A contradictory role of A1 adenosine receptor in carbon tetrachloride- and bile duct ligation-induced liver fibrosis in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 3, 2010, Pages 747-754

  Yang, Ping ^a   Han, Zheyi ^b   Chen, Peng ^a   Zhu, Lin ^c   Wang, Shiming ^a   Hua, Zichun ^d   Zhang, Jianfa ^a  

^a NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c JINLING HOSPITAL   (China)

^d NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR; BILE ACID; CARBON TETRACHLORIDE; COLLAGEN; CYTOCHROME P450 2E1; CYTOKINE; ION CHANNEL; METALLOPROTEINASE; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BILE DUCT LIGATION; CELL ACTIVATION; CELL DAMAGE; CONTROLLED STUDY; FIBROGENESIS; GENE EXPRESSION; LIVER CELL; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; ANIMAL; BILE DUCT; BIOSYNTHESIS; BLOOD; CHRONIC DISEASE; DOWN REGULATION; DRUG EFFECT; GENETICS; INTOXICATION; LIGATION; LIVER; LIVER CIRRHOSIS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BILE ACIDS AND SALTS; BILE DUCTS; CARBON TETRACHLORIDE POISONING; CHRONIC DISEASE; COLLAGEN; CYTOCHROME P-450 CYP2E1; CYTOKINES; DOWN-REGULATION; ION CHANNELS; LIGATION; LIVER; LIVER CIRRHOSIS; MALE; METALLOPROTEASES; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; RECEPTOR, ADENOSINE A1; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 77249154239     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.162727     Document Type: Article

References (36)

