Expression of oncogenes and tumor suppressor genes in lungs of rats exposed to sulfur dioxide and benzo(a)pyrene

Inhalation Toxicology

Volumn 22, Issue 4, 2010, Pages 322-329

  Qin, Guohua ^a   Meng, Ziqiang ^a  

^a SHANXI UNIVERSITY   (China)

Author keywords

C myc; Enzo(a)pyrene; H ras; P16; P53; Rb; Sulfur dioxide

Indexed keywords

BENZO[A]PYRENE; CELL CYCLE PROTEIN; MESSENGER RNA; MYC PROTEIN; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P16; PROTEIN P53; RETINOBLASTOMA PROTEIN; SULFUR DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; GENE EXPRESSION; GENE INTERACTION; LUNG TUMOR; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; ONCOGENE C FOS; ONCOGENE C MYC; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING; WISTAR RAT;

ADMINISTRATION, INHALATION; ANIMALS; BENZO(A)PYRENE; BLOTTING, WESTERN; DNA, COMPLEMENTARY; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION; GENES, P16; GENES, P53; GENES, RAS; GENES, RETINOBLASTOMA; GENES, TUMOR SUPPRESSOR; LUNG; MALE; ONCOGENES; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SULFUR DIOXIDE;

RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 77149174155     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958370903341891     Document Type: Article

References (44)

