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Volumn 7, Issue 1, 2010, Pages 28-36

Where the wild things are: Pathogenesis of SIV infection in African nonhuman primate hosts

Author keywords

African green monkey; CD4+ T cells; Immune activation; Innate immunity; Simian immunodeficiency virus; Sooty mangabey; Virus replication

Indexed keywords

ADAPTIVE IMMUNITY; APOPTOSIS; CD4 LYMPHOCYTE COUNT; INNATE IMMUNITY; LYMPHOCYTE FUNCTION; MUCOSAL IMMUNITY; NATURAL HOST; NONHUMAN; PRIMATE; RETROVIRUS INFECTION; REVIEW; SIMIAN IMMUNODEFICIENCY VIRUS; SIMIAN IMMUNODEFICIENCY VIRUS INFECTION; T LYMPHOCYTE SUBPOPULATION; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS TRANSMISSION;

EID: 77249139150     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-009-0034-8     Document Type: Review
Times cited : (66)

References (52)
  • 1
    • 39849096860 scopus 로고    scopus 로고
    • Immune activation and AIDS pathogenesis
    • DOI 10.1097/QAD.0b013e3282f2dbe7, PII 0000203020080219000001
    • DL Sodora G Silvestri 2008 Immune activation and AIDS pathogenesis AIDS 22 439 446 10.1097/QAD.0b013e3282f2dbe7 18301056 (Pubitemid 351317285)
    • (2008) AIDS , vol.22 , Issue.4 , pp. 439-446
    • Sodora, D.L.1    Silvestri, G.2
  • 2
    • 49849088558 scopus 로고    scopus 로고
    • Into the wild: Simian immunodeficiency virus (SIV) infection in natural hosts
    • 10.1016/j.it.2008.05.004 18676179 1:CAS:528:DC%2BD1cXhtVOiurbN
    • I Pandrea DL Sodora G Silvestri C Apetrei 2008 Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts Trends Immunol 29 419 428 10.1016/j.it.2008.05.004 18676179 1:CAS:528:DC%2BD1cXhtVOiurbN
    • (2008) Trends Immunol , vol.29 , pp. 419-428
    • Pandrea, I.1    Sodora, D.L.2    Silvestri, G.3    Apetrei, C.4
  • 3
    • 33750088152 scopus 로고    scopus 로고
    • Going wild: Lessons from naturally occurring T-lymphotropic lentiviruses
    • DOI 10.1128/CMR.00009-06
    • S VandeWoude C Apetrei 2006 Going wild: lessons from T-lymphotropic naturally occurring lentiviruses Clin Microbiol Rev 19 728 762 10.1128/CMR.00009-06 17041142 1:CAS:528:DC%2BD28Xht1WjsL7F (Pubitemid 44582979)
    • (2006) Clinical Microbiology Reviews , vol.19 , Issue.4 , pp. 728-762
    • VandeWoude, S.1    Apetrei, C.2
  • 5
    • 59649110073 scopus 로고    scopus 로고
    • AIDS in African nonhuman primate hosts of SIVs: A new paradigm of SIV infection
    • 10.2174/157016209787048456
    • I Pandrea G Silvestri C Apetrei 2009 AIDS in African nonhuman primate hosts of SIVs: a new paradigm of SIV infection Curr HIV Res 6 57 72 10.2174/157016209787048456
    • (2009) Curr HIV Res , vol.6 , pp. 57-72
    • Pandrea, I.1    Silvestri, G.2    Apetrei, C.3
  • 7
    • 43949085373 scopus 로고    scopus 로고
    • + T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feeding
    • DOI 10.1128/JVI.02555-07
    • I Pandrea R Onanga S Souquiere, et al. 2008 Paucity of CD4+CCR5+ T-cells may prevent breastfeeding transmission of SIV in natural non-human primate hosts J Virol 82 5501 5509 10.1128/JVI.02555-07 18385229 1:CAS:528: DC%2BD1cXmt1SlsL0%3D This study demonstrated that low CCR5 expression by CD4+ T cells may reduce the levels of SIV mucosal transmission (ie, breastfeeding transmission) in natural hosts (Pubitemid 351705257)
