A tolC mutant of Francisella tularensis is hypercytotoxic compared to the wild type and elicits increased proinflammatory responses from host cells

Infection and Immunity

Volumn 78, Issue 3, 2010, Pages 1022-1031

  Platz, Gabrielle J ^a   Bublitz, DeAnna C ^a   Mena, Patricio ^a   Benach, Jorge L ^a   Furie, Martha B ^a   Thanassi, David G ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 8; LACTATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; TOLC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRANCISELLA TULARENSIS; HOST CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MOUSE; NICK END LABELING; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SCANNING ELECTROCHEMICAL MICROSCOPY; TULAREMIA; WILD TYPE;

ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; CELL LINE; COLONY COUNT, MICROBIAL; ENDOTHELIAL CELLS; FRANCISELLA TULARENSIS; GENE DELETION; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIVER; LUNG; MACROPHAGES; MICE; SPLEEN; TULAREMIA; VIRULENCE FACTORS;

EID: 77349085520     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00992-09     Document Type: Article

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