Inhalation exposure systems for the development of rodent models of sulfur mustard-induced pulmonary injury

Toxicology Mechanisms and Methods

Volumn 20, Issue 1, 2010, Pages 14-24

  Weber, Waylon M ^a   Kracko, Dean A ^a   Lehman, Mericka R ^a   Irvin, Clinton M ^a   Blair, Lee F ^a   White, Richard K ^a   Benson, Janet M ^a   Grotendorst, Gary R ^a   Cheng, Yung Sung ^a   McDonald, Jacob D ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Aerosol; Inhalation; Rodents; Sulfur mustard

Indexed keywords

ALCOHOL; MUSTARD GAS;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXPOSURE; FEMALE; INTUBATION; LOWER RESPIRATORY TRACT; LUNG INJURY; NEBULIZATION; NONHUMAN; NOSE INJURY; PARTICLE SIZE; PRIORITY JOURNAL; RAT; UPPER RESPIRATORY TRACT;

AEROSOLS; ANIMALS; CHEMICAL WARFARE AGENTS; DISEASE MODELS, ANIMAL; FEMALE; INHALATION EXPOSURE; INTUBATION, INTRATRACHEAL; LUNG; LUNG DISEASES; MUSTARD GAS; PARTICLE SIZE; PILOT PROJECTS; RATS; RATS, INBRED F344; TURBINATES; VOLATILIZATION;

ANIMALIA; RODENTIA;

EID: 77149173220     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376510903483730     Document Type: Article

References (38)