    • (2008) Journal of Virology , vol.82 , Issue.11 , pp. 5501-5509
    • Pandrea, I.1    Onanga, R.2    Souquiere, S.3    Mouinga-Ondeme, A.4    Bourry, O.5    Makuwa, M.6    Rouquet, P.7    Silvestri, G.8    Simon, F.9    Roques, P.10    Apetrei, C.11
  • 10
    • 67749095197 scopus 로고    scopus 로고
    • SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through rapid coreceptor expansion in vivo
    • 10.1128/JVI.00444-09 19493994 1:CAS:528:DC%2BD1MXpsFOltrw%3D
    • R Gautam T Gaufin I Butler, et al. 2009 SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through rapid coreceptor expansion in vivo J Virol 83 7894 7908 10.1128/JVI.00444-09 19493994 1:CAS:528:DC%2BD1MXpsFOltrw%3D
    • (2009) J Virol , vol.83 , pp. 7894-7908
    • Gautam, R.1    Gaufin, T.2    Butler, I.3
  • 11
    • 67749145263 scopus 로고    scopus 로고
    • Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz
    • 10.1038/nature08200 19626114 1:CAS:528:DC%2BD1MXovFyls70%3D This study reported that chimpanzees, which acquired their species-specific SIVs through cross-species transmission (as humans acquired HIV), develop AIDS after SIV infection
    • BF Keele J Holland Jones K Terio, et al. 2009 Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz Nature 460 515 519 10.1038/nature08200 19626114 1:CAS:528:DC%2BD1MXovFyls70%3D This study reported that chimpanzees, which acquired their species-specific SIVs through cross-species transmission (as humans acquired HIV), develop AIDS after SIV infection
    • (2009) Nature , vol.460 , pp. 515-519
    • Keele, B.F.1    Holland Jones, J.2    Terio, K.3
  • 12
    • 33646446732 scopus 로고    scopus 로고
    • Simian immunodeficiency virus (SIV) SIVagm.sab infection of Caribbean African green monkeys: New model of the study of SIV pathogenesis in natural hosts
    • 10.1128/JVI.80.10.4858-4867.2006 16641277 1:CAS:528:DC%2BD28XkslChtLo%3D
    • I Pandrea C Apetrei J Dufour, et al. 2006 Simian immunodeficiency virus (SIV) SIVagm.sab infection of Caribbean African green monkeys: new model of the study of SIV pathogenesis in natural hosts J Virol 80 4858 4867 10.1128/JVI.80.10.4858-4867.2006 16641277 1:CAS:528:DC%2BD28XkslChtLo%3D
    • (2006) J Virol , vol.80 , pp. 4858-4867
    • Pandrea, I.1    Apetrei, C.2    Dufour, J.3
  • 13
    • 61449115882 scopus 로고    scopus 로고
    • Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection
    • 10.1371/journal.ppat.1000295 19214220 1:CAS:528:DC%2BD1MXisFyntL8%3D
    • D Favre S Lederer B Kanwar, et al. 2009 Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection Plos Pathogens 5 e1000295 10.1371/journal.ppat.1000295 19214220 1:CAS:528: DC%2BD1MXisFyntL8%3D
    • (2009) Plos Pathogens , vol.5 , pp. 1000295
    • Favre, D.1    Lederer, S.2    Kanwar, B.3
  • 14
    • 68349125557 scopus 로고    scopus 로고
    • CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection
    • 10.1038/nm.1970 19525963 1:CAS:528:DC%2BD1MXnt1Shtr8%3D This study reported that downregulation of CD4 by natural hosts results in the emergence of a T-cell subset that is not infected by SIV but maintains the helper function. This may contribute to the lack of disease progression in natural hosts
