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Volumn 8, Issue 2, 2010, Pages 216-222

Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; PROTEIN P53; PUMA PROTEIN; SERINE;

EID: 77249148005     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-09-0324     Document Type: Article
Times cited : (13)

References (36)
  • 1
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL, Levine AJ. The p53 pathway: positive and negative feedback loops. Oncogene 2005;24:2899-908.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 2
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 3
    • 0035751937 scopus 로고    scopus 로고
    • Assessing TP53 status in human tumours to evaluate clinical outcome
    • Soussi T, Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer 2001;1:233-40.
    • (2001) Nat Rev Cancer , vol.1 , pp. 233-240
    • Soussi, T.1    Beroud, C.2
  • 5
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia AJ, Kastan MB. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 1998;12:2973-83.
    • (1998) Genes Dev , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 6
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001;268: 2764-72.
    • (2001) Eur J Biochem , vol.268 , pp. 2764-2772
    • Appella, E.1    Anderson, C.W.2
  • 7
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • Banin S, Moyal L, Shieh S, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998;281:1674-7.
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1    Moyal, L.2    Shieh, S.3
  • 8
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman CE, Lim DS, Cimprich KA, et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998; 281:1677-9.
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1    Lim, D.S.2    Cimprich, K.A.3
  • 9
    • 0034710870 scopus 로고    scopus 로고
    • Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
    • Chao C, Saito S, Anderson CW, Appella E, Xu Y. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A 2000;97:11936-41.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11936-11941
    • Chao, C.1    Saito, S.2    Anderson, C.W.3    Appella, E.4    Xu, Y.5
  • 10
    • 0000303499 scopus 로고    scopus 로고
    • ATM associates with and phosphorylates p53: Mapping the region of interaction
    • Khanna KK, Keating KE, Kozlov S, et al. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet 1998;20:398-400.
    • (1998) Nat Genet , vol.20 , pp. 398-400
    • Khanna, K.K.1    Keating, K.E.2    Kozlov, S.3
  • 12
    • 0032962641 scopus 로고    scopus 로고
    • Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks
    • Nakagawa K, Taya Y, Tamai K, Yamaizumi M. Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks. Mol Cell Bio 1999;19:2828-34.
    • (1999) Mol Cell Bio , vol.19 , pp. 2828-2834
    • Nakagawa, K.1    Taya, Y.2    Tamai, K.3    Yamaizumi, M.4
  • 13
    • 1642458412 scopus 로고    scopus 로고
    • Phosphorylation of serine 18 regulates distinct p53 functions in mice
    • Sluss HK, Armata H, Gallant J, Jones SN. Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol 2004;24: 976-84.
    • (2004) Mol Cell Biol , vol.24 , pp. 976-984
    • Sluss, H.K.1    Armata, H.2    Gallant, J.3    Jones, S.N.4
  • 14
    • 37549003174 scopus 로고    scopus 로고
    • The ataxia telangiectasiamutated target site Ser18 is required for p53-mediated tumor suppression
    • Armata HL, Garlick DS, Sluss HK, Jones SN. The ataxia telangiectasiamutated target site Ser18 is required for p53-mediated tumor suppression. Cancer Res 2007;67:11696-703.
    • (2007) Cancer Res , vol.67 , pp. 11696-11703
    • Armata, H.L.1    Garlick, D.S.2    Sluss, H.K.3    Jones, S.N.4
  • 15
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-21.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 17
    • 0030463947 scopus 로고    scopus 로고
    • The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2
    • Jones SN, Sands AT, Hancock AR, et al. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A 1996; 93:14106-11.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14106-14111
    • Jones, S.N.1    Sands, A.T.2    Hancock, A.R.3
  • 18
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 1996;10:2411-22.
    • (1996) Genes Dev , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 19
    • 0029848286 scopus 로고    scopus 로고
    • Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
    • Elson A, Wang Y, Daugherty CJ, Morton CC, et al. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A 1996;93:13084-9.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13084-13089
    • Elson, A.1    Wang, Y.2    Daugherty, C.J.3    Morton, C.C.4
  • 20
    • 15844426692 scopus 로고    scopus 로고
    • Atm-deficient mice: A paradigm of ataxia telangiectasia
    • Barlow C, Hirotsune S, Paylor R, et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 1996;86:159-71.
