Neuromas of the Hand and Upper Extremity

Journal of Hand Surgery

Volumn 35, Issue 3, 2010, Pages 499-510

  Watson, Jonathan ^a   Gonzalez, Mark ^a   Romero, Alex ^a   Kerns, James ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Hand surgery; nerve; nerve injury; nerve repair; neuroma

Indexed keywords

BRADYKININ; CALCIUM CHANNEL; CYTOKINE; FIBROBLAST GROWTH FACTOR; GABAPENTIN; HISTAMINE; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN RECEPTOR P75; PREGABALIN; SEROTONIN; SILASTIC; SUBSTANCE P; TUMOR NECROSIS FACTOR ALPHA;

AMPUTATION STUMP; ARM; BALANCE IMPAIRMENT; BLOOD VESSEL; BLUNT TRAUMA; CARPAL TUNNEL SYNDROME; CELL PROLIFERATION; CRUSH TRAUMA; CYTOKINE PRODUCTION; DIARRHEA; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE PREDISPOSITION; DISEASE SEVERITY; DIZZINESS; DRUG ABSORPTION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG TRANSPORT; ENDOCYTOSIS; ENDURANCE; FIBROBLAST; GASTROINTESTINAL SYMPTOM; GATE CONTROL THEORY; GENE ACTIVATION; GLIA CELL; HAND; HAND MALFORMATION; HEADACHE; HISTOPATHOLOGY; HUMAN; HYPERALGESIA; INFECTION; INNERVATION; INSOMNIA; ISCHEMIA; LACERATION; MACROPHAGE; MICROTUBULE; MUSCLE TRANSPOSITION; NAUSEA; NERVE COMPRESSION; NERVE CONDUCTION; NERVE DEGENERATION; NERVE ENDING; NERVE EXCITABILITY; NERVE FIBER; NERVE FIBER REGENERATION; NERVE REGENERATION; NERVE SURGERY; NERVE TRANSECTION; NEUROFILAMENT; NEUROMA; NEUROPATHIC PAIN; NOCICEPTIVE RECEPTOR; PAIN ASSESSMENT; PERINEURIUM; PERIPHERAL EDEMA; PERIPHERAL NERVE INJURY; PHANTOM PAIN; PRESSURE; PRIORITY JOURNAL; PROGNOSIS; RADIAL NERVE; RECEPTOR BINDING; REVIEW; SCAR; SCAR FORMATION; SCHWANN CELL; SENSORY NERVE CELL; SKIN NERVE; SOMNOLENCE; SURGICAL APPROACH; SURGICAL TECHNIQUE; T LYMPHOCYTE; TISSUE FLAP; TISSUE SPECIFICITY; ULNAR NERVE; UPREGULATION; WEAKNESS; WITHDRAWAL SYNDROME;

HAND; HUMANS; NERVE REGENERATION; NEUROMA; PAIN; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; REOPERATION; SURGICAL FLAPS; UPPER EXTREMITY;

EID: 77249086596     PISSN: 03635023     EISSN: 15316564     Source Type: Journal    
DOI: 10.1016/j.jhsa.2009.12.019     Document Type: Review

References (51)

