Memory in humans is unaffected by central H1-antagonism, while objectively and subjectively measured sedation is increased

European Neuropsychopharmacology

Volumn 20, Issue 4, 2010, Pages 226-235

  Van Ruitenbeek, P ^a   Vermeeren, A ^a   Riedel, W J ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Antihistamines; Benzodiazepines; Cognition; Event related potentials; Memory; Sedation

Indexed keywords

DEXCHLORPHENIRAMINE; HISTAMINE H1 RECEPTOR; LORAZEPAM; PLACEBO;

ACCURACY; ADULT; ALERTNESS; ALPHA RHYTHM; AROUSAL; ARTICLE; BETA RHYTHM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DELTA RHYTHM; DOUBLE BLIND PROCEDURE; DROWSINESS; EFFECT SIZE; ELECTROENCEPHALOGRAM; EPISODIC MEMORY; FEMALE; HUMAN; HUMAN EXPERIMENT; LEARNING; MALE; MEMORY; NORMAL HUMAN; PRIORITY JOURNAL; REACTION TIME; RECEPTOR BLOCKING; SEDATION; SINGLE DRUG DOSE; TASK PERFORMANCE; THETA RHYTHM; VOLUNTEER; WORKING MEMORY;

ADOLESCENT; ADULT; AROUSAL; CHLORPHENIRAMINE; CONSCIOUS SEDATION; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; FEMALE; HISTAMINE H1 ANTAGONISTS; HUMANS; LORAZEPAM; MALE; MEMORY; MIDDLE AGED; PLACEBOS; PSYCHOMOTOR PERFORMANCE;

EID: 77349097564     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2009.12.003     Document Type: Article

References (67)