1. Andrade CM, Roesch GC, Wink MR, Guimarães EL, Souza LF, Jardim FR, Guaragna RM, Bernard EA, Margis R, Borojevic R, Battastini AM, and Guma FC (2008) Activity and expression of ecto-5′-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line. Life Sci 82:21-29.
2. 4-induced hepatotoxicity in Cyp2e1-null mice. Toxicology 228:310-322.
3. Bataller R and Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209-218.
4. Boison D, Scheurer L, Zumsteg V, Rülicke T, Litynski P, Fowler B, Brandner S, and Mohler H (2002) Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc Natl Acad Sci U S A 99:6985-6990.
5. Brown R, Ollerstam A, Johansson B, Skøtt O, Gebre-Medhin S, Fredholm B, and Persson AE (2001) Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol 281:R1362-R1367.
6. 2A receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol 148:1144-1155.
7. Demori I, Burlando B, Gerdoni E, Lanni A, Fugassa E, and Voci A (2008) Uncoupling protein-2 induction in rat hepatocytes after acute carbon tetrachloride liver injury. J Cell Physiol 216:413-418.
8. Ely SW and Berne RM (1992) Protective effects of adenosine in myocardial ischemia. Circulation 85:893-904.
9. Fishman P, Bar-Yehuda S, Madi L, and Cohn I (2002) A3 adenosine receptor as a target for cancer therapy. Anticancer Drugs 13:437-443.
10. Fishman P, Bar-Yehuda S, and Vagman L (1998) Adenosine and other low molecular weight factors released by muscle cells inhibit tumor cell growth. Cancer Res 58:3181-3187.
11. Guo Y, Bolli R, Bao W, Wu WJ, Black RG Jr, Murphree SS, Salvatore CA, Jacobson MA, and Auchampach JA (2001) Targeted deletion of the A3 adenosine receptor confers resistance to myocardial ischemic injury and does not prevent early preconditioning. J Mol Cell Cardiol 33:825-830.
12. Hashmi AZ, Hakim W, Kruglov EA, Watanabe A, Watkins W, Dranoff JA, and Mehal WZ (2007) Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 292:G395-G401.
13. 4-induced cirrhosis: protective role of adenosine administration. Hepatology 26:1100-1110.
14. Johansson B, Halldner L, Dunwiddie TV, Masino SA, Poelchen W, Giménez-Llort L, Escorihuela RM, Fernández-Teruel A, Wiesenfeld-Hallin Z, Xu XJ, Hårdemark A, Betsholtz C, Herlenius E, and Fredholm BB (2001) Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A 98:9407-9412.
15. Kasahara A, Hayashi N, Mochizuki K, Oshita M, Katayama K, Kato M, Masuzawa M, Yoshihara H, Naito M, Miyamoto T, Inoue A, Asai A, Hijioka T, Fusamoto H, and Kamada T (1997) Circulating matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 as serum markers of fibrosis in patients with chronic hepatitis C. Relationship to interferon response. J Hepatol 26:574-583.
16. Kim J, Kim M, Song JH, and Lee HT (2008) Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice. Liver Transpl 14:845-854.
17. Lee HT, Gallos G, Nasr SH, and Emala CW (2004) A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in mice. J Am Soc Nephrol 15:102-111.
18. MacLaughlin M, Martinez-Salgado C, Eleno N, Olivera A, and Lopez-Novoa JM (1997) Adenosine activates mesangial cell proliferation. Cell Signal 9:59-63.
19. Matherne GP, Linden J, Byford AM, Gauthier NS, and Headrick JP (1997) Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia. Proc Natl Acad Sci U S A 94:6541-6546.
20. Merighi S, Mirandola P, Milani D, Varani K, Gessi S, Klotz KN, Leung E, Baraldi PG, and Borea PA (2002) Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells. J Invest Dermatol 119:923-933.
21. Migchielsen AA, Breuer ML, van Roon MA, te Riele H, Zurcher C, Ossendorp F, Toutain S, Hershfield MS, Berns A, and Valerio D (1995) Adenosine-deaminase- deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. Nat Genet 10:279-287.
22. Miyoshi H, Rust C, Roberts PJ, Burgart LJ, and Gores GJ (1999) Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas. Gastroenterology 117:669-677.
23. Ohta A and Sitkovsky M (2001) Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414: 916-920.
24. Peng Z, Borea PA, Varani K, Wilder T, Yee H, Chiriboga L, Blackburn MR, Azzena G, Resta G, and Cronstein BN (2009) Adenosine signaling contributes to ethanol-induced fatty liver in mice. J Clin Invest 119:582-594.
25. Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan ES, and Cronstein BN (2008) Ecto-5′-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis. FASEB J 22:2263-2272.
26. Porkka-Heiskanen T, Alanko L, Kalinchuk A, and Stenberg D (2002) Adenosine and sleep. Sleep Med Rev 6:321-332.
27. Ralevic V and Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50:413-492.
28. Reichelt ME, Willems L, Molina JG, Sun CX, Noble JC, Ashton KJ, Schnermann J, Blackburn MR, and Headrick JP (2005) Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance. Circ Res 96:363-367.
29. Shen WK and Kurachi Y (1995) Mechanisms of adenosine-mediated actions on cellular and clinical cardiac electrophysiology. Mayo Clin Proc 70:274-291.
30. Stenberg D, Litonius E, Halldner L, Johansson B, Fredholm BB, and Porkka-Heiskanen T (2003) Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor. J Sleep Res 12:283-290.
31. Sweeney MI (1997) Neuroprotective effects of adenosine in cerebral ischemia: window of opportunity. Neurosci Biobehav Rev 21:207-217.
32. Taïeb D, Malicet C, Garcia S, Rocchi P, Arnaud C, Dagorn JC, Iovanna JL, and Vasseur S (2005) Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity. Hepatology 42: 176-182.
33. Trauner M, Fickert P, Halilbasic E, and Moustafa T (2008) Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases. Wien Med Wochenschr 158:542-548.
34. Weber LW, Boll M, and Stampfl A (2003) Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 33: 105-136.
35. Wong FW, Chan WY, and Lee SS (1998) Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol Appl Pharmacol 153:109-118.
36. Zollner G, Marschall HU, Wagner M, and TraunerM(2006) Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharm 3:231-251.