1. Birch R. The peripheral neuroma. In: Green D.P., Hotchkiss R.N., Pederson W.C., and Wolfe S. (Eds). Green's operative hand surgery. 5th ed. (2005), Churchill Livingstone, New York 1102-1111
2. Yüksel F., Kişlaoǧlu E., Durak N., Uçar C., and Karacaoǧlu E. Prevention of painful neuromas by epineural ligatures, flaps and grafts. Br J Plast Surg 50 (1997) 182-185
3. Sunderland S. Anatomical features of nerve trunks in relation to nerve injury and nerve repair. Clin Neurosurg 17 (1970) 38-62
4. Sunderland S. The anatomy and physiology of nerve injury. Muscle Nerve 13 (1990) 771-784
5. Lee S.K., and Wolfe S.W. Peripheral nerve injury and repair. J Am Acad Orthop Surg 8 (2000) 243-252
6. MacKinnon S.E., Dellon A.L., Hudson A.R., and Hunter D.A. Alteration of neuroma formation by manipulation of its microenvironment. Plast Reconstr Surg 76 (1985) 345-352
7. Koch H., Haas F., Hubmer M., Rappl T., and Scharnagl E. Treatment of painful neuroma by resection and nerve stump transplantation into a vein. Ann Plast Surg 51 (2003) 45-50
8. Nath R.K., and MacKinnon S.E. Management of neuromas in the hand. Hand Clin 12 (1996) 745-756
9. Rose J., Belsky M.R., Millender L.H., and Feldon P. Intrinsic muscle flaps: the treatment of painful neuromas in continuity. J Hand Surg 21A (1996) 671-674
10. Lundborg G. A 25 year perspective of peripheral nerve surgery; evolving neuroscientific concepts of clinical significance. J Hand Surg 25A (2000) 391-414
11. Atherton D.D., Taherzadeh O., Facer P., Elliot D., and Anand P. The potential role of nerve growth factor (NGF) in painful neuromas and the mechanism of pain relief by their relocation to muscle. J Hand Surg 31B (2006) 652-656
12. Orza F., Boswell M.V., and Rosenberg S.K. Neuropathic pain: Review of mechanisms and pharmacologic management. NeuroRehabilitation 14 (2000) 15-23
13. Dahl J.B., Mathiesen O., and Moiniche S. 'Protective premedication': an option with gabapentin and related drugs?. A review of gabapentin and pregabalin in the treatment of post-operative pain. Acta Anaesthesiol Scand 48 (2004) 1130-1136
14. Nicholson B. Gabapentin use in neuropathic pain syndromes. Acta Neurol Scand 101 (2000) 359-371
15. Melzack R., and Wall P.D. Pain mechanisms: a new theory. Science 150 (1965) 971-979
16. Pruimboom L., and van Dam A.C. Chronic pain: A non-use disease. Med Hypotheses 68 (2007) 506-511
17. Vernadakis A.J., Koch H., and MacKinnon S.E. Management of neuromas. Clin Plast Surg 30 (2003) 247-268
18. Dellon A.L., and Mackinnon S.E. Treatment of the painful neuroma by neuroma resection and muscle implantation. Plast Reconstr Surg 77 (1986) 427-438
19. Sood M.K., and Elliot D. Treatment of painful neuromas of the hand and wrist by relocation into the pronator quadratus. J Hand Surg 23B (1998) 214-219
20. Flor H. Phantom-limb pain: characteristics, causes and treatment. Lancet Neurol 1 (2002) 182-189
21. Howell A.E., and Leach R.E. Bowler's thumb: Perineural fibrosis of the digital nerve. J Bone Joint Surg 52A (1970) 379-381
22. Ostrovskiy D., and Wilbourn A. Acute bowler's thumb. Neurology 63 (2004) 938
23. Dobyns J.H., O'Brien E.T., Linscheld R.L., and Farrow G.M. Bowler's thumb: diagnosis and treatment. J Bone Joint Surg 54A (1972) 751-755
24. Dellon A.L., and MacKinnon S.E. Susceptibility of the superficial sensory branch of the radial nerve to form painful neuromas. J Hand Surg 9B (1984) 42
25. Atherton D.D., Fabre J., Anand P., and Elliot D. Relocation of painful neuromas in zone III of the hand and forearm. J Hand Surg 33B (2008) 155-162
26. Lanzetta M., and Nolli R. Nerve stripping: new treatment for neuromas of the palmar cutaneous branch of the median nerve. J Hand Surg 25B (2000) 151-153
27. Tung T.H., and Mackinnon S.E. Secondary carpal tunnel surgery. Plast Reconstr Surg 107 (2001) 1830-1843
