Role of IgA and IgA Fc receptors in inflammation

Journal of Clinical Immunology

Volumn 30, Issue 1, 2010, Pages 1-9

  Monteiro, Renato C ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Celiac disease; Fc receptor; IgA; IgA nephropathy; Immunotherapy; Inflammation

Indexed keywords

ANTIINFLAMMATORY AGENT; CD71 ANTIGEN; FC ALPHA RECEPTOR I; FC ALPHA RECEPTOR I ANTIBODY; FC RECEPTOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; BLOOD SAMPLING; CYTOKINE PRODUCTION; DOWN REGULATION; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNE RESPONSE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; ANTIGENS, CD; HUMANS; IMMUNE COMPLEX DISEASES; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOTHERAPY; INFLAMMATION; MICE; RECEPTOR AGGREGATION; RECEPTORS, FC; RECEPTORS, TRANSFERRIN; SIGNAL TRANSDUCTION;

EID: 77249170729     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-009-9338-0     Document Type: Review

References (62)

1. MA Kerr 1990 The structure and function of human IgA Biochem J 271 285 296 2241915 1:CAS:528:DyaK3cXlvV2htrw%3D
2. A Solomon 1980 Monoclonal immunoglobulins as biomarkers of cancer Cancer Markers 1 57 87
3. A Phalipon B Corthesy 2003 Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins Trends Immunol 24 55 58 10.1016/S1471-4906(02)00031-5 12547499 1:CAS:528:DC%2BD3sXltVGqsw%3D%3D (Pubitemid 36120638)
4. MK Boehm JM Woof MA Kerr SJ Perkins 1999 The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling J Mol Biol 286 1421 1447 10.1006/jmbi.1998.2556 10064707 1:CAS:528:DyaK1MXhsVClurw%3D (Pubitemid 29121726)
5. JM Woof MA Kerr 2006 The function of immunoglobulin A in immunity J Pathol 208 270 282 10.1002/path.1877 16362985 1:CAS:528:DC%2BD28XhsFKjsr0%3D (Pubitemid 43126119)
6. RC Monteiro JG Van De Winkel 2003 IgA Fc receptors Annu Rev Immunol 21 177 204 10.1146/annurev.immunol.21.120601.141011 12524384 1:CAS:528: DC%2BD3sXjtF2isr8%3D (Pubitemid 37174530)
7. J Mestecky M Tomana Z Moldoveanu BA Julian H Suzuki K Matousovic, et al. 2008 Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy Kidney Blood Press Res 31 29 37 10.1159/000112922 18182777 1:CAS:528:DC%2BD1cXisVeqsbo%3D (Pubitemid 351310031)
8. AJ Macpherson KD McCoy FE Johansen P Brandtzaeg 2008 The immune geography of IgA induction and function Mucosal Immunol 1 11 22 10.1038/mi.2007.6 19079156 1:CAS:528:DC%2BD1cXhtlWgsQ%3D%3D
9. DE Van Epps RC Williams Jr 1976 Suppression of leukocyte chemotaxis by human IgA myeloma components J Exp Med 144 1227 1242 10.1084/jem.144.5.1227 825608
10. DE Van Epps K Reed RC Williams Jr 1978 Suppression of human PMN bactericidal activity by human IgA paraproteins Cell Immunol 36 363 376 10.1016/0008-8749(78)90280-0 343924 (Pubitemid 8315518)
11. JM Wilton 1978 Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leucocytes Clin Exp Immunol 34 423 428 369752 1:CAS:528:DyaE1MXhtF2ls7k%3D
12. HM Wolf MB Fischer H Puhringer A Samstag E Vogel MM Eibl 1994 Human serum IgA downregulates the release of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6) in human monocytes Blood 83 1278 1288 8118031 1:CAS:528:DyaK2cXitFCrtr8%3D
