Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity

Hepatology

Volumn 42, Issue 1, 2005, Pages 176-182

  Taïeb, David ^a   Malicet, Cédric ^a   Garcia, Stéphane ^a   Rocchi, Palma ^a   Arnaud, Christiane ^a   Dagorn, Jean Charles ^a   Iovanna, Juan L ^a   Vasseur, Sophie ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CYTOCHROME P450 2E1; HEAT SHOCK PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; ENZYME INACTIVATION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE OVEREXPRESSION; LIVER TOXICITY; MOUSE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; STRESS; WILD TYPE;

ANIMALS; CARBON TETRACHLORIDE; CYTOCHROME P-450 CYP2E1; DNA-BINDING PROTEINS; DOWN-REGULATION; HEAT-SHOCK PROTEINS; HEPATITIS, TOXIC; MICE; MODELS, ANIMAL; NEOPLASM PROTEINS;

EID: 21344433221     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20759     Document Type: Article

References (27)

1. Mallo GV, Fiedler F, Calvo EL, Ortiz EM, Vasseur S, Keim V, et al. Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. J Biol Chem 1997;272:32360-32369.
2. Jiang YF, Vaccaro MI, Fiedler F, Calvo EL, Iovanna JL. Lipopolysaccharides induce p8 mRNA expression in vivo and in vitro. Biochem Biophys Res Commun 1999;260:686-690.
3. Garcia-Montero A, Vasseur S, Mallo GV, Soubeyran P, Dagorn JC, Iovanna JL. Expression of the stress-induced p8 mRNA is transiently activated after culture medium change. Eur J Cell Biol 2001;80:720-725.
4. Vasseur S, Mallo GV, Fiedler F, Bodeker H, Canepa E, Moreno S, et al. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. Eur J Biochem 1999;259:670-675.
5. Vasseur S, Hoffmeister A, Garcia-Montero A, Mallo GV, Feil R, Kuhbandner S, et al. p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis. Oncogene J 2002;21:1685-1694.
6. Bratland A, Risberg K, Maelandsmo GM, Gutzkow KB, Olsen OE, Moghaddam A, et al. Expression of a novel factor, com1, is regulated by 1,25-dihydroxyvitamin D3 in breast cancer cells. Cancer Res 2000;60: 5578-5583.
7. Garcia-Montero AC, Vasseur S, Giono LE, Canepa E, Moreno S, Dagorn JC, et al. Transforming growth factor beta-1 enhances Smad transcriptional activity through activation of p8 gene expression. Biochem J 2001; 357(Pt 1):249-253.
8. Vasseur S, Hoffmeister A, Garcia S, Bagnis C, Dagorn JC, Iovanna JL. p8 is critical for tumour development induced by rasV12 mutated protein and E1A oncogene. EMBO Rep 2002;3:165-170.
9. Encinar JA, Mallo GV, Mizyrycki C, Giono L, Gonzalez-Ros JM, Rico M, et al. Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation. J Biol Chem 2001;276:2742-2751.
10. Grosschedl R, Giese K, Pagel J. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet 1994; 10:94-100.
11. Reeves R, Nissen MS. Cell cycle regulation and functions of HMG-I(Y). Prog Cell Cycle Res 1995;1:339-349.
12. Bewley CA, Gronenborn AM, Clore GM. Minor groove-binding architectural proteins: structure, function, and DNA recognition. Annu Rev Biophys Biomol Struct 1998;27:105-131.
13. Tallini G, Dal Cin P. HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors. Adv Anat Pathol 1999;6:237-246.
14. Hoffmeister A, Ropolo A, Vasseur S, Mallo GV, Bodeker H, Ritz-Laser B, et al. The HMG-I/Y-related protein p8 binds to p300 and Pax2 transactivation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. J Biol Chem 2002;277:22314-22319.
15. Vasseur S, Hoffmeister A, Garcia-Montero A, Barthet M, Saint-Michel L, Berthezene P, et al. Mice with targeted disruption of p8 gene show increased sensitivity to lipopolysaccharide and DNA microarray analysis of livers reveals an aberrant gene expression response. BMC Gastroenterol 2003;3:25.
16. Czaja MJ. Liver regeneration following hepatic injury. In: Strain A, Diehl A, eds. Liver Growth and Repair. London: Chapman and Hall, 1998:28-49.
17. McCay PB, Lai EK, Poyer JL, DuBose CM, Janzen EG. Oxygen- and carbon-centered free radical formation during carbon tetrachloride metabolism. Observation of lipid radicals in vivo and in vitro. J Biol Chem 1984;259:2135-2143.
18. Williams AT, Burke RF. Carbon tetrachloride hepatotoxicity: an example of free radical-mediated injury. Semin Liver Dis 1990;10:279-284.
19. Fung KM, Messing A, Lee VM, Trojanowski JQ. A novel modification of the avidin-biotin complex method for immunohistochemical studies of transgenic mice with murine monoclonal antibodies. J Histochem Cytochem 1992;40:1319-1328.
20. Recknagel RO, Glende EA Jr, Dolak JA, Waller RL. Liver cell calcium homeostasis in carbon tetrachloride liver cell injury: new data with fura2. Pharmacol Ther 1989;43:139-154.
21. Wong FW, Chan WY, Lee SS. Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. Toxicol Appl Pharmacol 1998;15:109-118.
22. Hasumura Y, Teschke R, Lieber CS. Increased carbon tetrachloride hepatotoxicity, and its mechanism, after chronic ethanol consumption. Gastroenterology 1974;66:415-422.
23. Wang PY, Kaneko T, Tsukada H, Nakano M, Sato A. Dose- and route-dependent alterations in metabolism and toxicity of chemical compounds in ethanol-treated rats: difference between highly (chloroform) and poorly (carbon tetrachloride) metabolized hepatotoxic compounds. Toxicol Appl Pharmacol 1997;142:13-21.
24. Tsutsumi M, Lasker JM, Shimizu M, Rosman AS, Lieber CS. The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver. HEPATOLOGY 1989;10:437-446.
25. Roberts BJ, Song BJ, Soh Y, Park SS, Shoaf SE. Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. J Biol Chem 1995;270:29632-29635.
26. Vasseur S, Folch-Puy E, Hlouschek V, Garcia S, Fiedler F, Lerch MM, et al. p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I. J Biol Chem 2004;279:7199-7207.
27. Lewis DF, Lake BG, Dickins M. Substrates of human cytochromes P450 from families CYP1 and CYP2: analysis of enzyme selectivity and metabolism. Drug Metabol Drug Interact 2004;20:111-142.