1. Acevedo S.F., Ohtsu H., Benice T.S., Rizk-Jackson A., and Raber J. Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc(-/-)) mice. Brain Res. 1071 (2006) 113-123
2. Alvarez E.O., and Ruarte M.B. Glutamic acid and histamine-sensitive neurons in the ventral hippocampus and the basolateral amygdala of the rat: functional interaction on memory and learning processes. Behav. Brain Res. 152 (2004) 209-219
3. Bacciottini L., Passani M.B., Mannaioni P.F., and Blandina P. Interactions between histaminergic and cholinergic systems in learning and memory. Behav. Brain Res. 124 (2001) 183-194
4. Berchou R., Chayasirisobhon S., Green V., and Mason K. The pharmacodynamic properties of lorazepam and methylphenidate drugs on event-related potentials and power spectral analysis in normal subjects. Clin. Electroencephalogr. 17 (1986) 176-180
5. Blandina P., Efoudebe M., Cenni G., Mannaioni P., and Passani M.B. Acetylcholine, histamine, and cognition: two sides of the same coin. Learn Mem. 11 (2004) 1-8
6. Bond A., and Lader M. The use of analogue scales in rating subjective feelings. Br. J. Med. Psychol. 47 (1974) 211-218
7. Bond A., and Lader M. Differential effects of oxazepam and lorazepam on aggressive responding. Psychopharmacology (Berl) 95 (1988) 369-373
8. Borbely A.A. A two process model of sleep regulation. Hum. Neurobiol. 1 (1982) 195-204
9. Braver T.S., Cohen J.D., Nystrom L.E., Jonides J., Smith E.E., and Noll D.C. A parametric study of prefrontal cortex involvement in human working memory. Neuroimage 5 (1997) 49-62
10. Busto U.E., Kaplan H.L., Wright C.E., Gomez-Mancilla B., Zawertailo L., Greenblatt D.J., and Sellers E.M. A comparative pharmacokinetic and dynamic evaluation of alprazolam sustained-release, bromazepam, and lorazepam. J. Clin. Psychopharmacol. 20 (2000) 628-635
11. Curran H.V. Psychopharmacological perspectives on memory. In: Tulving E., and Craik F.I.M. (Eds). The Oxford Handbook of Memory (2000), Oxford University Press, Oxford
12. Curran H.V., Pooviboonsuk P., Dalton J.A., and Lader M.H. Differentiating the effects of centrally acting drugs on arousal and memory: an event-related potential study of scopolamine, lorazepam and diphenhydramine. Psychopharmacology (Berl) 135 (1998) 27-36
13. Dai H., Kaneko K., Kato H., Fujii S., Jing Y., Xu A., Sakurai E., Kato M., Okamura N., Kuramasu A., and Yanai K. Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors. Neurosci. Res. 57 (2007) 306-313
14. De Brabander A., and Deberdt W. Effect of hydroxyzine on attention and memory. Hum. Psychopharmacol. 5 (1990) 357-362
15. Dunlap W.P., Cortina J.M., Vaslow J.B., and Burke M.J. Meta-analysis of experiments with matched groups or repeated measures designs. Psychological Methods 1 (1996) 170-177
16. Ebert U., Oertel R., and Kirch W. Physostigmine reversal of midazolam-induced electroencephalographic changes in healthy subjects. Clin. Pharmacol. Ther. 67 (2000) 538-548
17. File S.E., and Lister R.G. Do lorazeam-induced deficits in learning result from impaired rehearsal, reduced motivation or increased sedation?. Br. J. Clin. Pharmacol. 14 (1982) 545-550
18. Friedman D., and Johnson Jr. R. Event-related potential (ERP) studies of memory encoding and retrieval: a selective review. Microsc. Res. Tech. 51 (2000) 6-28
19. Galliaud E., Taillard J., Sagaspe P., Valtat C., Bioulac B., and Philip P. Sharp and sleepy: evidence for dissociation between sleep pressure and nocturnal performance. J. Sleep Res. 17 (2008) 11-15
20. Garbarg M., Arrang J.M., Rouleau A., Ligneau X., Tuong M.D., Schwartz J.C., and Ganellin C.R. S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J. Pharmacol. Exp. Ther. 263 (1992) 304-310
21. Gevins A., Smith M.E., and McEvoy L.K. Tracking the cognitive pharmacodynamics of psychoactive substances with combinations of behavioral and neurophysiological measures. Neuropsychopharmacology 26 (2002) 27-39
22. Gomez C.M., Vaquero E., Lopez-Mendoza D., Gonzalez-Rosa J., and Vazquez-Marrufo M. Reduction of EEG power during expectancy periods in humans. Acta Neurobiol. Exp. (Wars) 64 (2004) 143-151
23. Greenblatt D.J. Clinical pharmacokinetics of oxazepam and lorazepam. Clin. Pharmacokinet. 6 (1981) 89-105
