Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis

Phytotherapy Research

Volumn 24, Issue 3, 2010, Pages 325-332

  Ekşioǧlu Demiralp, Emel ^a   Kardaş, E Riza ^a   Özgül, Seçkin ^a   Yaǧci, Tayfur ^a   Bilgin, Hüseyin ^a   Şehirli, Özer ^a   Ercan, Feriha ^a   Şener, Göksel ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Betulinic acid; Ischemia reperfusion; Kidney; Lipid peroxidation

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BETULIC ACID; CREATININE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLUTATHIONE; LACTATE DEHYDROGENASE; MALONALDEHYDE; MYELOPEROXIDASE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY INJURY; KIDNEY ISCHEMIA; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE; MALE; NEUTROPHIL; NONHUMAN; RAT; RENAL PROTECTION; REPERFUSION INJURY; RESPIRATORY BURST; TISSUE LEVEL; UREA NITROGEN BLOOD LEVEL;

ANIMALS; APOPTOSIS; KIDNEY; LEUKOCYTES; MALE; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, WISTAR; REPERFUSION INJURY; RESPIRATORY BURST; SODIUM-POTASSIUM-EXCHANGING ATPASE; TRITERPENES;

RATTUS;

EID: 77349095057     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2929     Document Type: Article

References (45)

