Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum

International Journal of Hyperthermia

Volumn 26, Issue 2, 2010, Pages 108-117

  Maluta, Sergio ^a   Romano, Mario ^a   Dall'Oglio, Stefano ^a   Genna, Michele ^a   Oliani, Cristina ^a   Pioli, Fabio ^a   Gabbani, Milena ^a   Marciai, Nadia ^a   Palazzi, Mario ^a  

^a UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

Hyperthermia; Preoperative chemo radiation; Rectal cancer

Indexed keywords

FLUOROURACIL; OXALIPLATIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL TRIAL; CONTINUOUS INFUSION; DISEASE COURSE; DISEASE FREE SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HYPERTHERMIC THERAPY; MAJOR CLINICAL STUDY; MALE; METASTASIS; PATIENT SAFETY; PREDICTOR VARIABLE; PREOPERATIVE RADIOTHERAPY; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION HAZARD; RECTUM CARCINOMA; THERAPY EFFECT; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; FEMALE; HUMANS; HYPERTHERMIA, INDUCED; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; PREOPERATIVE CARE; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 77149177998     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.3109/02656730903333958     Document Type: Article

References (50)

1. Grann A, Feng C, Wong D, Saltz L, Paty PP, Guillem JG, Cohen AM, Minsky BD. Preoperative combined modality therapy for clinically resectable uT3 rectal adenocarcinoma. Int J Radiat Oncol Biol Phys 2001;49:987-995
2. Luna-Perez P, Rodriguez-Ramirez S, Hernandez-Pacheco F, Gutierrez De La Barrera M, Fernandez R, Labastida S. Anal sphincter preservation in locally advanced low rectal adenocarcinoma after preoperative chemoradiation therapy and coloanal anastomosis. J Surg Oncol 2003;82:3-9
3. Pucciarelli S, Toppan P, Friso ML, Russo V, Pasetto L, Urso E, Marino F, Ambrosi A, Lise M. Complete pathologic response following preoperative chemoradiation therapy for middle to lower rectal cancer is not a prognostic factor for a better outcome. Dis Colon Rectum 2004;47:1798-1807
4. Capirci C, Valentini V, Cionini L, De Paoli A, Rödel C, Glynne-Jones R, Coco C, Romano M, Mantello G, Palazzi S, et al. Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: Longterm analysis of 566 ypCR patients. Int J Radiat Oncol Biol Phys 2008;72:99-107
5. Theodoropulos G, Padmanabhan A, Kerner BA, Taylor CW, Aguila PS, Khaduja KS. T-level downstaging and complete pathological response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 2002;45: 895-899
6. Mohiuddin M, Hayne M, Regine WF, Hanna N, Hagihara PF, McGrath P, Marks GM. Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent cancers. Int J Radiat Oncol Biol Phys 2000;48:1075-1080
7. Rö del C, Martus P, Papadoupolos T, Füzesi L, Klimpfinger M, Fietkau R, Liersch T, Hohenberger W, Raab R, Sauer R, et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 2005;23:8688-8696
8. Aschele C, Friso ML, Pucciarelli S, Lonardi S, Sartor L, Fabris G, Urso ED, Del Bianco P, Sotti G, Lise M, et al. A phase I - II study of weekly oxaliplatin, 5-fluorouracil continuous infusion and preoperative radiotherapy in locally advanced rectal cancer. Ann Oncol 2005;16:1140-1146
9. Gérard JP, Chapet O, Nemoz C, Romestaing P, Mornex F, Coquard R, Barbet N, Atlan D, Adeleine P, Freyer G. Preoperative concurrent chemoradiotherapy in locally advanced rectal cancer with high-dose radiation and oxaliplatin- containing regimen: The Lyon R0-04 phase II trial. J Clin Oncol 2003;21:1119-1124
10. Carraro S, Roca EL, Cartelli C, Rafailovici L, Castillo Odena S, Wasserman E, Gualdrini U, Huertas E, Barugel M, Ballarino G, et al. Radiochemotherapy with short daily infusion of low-dose oxaliplatin, leucovorin, and 5-FU in T3 - T4 unresectable rectal cancer: A phase II IATTGI study. Int J Radiat Oncol Biol Phys 2002;54:397-402
11. Gambacorta MA, Valentini V, Coco C, Morganti AG, Smaniotto D, Miccichè F, Mantini G, Barbaro B, Garcia- Vargas JE, Magistrelli P, et al. Chemoradiation with raltitrexed and oxaliplatin in preoperative treatment of stage II-III resectable rectal cancer: Phase I and II studies. Int J Radiat Oncol Biol Phys 2004;60:139-148 (Pubitemid 39165478)
12. Klautke G, Feyerherd P, Ludwig K, Prall F, Foitzik T, Fietkau R. Intensified concurrent chemoradiotherapy with 5-fluorouracil and irinotecan as neoadjuvant treatment in patients with locally advanced rectal cancer. Br J Cancer 2005;92:1215-1220
