberger RD Coletta AP Schulte M Varella-Garcia HL Ford, Cancer Res 2005 65 2668 2675 10.1158/0008-5472.CAN-04-4286 15805264
28. cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene. J Khan ML Bittner LH Saal U Teichmann DO Azorsa GC Gooden WJ Pavan JM Trent PS Meltzer, Proc Natl Acad Sci USA 1999 96 13264 13269 10.1073/pnas.96.23.13264 10557309
29. Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. CM Li M Guo A Borczuk CA Powell M Wei HM Thaker R Friedman U Klein B Tycko, Am J Pathol 2002 160 2181 2190 12057921
30. Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. EL McCoy R Iwanaga P Jedlicka NS Abbey LA Chodosh KA Heichman AL Welm HL Ford, J Clin Invest 2009 119 2663 2677 10.1172/JCI37691 19726883
31. The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. DS Micalizzi KL Christensen P Jedlicka RD Coletta AE Baron JC Harrell KB Horwitz D Billheimer KA Heichman AL Welm,, et al. J Clin Invest 2009 119 2678 2690 10.1172/JCI37815 19726885
32. Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. P Li X Yu K Ge J Melamed RG Roeder Z Wang, Am J Pathol 2002 161 1467 1474 12368219
33. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. CM D'Cruz EJ Gunther RB Boxer JL Hartman L Sintasath SE Moody JD Cox SI Ha GK Belka A Golant,, et al. Nat Med 2001 7 235 239 10.1038/84691 11175856
34. Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1. MT Lewis S Ross PA Strickland CW Sugnet E Jimenez MP Scott CW Daniel, Development 1999 126 5181 5193 10529434
35. Mammary ductal and alveolar development: lesson learned from genetically manipulated mice. ME Dunbar JJ Wysolmerski, Microsc Res Tech 2001 52 163 170 10.1002/1097-0029(20010115)52:2<163::AID-JEMT1002>3.0.CO;2-R 11169864
36. Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland. JL McManaman ME Reyland EC Thrower, J Mammary Gland Biol Neoplasia 2006 11 249 268 10.1007/s10911-006-9031-3 17136613
37. Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development. H Ozaki Y Watanabe K Takahashi K Kitamura A Tanaka K Urase T Momoi K Sudo J Sakagami M Asano,, et al. Mol Cell Biol 2001 21 3343 3350 10.1128/MCB.21.10.3343-3350.2001 11313460
38. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. A Kobayashi MT Valerius JW Mugford TJ Carroll M Self G Oliver AP McMahon, Cell Stem Cell 2008 3 169 181 10.1016/j.stem.2008.05.020 18682239
39. A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology. EJ Gunther GK Belka GB Wertheim J Wang JL Hartman RB Boxer LA Chodosh, FASEB J 2002 16 283 292 10.1096/fj.01-0551com 11874978
40. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. I Satokata L Ma H Ohshima M Bei I Woo K Nishizawa T Maeda Y Takano M Uchiyama S Heaney,, et al. Nat Genet 2000 24 391 395 10.1038/74231 10742104
41. Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. F Chen MR Capecchi, Proc Natl Acad Sci USA 1999 96 541 546 10.1073/pnas.96.2.541 9892669
42. Breast-feeding after breast cancer in childbearing women. B Camune E Gabzdyl, J Perinat Neonatal Nurs 2007 21 225 233 17700099