Chronic intermittent hypoxia from pedo-stage decreases glucose transporter 4 expression in adipose tissue and causes insulin resistance

Chinese Medical Journal

Volumn 123, Issue 4, 2010, Pages 463-470

  Chen, Lin ^a   Cao, Zhao Long ^a   Han, Fang ^a   Gao, Zhan Cheng ^a   He, Quan Ying ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Childhood; Glucose transporters; Hypoxia; Insulin resistance; Sleep apnea syndrome

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN;

ADENOTONSILLECTOMY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HYPOXIA; IMMUNOCYTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; SLEEP APNEA SYNDROME; WEIGHT CHANGE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANIMALS; ANOXIA; BLOOD GLUCOSE; BLOTTING, WESTERN; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORTER TYPE 4; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN RESISTANCE; MALE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77149147767     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2010.04.015     Document Type: Article

References (49)

1. Chau KW, Ng KK, Kwok KL, Cheung MY. Survey of children with obstructive sleep apnea syndrome in Hong Kong of China. Chin Med J 2004; 117: 657-660.
2. Marcus CL, Sleep-disordered breathing in children. Am J Respir Crit Care Med 2001; 164: 16-30.
3. Contencin P, Guilleminault C, Manach Y. Long-term follow-up and mechanisms of obstructive sleep apnea (OSA) and related syndromes through infancy and childhood. Int J Pediatr Otorhinolaryngol 2003; 67: 119-123.
4. Bixler EO, Vgontzas AN, Lin HM, Calhoun SL, Vela-Bueno A, Kales A. Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabeties and depression. J Clin Endocrinol Metabo 2005; 90: 4510-4515.
5. Feinberg I. Untreated type 2 diabetes as a cause of daytime somnolence. Sleep 1993; 16: 82.
6. Volgin DV, Kubin L. Chronic intermittent hypoxia alters hypothalamic transcription of genes involved in metabolic regulation. Auton Neurosci 2006; 126-127: 93-99.
7. Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005; 365: 1046-1053.
8. Peppard P, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. J Am Med Assoc 2000; 284: 3015-3021.
9. Yaggi HK, Araujo AB, McKinlay JB. Sleep duration as a risk factor for the development of type 2 diabetes. Diabetes Care 2006; 29: 657-661.
10. Vgontzas AN, Bixler EO, Chrousos GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 2005; 9: 211-224.
11. Ma S, Mifflin SW, Cunningham JT, Morilak DA. Chronic intermittent hypoxia sensitizes acute hypothalamic-pituitaryadrenal stress reactivity and Fos induction in the rat locus coeruleus in response to subsequent immobilization stress. Neuroscience 2008; 154: 1639-1647.
12. Tasali E, Ip MS. Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation. Proc Am Thorac Soc 2008; 5: 207-217.
13. Grunstein RR. Metabolic aspects of sleep apnea. Sleep 1996; 19: 218-220.
14. Dietz WH. Health consequences of obesity in youth: childhood predictors of adult disease. Pediatrics 1998; 101: 518-525.
15. Elmasry A, Janson C, Lindberg E, Gislason T, Tageldin MA, Boman G. The role of habitual snoring and obesity in the development of diabetes: a 10-year follow-up study in a male population. J Intern Med 2000; 248: 13-20.
16. Strohl KP, Novak RD, Singer W, Cahan C, Boehm KD, Denko CW, et al. Insulin levels, blood pressure and sleep apnea. Sleep 1994; 17: 614-618.
17. Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002; 165: 670-676.
18. Marsden PJ, Murdoch AP, Taylor R. Adipocyte insulin action following ovulation in polycystic ovarian syndrome. Human Reproduction 1999; 14: 2216-2222.
19. Klöting N, Blüher M, Klöting I. The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue. Diabetes Metab Res Rev 2006; 22: 146-154.
20. Hu XJ, Peng F, Zhou HQ, Zhang ZH, Cheng WY, Feng HF. The abnormality of glucose transporter in the erythrocyte membrane of Chinese type 2 diabetic patients. Biochim Biophys Acta 2000; 1466: 306-314.
21. Gould GW, Holman GD. The glucose transporter family: structure, function, and tissue-specific expression. Biochem J 1993; 295: 329-341.
22. Shepherd PR, Kahn BB. Glucose transporter and insulin resistance - implication for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341: 248-257.