1. Baeza-Squiban A, Delcher L, Kukreti R, Joly AC, Guennou C, Houcine O, Marano F. 2000. Responses of the rabbit tracheal epithelium in vitro to H(2)O(2)-induced oxidative stress. Toxicol In Vitro 14:159-167.
2. Bai J, Meng Z. 2005. Effects of sulfur dioxide on apoptosis-related gene expression in lungs from rats. Regul. Toxicol. Pharmacol. 43:272-279. (Pubitemid 41616393)
3. Constantin D, Mehrotra K, Wallin A, Moldeus P, Jernstrom B. 1995. Studies on the effect of sulfite on benzo[a]pyrene-78-dihydrodiol activation to reactive intermediates in human polymorphonuclear leukocytes. Chem-Biol. Interact. 94:73-82.
4. Feng Z, Hu W, Chen JX, Pao A, Li H, Rom W, Hung MC, Tang MS. 2002. Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J. Natl. Cancer. Inst. 94:1527-1536.
5. Fields WR, Desiderio JG, Leonard RM, Burger EE, Brown BG, Doolittle DJ. 2004. Differential c-myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene benzo[a]pyrene-45 epoxide and benzo[a]pyrene-78-910 diol epoxide. Mol. Carcinog. 40: 79-89.
6. Garçon G, Gosset P, Zerimech F, Grave-Descampiaux B, Shirali P. 2004. Effect of Fe2O3 on the capacity of benzo(a)pyrene to induce polycyclic aromatic hydrocarbon-metabolizing enzymes in the respiratory tract of Sprague- Dawley rats. Toxicol. Lett 150:179-189.
7. Green JL, Reed GA. 1990. Benzo[a]pyrene bay-region sulfonates a novel class of reactive intermediates. Chem. Res. Toxicol. 3:59-64.
8. Goyal SK. 2001. Use of rosaniline hydrochloride dye for atmospheric SO2 determination and method sensitivity analysis. J. Environ. Monit. 3:666-670.
9. Higgins ITT. 1971. Effects of the sulfur oxides and particulates on human health. Arch. Environ. Health. 22:584-590.
10. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, Phillips DH. 2007. AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. Chem. Res. Toxicol. 20:1797-1810.
11. Jin P, Ringertz NR. 1990. Cadmium induces transcription of oncogenes c-jun and c-myc in rat L6 myoblasts. J. Biol. Chem. 265:14061-14064.
12. Kampa M, Castanas E. 2008. Human health effects of air pollution. Environ. Pollut. 151:362-367.
13. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. 1991. Participation of p53 protein in the cellular response to DNA damage. Cancer. Res. 51: 6304-6311.
14. Kim K.B, Lee BM. 1997. Oxidative stress to DNA protein and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a) pyrene. Cancer. Lett. 113:205-212.
15. 3) in vitro. Hum. Exp. Toxicol. 17: 600-605.
16. Laskin S, Kuscher M, Sellakumar A, Katz GV. 1976. Combined carcinogen-irritant animal inhalation studies. In: Aharanson EF, Ben-David A, Klingsberg MA, eds. Air Pollution and the Lung. New York: John Wiley and Sons, 190-213.
17. Lave LB, Liskin EP. 1970. Air pollution and health. Science. 169:723-733.
18. Lee AM, Fraumeni JF Jr. 1969. Arsenic and respiratory cancer in man: an occupational study. J. Natl. Cancer. Inst. 42:1045-1052.
19. Lee JT, Kim H, Hong YC, Kwon HJ, Schwartz J, Christiani DC. 2000. Air pollution and daily mortality in seven major cities of Korea 1991-1997. Environ. Res. 84:247-254.
20. Lee WJ, Teschke K, Kauppinen T, Andersen A, Jäppinen P, Szadkowska-Stanczyk I, Pearce N, Persson B, Bergere A, Facchini L.A, Kishi R, Kielkowski D, Rix BA, Henneberger P, Sunyer J, Colin D, Kogevinas M, Boffetta P. 2002. Mortality from lung cancer in workers exposed to sulfur dioxide in the pulp and paper industry. Environ. Health. Perspect. 110:991-995. (Pubitemid 35175040)
21. Leung KH, Keller DA, Menzel DB. 1989. Effect of sulfite on the covalent reaction of benzo[a]pyrene metabolites with DNA. Carcinogenesis. 10: 259-264.
22. Little CD, Nau MM, Carney DN, Gazdar AF, Minna JD. 1983. Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature. 306:194-196.
23. Meng Z, Qin G, Zhang B. 2005. DNA damage in mice treated with sulfur dioxide by inhalation. Environ. Mol. Mutagen. 46:150-155.
24. Meng Z, Qin G, Zhang B, Bai J. 2004. DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice. Mutagenesis. 19:465-468.
25. Meng Z, Qin G, Zhang B, Geng H, Bai Q, Bai W, Liu C. 2003. Oxidative damage of sulfur dioxide inhalation on lungs and hearts of mice. Environ. Res. 93:285-292. (Pubitemid 37393249)
26. Milde-Langosch K. 2005. The Fos family of transcription factors and their role in tumourigenesis. Eur. J. Cancer. 41:2449-2461.
27. Nisbet ICT, Schneiderman MA, Karch NJ, Siegal DM. 1984. Review and Evaluation of the Evidence for Cancer Associated with Air Pollution: Final Report. Research Triangle Park, NC: Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency. EPA-450/5-83-006R.
28. Park SY, Lee SM, Ye SK, Yoon SH, Chung MH, Choi J. 2006. Benzo[a]pyreneinduced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment. Toxicol. Lett. 167:27-33.
29. Pauluhn J, Thyssen J, Althoff J, Kimmerle G, Mohr U. 1985. Long-term inhalation study with benzo[a]pyrene and SO2 in Syrian golden hamsters. Exp. Pathol. 28:31.
30. Perera F. 1981. Carcinogenicity of airborne fine particulate benzo(a)pyrene: An appraisal of the evidence and the need for control. Environ. Health. Perspect. 42:163-185.
31. Qin G, Meng Z. 2006. The expression of protooncogenes and CYP1A in lungs of rats exposed to sulfur dioxide and benzo(a)pyrene. Regul. Toxicol. Pharmacol. 45:36-43.
32. Reddy APM, Mossmann BT. 2002. Role and regulation of activator protein-1 in toxicant-induced responses of the lung. Am. J. Physiol. Lung. Cell. Mol. Physiol. 283: L1161-L1178.
33. Reed GA. 1987. Sulfite-dependent mutagenicity of benzo[a]pyrene derivatives. Carcinogenesis 8:1145-1148.
34. Reed GA, Curtis JF, Mottley C, Eling TE, Mason RP. 1986. Epoxidation of (+/?)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: Activation of a procarcinogen by a cocarcinogen. Proc. Natl. Acad. Sci. USA. 83:7499-7502.
35. Rencher AC, Carter MW, Mekee DW. 1977. A retrospective epidemiological study of mortality at a large western copper smelter. J. Occup. Med. 19:754-758.
36. Saha P, Banerjee S, Ganguly C, Manna S, Panda CK, Das S. 2005. Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia dysplasia and carcinoma in situ. J. Environ. Pathol. Toxicol. Oncol. 24:211-224.
37. Shackelford RE, Kaufmann WK, Paules RS. 1999. Cell cycle control checkpoint mechanisms and genotoxic stress. Environ. Health. Perspect. 107: 5-24.
38. Shubik P. 1995. Chemical carcinogens and human cancer. Cancer. Lett. 93:3-7.
39. Supino R, Perego P, Gatti L, Caserini C, Leonetti C, Colantuono M, Zuco V, Carenini N, Zupi G, Zunino F. 2001. A role for c-myc in DNA damageinduced apoptosis in a human TP53-mutant small-cell lung cancer cell line. Eur. J. Cancer. 37:2247-2256.
40. Takahashi T, Nau MM, Chiba I, Birrer MJ, Rosenberg RK, Vinocour M, Levit M, Pass H, Gazdar AF, Minna JD. 1989. p53: A frequent target for genetic abnormalities in lung cancer. Science 246:491-494.
41. Toyokuni S. 2008. Molecular mechanisms of oxidative stress-induced carcinogenesis: From epidemiology to oxygenomics. IUBMB Life 60:441-447.
42. Wang Z, Zheng R, Fu S, Chen Y, Duan G, Qin D, Liu G. 1998. Role of superoxide anion on the proliferation and c-Ha-ras or p53 expression in prostate cancer cell line PC3. Urol. Res. 26:349-353.
43. Yan LP, Zhang HW, Tao MX. 2007. Benzo(a)pyrene induces quiescent diploid human embryonic lung fibroblast cells undergoing a reversible G1 arrest. Zhonghua Yu Fang Yi Xue Za Zhi 41:387-390.
44. Zhang Y, Ramos KS. 1997. The induction of proliferative vascular smooth muscle cell phenotypes by benzo[a]pyrene does not involve mutational activation of ras genes. Mutat. Res. 373:285-292.