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Volumn 20, Issue 5, 2009, Pages 906-912

Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study

Author keywords

Chemoradiotherapy; Neo adjuvant; Rectal cancer

Indexed keywords

CAPECITABINE; OXALIPLATIN;

EID: 65549151863     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdn719     Document Type: Article
Times cited : (51)

References (40)
  • 1
    • 33646568784 scopus 로고    scopus 로고
    • Pattern of incidence, mortality and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world
    • Kamangar F, Dores GM, Anderson WF. Pattern of incidence, mortality and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 2006; 24: 2137-2150.
    • (2006) J Clin Oncol , vol.24 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3
  • 2
    • 0021792174 scopus 로고
    • Prolongation of the disease-free interval in surgically treated rectal carcinoma
    • GITSG
    • GITSG. Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med 1985; 312: 1465-1472.
    • (1985) N Engl J Med , vol.312 , pp. 1465-1472
  • 3
    • 0026071185 scopus 로고
    • Effective surgical adjuvant therapy for high-risk rectal carcinoma
    • Krook JE, Moertel CG, Gunderson LL et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. New Engl J Med 1991; 324: 709-715.
    • (1991) New Engl J Med , vol.324 , pp. 709-715
    • Krook, J.E.1    Moertel, C.G.2    Gunderson, L.L.3
  • 4
    • 0030805013 scopus 로고    scopus 로고
    • Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer
    • Tveit KM, Guldvog I, Hagen S et al. Randomized controlled trial of postoperative radiotherapy and short-term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer. Br J Surg 1997; 84: 1130-1135.
    • (1997) Br J Surg , vol.84 , pp. 1130-1135
    • Tveit, K.M.1    Guldvog, I.2    Hagen, S.3
  • 5
    • 0034706001 scopus 로고    scopus 로고
    • Preoperative radiotherapy for respectable rectal cancer: A meta-analysis
    • Cammà C, Giunta M, Fiorica F et al. Preoperative radiotherapy for respectable rectal cancer: A meta-analysis. JAMA 2000; 284: 1008-1015.
    • (2000) JAMA , vol.284 , pp. 1008-1015
    • Cammà, C.1    Giunta, M.2    Fiorica, F.3
  • 6
    • 65549088002 scopus 로고    scopus 로고
    • Adjuvant therapy for rectal cancer: A systemic review of 22 randomized trials involved 8507 patients
    • Colorectal Cancer Collaborative Group
    • Colorectal Cancer Collaborative Group. Adjuvant therapy for rectal cancer: A systemic review of 22 randomized trials involved 8507 patients. Lancet 2001; 358: 1291-1304.
    • (2001) Lancet , vol.358 , pp. 1291-1304
  • 7
    • 34548557656 scopus 로고    scopus 로고
    • The TME trial after a median follow-up of 6 years. Increased local control but no survival benefit in irradiated patients with respectable rectal carcinoma
    • Peeters KCMY, Marijnen CAM, Nagtegaal ID et al. The TME trial after a median follow-up of 6 years. Increased local control but no survival benefit in irradiated patients with respectable rectal carcinoma. Ann Surg 2007; 246: 693-701.
    • (2007) Ann Surg , vol.246 , pp. 693-701
    • Peeters, K.C.M.Y.1    Marijnen, C.A.M.2    Nagtegaal, I.D.3
  • 8
    • 33750580102 scopus 로고    scopus 로고
    • Preoperative radiotherapy, with or without concurrent 5fluorouracil and leucovorin in T3-T4 rectal cancers: Results of the FFCD 9203 trial
    • Gerard JP, Conroy T, Bonnetain F et al. Preoperative radiotherapy, with or without concurrent 5fluorouracil and leucovorin in T3-T4 rectal cancers: Results of the FFCD 9203 trial. J Clin Oncol 2006; 24: 4620-4625.
    • (2006) J Clin Oncol , vol.24 , pp. 4620-4625
    • Gerard, J.P.1    Conroy, T.2    Bonnetain, F.3
  • 9
    • 33748676449 scopus 로고    scopus 로고
    • Chemotherapy with preoperative radiotherapy in rectal cancer
    • Bosset JF, Colette L, Calais G et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006; 355: 1114-1123.
    • (2006) N Engl J Med , vol.355 , pp. 1114-1123
    • Bosset, J.F.1    Colette, L.2    Calais, G.3
  • 10
    • 6044226542 scopus 로고    scopus 로고
    • Preoperative versus postoperative chemoradiotherapy for rectal cancer
    • Sauer R, Becker H, Hohenberger W et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. New Engl J Med 2004; 351: 1731-1740.
