The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment

Cancer Letters

Volumn 290, Issue 1, 2010, Pages 114-122

  Lee, Meng Huee ^a   Atkinson, Susan ^a   Rapti, Magdalini ^a   Handsley, Madeleine ^b   Curry, Valerie ^a   Edwards, Dylan ^b   Murphy, Gillian ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Cancer therapeutics; Cell based assays; MT1 MMP; Site directed mutagenesis; TIMP 1

Indexed keywords

COLLAGEN; GELATIN; GELATINASE A; HERMES ANTIGEN; MATRIX METALLOPROTEINASE 14; MUTANT PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENZYME ACTIVITY; FIBROSARCOMA; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; VASCULAR ENDOTHELIUM;

ANTIGENS, CD44; BLOTTING, WESTERN; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEOVASCULARIZATION, PHYSIOLOGIC; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 77249103958     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.08.029     Document Type: Article

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