-
1
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
Harris SL, Levine AJ. The p53 pathway: positive and negative feedback loops. Oncogene 2005;24:2899-908.
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
2
-
-
0036674617
-
Live or let die: The cell's response to p53
-
Vousden KH, Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2002;2:594-604.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 594-604
-
-
Vousden, K.H.1
Lu, X.2
-
3
-
-
0035751937
-
Assessing TP53 status in human tumours to evaluate clinical outcome
-
Soussi T, Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer 2001;1:233-40.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 233-240
-
-
Soussi, T.1
Beroud, C.2
-
5
-
-
0032192140
-
The complexity of p53 modulation: Emerging patterns from divergent signals
-
Giaccia AJ, Kastan MB. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 1998;12:2973-83.
-
(1998)
Genes Dev
, vol.12
, pp. 2973-2983
-
-
Giaccia, A.J.1
Kastan, M.B.2
-
6
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001;268: 2764-72.
-
(2001)
Eur J Biochem
, vol.268
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
7
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S, Moyal L, Shieh S, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998;281:1674-7.
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
-
8
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman CE, Lim DS, Cimprich KA, et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998; 281:1677-9.
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
-
9
-
-
0034710870
-
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage
-
Chao C, Saito S, Anderson CW, Appella E, Xu Y. Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A 2000;97:11936-41.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 11936-11941
-
-
Chao, C.1
Saito, S.2
Anderson, C.W.3
Appella, E.4
Xu, Y.5
-
10
-
-
0000303499
-
ATM associates with and phosphorylates p53: Mapping the region of interaction
-
Khanna KK, Keating KE, Kozlov S, et al. ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet 1998;20:398-400.
-
(1998)
Nat Genet
, vol.20
, pp. 398-400
-
-
Khanna, K.K.1
Keating, K.E.2
Kozlov, S.3
-
11
-
-
0031435944
-
DNA damage induces phosphorylation of the amino terminus of p53
-
Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E, Kastan MB. DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev 1997;11:3471-81.
-
(1997)
Genes Dev
, vol.11
, pp. 3471-3481
-
-
Siliciano, J.D.1
Canman, C.E.2
Taya, Y.3
Sakaguchi, K.4
Appella, E.5
Kastan, M.B.6
-
12
-
-
0032962641
-
Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks
-
Nakagawa K, Taya Y, Tamai K, Yamaizumi M. Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks. Mol Cell Bio 1999;19:2828-34.
-
(1999)
Mol Cell Bio
, vol.19
, pp. 2828-2834
-
-
Nakagawa, K.1
Taya, Y.2
Tamai, K.3
Yamaizumi, M.4
-
13
-
-
1642458412
-
Phosphorylation of serine 18 regulates distinct p53 functions in mice
-
Sluss HK, Armata H, Gallant J, Jones SN. Phosphorylation of serine 18 regulates distinct p53 functions in mice. Mol Cell Biol 2004;24: 976-84.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 976-984
-
-
Sluss, H.K.1
Armata, H.2
Gallant, J.3
Jones, S.N.4
-
14
-
-
37549003174
-
The ataxia telangiectasiamutated target site Ser18 is required for p53-mediated tumor suppression
-
Armata HL, Garlick DS, Sluss HK, Jones SN. The ataxia telangiectasiamutated target site Ser18 is required for p53-mediated tumor suppression. Cancer Res 2007;67:11696-703.
-
(2007)
Cancer Res
, vol.67
, pp. 11696-11703
-
-
Armata, H.L.1
Garlick, D.S.2
Sluss, H.K.3
Jones, S.N.4
-
15
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-21.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
-
16
-
-
0027521657
-
Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice
-
Harvey M, McArthur MJ, Montgomery CA, Jr., Butel JS, Bradley A, Donehower LA. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet 1993;5:225-9.
-
(1993)
Nat Genet
, vol.5
, pp. 225-229
-
-
Harvey, M.1
McArthur, M.J.2
Montgomery Jr., C.A.3
Butel, J.S.4
Bradley, A.5
Donehower, L.A.6
-
17
-
-
0030463947
-
The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2
-
Jones SN, Sands AT, Hancock AR, et al. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A 1996; 93:14106-11.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14106-14111
-
-
Jones, S.N.1
Sands, A.T.2
Hancock, A.R.3
-
18
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 1996;10:2411-22.
-
(1996)
Genes Dev
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
Bronson, R.T.4
Meyn, M.S.5
Baltimore, D.6
-
19
-
-
0029848286
-
Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
-
Elson A, Wang Y, Daugherty CJ, Morton CC, et al. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A 1996;93:13084-9.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13084-13089
-
-
Elson, A.1
Wang, Y.2
Daugherty, C.J.3
Morton, C.C.4
-
20
-
-
15844426692
-
Atm-deficient mice: A paradigm of ataxia telangiectasia
-
Barlow C, Hirotsune S, Paylor R, et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 1996;86:159-71.