    • (2004) New Engl J Med , vol.351 , pp. 1731-1740
    • Sauer, R.1    Becker, H.2    Hohenberger, W.3
  • 11
    • 0037083343 scopus 로고    scopus 로고
    • Importance of tumour regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy
    • Bouzourene H, Bosman FT, Seelentag W et al. Importance of tumour regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy. Cancer 2002; 94: 11212-21130.
    • (2002) Cancer , vol.94 , pp. 11212-21130
    • Bouzourene, H.1    Bosman, F.T.2    Seelentag, W.3
  • 12
    • 33644842988 scopus 로고    scopus 로고
    • Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer
    • Rödel C, Martus P, Papadopulos T et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 2005; 23: 8688-8696.
    • (2005) J Clin Oncol , vol.23 , pp. 8688-8696
    • Rödel, C.1    Martus, P.2    Papadopulos, T.3
  • 13
    • 13844280929 scopus 로고    scopus 로고
    • Post-treatment TNM staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy
    • Chan AKP, Wong A, Jenken D et al. Post-treatment TNM staging is a prognostic indicator of survival and recurrence in tethered or fixed rectal carcinoma after preoperative chemotherapy and radiotherapy. Int J Rad Oncol Biol Phys 2005; 61: 665-676.
    • (2005) Int J Rad Oncol Biol Phys , vol.61 , pp. 665-676
    • Chan, A.K.P.1    Wong, A.2    Jenken, D.3
  • 14
    • 27744566164 scopus 로고    scopus 로고
    • Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: Analysis of phase II/III trials
    • Hartley A, Ho KF, McConkey C, Geh JI. Pathological complete response following pre-operative chemoradiotherapy in rectal cancer: Analysis of phase II/III trials. Br J Radiol 2005; 78: 934-938.
    • (2005) Br J Radiol , vol.78 , pp. 934-938
    • Hartley, A.1    Ho, K.F.2    McConkey, C.3    Geh, J.I.4
  • 15
    • 37349117649 scopus 로고    scopus 로고
    • Capecitabine and radiotherapy as neoadjuvant treatment for rectal cancer
    • Ben-Josef E. Capecitabine and radiotherapy as neoadjuvant treatment for rectal cancer. Am J Clin Oncol 2007; 30: 649-655.
    • (2007) Am J Clin Oncol , vol.30 , pp. 649-655
    • Ben-Josef, E.1
  • 16
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • De Gramont A, Figer A, Seymour M et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18: 2938-2967.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2967
    • De Gramont, A.1    Figer, A.2    Seymour, M.3
  • 17
    • 36549035947 scopus 로고    scopus 로고
    • Oxaliplatin/5FU/LV in adjuvant colon cancer: Updated efficacy results of the MOSAIC trial, including survival, with a median follow up of six years
    • 18S Suppl, Abstr 4007
    • De Gramont A, Boni C, Navarro M et al. Oxaliplatin/5FU/LV in adjuvant colon cancer: Updated efficacy results of the MOSAIC trial, including survival, with a median follow up of six years. J Clin Oncol 2007; 25 (18S Suppl): (Abstr 4007).
    • (2007) J Clin Oncol , pp. 25
    • De Gramont, A.1    Boni, C.2    Navarro, M.3
  • 18
    • 34250210799 scopus 로고    scopus 로고
    • Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07
    • Kuebler JP, Wieand HS, O'Connel MJ et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: Results from NSABP C-07. J Clin Oncol 2007; 25: 2198-2204.
    • (2007) J Clin Oncol , vol.25 , pp. 2198-2204
    • Kuebler, J.P.1    Wieand, H.S.2    O'Connel, M.J.3
  • 19
    • 34948892881 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish cooperative group for treatment of digestive tumors trial
    • Diaz-Rubio E, Tabernero J, Gomez-Espana A et al. Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: Final report of the Spanish cooperative group for treatment of digestive tumors trial. J Clin Oncol 2007; 25: 4224-4230.
    • (2007) J Clin Oncol , vol.25 , pp. 4224-4230
    • Diaz-Rubio, E.1    Tabernero, J.2    Gomez-Espana, A.3
  • 20
    • 34948857445 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO colorectal study group
    • Porschen R, Arkenau HT, Kubicka S et al. Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: A final report of the AIO colorectal study group. J Clin Oncol 2007; 25: 4217-4223.
    • (2007) J Clin Oncol , vol.25 , pp. 4217-4223
    • Porschen, R.1    Arkenau, H.T.2    Kubicka, S.3
  • 21
    • 42949150908 scopus 로고    scopus 로고
    • Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line treatment for metastatic colorectal cancer
    • Cassidy J, Clarke S, Diaz-Rubio E et al. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line treatment for metastatic colorectal cancer. J Clin Oncol 2008; 26: 2006-2012.
    • (2008) J Clin Oncol , vol.26 , pp. 2006-2012
    • Cassidy, J.1    Clarke, S.2    Diaz-Rubio, E.3
  • 22
    • 49049105525 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study
    • Hochster HS, Hart LL, Ramanathan RK et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study. J Clin Oncol 2008; 26: 3523-3529.
    • (2008) J Clin Oncol , vol.26 , pp. 3523-3529
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3
  • 23
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III trial
    • Saltz L, Clarke S, Diaz-Rubio E et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III trial. J Clin Oncol 2008; 26: 2013-2019.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.1    Clarke, S.2    Diaz-Rubio, E.3
  • 24
    • 0032695102 scopus 로고    scopus 로고
    • X-ray irradiation induces thymidine-phosphorylase and enhances the efficacy of capecitabne (xeloda) in human cancer xenografts
    • Sawada N, Ishikawa T, Sekiguchi F et al. X-ray irradiation induces thymidine-phosphorylase and enhances the efficacy of capecitabne (xeloda) in human cancer xenografts. Clin Cancer Res 1999; 5: 2948-2953.
    • (1999) Clin Cancer Res , vol.5 , pp. 2948-2953
    • Sawada, N.1    Ishikawa, T.2    Sekiguchi, F.3
  • 25
    • 0037086328 scopus 로고    scopus 로고
    • Radiosensitization by oxaliplatin in a mouse adenocarcinoma: Influence of treatment schedule
    • Cividalli A, Ceciarelli F, Livdi E et al. Radiosensitization by oxaliplatin in a mouse adenocarcinoma: Influence of treatment schedule. Int J Radiat Oncol Biol Phys 2002; 52: 1092-1098.
    • (2002) Int J Radiat Oncol Biol Phys , vol.52 , pp. 1092-1098
    • Cividalli, A.1    Ceciarelli, F.2    Livdi, E.3
  • 26
    • 0041912759 scopus 로고    scopus 로고
    • Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer
    • Rödel C, Grabenbauer GG, Papadopoulos T et al. Phase I/II trial of capecitabine, oxaliplatin, and radiation for rectal cancer. J Clin Oncol 2003; 21: 3098-3104.
    • (2003) J Clin Oncol , vol.21 , pp. 3098-3104
    • Rödel, C.1    Grabenbauer, G.G.2    Papadopoulos, T.3
  • 27
    • 0028305674 scopus 로고
    • Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma
    • Mandard AM, Dalibard F, Mandard JC et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Cancer 1994; 73: 2680-2686.
    • (1994) Cancer , vol.73 , pp. 2680-2686
    • Mandard, A.M.1    Dalibard, F.2    Mandard, J.C.3
  • 28
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials 1989; 10: 1-13.
    • (1989) Control Clin Trials , vol.10 , pp. 1-13
    • Simon, R.1
  • 29
    • 20344373122 scopus 로고    scopus 로고
    • The relationship of pathological tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer
    • Vecchio FM, Valentini V, Minsky B et al. The relationship of pathological tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer. Int J Radiat Oncol Biol Phys 2005; 62: 752-760.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 752-760
    • Vecchio, F.M.1    Valentini, V.2    Minsky, B.3
  • 30
    • 0036311025 scopus 로고    scopus 로고
    • T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival
    • Theodoropoulos G, Wise WE, Padmanabhan A et al. T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 2002; 45: 895-903.
    • (2002) Dis Colon Rectum , vol.45 , pp. 895-903
    • Theodoropoulos, G.1    Wise, W.E.2    Padmanabhan, A.3
  • 31
    • 34648829042 scopus 로고    scopus 로고
    • Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy?
    • Kuo LJ, Liu MC, Jian JJ et al. Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? Ann Surg Oncol 2007; 14: 2766-2772.
    • (2007) Ann Surg Oncol , vol.14 , pp. 2766-2772
    • Kuo, L.J.1    Liu, M.C.2    Jian, J.J.3
  • 32
    • 45049088412 scopus 로고    scopus 로고
    • Prognostic value of complete response after neoadjuvant therapy in locally advanced rectal cancer: Long-term analysis of 566 ypCR patients
    • Capirci C, Velantini V, Cionini L et al. Prognostic value of complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients. Int J Radiat Oncol Biol Phys 2008; 72: 99-107.