13. EB Nikolova MW Russell 1995 Dual function of human IgA antibodies: inhibition of phagocytosis in circulating neutrophils and enhancement of responses in IL-8-stimulated cells J Leukoc Biol 57 875 882 7790770 1:CAS:528:DyaK2MXmsFyqtr4%3D
14. HM Wolf I Hauber H Gulle A Samstag MB Fischer RU Ahmad, et al. 1996 Anti-inflammatory properties of human serum IgA: induction of IL-1 receptor antagonist and Fc alpha R (CD89)-mediated down-regulation of tumour necrosis factor-alpha (TNF-alpha) and IL-6 in human monocytes Clin Exp Immunol 105 537 543 10.1046/j.1365-2249.1996.d01-793.x 8809146 1:CAS:528:DyaK28XmtFWhtLo%3D
15. K Olas H Butterweck W Teschner HP Schwarz B Reipert 2005 Immunomodulatory properties of human serum immunoglobulin A: anti-inflammatory and pro-inflammatory activities in human monocytes and peripheral blood mononuclear cells Clin Exp Immunol 140 478 490 10.1111/j.1365-2249.2005.02779.x 15932509 1:CAS:528:DC%2BD2MXlvFOisb4%3D (Pubitemid 40813958)
16. CM Jacob AC Pastorino K Fahl M Carneiro-Sampaio RC Monteiro 2008 Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper J Clin Immunol 28 Suppl 1 S56 S61 10.1007/s10875-007-9163-2 18202833 1:CAS:528:DC%2BD1cXptFyqs7Y%3D
17. BD Wines CT Sardjono HH Trist CS Lay PM Hogarth 2001 The interaction of Fc alpha RI with IgA and its implications for ligand binding by immunoreceptors of the leukocyte receptor cluster J Immunol 166 1781 1789 11160224 1:CAS:528:DC%2BD3MXhtVSju7c%3D
18. DA Lawrence WO Weigle HL Spiegelberg 1975 Immunoglobulins cytophilic for human lymphocytes, monocytes and neutrophils J Clin Invest 55 368 372 10.1172/JCI107940 1127105 1:CAS:528:DyaE2MXps1eltg%3D%3D
19. B Grossetete P Launay A Lehuen P Jungers JF Bach RC Monteiro 1998 Down-regulation of Fc alpha receptors on blood cells of IgA nephropathy patients: evidence for a negative regulatory role of serum IgA Kidney Int 53 1321 1335 10.1046/j.1523-1755.1998.00885.x 9573548 1:CAS:528:DyaK1cXjtV2hs74%3D (Pubitemid 28316894)
20. B Pasquier P Launay Y Kanamaru IC Moura S Pfirsch C Ruffie, et al. 2005 Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM Immunity 22 31 42 15664157 1:CAS:528:DC%2BD2MXht1CgsLk%3D
21. P Launay C Patry A Lehuen B Pasquier U Blank RC Monteiro 1999 Alternative endocytic pathway for immunoglobulin A Fc receptors (CD89) depends on the lack of FcRgamma association and protects against degradation of bound ligand J Biol Chem 274 7216 7225 10.1074/jbc.274.11.7216 10066783 1:CAS:528:DyaK1MXhvFWqtrc%3D (Pubitemid 29140537)
22. AB Herr ER Ballister PJ Bjorkman 2003 Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc Nature 423 614 620 10.1038/nature01685 12768205 1:CAS:528: DC%2BD3sXkt1yrsrg%3D (Pubitemid 36713216)
23. RS Davis G Dennis Jr MR Odom AW Gibson RP Kimberly PD Burrows, et al. 2002 Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family Immunol Rev 190 123 136 10.1034/j.1600-065X.2002.19009.x 12493010 1:CAS:528:DC%2BD3sXnt12ktg%3D%3D (Pubitemid 36071930)