23. Liu K, Yee B, Philips C, Grunstein RR. Sleep apnea and neuroendocrine function. Sleep Medicin Clinics 2007; 2: 225-236.
24. Liu PY, Yee B, Wishart SM, Jimenez M, Jung DG, Ronald R, et al. The short-term effects of high-dose testosterone on sleep, breathing, and function in older men. J Clin Endocrinol Metab 2003; 88: 3605-3613.
25. Zhou XS, Rowley JA, Demirovic F, Diamond M, Badr M. Effect of testosterone on the apneic threshold in women during NREM sleep. J Appl Physiol 2003; 94: 101-107.
26. Gozal D, Daniel JM, Dohanich GP. Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. J Neurochem 2001; 21: 2442-2450.
27. Gozal D, Row BW, Kheirandish L, Liu R, Guo SZ, Qiang F, et al. Increased susceptibility to intermittent hypoxia in aging rats: changes in proteasomal activity, neuronal apoptosis and spatial function. J Neurochem 2003; 86: 1545-1552.
28. de Carvalho Papa P, Vargas AM, da Silva JL, Nunes MT, Machado UF. GLUT-4 protein is differently modulated during development of obesity in monosodium glutamate-treated mice. Life Sciences 2002; 71: 1917-1928.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
30. Tasker C, Crosby JH, Strading JR. Evidence for persistence of upper airway narrowing during sleep, 12 years after adenotonsillectomy. Arch Dis Child 2002; 86: 34-37.
31. de la Eva RC, Baur LA, Donaghue KC, Waters KA. Metabolic correlates with obstructive sleep apnea in obese subjects. J Pediatr 2002; 140: 654-659.
32. Spiegel K, Leproult R, Van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet 1999; 354: 1435-1439.
33. Zhang XL, Yin KS, Mao H, Wang H, Yang Y. Serum adiponectin level in patients with obstructive sleep apnea hypopnea syndrome. Chin Med J 2004; 117: 1603-1606.
34. Zhang XL, Yin KS, Li C, Jia EZ, Li YQ, Gao ZF. Effect of continuous positive airway pressure treatment on serum adiponectin level and mean arterial pressure in male patients with obstructive sleep apnea syndrome. Chin Med J 2007; 120: 1477-1481.
35. Han F. Obstructive sleep apnea hypopnea syndrome: a proinflammatory disorder. Chin Med J 2007; 120: 1475-1476.
36. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, Lin HM, et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 2000; 85: 1151-1158.
37. Cheng N, Cai W, Jiang M, Wu S. Effect of hypoxia on blood glucose, hormones, and insulin receptor functions in newborn calves. Pediatric Research 1997; 41: 852-856.
38. Raff H, Bruder ED, Jankowski BM, Colman RJ. Effect of neonatal hypoxia on leptin, insulin, growth hormone and body composition in the rat. Horm Metab Res 2001; 33: 151-155.
39. Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995; 96: 1897-1904.
40. Narkiewicz K, van de Borne PJ, Cooley RL, Dyken ME, Somers VK. Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation 1998; 98: 772-776.
41. Watanabe T, Mano T, Iwase S, Sugiyama Y, Okada H, Takeuchi S, et al. Enhanced muscle sympathetic nerve activity during sleep apnea in the elderly. J Auton Nerv Syst 1992; 37: 223-226.
42. Coy TV, Dimsdale JE, Ancoli-Israel S, Clausen J. Sleep apnoea and sympathetic nervous system activity: a review. J Sleep Res 1996; 5: 42-50.
43. Dimsdale JE, Coy T, Ancoli-Israel S, Mills P, Clausen J, Ziegler MG. Sympathetic nervous system alterations in sleep apnea: the relative importance of respiratory disturbance, hypoxia, and sleep quality. Chest 1997; 111: 639-642.
44. Dimsdale JE, Coy T, Ziegler MG, Ancoli-Israel S, Clausen J. The effect of sleep apnea on plasma and urinary catecholamines. Sleep 1995; 18: 377-381.
45. Harsch IA, Schahin SP, Radespiel-Troger M, Weintz O, Jahreiss H, Fuchs FS, et al. Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2004; 169: 156-162.
46. Guilleminault C, Partinen M, Praud JP, Quera-Salva MA, Powell N, Riley R. Morphometric facial changes and obstructive sleep apnea in adolescent. J Pediatr 1989; 114: 997-999.
47. Waters KA, Sitha S, O'brien LM, Bibby S, de Torres C, Vella S, et al. Follow-up on metabolic markers in children treated for obstructive sleep apnea. Am J Respir Crit Care Med 2006; 174: 455-460.
48. Tasali E, Mokhlesi B, Van Cauter E. Obstructive sleep apnea and type 2 diabetes: interacting epidemics. Chest 2008; 133: 496-506.
49. Kirk VG, O'Donnell AR. Continuous positive airway pressure for children: a discussion on how to maximize compliance. Sleep Med Rev 2006; 10: 119-127.