Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens

Cellular Immunology

Volumn 262, Issue 1, 2010, Pages 1-5

  Taylor, Patricia R ^a   Paustian, Christopher C ^b   Koski, Gary K ^b   Zimmerman, Daniel H ^c   Rosenthal, Ken S ^a  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c CEL SCI Corporation   (United States)

Author keywords

Dendritic cell; Human; LEAPS; Monocyte; Vaccine

Indexed keywords

ANGIOGENIN; BETA 2 MICROGLOBULIN; BINDING PROTEIN; COLONY STIMULATING FACTOR 1; CXCL9 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAG PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 14; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN P17; RANTES; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ALLOTYPE; ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOCOMPETENT CELL; MONOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TH1 CELL;

ANTIGEN PRESENTATION; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; DENDRITIC CELLS; EPITOPES; HUMANS; IMMUNOGLOBULIN J-CHAINS; INTERLEUKIN-12;

HUMAN HERPESVIRUS 1;

EID: 77349122081     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2010.01.003     Document Type: Article

References (19)

1. Roses R., Xu S., Xu M., Koldovsky U., Koski G., and Czerniecki B. Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists. Journal of Immunology 181 (2008) 5120-5127
2. Czerniecki B., Koski G., Koldovsky U., Xu S., Cohen P., Mick R., Nisenbaum H., Pasha T., Xu M., Fox K., Weinstein S., Orel S., Vonderheide R., Coukas G., DeMichele A., Araujo L., Spitz F., Rosen M., Levine B., June C., and Zhang P. Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion. Cancer Research 67 4 (2007) 1842-1852
3. Kapsenberg M., Hilkens U., Wierenga A., and Kalinski P. The paradigm of type 1 and type 2 antigen presenting cells. Implications for atopic allergy. Clinical and Experimental Allergy 29 2 (1999) 33-36
4. Shimizu K., Kuriyama H., Kjaergaard J., Lee W., Tanaka H., and Shu S. Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy. Journal Immunotherapy 27 (2004) 265-272
5. Inaba K., Inaba M., Romani N., Ava H., Deguchi M., Ikehara S., Muramatsu S., and Steinman R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with a granulocyte macrophage stimulating factor. The Journal of Experimental Medicine 176 (1992) 1693-1702
6. Snijders A., Kaliniski P., Hilkens C.M., and Kaspenberg M.L. High level IL-12 production by human DCs requires 2 signals. International Immunology 10 11 (1998) 1593-1598
7. + dendritic cells is modulated under serum-free conditions by exogenously added IFN-gamma and endogenously produced IL-10. European Journal of Immunology 31 (2001) 3773-3781
8. Mosca P., Hobeika A., Clay T., Nair S., Thomas E., Morse M., and Lyerly H. A subset of human monocyte-derived dendritic cells express high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. Blood 96 (2000) 3499-3504
9. Hocherein H., Keeffe M., Luft T., Vandenbeele S., Grumont R., Maraskovsky E., and Shortman K. Interleukin-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. The Journal of Experimental Medicine 192 6 (2000) 823-833
10. Czernicki B., Carter C., Rivoltini L., Koski G., Kim H., Weng D., Roros J., Hijazi Y., Xu S., Rosenberg S., and Cohen P. Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells. Journal of Immunology 159 (1997) 3823-3837
11. Zimmerman D.H., and Rosenthal K.S. The L.E.A.P.S. approach to vaccine development. Frontiers of Bioscience 10 (2005) 790-798
12. Goel N., Rong Q., Zimmerman D., and Rosenthal K.S. A L.E.A.P.S. heteroconjugate vaccine containing a T cell epitope from HSV-1 glycoprotein D elicits Th1 responses and protection. Vaccine 21 (2003) 4410-4420
13. Zimmerman D.H., Lloyd J.P., Heisey D., Winship M.D., Siwek M., Taylor E., and Sarin P.S. Induction of cross clade reactive antibodies in mice conjugates of HGP-30 peptide analog of HIV-1 (SF2 p17) and peptide segments of human beta-2-microglobulin or MHC II beta chain. Vaccine 19 (2001) 4750-4759
14. Napolitani G., Rinaldi A., Bertoni F., Sallusto F., and Lazavecchia A. Selected toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nature Immunology 6 (2005) 769-776
15. + T cells to tumor antigens by dendritic cells leads to enhanced functional avidity and direct tumor recognition through an IL-12-dependent mechanism. Journal of Immunology 171 (2003) 2251-2261
16. Banchereau J., and Steinman R. Dendritic cells and the control of immunity. Nature 392 (1998) 245-252
17. Schnurr M., Then F., Galambos P., Scholz C., Siegmund B., Endres S., and Eigler A. Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells. Journal of Immunology 165 (2000) 4704-4709
18. Zheng R., Cohen P.A., Paustian C., Johnson T.D., Lee W.T., Shu S., and Koski G.K. Paired TLR agonists enhance vaccine therapy through induction of IL-12. Cancer Research 68 11 (2008) 4045-4049
19. P. Taylor, G. Koski, P. Cohen, F.B.G. Moore, D.H. Zimmerman, K.S. Rosenthal, J-L.E.A.P.S.™ vaccines initiate murine Th1 responses by activating dendritic cells, submitted for publication.