    • (1996) Cell , vol.86 , pp. 159-171
    • Barlow, C.1    Hirotsune, S.2    Paylor, R.3
  • 21
    • 0022380768 scopus 로고
    • The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • Adams JM, Harris AW, Pinkert CA, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985;318:533-8.
    • (1985) Nature , vol.318 , pp. 533-538
    • Adams, J.M.1    Harris, A.W.2    Pinkert, C.A.3
  • 22
    • 0033569422 scopus 로고    scopus 로고
    • Disruption of the ARF-Mdm2-53 tumor suppressor pathway in Myc-induced lymphomagenesis
    • Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. Disruption of the ARF-Mdm2-53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 1999;13:2658-69.
    • (1999) Genes Dev , vol.13 , pp. 2658-2669
    • Eischen, C.M.1    Weber, J.D.2    Roussel, M.F.3    Sherr, C.J.4    Cleveland, J.L.5
  • 24
    • 47949129564 scopus 로고    scopus 로고
    • Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis
    • Garrison SP, Jeffers JR, Yang C, et al. Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol 2008;28:5391-402.
    • (2008) Mol Cell Biol , vol.28 , pp. 5391-5402
    • Garrison, S.P.1    Jeffers, J.R.2    Yang, C.3
  • 25
    • 0942290415 scopus 로고    scopus 로고
    • Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth
    • Steinman H, Sluss H, Sands A, et al. Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth. Oncogene 2004;23:303-6.
    • (2004) Oncogene , vol.23 , pp. 303-306
    • Steinman, H.1    Sluss, H.2    Sands, A.3
  • 26
    • 34547129356 scopus 로고    scopus 로고
    • Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis
    • Maclean KH, Kastan MB, Cleveland JL. Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. Mol Cancer Res 2007;5:705-11.
    • (2007) Mol Cancer Res , vol.5 , pp. 705-711
    • Maclean, K.H.1    Kastan, M.B.2    Cleveland, J.L.3
  • 27
    • 0023022625 scopus 로고
    • The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice
    • Langdon WY, Harris AW, Cory S, Adams JM. The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell 1986;47:11-8.
    • (1986) Cell , vol.47 , pp. 11-18
    • Langdon, W.Y.1    Harris, A.W.2    Cory, S.3    Adams, J.M.4
  • 28
    • 33845893896 scopus 로고    scopus 로고
    • Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase
    • Shreeram S, Hee WK, Demidov ON, et al. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med 2006;203:2793-9.
    • (2006) J Exp Med , vol.203 , pp. 2793-2799
    • Shreeram, S.1    Hee, W.K.2    Demidov, O.N.3
  • 29
    • 10744228800 scopus 로고    scopus 로고
    • Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
    • Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003;4:321-8.
    • (2003) Cancer Cell , vol.4 , pp. 321-328
    • Jeffers, J.R.1    Parganas, E.2    Lee, Y.3
  • 30
    • 0345268720 scopus 로고    scopus 로고
    • Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis
    • Alt JR, Greiner TC, Cleveland JL, Eischen CM. Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J 2003;22:1442-50.
    • (2003) EMBO J , vol.22 , pp. 1442-1450
    • Alt, J.R.1    Greiner, T.C.2    Cleveland, J.L.3    Eischen, C.M.4
  • 31
    • 10644273575 scopus 로고    scopus 로고
    • Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development
    • Eischen CM, Alt JR, Wang P. Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development. Oncogene 2004;23:8931-40.
    • (2004) Oncogene , vol.23 , pp. 8931-8940
    • Eischen, C.M.1    Alt, J.R.2    Wang, P.3
  • 32
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek J, Bartkova J, Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007;26:7773-9.
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 33
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005;434:907-13.
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3
  • 34
    • 31944451363 scopus 로고    scopus 로고
    • ATM promotes apoptosis and suppresses tumorigenesis in response to Myc
    • Pusapati RV, Rounbehler RJ, Hong S, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A 2006;103:1446-51.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1446-1451
    • Pusapati, R.V.1    Rounbehler, R.J.2    Hong, S.3
  • 35
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy F, Eischen CM, Randle DH, et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 1998;12:2424-33.
    • (1998) Genes Dev , vol.12 , pp. 2424-2433
    • Zindy, F.1    Eischen, C.M.2    Randle, D.H.3
  • 36
    • 65549105965 scopus 로고    scopus 로고
    • Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
    • Efeyan A, Murga M, Martinez-Pastor B, et al. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS ONE 2009;4:e5475.
    • (2009) PLoS ONE , vol.4
    • Efeyan, A.1    Murga, M.2    Martinez-Pastor, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.