    • CM Beaumier LD Harris S Goldstein, et al. 2009 CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection Nat Med 15 879 885 10.1038/nm.1970 19525963 1:CAS:528:DC%2BD1MXnt1Shtr8%3D This study reported that downregulation of CD4 by natural hosts results in the emergence of a T-cell subset that is not infected by SIV but maintains the helper function. This may contribute to the lack of disease progression in natural hosts
    • (2009) Nat Med , vol.15 , pp. 879-885
    • Beaumier, C.M.1    Harris, L.D.2    Goldstein, S.3
  • 16
    • 0032791506 scopus 로고    scopus 로고
    • An African green monkey lacking peripheral CD4 lymphocytes that retains helper T cell activity and coexists with SIVagm
    • DOI 10.1046/j.1365-2249.1999.00999.x
    • Y Murayama R Mukai M Inoue-Murayama Y Yoshikawa 1999 An African green monkey lacking peripheral CD4 lymphocytes that retains helper T cell activity and coexists with SIVagm Clin Exp Immunol 117 504 512 10.1046/j.1365-2249.1999. 00999.x 10469054 1:STN:280:DyaK1MzpvFSjtw%3D%3D (Pubitemid 29398297)
    • (1999) Clinical and Experimental Immunology , vol.117 , Issue.3 , pp. 504-512
    • Murayama, Y.1    Mukai, R.2    Inoue-Murayama, M.3    Yoshikawa, Y.4
  • 18
    • 53549103852 scopus 로고    scopus 로고
    • Divergent TLR7 and TLR9 signaling and type i interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
    • 10.1038/nm.1871 18806803 1:CAS:528:DC%2BD1cXht1Slu7vF
    • JN Mandl AP Barry TH Vanderford, et al. 2008 Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections Nat Med 14 1077 1087 10.1038/nm.1871 18806803 1:CAS:528:DC%2BD1cXht1Slu7vF
    • (2008) Nat Med , vol.14 , pp. 1077-1087
    • Mandl, J.N.1    Barry, A.P.2    Vanderford, T.H.3
  • 20
    • 33745945059 scopus 로고    scopus 로고
    • Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: Common patterns and species-specific differences
    • DOI 10.1111/j.1600-0684.2006.00168.x
    • I Pandrea G Silvestri R Onanga, et al. 2006 Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differences J Med Primatol 35 194 201 10.1111/j.1600-0684. 2006.00168.x 16872282 (Pubitemid 44057343)
    • (2006) Journal of Medical Primatology , vol.35 , Issue.4-5 , pp. 194-201
    • Pandrea, I.1    Silvestri, G.2    Onanga, R.3    Veazey, R.S.4    Marx, P.A.5    Hirsch, V.6    Apetrei, C.7
  • 21
    • 0029940996 scopus 로고    scopus 로고
    • Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: Effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara
    • 8648709 1:CAS:528:DyaK28XivF2msb8%3D
    • VM Hirsch TR Fuerst G Sutter, et al. 1996 Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara J Virol 70 3741 3752 8648709 1:CAS:528:DyaK28XivF2msb8%3D
    • (1996) J Virol , vol.70 , pp. 3741-3752
    • Hirsch, V.M.1    Fuerst, T.R.2    Sutter, G.3
  • 22
    • 0030070991 scopus 로고    scopus 로고
    • Prognosis in HIV-1 infection predicted by the quantity of virus in plasma
    • 10.1126/science.272.5265.1167 8638160 1:CAS:528:DyaK28XjtF2nsrg%3D
    • JW Mellors CR Rinaldo Jr P Gupta, et al. 1996 Prognosis in HIV-1 infection predicted by the quantity of virus in plasma Science 272 1167 1170 10.1126/science.272.5265.1167 8638160 1:CAS:528:DyaK28XjtF2nsrg%3D