24. Blank U, Launay P, Benhamou M, Monteiro RC. Inhibitory ITAMs as novel regulators of immunity. Immunol Rev. 2009;232.
25. P Launay A Lehuen T Kawakami U Blank RC Monteiro 1998 IgA Fc receptor (CD89) activation enables coupling to syk and Btk tyrosine kinase pathways: differential signaling after IFN-gamma or phorbol ester stimulation J Leukoc Biol 63 636 642 9581809 1:CAS:528:DyaK1cXislaqs7g%3D
26. Y Kanamaru M Arcos-Fajardo IC Moura T Tsuge H Cohen M Essig, et al. 2007 Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor Eur J Immunol 37 1116 1128 10.1002/eji.200636826 17393381 1:CAS:528:DC%2BD2sXkvVSgsbs%3D (Pubitemid 46925347)
27. Y Kanamaru S Pfirsch M Aloulou F Vrtovsnik M Essig C Loirat, et al. 2008 Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation J Immunol 180 2669 2678 18250479 1:CAS:528:DC%2BD1cXhsVSgsLo%3D
28. RC Monteiro RW Hostoffer MD Cooper JR Bonner GL Gartland H Kubagawa 1993 Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals J Clin Invest 92 1681 1685 10.1172/JCI116754 8408621 1:CAS:528:DyaK2cXmsVOm
29. M Chiamolera P Launay V Montenegro MC Rivero IT Velasco RC Monteiro 2001 Enhanced expression of Fc alpha receptor I on blood phagocytes of patients with Gram-negative bacteremia is associated with tyrosine phosphorylation of the FcR-gamma subunit Shock 16 344 348 10.1097/00024382-200116050-00004 11699071 1:STN:280:DC%2BD3MnkslClug%3D%3D
30. DL Delacroix KB Elkom AP Geubel HF Hodgson C Dive JP Vaerman 1983 Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A J Clin Invest 71 358 367 10.1172/JCI110777 6401770 1:STN:280:DyaL3s7gvFKmuw%3D%3D
31. V Montenegro RC Monteiro 1999 Elevation of serum IgA in spondyloarthropathies and IgA nephropathy and its pathogenic role Curr Opin Rheumatol 11 265 272 10.1097/00002281-199907000-00007 10411380 1:CAS:528:DyaK1MXksFalurY%3D (Pubitemid 29383856)
32. RC Monteiro L Halbwachs-Mecarelli MC Roque-Barreira LH Noel J Berger P Lesavre 1985 Charge and size of mesangial IgA in IgA nephropathy Kidney Int 28 666 671 10.1038/ki.1985.181 3910914 1:CAS:528:DyaL28XksFCg
33. A Almogren MA Kerr 2008 Irreversible aggregation of the Fc fragment derived from polymeric but not monomeric serum IgA1-implications in IgA-mediated disease Mol Immunol 45 87 94 10.1016/j.molimm.2007.05.002 17606293 1:CAS:528:DC%2BD2sXpsl2hsbg%3D (Pubitemid 47331651)
34. AC Allen EM Bailey PE Brenchley KS Buck J Barratt J Feehally 2001 Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients Kidney Int 60 969 973 10.1046/j.1523-1755.2001. 060003969.x 11532091 1:CAS:528:DC%2BD3MXmvFKjt7Y%3D (Pubitemid 34205796)
35. J Novak BA Julian M Tomana J Mestecky 2008 IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy Semin Nephrol 28 78 87 10.1016/j.semnephrol.2007.10.009 18222349 1:CAS:528:DC%2BD1cXisFClsLc%3D
36. M Tomana J Novak BA Julian K Matousovic K Konecny J Mestecky 1999 Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies J Clin Invest 104 73 81 10.1172/JCI5535 10393701 1:CAS:528:DyaK1MXktlOgsLc%3D
