Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4486-4495

  Venkatraman, Srikanth ^a   Blackman, Mellissa ^a   Wu, Wanli ^a   Nair, Latha ^a   Arasappan, Ashok ^a   Padilla, Angela ^a   Bogen, Stéphane ^a   Bennett, Frank ^a   Chen, Kevin ^a   Pichardo, John ^a   Tong, Xiao ^a   Prongay, Andrew ^a   Cheng, Kuo Chi ^a   Girijavallabhan, Viyyoor ^a   George Njoroge, F ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Boceprevir; HCV; Replicon

Indexed keywords

ANTIVIRUS AGENT; BOCEPREVIR; NONSTRUCTURAL PROTEIN 3; PROTEINASE INHIBITOR; SULFONAMIDE; VIRUS PROTEIN; NS3 PROTEIN, HEPATITIS C VIRUS;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; NONHUMAN; PROTEINASE INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REPLICON; STRUCTURE ACTIVITY RELATION; VIRUS HEPATITIS; VIRUS INHIBITION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PROTEIN BINDING; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY;

HEPATITIS C VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; HEPACIVIRUS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 66749113550     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.012     Document Type: Article

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