28. Evans G.R.D., and Dellon A.L. Implantation of the palmar cutaneous branch of the median nerve into the pronator quadratus for treatment of painful neuroma. J Hand Surg 19A (1994) 203-206
29. Louis D.S., Greene T.L., and Noellert R.C. Complications of carpal tunnel surgery. J Neurosurg 62 (1985) 352-356
30. Ducic I., Mesbahi A.N., Attinger C.E., and Graw K. The role of peripheral nerve surgery in the treatment of chronic pain associated with amputation stumps. Plast Reconstr Surg 121 (2008) 908
31. Meek M.F., Coert J.H., and Robinson P.H. Poor results after nerve grafting in the upper extremity: Quo vadis?. Microsurgery 25 (2005) 396-402
32. Atherton D.D., Leong J.C.S., Anand P., and Elliot D. Relocation of painful end neuromas and scarred nerves from the zone II territory of the hand. J Hand Surg 32B (2007) 38-44
33. Herbert T.J., and Filan S. Vein implantation for treatment of painful cutaneous neuromas. A preliminary report. J Hand Surg 23B (1998) 220-224
34. Koch H., Herbert T.J., Kleinert R., Hubmer M., Scharnagl E., and Pierer G. Influence of nerve stump transplantation into a vein on neuroma formation. Ann Plast Surg 50 (2003) 354-360
35. Mass D.P., Ciano M.C., Tortosa R., Newmeyer W.L., and Kilgore E.S. Treatment of painful hand neuromas by their transfer into bone. Plast Reconstr Surg 74 (1984) 182-185
36. Hazari A., and Eliot D. Treatment of end-neuromas, neuromas-in-continuity and scarred nerves of the digits by proximal relocation. J Hand Surg 29B (2004) 338-350
37. Gorkisch K., Boese-Landgraf J., and Vaubel E. Treatment and prevention of amputation neuromas in hand surgery. Plast Reconstr Surg 73 (1984) 293-299
38. Belcher H.J., and Pandya A.N. Centro-central union for the prevention of neuroma formation after finger amputation. J Hand Surg 25B (2000) 154-159
39. Barbera J., and Albert-Pamplo R. Centrocentral anastamosis of the proximal nerve stump in the treatment of painful amputation neuromas of major nerves. J Neurosurg 79 (1993) 331-334
40. Krishnan K.G., Pinzer T., and Schackert G. Coverage of painful peripheral nerve neuromas with vascularized soft tissue: method and results. Neurosurgery 56 (2005) 369-378
41. Adani R., Tarallo L., Battiston B., and Marcoccio I. Management of neuromas in continuity of the median nerve with the pronator quadratus muscle flap. Ann Plast Surg 48 (2002) 35-40
42. Foucher G., Sammut D., Greant P., Braun F.M., Ehrler S., and Buch N. Indications and results of skin flaps in painful digital neuroma. J Hand Surg 16B (1991) 25-29
43. Tupper J.W., and Booth D.M. Treatment of painful neuromas of sensory nerves in the hand: a comparison of traditional and newer methods. J Hand Surg 1 (1976) 144-151
44. Herndon J.H., Eaton R.G., and Littler J.W. Management of painful neuromas in the hand. J Bone Joint Surg 58A (1976) 369-373
45. Geraghty T.J., and Jones L.E. Painful neuromata following upper limb amputation. Prosthet Orthot Int 20 (1996) 176-181
46. Laborde K.J., Kalisman M., and Tsai T. Results of surgical treatment of painful neuromas of the hand. J Hand Surg 7 (1982) 190-193
47. Backonja M, Glanzman RL. Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. Clin Ther;25:81-104.
48. Freynhagen R., Strojek K., Griesing T., Whalen E., and Balkenohl M. Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens. Pain 115 (2005) 254-263
49. Gidal B.E. New and emerging treatment options for neuropathic pain. Am J Manag Care 12 (2006) S269-S278
50. Rosenstock J., Tuchman M., La Moreaux L., and Sharma U. Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain 110 (2004) 628-638
51. Guay D.R. Pregabalin in neuropathic pain: a more "pharmaceutically elegant" gabapentin?. Am J Geriatr Pharmacother 4 (2005) 274-287