37. H Suzuki Z Moldoveanu S Hall R Brown HL Vu L Novak, et al. 2008 IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1 J Clin Invest 118 629 639 18172551 1:CAS:528: DC%2BD1cXhsFOmsrc%3D
38. T Kokubo Y Hiki H Iwase A Horii A Tanaka J Nishikido, et al. 1997 Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA1 interaction in IgA nephropathy J Am Soc Nephrol 8 915 919 9189858 1:CAS:528: DyaK2sXktVWrtr0%3D
39. B Grossetete JP Viard A Lehuen JF Bach RC Monteiro 1995 Impaired Fc alpha receptor expression is linked to increased immunoglobulin A levels and disease progression in HIV-1-infected patients Aids 9 229 234 7755910 1:STN:280:DyaK2M3nsFCmtA%3D%3D
40. C Silvain C Patry P Launay A Lehuen RC Monteiro 1995 Altered expression of monocyte IgA Fc receptors is associated with defective endocytosis in patients with alcoholic cirrhosis. Potential role for IFN-gamma J Immunol 155 1606 1618 7636220 1:CAS:528:DyaK2MXntFWmsb8%3D
41. V Montenegro M Chiamolera P Launay CR Goncalves RC Monteiro 2000 Impaired expression of IgA Fc receptors (CD89) by blood phagocytic cells in ankylosing spondylitis J Rheumatol 27 411 417 10685807 1:CAS:528:DC%2BD3cXht1amsb4%3D
42. P Launay B Grossetete M Arcos-Fajardo E Gaudin SP Torres L Beaudoin, et al. 2000 Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice J Exp Med 191 1999 2009 10.1084/jem.191.11.1999 10839814 1:CAS:528:DC%2BD3cXjvFyntbg%3D (published erratum appears in J Exp Med 2000 Jul 17;192(2):following 309) (Pubitemid 30390361)
43. J Novak BA Julian M Tomana J Mestecky 2001 Progress in molecular and genetic studies of IgA nephropathy J Clin Immunol 21 310 327 10.1023/A:1012284402054 11720004 1:CAS:528:DC%2BD3MXovFSjurY%3D (Pubitemid 33015802)
44. PJ van der Boog G van Zandbergen JW de Fijter N Klar-Mohamad A van Seggelen P Brandtzaeg, et al. 2002 Fc alpha RI/CD89 circulates in human serum covalently linked to IgA in a polymeric state J Immunol 168 1252 1258 11801662
45. G van Zandbergen R Westerhuis NK Mohamad JG van De Winkel MR Daha C van Kooten 1999 Crosslinking of the human Fc receptor for IgA (FcalphaRI/CD89) triggers FcR gamma-chain-dependent shedding of soluble CD89 J Immunol 163 5806 5812 10570263
46. RJ Pleass JI Dunlop CM Anderson JM Woof 1999 Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89 J Biol Chem 274 23508 23514 10.1074/jbc.274.33.23508 10438530 1:CAS:528:DyaK1MXltlKnu7Y%3D (Pubitemid 29388107)
47. PJ van der Boog C van Kooten G van Zandbergen N Klar-Mohamad B Oortwijn NA Bos, et al. 2004 Injection of recombinant FcalphaRI/CD89 in mice does not induce mesangial IgA deposition Nephrol Dial Transplant 19 2729 2736 10.1093/ndt/gfh459 15340093 1:CAS:528:DC%2BD2cXovVOitrg%3D (Pubitemid 39480965)
48. M van Egmond E van Garderen AB van Spriel CA Damen ES van Amersfoort G van Zandbergen, et al. 2000 FcalphaRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity Nat Med 6 680 685 10.1038/76261 10835685 (Pubitemid 30398792)
49. F Geissmann P Launay B Pasquier Y Lepelletier M Leborgne A Lehuen, et al. 2001 A subset of human dendritic cells expresses IgA Fc receptor (CD89), which mediates internalization and activation upon cross-linking by IgA complexes J Immunol 166 346 352 11123311 1:CAS:528:DC%2BD3MXis1eiug%3D%3D
