Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia

Neuropsychopharmacology

Volumn 15, Issue 6, 1996, Pages 587-594

  Chambers, R Andrew ^a   Moore, Jonathan ^a   McEvoy, Joseph P ^a   Levin, Edward D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hippocampus; Learning; Lesion; Memory; Neonatal; Radi al arm Maze; Schizophrenia

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; COGNITION; HIPPOCAMPUS; LEARNING; MEMORY; MODEL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA;

EID: 0030561083     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(96)00132-7     Document Type: Article

References (24)

1. Cornblatt BA, Keilp JG (1994): Impaired attention, genetics, and the pathophysiology of schizophrenia. Schiz Bull 20:31-46
2. Duffy L, Ocarroll R (1994): Memory impairment in schizophrenia - A comparison with that observed in the alcoholic Korsakoff syndrome. Psychol Med 24:155-165
3. Freeman JH, Stanton ME (1991): Fimbria-fornix transections disrupt the ontogeny of delayed alternation but not position discrimination in the rat. Behav Neurosci 105: 386-395
4. Jarrard LE (1993): On the role of the hippocampus in learning and memory in the rat. Behav Neural Biol 60:9-26
5. Kim J, Levin E (1996): Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: Effects on spatial working memory in rats. Brain Res 725:231-240
6. Kolb B (1995): Brain Plasticity and Behavior. Mahwah, NJ Erlbaum
7. Kolb B, Sutherland RJ (1992): Noradreneline depletion blocks behavioral sparing and alters cortical morphogenesis after frontal cortex damage in rats. J Neurosci 12:2321-2330
8. Kolb B, Whishaw IQ (1985): Earlier is not always better: Behavioral dysfunction and abnormal cerebral morphogenesis following neonatal cortical lesions in the rat. Behav Brain Res 17:25-43
9. Levin ED (1988): Psychopharmacological effects in the radial-arm maze. Neurosci Biobehav Rev 12:169-175
10. Levin ED (1992): Nicotinic systems and cognitive function. Psychophamacology 108:417-431
11. 2 interactions with nicotinic and muscarinic systems for working memory function. In Levin ED, Decker MW, Butcher LL (eds), Neurotransmitter Interactions and Cognitive Function. Boston, Birkhäuser, pp 144-158
12. Levin ED, Torry D (1995): Nicotine effects on memory performance. In Clarke PBS, Quik M, Thurau K, Adlkofer F (eds), International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II. Boston, Birkhäuser, pp 329-336
13. Levin ED, Torry D (1996): Acute and chronic nicotine effects on working memory in aged rats. Psychopharmacology 123:88-97
14. Lipska BK, Weinberger DR (1983): Delayed effects of neonatal hippocampal damage on haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat. Dev Brain Res 75:213-222
15. Lipska BK, Weinberger DR (1994): Subchronic treatment with haloperidol and clozapine in rats with neonatal excitotoxic hippocampal damage. Neuropsychopharmacology 10:199-205
16. Lipska BK, Jaskiw GE, Weinberger DR (1993): Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia. Neuropsychopharmacology 9:67-75
17. Lipska BK, Chrapsusta SJ, Egan MF, Weinberger DR (1995a): Neonatal excitotoxic ventral hippocampal damage alters dopamine response to mild repeated stress and to chronic haloperidol. Synapse 20:125-130
18. Lipska BK, Swerdlow NR, Geyer MA, Jaskiw GE, Braff DL, Weinberger DR (1995b): Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology in 122:35-43
19. Lohr JB, Flynn K (1992): Smoking and schizophrenia. Schiz Res 8:93-102
20. McGurk SR, Levin ED, Butcher LL (1991): Impairment of radial-arm maze performance in rats following lesions involving the cholinergic medial pathway: Reversal by arecoline and differential effects of muscarinic and nicotinic antagonists. Neuroscience 44:137-147
21. Olton DS, Samuelson RJ (1976): Remembrance of places passed: Spatial memory in rats. J Exp Psychol 2:97-116
22. Olton DS, Walker JA, Gage FH (1978): Hippocampal connections and spatial discrimination. Brain Res 139:295-308
23. Pelligrino LJ, Pelligrino AS, Cushman AJ (1979): A Stereotaxic Atlas of the Rat Brain. New York, Plenum
24. Tandon R, Greden JF (1989): Cholinergic hyperactivity and negative schizophrenic systems. Arch Gen Psychiatr 46: 745-753