    • (1996) Science , vol.272 , pp. 1167-1170
    • Mellors, J.W.1    Rinaldo Jr, C.R.2    Gupta, P.3
  • 24
    • 0035824720 scopus 로고    scopus 로고
    • Chronic SIV infection ultimately causes immunodeficiency in African non-human primates [3]
    • DOI 10.1097/00002030-200112070-00019
    • I Pandrea R Onanga P Rouquet, et al. 2001 Chronic SIV infection ultimately causes immunodeficiency in African non-human primates AIDS 15 2461 2462 10.1097/00002030-200112070-00019 11826852 1:STN:280: DC%2BD38%2Fps1GgsA%3D%3D (Pubitemid 34014620)
    • (2001) AIDS , vol.15 , Issue.18 , pp. 2461-2462
    • Pandrea, I.1    Onanga, R.2    Rouquet, P.3    Bourry, O.4    Ngari, P.5    Wickings, E.J.6    Roques, P.7    Apetrei, C.8
  • 25
    • 36048989674 scopus 로고    scopus 로고
    • Virally-induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host
    • 17709519 1:CAS:528:DC%2BD2sXpt1Smsb0%3D
    • JM Milush JD Reeves S Gordon, et al. 2007 Virally-induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host J Immunol 179 3047 3056 17709519 1:CAS:528:DC%2BD2sXpt1Smsb0%3D
    • (2007) J Immunol , vol.179 , pp. 3047-3056
    • Milush, J.M.1    Reeves, J.D.2    Gordon, S.3
  • 26
    • 58149177783 scopus 로고    scopus 로고
    • Experimentally-induced immune activation in natural hosts of SIV induces significant increases in viral replication and CD4+ T cell depletion
    • 18981083 1:CAS:528:DC%2BD1cXhtlaisr7I This provides proof of concept that microbial translocation (modeled here by lipopolysaccharide administration) results in increased immune activation, increased viral replication, and CD4+ T-cell depletion
    • I Pandrea T Gaufin JM Brenchley, et al. 2008 Experimentally-induced immune activation in natural hosts of SIV induces significant increases in viral replication and CD4+ T cell depletion J Immunol 181 6687 6691 18981083 1:CAS:528:DC%2BD1cXhtlaisr7I This provides proof of concept that microbial translocation (modeled here by lipopolysaccharide administration) results in increased immune activation, increased viral replication, and CD4+ T-cell depletion
    • (2008) J Immunol , vol.181 , pp. 6687-6691
    • Pandrea, I.1    Gaufin, T.2    Brenchley, J.M.3
  • 27
    • 45749156336 scopus 로고    scopus 로고
    • Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys
    • 18497876 1:CAS:528:DC%2BD1cXntVCmt7o%3D
    • NR Klatt F Villinger P Bostik, et al. 2008 Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys J Clin Invest 118 2039 2049 18497876 1:CAS:528:DC%2BD1cXntVCmt7o%3D
    • (2008) J Clin Invest , vol.118 , pp. 2039-2049
    • Klatt, N.R.1    Villinger, F.2    Bostik, P.3
  • 28
    • 0035121414 scopus 로고    scopus 로고
    • Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease
    • DOI 10.1128/JVI.75.5.2262-2275.2001
    • SR Broussard SI Staprans R White, et al. 2001 Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease J Virol 75 2262 2275 10.1128/JVI.75.5.2262-2275.2001 11160730 1:CAS:528:DC%2BD3MXhtlGgsbc%3D (Pubitemid 32147565)
    • (2001) Journal of Virology , vol.75 , Issue.5 , pp. 2262-2275
    • Broussard, S.R.1    Staprans, S.I.2    White, R.3    Whitehead, E.M.4    Feinberg, M.B.5    Allan, J.S.6
  • 29