1. Afshinniaz F, Ghanei M. 1995. Relationship of the chronic respiratory symptoms with spirometric and laboratory parameters (Dissertation). Isfahan University of Medical Sciences, Isfahan, Iran.
2. Anderson DR, Yourick JJ, Moeller RB, Petralim JP, Young GD. 1996. Pathologic changes in rat lungs following acute sulfur mustard inhalation. Inhal Toxicol 8:285-297.
3. Anslow WP, Houk CR. Systemic pharmacology and pathology of sulfur and nitrogen mustards. In: Chemical Warfare Agents, and Related Chemical Problems, Vol 1, parts III-VI, Office of Scientific Research and Development. Washington, DC: National Defense Research Committee, 1946; 470-478.
4. Aslani J. 2000. Late respiratory complications of sulphur mustard. In: Cheraghali AM, editor. Prevention and treatment of complications of chemical warfare agents. Tehran, Iran: Chemical Warfare Research Centre. pp 76-79.
5. Balali M, Tabarestani M, Farhoodi M, Panjvani FA. 1991. Study of clinical and laboratory findings of sulfur mustard in 329 war victims. Med J MUMS 34:7-15.
6. Balali-Mood M. 1986. First report of delayed toxic effects of Yperite poisoning in Iranian fighters. In: Heyndrickx B, editor. Proceedings of the Second World Congress on New Compounds in Biological and Chemical Warfare. Ghent, Belgium: Rijksuniversiteit. pp 489-495.
7. Balali-Mood M, Navaeian A. 1986. Clinical and paraclinical findings in 233 patients with sulfur mustard poisoning. In: Heyndrickx B, editor. Proceedings of the Second World Congress on New Compounds in Biological and Chemical Warfare. Ghent, Belgium: Rijksuniversiteit. pp 464-473.
8. Balali-Mood M, Hefazi M. 2005. Te pharmacology, toxicology, and medical treatment of sulfur mustard poisoning. Fund Clin Pharmacol 19:297-315.
9. Bijani KH, Moghadamnia AA. 2002. Long-term effects of chemical weapons on respiratory tract in Iran-Iraq was victims living in Babol (North of Iran). Ecotoxicol Environ Saf 53:422-424.
10. Canelli AF. 1918. Contrbuto alla conoscenza dell' intossicazione acuta da 'Yperite' ed in particolare del suo reperto anatomo-patologico. Rivista Ospedaliera Italiana 8:2-7.
11. Capacio BR, Smith JR, Lawrence RJ, Boyd BL, Witriol AM, Conti ML, Collins JL, Scuito AM. 2008. Gas chromatographic-mass spectrometric analysis of sulfur mustard-plasma protein adducts: validation and use in a rat inhalation model. J Anal Toxicol 32:37-43.
12. Connors TA. 1966. Protection against the toxicity of all alkylating agents by thiols: the mechanism of protection and its relevance to cancer chemotherapy. Eur J Cancer 2:293-305.
13. Connors TA, Jeney A, Jones M. 1964. Reduction of the toxicity of 'radiomimetic' alkylating agents in rats by thiol pretreatment. the mechanism of the protective action of thiosulfate. Biochem Pharmacol 13:1545-1550.
14. DHHS (Department of Health and Human Services). 2007. Agency for Toxic Substances and Disease Registry, Medical Management Guidelines (MMG) for Blister Agents: Sulfur Mustard Agent H or HD (C4H8Cl2S) and Sulfur Mustard Agent HT. Available online at: http://www.atsdr.cdc.gov/MHMI/mmg165.pdf. Accessed 14 December 2009
15. DHS (Department of Homeland Security). 2007. 6 CFR Part 27, Appendix to Chemical Facility Anti-Terrorism Standards; Final Rule (November 2007). Available online at: http://www.dhs.gov/xlibrary/assets/chemsec-appen- dixafinalrule.pdf. Accessed 14 December 2009
16. Dorman DC, Struve MF, Wong BA, Gross EA, Parkinson C, Willson GA, Tan YM, Campbell JL, Teeguarden JG, Clewell III HJ, Andersen ME. 2008. Derivation of an inhalation concentration based upon olfactory neuro-nal loss in male rats following subchronic acetaldehyde inhalation. Inhal Toxicol 20:245-256.
17. Emad A, Rezaian GR. 1997. Te diversity of effects of sulphur mustard gas inhalation of respiratory system 10 years after a single heavy exposure: analysis of 197 cases. Chest 112:734-738.
18. Fairhall SJ, Brown RFR, Jugg BJA, Smith AJ, Mann TM, Jenner J, Scuito AM. 2008. Preliminary studies of sulfur mustard-induced lung injury in the terminally anesthetized pig: exposure system and methodology. Toxicol Mechan Methods 18:355-362.
19. FDA (Food and Drug Administration). 2008. Animal Models - Essential Elements to Address Efficacy Under the Animal Rule (September 2008). Available online at: http://www.fda.gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/ucm072214.pdf; Accessed 14 December 2009.
20. Foster JH, Lewis MR, Jacobs JK. 1962. Tiosulfate protection against the toxic effects of nitrogen mustard in perfusion of the liver. Am Surg 28:461-464.
21. Freitage L, Firusian N, Stamatis G, Grescheuchua D. 1991. Te role of bronchoscopy in pulmonary complications due to mustard gas inhalation. Chest 100:1436-1441.
22. Ghanei M, Akhlaghpoor S, Moahammad MM, Aslani J. 2004. Tracheobronchial stenosis following sulfur mustard inhalation. Inhal Toxicol 16:845-849.
23. Ghanei M, Harandi AA. 2007. Long term consequences from exposure to sulfur mustard: a review. Inhal Toxicol 19:451-456.
24. Hosseini K, Moradi A, Vessal K. 1989. Pulmonary manifestations of mustard gas injury: a review of 61 cases. Iran J Med Sci 14:20-26.
25. Kehe K, Balszuweit F, Emmler J, Kreppel H, Jochum M, Tiermann H. 2008. Sulfur mustard research-strategies for the development of improved medical therapy. Eplasty 8:e32.
26. McClellan RO, Henderson RF. 1995. Concepts in inhalation toxicology. 2nd ed. Washington DC, USA: Taylor and Francis Publishing Company.
27. NRC (National Research Council) 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington DC.
28. Pant SC, Vijayaraghavan R. 1999. Histomorphological and histochemical alterations following short-term inhalation exposure to sulfur mustard of visceral organs of mice. Biomed Environ Sci 12:201-213.
29. Rabbe OG. 1982. Disposition and clearance of inhaled aerosols. In: Witschi H, editor. Mechanisms in respiratory toxicology. Boca Raton, FL: CRC Press. pp 27-76.
30. Sidell FR, Hurst CG. Clinical considerations in mustard gas poisoning. In: Somani SM (ed). Chemical Warfare Agents. Academic Press: San Diego, USA, 1992, pp 156-194.
31. Stepanov AA, Popov VN. 1962. Chemical weapons and principles of antichemi-cal defense. Translated by Joint Publications Research Service. JPRS 15107. Washington, DC: JPRS.
32. Teeguarden JG, Bogdanffy MS, Covington TR, Tan C, Jarabek AM. 2008. A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative tar and human nasal tissue acetaldehyde dosimetry. Inhal Toxicol 20:375-390.
33. US Army. 2004. U.S. Army Center for Health Promotion and Preventive Medicine - Federal Register 69(85), 24164-24168. Available online at: http://usachppm.amedd.army.mil/chemicalagent/pdffiles/cdcfedreg-sulfurmustard- may2004.pdf. Accessed 14 December 2009.
34. van Helden HPM, Kuijpers WC, Diemel RV. 2004. Asthma like symptoms following intratracheal exposure of guinea pigs to sulfur mustard aerosol: therapeutic efficacy of exogenous lung surfactant curosurf and salbutamol. Inhal Toxicol 16:537-548.
35. Vijayaraghavan R. 1997. Modifications of breathing pattern induced by inhaled sulphur mustard in mice. Arch Toxicol 71:157-164.
36. Warthin AS, Weller C V. 1919. Te lesions of the respiratory and gastrointestinal tract produced by mustard gas (dichloroethyl sulphide). J Lab Clin Med 4:229-264.
37. Willems JL. 1989. Clinical management of mustard gas casualties. Ann Med Mil Belg 3(suppl.):1-61.
38. Young JT. 1981. Histopathologic examination of the rat nasal cavity. Fund Appl Toxicol 1:309-312.