13. Rödel C, Sauer R. Integration of novel agents into combinedmodality treatment for rectal cancer patients. Strahlenther Onkol 2007;183:227-235
14. Dunst J, Reese T, Sutter T, Zü hlke H, Hinke A, Kölling- Schlebusch K, Frings S. Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. J Clin Oncol 2002;20:3983-3991
15. Rödel C, Grabenbauer GG, Papadopoulos T, Hohenberger W, Schmoll HJ, Sauer R. Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer. J Clin Oncol 2003;21:3098-3104
16. Rödel C, Liersch T, Hermann RM, Arnold D, Reese T, Hipp M, Fü rst A, Schwella N, Bieker M, Hellmich G, et al. Multicenter phase II trial of chemoradiation with oxaliplatin for rectal cancer. J Clin Oncol 2007;25:110-117
17. Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, et al. Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study. Ann Oncol 2009;20: 906-912
18. Horisberger K, Treschl A, Mai S, Barreto-Miranda M, Kienle P, Ströbel P, Erben P, Woernle C, Dinter D, Kähler G, et al. Cetuximab in Combination with Capecitabine, Irinotecan, and Radiotherapy for Patients with Locally Advanced Rectal Cancer: Results of a Phase II MARGIT Trial. Int J Radiat Oncol Biol Phys 2009;74:1487-1493
19. Bertolini F, Chiara S, Bengala C, Antognoni P, Dealis C, Zironi S, Malavasi N, Scolaro T, Depenni R, Jovic G, et al. Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: A phase II study in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 2009;73:466-472
20. Rödel C, Arnold D, Hipp M, Liersch T, Dellas K, Iesalnieks I, Hermann RM, Lordick F, Hinke A, Hohenberger W, et al. Phase I-II trial of cetuximab, capecitabine, oxaliplatin, and radiotherapy as preoperative treatment in rectal cancer. Int J Radiat Oncol Biol Phys. 2008;70:1081-1086
21. Valentini V, De Paoli A, Gambacorta MA, Mantini G, Ratto C, Vecchio FM, Barbaro B, Innocente R, Rossi C, Boz G, et al. Infusional 5-fluorouracil and ZD1839 Gefitinib-Iressa in combination with preoperative radiotherapy in patients with locally advanced rectal cancer: A phase I and II Trial 1839IL/ 0092. Int J Radiat Oncol Biol Phys 2008;72:644-649
22. Czito BG, Bendell JC, Willett CG, Morse MA, Blobe GC, Tyler DS, Thomas J, Ludwig KA, Mantyh CR, Ashton J, et al. Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results. Int J Radiat Oncol Biol Phys 2007;68:472-478
23. Willett CG, Duda DG, Tomaso di, Boucher E, Czito Y, Vujaskovic BG, Vlahovic Z, Bendell G, Cohen J, Hurwitz KS, et al. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nat Clin Pract Oncol 2007;4:316-321
24. Urso E, Serpentini S, Pucciarelli S, De Salvo GL, Friso ML, Fabris G, Lonardi S, Ferraro B, Bruttocao A, Aschele C, et al. Complications, functional outcome and quality of life after intensive preoperative chemoradiotherapy for rectal cancer. Eur J Surg Oncol 2006;32:1201-1208
25. Schulze T, Wust P, Gellermann J, Hildebrandt B, Riess H, Felix R, Rau B. Influence of neoadjuvant radiochemotherapy combined with hyperthermia on the quality of life in rectum cancer patients. Int J Hyperthermia 2006;22:301-318
26. Fietkau R, Barten M, Klautke G, Klar E, Ludwig K, Thomas H, Brinckmann W, Friedrich A, Prall F, Hartung G, Kü chenmeister U, Kundt G. Postoperative chemotherapy may not be necessary for patients with ypN0-category after neoadjuvant chemoradiotherapy of rectal cancer. Dis Colon Rectum. 2006;49:1284-1292
27. Collette L, Bosset JF, den Dulk M, Nguyen F, Mineur L, Maingon P, Radosevic-Jelic L, Piérart M, Calais G, European Organisation for Research and Treatment of Cancer Radiation Oncology Group. Patients with curative resection of cT3-4 rectal cancer after preoperative radiotherapy or radiochemotherapy: Does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group. J Clin Oncol 2007;25: 4379-4386
28. Fietkau R, Klautke G. Adjuvant chemotherapy following neoadjuvant therapy of rectal cancer: The type of neoadjuvant therapy chemoradiotherapy or radiotherapy may be important for selection of patients. J Clin Oncol. 2008;26:507-508
29. Rau B, Wust P, Hohenberger P, Lö ffel J, Hü nerbein M, Below C, Gellermann J, Speidel A, Vogl T, Riess H, et al. Preoperative hyperthermia combined with radiochemotherapy in locally advanced rectal cancer: A phase II clinical trial. Ann Surg 1998;227:380-389 (Pubitemid 28131019)