24. Greenblatt D.J., von Moltke L.L., Harmatz J.S., Durol A.L., Daily J.P., Graf J.A., Mertzanis P., Hoffman J.L., and Shader R.I. Differential impairment of triazolam and zolpidem clearance by ritonavir. J. Acquir. Immune. Defic. Syndr. 24 (2000) 129-136
25. Griffiths M.J., Preece A.W., and Green J.L. Monitoring sedation levels by EEG spectral analysis. Anesth. Prog. 38 (1991) 227-231
26. Hanks G.W., O'Neill W.M., Simpson P., and Wesnes K. The cognitive and psychomotor effects of opioid analgesics. II. A randomized controlled trial of single doses of morphine, lorazepam and placebo in healthy subjects. Eur. J. Clin. Pharmacol. 48 (1995) 455-460
27. Hindmarch, and Shamsi Z. The effects of single and repeated administration of ebastine on cognition and psychomotor performance in comparison to triprolidine and placebo in healthy volunteers. Curr. Med. Res. Opin. 17 (2001) 273-281
28. Jasper H.H. The ten-twenty electrode system of the international federation. Electroencephalogr. Clin. Neurophysiol. 10 (1957) 371-375
29. Klapdor K., Hasenohrl R.U., and Huston J.P. Facilitation of learning in adult and aged rats following bilateral lesions of the tuberomammillary nucleus region. Behav. Brain Res. 61 (1994) 113-116
30. Mintzer M.Z., and Griffiths R.R. Lorazepam and scopolamine: a single-dose comparison of effects on human memory and attentional processes. Exp. Clin. Psychopharmacol. 11 (2003) 56-72
31. Mintzer M.Z., and Griffiths R.R. Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamine. Exp. Clin. Psychopharmacol. 13 (2005) 336-347
32. Miyazaki S., Imaizumi M., and Onodera K. Ameliorating effects of histidine on scopolamine-induced learning deficits using an elevated plus-maze test in mice. Life Sci. 56 (1995) 1563-1570
33. Otten L.J., and Donchin E. Relationship between P300 amplitude and subsequent recall for distinctive events: dependence on type of distinctiveness attribute. Psychophysiology 37 (2000) 644-661
34. Palacios J.M., Wamsley J.K., and Kuhar M.J. The distribution of histamine H1-receptors in the rat brain: an autoradiographic study. Neuroscience 6 (1981) 15-37
35. Parsons M.E., and Ganellin C.R. Histamine and its receptors. Br. J. Pharmacol. 147 Suppl 1 (2006) S127-S135
36. Passani M.B., Bacciottini L., Mannaioni P.F., and Blandina P. Central histaminergic system and cognition. Neurosci. Biobehav. Rev. 24 (2000) 107-113
37. Passani M.B., Lin J.S., Hancock A., Crochet S., and Blandina P. The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders. Trends Pharmacol. Sci. 25 (2004) 618-625
38. Patat A., Gram L.F., Dubruc C., Brohier S., Cabanis M.J., and Rosenzweig P. Effects of mizolastine, a new antihistamine, on psychomotor performance and memory in elderly subjects. Int. Clin. Psychopharmacol. 9 (1994) 101-108
39. Polich J. Updating P300: an integrative theory of P3a and P3b. Clin. Neurophysiol. 118 (2007) 2128-2148
40. Preston G.C., Broks P., Traub M., Ward C., Poppleton P., and Stahl S.M. Effects of lorazepam on memory, attention and sedation in man. Psychopharmacology (Berl) 95 (1988) 208-215
41. Ramaekers J.G., Uiterwijk M.M., and O'Hanlon J.F. Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving. Eur. J. Clin. Pharmacol. 42 (1992) 363-369
42. Rammsayer T.H., Rodewald S., and Groh D. Dopamine-antagonistic, anticholinergic, and GABAergic effects on declarative and procedural memory functions. Brain Res. Cogn. Brain Res. 9 (2000) 61-71
43. Rey, A., 1964. L'exam psychologique dans les cas d'encéphalopathie traumatique. Presses Universitaires de France.
44. Riedel W.J., Klaassen T., Deutz N.E., van Someren A., and van Praag H.M. Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation. Psychopharmacology (Berl) 141 (1999) 362-369
45. Riedel W.J., and Van Praag H. Avoiding and managing anticholinergic effects of antidepressants. CNS Drugs 3 (1995) 245-259
46. Saletu B., Grunberger J., and Sieghart W. Pharmaco-EEG, behavioural methods and blood levels in the comparison of temazepam and flunitrazepam. Acta Psychiatr. Scand. Suppl. 332 (1986) 67-94