1. Abernethy VE, Lieberthal W. 2002. Acute renal failure in the critically ill patient. Crit Care Clin 18: 203-222.
2. Aiken C, Chen CH. 2005. Betulinic acid derivatives as HIV-1 antivirals. Trends Mol Med 11: 31-36.
3. Alakurtti S, Mäkelä T, Koskimies S, Yli-Kauhaluoma J. 2006. Pharmacological properties of the ubiquitous natural product betulin. Eur J Pharm Sci 29: 1-13.
4. Aperia A. 2007. New roles for an old enzyme: Na,K-ATPase emerges as an interesting drug target. J Intern Med 261: 44-52.
5. Bernard P, Scior T, Didier B, Hibert M, Berthon JY. 2001. Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A2 inhibitors. Phytochemistry 58: 865-874.
6. Beuge JA, Aust SD. 1978. Microsomal lipid peroxidation. Meth Enzymol 53: 302-311.
7. Beutler E, Duron O, Kelly BM. 1963. Improved method for the determination of blood glutathione. J Lab Clin Med 61: 882-888.
8. Boros P, Bromberg JS. 2006. New cellular and molecular immune pathways in ischemia/reperfusion injury. Am J Transplant 6: 652-658.
9. Bureeva S, Andia-Pravdivy J, Symon A et al. 2007. Selective inhibition of the interaction of C1q with immunoglobulins and the classical pathway of complement activation by steroids and triterpenoids sulfates. Bioorg Med Chem 15: 3489-3498.
10. Chatterjee PK. 2007. Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury: a comprehensive review. Naunyn Schmiedebergs Arch Pharmacol 376: 1-43.
11. Chatterjee PK, Cuzzocrea S, Brown PA et al. 2000. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int 58: 658-673.
12. Chen CF, Tsai SY, Ma MC, Wu MS. 2003. Hypoxic preconditioning enhances renal superoxide dismutase levels in rats. J Physiol 552(Pt 2): 561-569.
13. Fiske CH, Subbarow Y. 1925. The colorimetric determination of phosphorus. J Biol Chem 66: 375-400.
14. Fulda S, Debatin KM. 2000. Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors. Med Pediat Oncol 35: 616-618.
15. Granger DN, Korthuis RJ. 1995. Physiological mechanisms of postischemic tissue injury. Ann Rev Physiol 57: 311-332.
16. Guz G, Demirogullari B, Ulusu NN et al. 2007. Stobadine protects rat kidney against ischaemia/reperfusion injury. Clin Exp Pharmacol Physiol 34: 210-216.
17. Heinzelmann M, Mercer-Jones MA, Passmore JC. 1999. Neutrophils and renal failure. Am J Kidney Dis 34: 384-399.
18. Hillegass LM, Griswold DE, Brickson B, Albrightson-Winslow C. 1990. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Meth 24: 285-295.
19. Kettle AJ, Winterbourn CC. 1997. Myeloperoxidase: A key regulator of neutrophil oxidant production. Redox Rep 3: 3-15.
20. Kim YK, Lee SH, Goldinger JM, Hong SK. 1986. Effect of ethanol on organic ion transport in rabbit kidney. Toxicol Appl Pharmacol 86: 411-420.
21. Lieberthal W, Nigam SK. 2000. Acute renal failure. II. Experimental models of acute renal failure: imperfect but indispensable. Am J Physiol Renal Physiol 278: F1-F12.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurements with the folin phenol reagent. J Biol Chem 193: 265-275.
23. Martinek RG. 1972. A rapid ultraviolent spectrophotomeetric lactic dehydrogenase assay. Clin Chim Acta 40: 91-99.
24. Matsuzaki T, Watanabe H, Yoshitome K et al. 2007. Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute (corrected) renal failure. Kidney Int 71: 539-547.
25. Nguemfo EL, Dimo T, Dongmo AB et al. 2009. Anti-oxidative and anti-inflammatory activities of some isolated constituents from the stem bark of Allanblackia monticola Staner L.C (Guttiferae). Inflammopharmacology 17: 37-41.
26. Nose K. 2000. Role of reactive oxygen species in the regulation of physiological functions. Biol Pharm Bull 23: 897-903.
27. Paller MS. 1994. The cell biology of reperfusion injury in the kidney. J Investig Med 42: 632-639.
28. Parks DA, Granger DN. 1988. Ischemia-reperfusion injury: a radical view. Hepatology 8: 680-682.
29. Pisha E, Chai H, Lee IS et al. 1995. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1: 1046-1051.
30. Reading HW, Isbir T. 1980. The role of cation activated ATPase in transmitter release from the rat iris. Q J Exp Physiol 65: 105-116.
31. Recio MC, Giner RM, Manez S et al. 1995. Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. Planta Med 61: 9-12.
32. Robinson JP. 1993. Handbook of Flow Cytometry Methods. Oxidative Burst. Willey-Liss Inc.: New York, 145-154.
33. Ross D. 1988. Glutathione, free radicals and chemotherapeutic agents. Pharmacol Ther 37: 231-249.
34. Ryu SY, Oak MH, Yoon SK et al. 2000. Anti-allergic and anti-inflammatory triterpenes from herb of Prunella vulgaris. Planta Med 66: 358-360.
35. Schmidt ML, Kuzmanoff KL, Ling-Indeck L, Pezzuto JM. 1997. Betulinic acid induces apoptosis in human neuroblastoma cell lines. Eur J Cancer 33: 2007-2010.
36. Sehirli O, Sener E, Cetinel S et al. 2008. Alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats. Clin Exp Pharmacol Physiol 35: 249-255.
37. Sener G, Sehirli O, Veliogcombining brevelu-Ogcombining breveünç A et al. 2006a. Montelukast protects against renal ischemia/reperfusion injury in rats. Pharmacol Res 54: 65-71.
38. Sener G, Tugcombining brevetepe H, Yüksel M et al. 2006b. Resveratrol improves ischemia/reperfusion-induced oxidative renal injury in rats. Arch Med Res 37: 822-829.
39. Singri N, Ahya SN, Levin ML. 2003. Acute renal failure. JAMA 289: 747-751.
40. Slot C. 1965. Plasma creatinine determination. A new and specific Jaffe reaction method. Scand J Clin Lab Invest 17: 381-387.
41. Stark G. 2005. Functional consequences of oxidative membrane damage. J Membr Biol 205: 1-16.
42. Talke H, Schubert GE. 1965. Enzymatic urea determination in the blood and serum in the Warburg optical test. Klin Wochenschr 43: 174-175.
43. Weight SC, Bell PR, Nicholson ML. 1996. Renal ischaemia - reperfusion injury. Br J Surg 83: 162-170.
44. Werns SW, Lucchesi BR. 1990. Free radical and ischemic tissue injury. Trends Pharmacol Sci 11: 161-166.
45. Willerson JT. 1997. Pharmacological approaches to reperfusion injury. Adv Pharmacol 39: 291-312.