    • 36048989052 scopus 로고    scopus 로고
    • Acute loss of intestinal CD4+ T cells is not predictive of SIV virulence
    • 17709518 1:CAS:528:DC%2BD2sXpt1Smsbw%3D
    • I Pandrea R Gautam R Ribeiro, et al. 2007 Acute loss of intestinal CD4+ T cells is not predictive of SIV virulence J Immunol 179 3035 3046 17709518 1:CAS:528:DC%2BD2sXpt1Smsbw%3D
    • (2007) J Immunol , vol.179 , pp. 3035-3046
    • Pandrea, I.1    Gautam, R.2    Ribeiro, R.3
  • 30
    • 35448976736 scopus 로고    scopus 로고
    • Severe depletion of mucosal CD4+ T cells in AIDS-free SIV-infected sooty mangabeys
    • 17709517 1:CAS:528:DC%2BD2sXpt1Smsb8%3D
    • S Gordon NR Klatt JM Milush, et al. 2007 Severe depletion of mucosal CD4+ T cells in AIDS-free SIV-infected sooty mangabeys J Immunol 179 3026 3034 17709517 1:CAS:528:DC%2BD2sXpt1Smsb8%3D
    • (2007) J Immunol , vol.179 , pp. 3026-3034
    • Gordon, S.1    Klatt, N.R.2    Milush, J.M.3
  • 31
    • 53449093632 scopus 로고    scopus 로고
    • Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
    • 10.1182/blood-2008-05-159301 18664624 1:CAS:528:DC%2BD1cXht1Srtb%2FJ
    • JM Brenchley M Paiardini KS Knox, et al. 2008 Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections Blood 112 2826 2835 10.1182/blood-2008-05-159301 18664624 1:CAS:528:DC%2BD1cXht1Srtb%2FJ
    • (2008) Blood , vol.112 , pp. 2826-2835
    • Brenchley, J.M.1    Paiardini, M.2    Knox, K.S.3
  • 32
    • 41149146472 scopus 로고    scopus 로고
    • Simian immunodeficiency virus SIVagm dynamics in African green monkeys
    • 10.1128/JVI.02402-07 18216122 1:CAS:528:DC%2BD1cXjvFent7o%3D
    • I Pandrea RM Ribeiro R Gautam, et al. 2008 Simian immunodeficiency virus SIVagm dynamics in African green monkeys J Virol 82 3713 3724 10.1128/JVI.02402-07 18216122 1:CAS:528:DC%2BD1cXjvFent7o%3D
    • (2008) J Virol , vol.82 , pp. 3713-3724
    • Pandrea, I.1    Ribeiro, R.M.2    Gautam, R.3
  • 33
    • 41149083421 scopus 로고    scopus 로고
    • Short-lived infected cells support the bulk of virus replication in naturally SIV-infected sooty mangabeys: Implications for AIDS pathogenesis
    • 10.1128/JVI.02408-07 18216113 1:CAS:528:DC%2BD1cXjvFent7s%3D
    • S Gordon RM Dunham JC Engram, et al. 2008 Short-lived infected cells support the bulk of virus replication in naturally SIV-infected sooty mangabeys: implications for AIDS pathogenesis J Virol 82 3725 3735 10.1128/JVI.02408-07 18216113 1:CAS:528:DC%2BD1cXjvFent7s%3D
    • (2008) J Virol , vol.82 , pp. 3725-3735
    • Gordon, S.1    Dunham, R.M.2    Engram, J.C.3
  • 35
    • 36048970455 scopus 로고    scopus 로고
    • HIV controllers: How do they tame the virus?
    • DOI 10.1016/j.it.2007.09.002, PII S1471490607002438
    • A Saez-Cirion G Pancino M Sinet, et al. 2007 HIV controllers: how do they tame the virus? Trends Immunol 28 532 540 10.1016/j.it.2007.09.002 17981085 1:CAS:528:DC%2BD2sXhtlajtrbF (Pubitemid 350101419)
    • (2007) Trends in Immunology , vol.28 , Issue.12 , pp. 526-534
    • Saez-Cirion, A.1    Pancino, G.2    Sinet, M.3    Venet, A.4    Lambotte, O.5
  • 36
    • 2342660749 scopus 로고    scopus 로고
    • What can natural infection of African monkeys with simian immunodeficiency virus tell us about the pathogenesis of AIDS?
