Comparison of the anti-allergic activity of Syk inhibitors with optimized Syk siRNAs in FcεRI-activated RBL-2H3 basophilic cells

Cellular Immunology

Volumn 262, Issue 1, 2010, Pages 28-34

  Sanderson, Michael P ^a   Gelling, Stephen J ^a   Rippmann, Jörg F ^a   Schnapp, Andreas ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Allergy; BAY61 3606; Fc RI; IgE; Inflammation; Piceatannol; R406; RBL 2H3; siRNA; Spleen tyrosine kinase (Syk)

Indexed keywords

ALLERGEN; ANTISENSE OLIGONUCLEOTIDE; BAY 61 306; BAY 61 3606; FC RECEPTOR; HISTAMINE; IMMUNOGLOBULIN E; PICEATANNOL; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; R 406; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL CELL; ARTICLE; BASOPHIL; CELL ACTIVATION; CELL TYPE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EOSINOPHIL; INHIBITION KINETICS; MAST CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN MOTIF; RAT; RECEPTOR UPREGULATION; RNA SEQUENCE; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

ANIMALS; ANTI-ALLERGIC AGENTS; BASOPHILS; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NIACINAMIDE; OXAZINES; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PYRIDINES; PYRIMIDINES; RATS; RECEPTORS, IGE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77349087551     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2009.12.004     Document Type: Article

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