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
Hirotsune, S.2
Paylor, R.3
-
21
-
-
0022380768
-
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
-
Adams JM, Harris AW, Pinkert CA, et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985;318:533-8.
-
(1985)
Nature
, vol.318
, pp. 533-538
-
-
Adams, J.M.1
Harris, A.W.2
Pinkert, C.A.3
-
22
-
-
0033569422
-
Disruption of the ARF-Mdm2-53 tumor suppressor pathway in Myc-induced lymphomagenesis
-
Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. Disruption of the ARF-Mdm2-53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 1999;13:2658-69.
-
(1999)
Genes Dev
, vol.13
, pp. 2658-2669
-
-
Eischen, C.M.1
Weber, J.D.2
Roussel, M.F.3
Sherr, C.J.4
Cleveland, J.L.5
-
23
-
-
0033569423
-
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
-
Schmitt CA, McCurrach ME, de Stanchina E, Wallace-Brodeur RR, Lowe SW. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev 1999;13: 2670-7.
-
(1999)
Genes Dev
, vol.13
, pp. 2670-2677
-
-
Schmitt, C.A.1
McCurrach, M.E.2
de Stanchina, E.3
Wallace-Brodeur, R.R.4
Lowe, S.W.5
-
24
-
-
47949129564
-
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis
-
Garrison SP, Jeffers JR, Yang C, et al. Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol 2008;28:5391-402.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5391-5402
-
-
Garrison, S.P.1
Jeffers, J.R.2
Yang, C.3
-
25
-
-
0942290415
-
Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth
-
Steinman H, Sluss H, Sands A, et al. Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth. Oncogene 2004;23:303-6.
-
(2004)
Oncogene
, vol.23
, pp. 303-306
-
-
Steinman, H.1
Sluss, H.2
Sands, A.3
-
26
-
-
34547129356
-
Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis
-
Maclean KH, Kastan MB, Cleveland JL. Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. Mol Cancer Res 2007;5:705-11.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 705-711
-
-
Maclean, K.H.1
Kastan, M.B.2
Cleveland, J.L.3
-
27
-
-
0023022625
-
The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice
-
Langdon WY, Harris AW, Cory S, Adams JM. The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell 1986;47:11-8.
-
(1986)
Cell
, vol.47
, pp. 11-18
-
-
Langdon, W.Y.1
Harris, A.W.2
Cory, S.3
Adams, J.M.4
-
28
-
-
33845893896
-
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase
-
Shreeram S, Hee WK, Demidov ON, et al. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med 2006;203:2793-9.
-
(2006)
J Exp Med
, vol.203
, pp. 2793-2799
-
-
Shreeram, S.1
Hee, W.K.2
Demidov, O.N.3
-
29
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers JR, Parganas E, Lee Y, et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 2003;4:321-8.
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
-
30
-
-
0345268720
-
Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis
-
Alt JR, Greiner TC, Cleveland JL, Eischen CM. Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J 2003;22:1442-50.
-
(2003)
EMBO J
, vol.22
, pp. 1442-1450
-
-
Alt, J.R.1
Greiner, T.C.2
Cleveland, J.L.3
Eischen, C.M.4
-
31
-
-
10644273575
-
Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development
-
Eischen CM, Alt JR, Wang P. Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development. Oncogene 2004;23:8931-40.
-
(2004)
Oncogene
, vol.23
, pp. 8931-8940
-
-
Eischen, C.M.1
Alt, J.R.2
Wang, P.3
-
32
-
-
36949005417
-
DNA damage signalling guards against activated oncogenes and tumour progression
-
Bartek J, Bartkova J, Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007;26:7773-9.
-
(2007)
Oncogene
, vol.26
, pp. 7773-7779
-
-
Bartek, J.1
Bartkova, J.2
Lukas, J.3
-
33
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005;434:907-13.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
-
34
-
-
31944451363
-
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc
-
Pusapati RV, Rounbehler RJ, Hong S, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A 2006;103:1446-51.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1446-1451
-
-
Pusapati, R.V.1
Rounbehler, R.J.2
Hong, S.3
-
35
-
-
0032145569
-
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
-
Zindy F, Eischen CM, Randle DH, et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 1998;12:2424-33.
-
(1998)
Genes Dev
, vol.12
, pp. 2424-2433
-
-
Zindy, F.1
Eischen, C.M.2
Randle, D.H.3
-
36
-
-
65549105965
-
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
-
Efeyan A, Murga M, Martinez-Pastor B, et al. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS ONE 2009;4:e5475.
-
(2009)
PLoS ONE
, vol.4
-
-
Efeyan, A.1
Murga, M.2
Martinez-Pastor, B.3
|