    • 15168740
    • VM Hirsch 2004 What can natural infection of African monkeys with simian immunodeficiency virus tell us about the pathogenesis of AIDS? AIDS Rev 6 40 53 15168740
    • (2004) AIDS Rev , vol.6 , pp. 40-53
    • Hirsch, V.M.1
  • 37
    • 62749107947 scopus 로고    scopus 로고
    • Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys
    • 10.1128/JVI.01841-08 19109377 1:CAS:528:DC%2BD1MXjtFShurk%3D
    • JM Lozano Reina D Favre Z Kasakow, et al. 2009 Gag p27-specific B- and T-cell responses in simian immunodeficiency virus SIVagm-infected African green monkeys J Virol 83 2770 2777 10.1128/JVI.01841-08 19109377 1:CAS:528: DC%2BD1MXjtFShurk%3D
    • (2009) J Virol , vol.83 , pp. 2770-2777
    • Lozano Reina, J.M.1    Favre, D.2    Kasakow, Z.3
  • 38
    • 0033145590 scopus 로고    scopus 로고
    • Neutralizing antibody responses in African green monkeys naturally infected with simian immunodeficiency virus (SIVagm)
    • 10475110 1:STN:280:DyaK1Mvgt1Sqtw%3D%3D
    • MM Gicheru M Otsyula P Spearman, et al. 1999 Neutralizing antibody responses in African green monkeys naturally infected with simian immunodeficiency virus (SIVagm) J Med Primatol 28 97 104 10475110 1:STN:280:DyaK1Mvgt1Sqtw%3D%3D
    • (1999) J Med Primatol , vol.28 , pp. 97-104
    • Gicheru, M.M.1    Otsyula, M.2    Spearman, P.3
  • 39
    • 70349733184 scopus 로고    scopus 로고
    • Effect of B cell depletion on viral replication and clinical outcome of SIV infection in a natural host
    • 10.1128/JVI.00880-09 19656874 1:CAS:528:DC%2BD1MXhtlClsbjL
    • T Gaufin M Pattison R Gautam, et al. 2009 Effect of B cell depletion on viral replication and clinical outcome of SIV infection in a natural host J Virol 83 10347 10357 10.1128/JVI.00880-09 19656874 1:CAS:528:DC%2BD1MXhtlClsbjL
    • (2009) J Virol , vol.83 , pp. 10347-10357
    • Gaufin, T.1    Pattison, M.2    Gautam, R.3
  • 40
    • 63149158471 scopus 로고    scopus 로고
    • Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain
    • 10.1182/blood-2008-09-177741 19168789 1:CAS:528:DC%2BD1MXlvVGisb4%3D
    • T Gaufin R Gautam M Kasheta, et al. 2009 Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strain Blood 113 4250 4261 10.1182/blood-2008-09-177741 19168789 1:CAS:528: DC%2BD1MXlvVGisb4%3D
    • (2009) Blood , vol.113 , pp. 4250-4261
    • Gaufin, T.1    Gautam, R.2    Kasheta, M.3
  • 42
    • 56449120795 scopus 로고    scopus 로고
    • Simian immunodeficiency virus (SIV)-specific CD8+ T cell responses in chronically SIVagm-infected vervet African green monkeys
    • 10.1128/JVI.01779-08 18829748 1:CAS:528:DC%2BD1cXhsVaqsrrO
    • RC Zahn MD Rett B Korioth-Schmitz, et al. 2008 Simian immunodeficiency virus (SIV)-specific CD8+ T cell responses in chronically SIVagm-infected vervet African green monkeys J Virol 82 11577 11588 10.1128/JVI.01779-08 18829748 1:CAS:528:DC%2BD1cXhsVaqsrrO
    • (2008) J Virol , vol.82 , pp. 11577-11588
    • Zahn, R.C.1    Rett, M.D.2    Korioth-Schmitz, B.3
  • 43
    • 33644749300 scopus 로고    scopus 로고
    • + T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys
    • DOI 10.1128/JVI.80.6.2771-2783.2006
    • Z Wang B Metcalf RM Ribeiro, et al. 2006 Th-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys J Virol 80 2771 2783 10.1128/JVI.80.6.2771-2783.2006 16501086 1:CAS:528:DC%2BD28Xis1Cqsb8%3D (Pubitemid 43346372)
    • (2006) Journal of Virology , vol.80 , Issue.6 , pp. 2771-2783
    • Wang, Z.1    Metcalf, B.2    Ribeiro, R.M.3    McClure, H.4    Kaur, A.5
  • 44
    • 74549210553 scopus 로고    scopus 로고
    • Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys
    • In revision
    • Schmitz JE, Zahn RC, Brown CR, et al.: Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys. PLoS Pathog 2009, In revision.