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , pp. 99-107
    • Capirci, C.1    Velantini, V.2    Cionini, L.3
  • 33
    • 28444461463 scopus 로고    scopus 로고
    • Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: The RadiOxCape Study
    • Machiels JP, Duck L, Honhon B et al. Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: The RadiOxCape Study. Ann Oncol 2005; 16: 1898-1905.
    • (2005) Ann Oncol , vol.16 , pp. 1898-1905
    • Machiels, J.P.1    Duck, L.2    Honhon, B.3
  • 34
    • 34247180454 scopus 로고    scopus 로고
    • Multicenter phase II trial of chemotherapy with oxaliplatin for rectal cancer
    • Rödel C, Liersch T, Hermann RM et al. Multicenter phase II trial of chemotherapy with oxaliplatin for rectal cancer. J Clin Oncol 2007; 25: 110-117.
    • (2007) J Clin Oncol , vol.25 , pp. 110-117
    • Rödel, C.1    Liersch, T.2    Hermann, R.M.3
  • 35
    • 34648814228 scopus 로고    scopus 로고
    • Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal cancer. A phase I-II multicenter study of the Dutch Colorectal Cancer Group
    • Hospers GA, Punt CJ, Tesselaar ME et al. Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal cancer. A phase I-II multicenter study of the Dutch Colorectal Cancer Group. Ann Surg Oncol 2007; 14: 2773-2779.
    • (2007) Ann Surg Oncol , vol.14 , pp. 2773-2779
    • Hospers, G.A.1    Punt, C.J.2    Tesselaar, M.E.3
  • 36
    • 52949095388 scopus 로고    scopus 로고
    • A phase II study of weekly intravenous oxaliplatin with oral daily capecitabine and radiotherapy with biological correlates in neoadjuvant treatment of rectal adenocarcinoma
    • Fakih MG, Bullard Dun K, Yang GY et al. A phase II study of weekly intravenous oxaliplatin with oral daily capecitabine and radiotherapy with biological correlates in neoadjuvant treatment of rectal adenocarcinoma. Int J Rad Oncol Biol Phys 2008; 72: 650-657.
    • (2008) Int J Rad Oncol Biol Phys , vol.72 , pp. 650-657
    • Fakih, M.G.1    Bullard Dun, K.2    Yang, G.Y.3
  • 37
    • 33845323090 scopus 로고    scopus 로고
    • Capecitabine, oxaliplatin, radiotherapy and excision (CORE) in patients with MRI-defined locally advanced rectal adenocarcinoma: Results of an international multicenter phase II study
    • Abstr 3528
    • Rutten H, Sebag-Montefiore D, Glynne-Jones R et al. Capecitabine, oxaliplatin, radiotherapy and excision (CORE) in patients with MRI-defined locally advanced rectal adenocarcinoma: Results of an international multicenter phase II study. J Clin Oncol 2006; 24 (Suppl): (Abstr 3528).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Rutten, H.1    Sebag-Montefiore, D.2    Glynne-Jones, R.3
  • 38
    • 41649119878 scopus 로고    scopus 로고
    • Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal carcinoma: A phase II trial
    • Abstr 4044
    • Alonso V, Lambea J, Salud A et al. Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal carcinoma: A phase II trial. J Clin Oncol 2007; 25 (Suppl): (Abstr 4044).
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL.
    • Alonso, V.1    Lambea, J.2    Salud, A.3
  • 39
    • 65549122076 scopus 로고    scopus 로고
    • Phase II clinical trial of weekly oxaliplatin with concurrent capecitabine plus preoperative radiotherapy in locally advanced respectable rectal cancer
    • Abstr 15013
    • Majem M, Navarro M, Losa F et al. Phase II clinical trial of weekly oxaliplatin with concurrent capecitabine plus preoperative radiotherapy in locally advanced respectable rectal cancer. J Clin Oncol 2008; 26 (Suppl): (Abstr 15013).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Majem, M.1    Navarro, M.2    Losa, F.3
  • 40
    • 0036467652 scopus 로고    scopus 로고
    • Acute effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: Report of a multicenter randomized trial
    • Marijnen CAM, Kapiteijn E, van de Velde CJH et al. Acute effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer: Report of a multicenter randomized trial. J Clin Oncol 2002; 20: 817-825.
    • (2002) J Clin Oncol , vol.20 , pp. 817-825
    • Marijnen, C.A.M.1    Kapiteijn, E.2    van de Velde, C.J.H.3


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