Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2010, Pages 1395-1402

  Chou, Li Chen ^a   Huang, Li Jiau ^a   Hsu, Mei Hua ^a   Fang, Mei Chi ^a   Yang, Jai Sing ^a   Zhuang, Shi Hong ^a   Lin, Hui Yi ^a   Lee, Fang Yu ^b   Teng, Che Ming ^c   Kuo, Sheng Chu ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Yung Shin Pharmaceutical Industry Co Ltd   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Cytotoxicity; Furopyrazole; Selenolopyrazole; Structure activity relationships (SAR); Thienopyrazole; YC 1 analogs

Indexed keywords

1 BENZYL 3 (4 HYDROXYCARBONYLPHENYL)SELENOLO[3,2 C]PYRAZOLE; 1 BENZYL 3 (4 HYDROXYMETHYLPHENYL)SELENOLO[3,2 C]PYRAZOLE; 1 BENZYL 3 (4 METHOXYCARBONYLPHENYL)SELENOLO[3,2 C]PYRAZOLE; 1 BENZYL 3 (5 HYDROXYCARBONYL 2 FURYL)SELENOLO[3,2 C]PYRAZOLE; 1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL) 5 METHYLSELENOLO[3,2 C]PYRAZOLE; 1 BENZYL 3 (5 HYDROXYMETHYL 2 FURYL)SELENOLO[3,2 C]PYRAZOLE; 1 BENZYL 3 (5 METHOXYCARBONYL 2 FURYL) 5 METHYLSELENOLO[3,2 C]PYRAZOLE; 1 BENZYL 3 (5 METHOXYCARBONYL 2 FURYL)SELENOLO[3,2 C]PYRAZOLE; 1 PHENYL 3 (4 HYDROXYMETHYLPHENYL)SELENOLO[3,2 C]PYRAZOLE; 1 PHENYL 3 (4 METHOXYCARBONYLPHENYL)SELENOLO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 HYDROXYCARBONYL 2 FURYL) 5 METHYLSELENOLO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 HYDROXYCARBONYL 2 FURYL)SELENOLO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 HYDROXYMETHYL 2 FURYL) 5 METHYLSELENOLO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 HYDROXYMETHYL 2 FURYL)SELENOLO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 METHOXYCARBONYL 2 FURYL) 5 METHYLSELENOLO[3,2 C]PYRAZOLE; 1 PHENYL 3 (5 METHOXYCARBONYL 2 FURYL)SELENOLO[3,2 C]PYRAZOLE; ANTINEOPLASTIC AGENT; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; KIDNEY CANCER; LUNG NON SMALL CELL CANCER;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PYRAZOLES; SPECTROPHOTOMETRY, INFRARED;

EID: 77349116794     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.039     Document Type: Article

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