47. Sannita W.G., Crimi E., Riela S., Rosadini G., and Brusasco V. Cutaneous antihistaminic action of cetirizine and dose-related EEG concomitants of sedation in man. Eur. J. Pharmacol. 300 (1996) 33-41
48. Schreckenberger M., Lange-Asschenfeldt C., Lochmann M., Mann K., Siessmeier T., Buchholz H.G., Bartenstein P., and Grunder G. The thalamus as the generator and modulator of EEG alpha rhythm: a combined PET/EEG study with lorazepam challenge in humans. Neuroimage 22 (2004) 637-644
49. Semlitsch H.V., Anderer P., Schuster P., and Presslich O. A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. Psychophysiology 23 (1986) 695-703
50. Simons F.E., Reggin J.D., Roberts J.R., and Simons K.J. Benefit/risk ratio of the antihistamines (H1-receptor antagonists) terfenadine and chlorpheniramine in children. J. Pediatr. 124 (1994) 979-983
51. Tashiro M., Mochizuki H., Iwabuchi K., Sakurada Y., Itoh M., Watanabe T., and Yanai K. Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 receptors in human brain. Life Sci. 72 (2002) 409-414
52. Theunissen E.L., Jonkman L.M., Kuypers K.P., and Ramaekers J.G. A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance. J. Psychopharmacol. 20 (2006) 496-505
53. Theunissen E.L., Vermeeren A., van Oers A.C., van Maris I., and Ramaekers J.G. A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo. Clin. Exp. Allergy 34 (2004) 250-258
54. Turner C., Handford A.D., and Nicholson A.N. Sedation and memory: studies with a histamine H-1 receptor antagonist. J. Psychopharmacol. 20 (2006) 506-517
55. Van Ruitenbeek P., Vermeeren A., and Riedel W.J. Histamine H1-receptor blockade in humans affects psychomotor performance but not memory. J. Psychopharmacol. 22 (2008) 663-672
56. Veltman D.J., Rombouts S.A., and Dolan R.J. Maintenance versus manipulation in verbal working memory revisited: an fMRI study. Neuroimage 18 (2003) 247-256
57. Vermeeren A., Jackson J.L., Muntjewerff N.D., Quint P.J., Harrison E.M., and O'Hanlon J.F. Comparison of acute alprazolam (0.25, 0.50 and 1.0 mg) effects versus those of lorazepam 2 mg and placebo on memory in healthy volunteers using laboratory and telephone tests. Psychopharmacology (Berl) 118 (1995) 1-9
58. Verster J.C., Volkerts E.R., van Oosterwijck A.W., Aarab M., Bijtjes S.I., De Weert A.M., Eijken E.J., and Verbaten M.N. Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. J. Allergy Clin. Immunol. 111 (2003) 623-627
59. Volkerts E.R., Van Willigenburg A.P., Van Laar M.W., and Maes R.A. Does cetirizine belong to the new generation of antihistamines? An investigation into its acute and subchronic effects on highway driving, psychometric test performance and daytime sleepiness. Hum. Psychopharm. Clin. Exp. 7 (1992) 227-238
60. Vuurman E.F., Uiterwijk M.M., Rosenzweig P., and O'Hanlon J.F. Effects of mizolastine and clemastine on actual driving and psychomotor performance in healthy volunteers. Eur. J. Clin. Pharmacol. 47 (1994) 253-259
61. Vuurman E.F., Rikken G.H., Muntjewerff N.D., de Halleux F., and Ramaekers J.G. Effects of desloratadine, diphenhydramine, and placebo on driving performance and psychomotor performance measurements. Eur. J. Clin. Pharmacol. 60 (2004) 307-313
62. Watter S., Geffen G.M., and Geffen L.B. The n-back as a dual-task: P300 morphology under divided attention. Psychophysiology 38 (2001) 998-1003
63. Wiech N.L., and Martin J.S. Absence of an effect of terfenadine on guinea pig brain histamine H1-receptors in vivo determined by receptor binding techniques. Arzneimittelforschung 32 (1982) 1167-1170
64. Wijtmans M., Leurs R., and de Esch I. Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas. Expert Opin. Investig. Drugs. 16 (2007) 967-985
65. World-Medical-Association, 1964. World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects.
66. Yanai K., Watanabe T., Yokoyama H., Meguro K., Hatazawa J., Itoh M., Iwata R., Ishiwata K., Takahashi T., and Ido T. Histamine H1 receptors in human brain visualized in vivo by [11C]doxepin and positron emission tomography. Neurosci. Lett. 137 (1992) 145-148
67. Zarrindast M.R., Parsaei L., and Ahmadi S. Repeated administration of histamine improves memory retrieval of inhibitory avoidance by lithium in mice. Pharmacology 81 (2008) 187-194