Gap junction hemichannels contribute to the generation of diarrhoea during infectious enteric disease

Gut

Volumn 59, Issue 2, 2010, Pages 218-226

  Guttman, Julian Andrew ^a,b   Lin, Ann En Ju ^a,b   Li, Yuling ^a   Bechberger, John ^c   Naus, Christian C ^c   Vogl, A Wayne ^c   Finlay, B Brett ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SIMON FRASER UNIVERSITY   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CITROBACTER RODENTIUM; COLON; COMPARATIVE STUDY; CONTROLLED STUDY; DIARRHEA; DISEASE ASSOCIATION; FEMALE; GAP JUNCTION; IMMUNOLOCALIZATION; IN VIVO STUDY; INTESTINE CELL; INTESTINE INFECTION; MALE; MOUSE; MUTANT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

ANIMALS; BODY WATER; CITROBACTER RODENTIUM; COLON; CONNEXIN 43; DIARRHEA; ENTEROBACTERIACEAE INFECTIONS; FLUORESCENT DYES; GAP JUNCTIONS; GENOTYPE; ISOQUINOLINES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, IMMUNOELECTRON; POLYMERASE CHAIN REACTION;

EID: 77149156315     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2008.170464     Document Type: Article

References (37)

1. Simonovic I, Rosenberg J, Koutsouris A, et al. Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions. Cell Microbiol 2000;2:305-15.
2. Guttman JA, Li Y, Wickham ME, et al. Attaching and effacing pathogen-induced tight junction disruption in vivo. Cell Microbiol 2006;8:634-45.
3. Ma C, Wickham ME, Guttman JA, et al. Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map). Cell Microbiol 2006;8:1669-86.
4. Saez JC, Retamal MA, Basilio D, et al. Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta 2005;1711:215-24.
5. Cherian PP, Siller-Jackson AJ, Gu S, et al. Mechanical strain opens connexin 43 hemichannels in osteocytes: a novel mechanism for the release of prostaglandin. Mol Biol Cell 2005;16:3100-06.
6. Thompson RJ, Zhou N, MacVicar BA. Ischemia opens neuronal gap junction hemichannels. Science 2006;312:924-7.
7. Crane JK, Olson RA, Jones HM, et al. Release of ATP during host cell killing by enteropathogenic E. coli and its role as a secretory mediator. Am J Physiol Gastrointest Liver Physiol 2002;283:G74-86.
8. Crane JK, Naeher TM, Choudhari SS, et al. Two pathways for ATP release from host cells in enteropathogenic Escherichia coli infection. Am J Physiol Gastrointest Liver Physiol 2005;289:G407-17.
9. Collington GK, Booth IW, Knutton S. Rapid modulation of electrolyte transport in Caco-2 cell monolayers by enteropathogenic Escherichia coli (EPEC) infection. Gut 1998;42:200-7.
10. Mundy R, Girard F, Fitzgerald AJ, et al. Comparison of colonization dynamics and pathology of mice infected with enteropathogenic Escherichia coli, enterohaemorrhagic E. coli and Citrobacter rodentium. FEMS Microbiol Lett 2006;265:126-32.
11. Deng W, Puente JL, Gruenheid S, et al. Dissecting virulence: systematic and functional analyses of a pathogenicity island. Proc Natl Acad Sci U S A 2004;101:3597-602.
12. Guttman JA, Samji FN, Li Y, et al. Evidence that tight junctions are disrupted due to intimate bacterial contact and not inflammation during attaching and effacing pathogen infection in vivo. Infect Immun 2006;74:6075-84.
13. Deng W, Vallance BA, Li Y, et al. Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice. Mol Microbiol 2003;48:95-115.
14. Theis M, de Wit C, Schlaeger TM, et al. Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis 2001;29:1-13.
15. Guttman JA, Samji FN, Li Y, et al. Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens. Cell Microbiol 2007;9:131-41.
16. Gruenheid S, DeVinney R, Bladt F, et al. Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Nat Cell Biol 2001;3:856-9.
17. Evans WH, Carlile G, Rahman S, et al. Gap junction communication channel: peptides and anti-peptide antibodies as structural probes. Biochem Soc Trans 1992;20:856-61.
18. Boitano S, Evans WH. Connexin mimetic peptides reversibly inhibit Ca(2+) signaling through gap junctions in airway cells. Am J Physiol Lung Cell Mol Physiol 2000;279:L623-30.
19. Leybaert L, Braet K, Vandamme W, et al. Connexin channels, connexin mimetic peptides and ATP release. Cell Commun Adhes 2003;10:251-7.
20. Simon AM, McWhorter AR. Role of connexin37 and connexin40 in vascular development. Cell Commun Adhes 2003;10:379-85.
21. Grubb BR, Gabriel SE. Intestinal physiology and pathology in gene-targeted mouse models of cystic fibrosis. Am J Physiol 1997;273:G258-66.
22. Reaume AG, de Sousa PA, Kulkarni S, et al. Cardiac malformation in neonatal mice lacking connexin43. Science 1995;267:1831-4.
23. Tran Van Nhieu G, Clair C, Bruzzone R, et al. Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells. Nat Cell Biol 2003;5:720-6.
24. Gershon MD. Serotonin and its implication for the management of irritable bowel syndrome. Rev Gastroenterol Disord 2003;3(Suppl 2):S25-34.
25. Hecht G, Koutsouris A. Enteropathogenic E. coli attenuates secretagogue-induced net intestinal ion transport but not Cl- secretion. Am J Physiol 1999;276: G781-88.
26. Guttman JA, Finlay BB. Subcellular alterations that lead to diarrhea during bacterial pathogenesis. Trends Microbiol 2008;16:535-42.
27. Guttman JA, Finlay BB. Tight junctions as targets of infectious agents. Biochim Biophys Biophys Acta 2009;1788:832-41.
28. Woo H, Okamoto S, Guiney D, et al. A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice. PLoS One 2008;3:e1603.
29. Cheng C, Tennant SM, Azzopardi KI, et al. Contribution of the pst-phoU operon to cell adherence by atypical enteropathogenic Escherichia coli and virulence of Citrobacter rodentium. Infect Immun 2009;77:1936-44.
30. Gershon MD. Review article: serotonin receptors and transporters e roles in normal and abnormal gastrointestinal motility. Aliment Pharmacol Ther 2004;20(Suppl 7):3-14.
31. Walker NM, Simpson JE, Levitt RC, et al. Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome. J Pharmacol Exp Ther 2006;317:275-83.
32. Huettner JE, Lu A, Qu Y, et al. Gap junctions and connexon hemichannels in human embryonic stem cells. Stem Cells 2006;24:1654-67.
33. Goodenough DA, Paul DL. Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol 2003;4:285-94.
34. Guttman JA, Kazemi P, Lin AE, et al. Desmosomes are unaltered during infections by attaching and effacing pathogens. Anat Rec (Hoboken) 2007;290:199-205.
35. McLean IW, Nakane PK. Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy. J Histochem Cytochem 1974;22:1077-83.
36. Young JS, Guttman JA, Vaid KS, et al. Cortactin (CTTN), N-WASP (WASL), and clathrin (CLTC) are present at podosome-like tubulobulbar complexes in the rat testis. Biol Reprod 2009;80:153-61.
37. Young JS, Guttman JA, Vaid KS, et al. Tubulobulbar complexes are intercellular podosome-like structures that internalize intact intercellular junctions during epithelial remodeling events in the rat testis. Biol Reprod 2009;80:162-74.