50. TJ Reterink EW Levarht N Klar-Mohamad LA Van Es MR Daha 1996 Transforming growth factor-beta 1 (TGF-beta 1) down-regulates IgA Fc- receptor (CD89) expression on human monocytes Clin Exp Immunol 103 161 166 10.1046/j.1365-2249. 1996.00918.x 8565277 1:CAS:528:DyaK28Xhtl2ks7g%3D
51. HC Heystek C Moulon AM Woltman P Garonne C van Kooten 2002 Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation J Immunol 168 102 107 11751952 1:CAS:528: DC%2BD38Xht1GhtQ%3D%3D
52. A Bonner A Almogren PB Furtado MA Kerr SJ Perkins 2009 The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses J Biol Chem 284 5077 5087 10.1074/jbc.M807529200 19109255 1:CAS:528:DC%2BD1MXhvVSnsbs%3D
53. RL Mazengera MA Kerr 1990 The specificity of the IgA receptor purified from human neutrophils Biochem J 272 159 165 2264821 1:CAS:528: DyaK3cXmt12htro%3D
54. RC Monteiro IC Moura P Launay T Tsuge E Haddad M Benhamou, et al. 2002 Pathogenic significance of IgA receptor interactions in IgA nephropathy Trends Mol Med 8 464 10.1016/S1471-4914(02)02405-X 12383768 1:CAS:528: DC%2BD38XnsF2lsr0%3D
55. IC Moura MN Centelles M Arcos-Fajardo DM Malheiros JF Collawn MD Cooper, et al. 2001 Identification of the transferrin receptor as a novel immunoglobulin (Ig)A1 receptor and its enhanced expression on mesangial cells in IgA nephropathy J Exp Med 194 417 425 10.1084/jem.194.4.417 11514599 1:CAS:528:DC%2BD3MXmt1egtbg%3D (Pubitemid 32835038)
56. IC Moura M Arcos-Fajardo C Sadaka V Leroy M Benhamou J Novak, et al. 2004 Glycosylation and size of IgA1 are essential for interaction with mesangial transferrin receptor in IgA nephropathy J Am Soc Nephrol 15 622 634 10.1097/01.ASN.0000115401.07980.0C 14978164 1:CAS:528:DC%2BD2cXhtlShurY%3D (Pubitemid 38294792)
57. IC Moura M Arcos-Fajardo A Gdoura V Leroy C Sadaka N Mahlaoui, et al. 2005 Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy J Am Soc Nephrol 16 2667 2676 10.1681/ASN.2004111006 15987753 1:CAS:528:DC%2BD2MXhtFeisLrI
58. T Matysiak-Budnik IC Moura M Arcos-Fajardo C Lebreton S Menard C Candalh, et al. 2008 Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease J Exp Med 205 143 154 10.1084/jem.20071204 18166587 1:CAS:528:DC%2BD1cXht1yktLw%3D (Pubitemid 351185722)
59. P Imbach S Barandun V d'Apuzzo C Baumgartner A Hirt A Morell, et al. 1981 High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood Lancet 1 1228 1231 10.1016/S0140-6736(81)92400-4 6112565 1:STN:280:DyaL3M7ps1Cjtw%3D%3D
60. J Fehr V Hofmann U Kappeler 1982 Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gamma globulin N Engl J Med 306 1254 1258 6803159 1:STN:280:DyaL387ntlSltQ%3D%3D
61. R Clynes 2007 Protective mechanisms of IVIG Curr Opin Immunol 19 646 651 10.1016/j.coi.2007.09.004 18032008 1:CAS:528:DC%2BD2sXhsVCksb%2FN (Pubitemid 350236813)
62. F Nimmerjahn JV Ravetch 2008 Anti-inflammatory actions of intravenous immunoglobulin Annu Rev Immunol 26 513 533 10.1146/annurev.immunol.26.021607. 090232 18370923 1:CAS:528:DC%2BD1cXltlWktr0%3D (Pubitemid 351600384)