30. Wust P, Rau B, Gellerman J, Pegios W, Lö ffel J, Riess H, Felix R, Schlag PM. Radiochemotherapy and hyperthermia in the treatment of rectal cancer. Recent Results Cancer Res 1998;146:175-191
31. Anscher MS, Lee C, Hurwitz H, Tyler D, Prosnitz LR, Jowell P, Rosner G, Samulski T, Dewhirst MW. A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer. Int J Radiat Oncol Biol Phys 2000;47:719-724
32. Fritzmann J, Hünerbein M, Slisow W, Gellermann J, Wust P, Rau B. Influence of preoperative hyperthermic radiochemotherapy on manometric anal sphincter function in locally advanced rectal cancer. Strahlenther Onkol 2004;180: 281-288 (Pubitemid 38667748)
33. Elias DM, Sideris L. Pharmacokinetics of heated intraoperative intraperitoneal oxaliplatin after complete resection of peritoneal carcinomatosis. Surg Oncol Clin N Am 2003;12: 755-769
34. Liang H, Zhan HJ, Wang BG, Pan Y, Hao XS. Change in expression of apoptosis genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer transplanted into nude mice. World J Gastroenterol 2007;13:4365-4371
35. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group RTOG and the European Organization for Research and Treatment of Cancer EORTC. Int J Radiat Oncol Biol Phys. 1995;31:1341-1346
36. Knight CD, Griffen FD. An improved technique for low anterior resection of the rectum using the EEA stapler. Surgery 1980;88:710-714
37. Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004;351:1731-1740
38. Gérard JP, Conroy T, Bonnetain F, Bouché O, Chapet O, Closon-Dejardin MT, Untereiner M, Leduc B, Francois E, Maurel J, et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: Results of FFCD 9203. J Clin Oncol 2006;24:4620-4625
39. Pucciarelli S, Gagliardi G, Maretto I, Lonardi S, Friso ML, Urso E, Toppan P, Nitti D. Long-term oncologic results and complications after preoperative chemoradiotherapy for rectal cancer: A single-institution experience after a median followup of 95 months. Ann Surg Oncol 2009;16:893-899
40. Klautke G, Fietkau R. Intensified neoadjuvant radiochemotherapy for locally advanced rectal cancer: A review. Int J Colorectal Dis. 2007;22:457-465
41. Gosens MJ, Klaassen RA, Tan-Go I, Rutten HJ, Martijn H, Van Den Brule AJ, Nieuwenhuijzen GA, van Krieken JH, Nagtegaal ID. Circumferential margin involvement is the crucial prognostic factor after multimodality treatment in patients with locally advanced rectal carcinoma. Clin Cancer Res. 2007;13:6617-6623
42. Ceelen WP, Van Nieuwenhove Y, Fierens K. Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer. Cochrane Database Syst Rev 2009 Jan 21;1:CD006041
43. Kido Y, Kuwano H, Maehara Y, Mori M, Matsuoka H, Sugimachi K. Increased cytotoxicity of low-dose, longduration exposure to 5-fluorouracil of V-79 cells with hyperthermia. Cancer Chemother Pharmacol 1991;28: 251-254
44. Matsuoka H, Sugimachi K, Abe R, Ueo H, Akiyoshi T. Enhancement of cytotoxicity by hyperthermia after a longterm culture with 5-fluorouracil in transformed cells. Anticancer Res 1992;12:1621-1625
45. Maeta M, Sawata T, Kaibara N. Effects of hyperthermia on the metabolism of 5-fluorouracil in vitro. Int J Hyperthermia 1993;9:105-113
46. van der Zee J, González González D, van Rhoon GC, van Dijk JD, van Putten WL, Hart AA. Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: A prospective, randomised, multicentre trial. Dutch Deep Hyperthermia Group. Lancet 2000;355: 1119-1125
47. Wust P, Cho CH, Hildebrandt B, Gellermann J. Thermal monitoring: Invasive, minimal-invasive and non-invasive approaches. Int J Hyperthermia. 2006;22:255-262
48. Leopold KA, Dewhirst MW, Samulski TV, Dodge RK, George SL, Blivin JL, Prosnitz LR, Oleson JR. Cumulative minutes with T90 greater than Tempindex is predictive of response of superficial malignancies to hyperthermia and radiation. Int J Radiat Oncol Biol Phys 1993;25:841-847
49. Tilly W, Gellermann J, Graf R, Hildebrandt B, Weissbach L, Budach V, Felix R, Wust P. Regional hyperthermia in conjunction with definitive radiotherapy against recurrent or locally advanced prostate cancer T3 pN0 M0. Strahlenther Onkol. 2005;181:35-41
50. Bosset JF, Collette L, Calais G, Mineur L, Maingon P, Radosevic-Jelic L, Daban A, Bardet E, Beny A, Ollier JC, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006;355:1114-1123