    • (2009) PLoS Pathog
    • Schmitz, J.E.1    Zahn, R.C.2    Brown, C.R.3
  • 45
    • 34250184098 scopus 로고    scopus 로고
    • Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immunodeficiency virus reveals limited role for immune control of virus replication in a natural host species
    • 17548637 1:CAS:528:DC%2BD2sXmtVKnsL8%3D
    • AP Barry G Silvestri JT Safrit, et al. 2007 Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immunodeficiency virus reveals limited role for immune control of virus replication in a natural host species J Immunol 178 8002 8012 17548637 1:CAS:528:DC%2BD2sXmtVKnsL8%3D
    • (2007) J Immunol , vol.178 , pp. 8002-8012
    • Barry, A.P.1    Silvestri, G.2    Safrit, J.T.3
  • 46
    • 38349116864 scopus 로고    scopus 로고
    • Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus
    • 10.1128/JVI.02197-07 18032490 1:CAS:528:DC%2BD1cXhtFOktrk%3D
    • A Kaur M Di Mascio A Barabasz, et al. 2008 Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus J Virol 82 1084 1093 10.1128/JVI.02197-07 18032490 1:CAS:528:DC%2BD1cXhtFOktrk%3D
    • (2008) J Virol , vol.82 , pp. 1084-1093
    • Kaur, A.1    Di Mascio, M.2    Barabasz, A.3
  • 47
    • 58149526779 scopus 로고    scopus 로고
    • Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection
    • 10.1128/JVI.01715-08 18987149 1:CAS:528:DC%2BD1MXotlCmsLc%3D
    • M Meythaler A Martinot Z Wang, et al. 2009 Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection J Virol 83 572 583 10.1128/JVI.01715-08 18987149 1:CAS:528:DC%2BD1MXotlCmsLc%3D
    • (2009) J Virol , vol.83 , pp. 572-583
    • Meythaler, M.1    Martinot, A.2    Wang, Z.3
  • 48
    • 4344630794 scopus 로고    scopus 로고
    • CD4+ T cell signaling in the natural SIV host-implications for disease pathogenesis
    • 10.2741/1147 12957876 1:CAS:528:DC%2BD3sXksF2rtLs%3D
    • P Bostik GL Dodd AA Ansari 2003 CD4+ T cell signaling in the natural SIV host-implications for disease pathogenesis Front Biosci 8 s904 s912 10.2741/1147 12957876 1:CAS:528:DC%2BD3sXksF2rtLs%3D
    • (2003) Front Biosci , vol.8
    • Bostik, P.1    Dodd, G.L.2    Ansari, A.A.3
  • 49
    • 20144387661 scopus 로고    scopus 로고
    • Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
    • 15761496 1:CAS:528:DC%2BD2MXjtFyltLs%3D
    • C Kornfeld MJ Ploquin I Pandrea, et al. 2005 Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS J Clin Invest 115 1082 1091 15761496 1:CAS:528:DC%2BD2MXjtFyltLs%3D
    • (2005) J Clin Invest , vol.115 , pp. 1082-1091
    • Kornfeld, C.1    Ploquin, M.J.2    Pandrea, I.3


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