High pH tolerance of a chitosan-PAA nanosuspension for ophthalmic delivery of pilocarpine

Journal of Biomaterials Science, Polymer Edition

Volumn 21, Issue 2, 2010, Pages 141-157

  Lin, Hong Ru ^a   Yu, Shi Ping ^a   Lin, Yiu Jiuan ^b   Wang, Tsui Shuang ^c  

^a SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

Author keywords

Chitosan; Nanoparticle; Ophthalmic delivery; Pilocarpine; Poly(acrylic acid)

Indexed keywords

CARBOXYLIC ACIDS; CONTROLLED DRUG DELIVERY; HYDROGEN PEROXIDE; MOLECULAR WEIGHT; NANOPARTICLES; OXIDATION; PARTICLE SIZE; PEROXIDES; PH; POLYMERIZATION; TARGETED DRUG DELIVERY;

HYDROGEN PEROXIDE CONCENTRATION; NEUTRAL CONDITIONS; OPHTHALMIC DELIVERY; PHYSIOLOGICAL CONDITION; PILOCARPINE; POLY(ACRYLIC ACID ); REACTION TEMPERATURE; TEMPLATE POLYMERIZATION;

CHITOSAN;

ACRYLIC ACID; CHITOSAN; DRUG CARRIER; EYE DROPS; HYDROGEN PEROXIDE; NANOPARTICLE; PILOCARPINE;

ACID TOLERANCE; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; LACRIMAL FLUID; MOLECULAR WEIGHT; NANOTECHNOLOGY; NONHUMAN; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; RABBIT; SUSPENSION;

EID: 77149139816     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1163/156856209X410274     Document Type: Article

References (30)

1. L. Illum, J. Wright and S. S. Davis, Int. J. Pharm. 52, 221 (1989).
2. K. Zimmer and J. Kreuter, Adv. Drug Deliv. Rev. 16, 61 (1995).
3. L. Brannon-Peppas, Int. J. Pharm. 116, 1 (1995).
4. A. Ludwig, Adv. Drug Deliv. Rev. 57, 1595 (2005).
5. J. R. Robinson, STP Pharm. Sci. 5, 839 (1989).
6. N. M. Davies, S. J. Farr, J. Hadgraft and I. W. Kellaway, Pharm. Res. 8, 1039 (1991).
7. P. Molyneux,Water-Soluble Synthetic Polymer: Properties and Behavior. CRC Press, Boca Raton, FL (1985).
8. M. Prabaharan, J. Biomater. Appl. 23, 5 (2008).
9. S. A. Agnihotri, N. N. Mallikarjuna and T. M. Aminabhavi, J. Control. Rel. 100, 5 (2004).
10. M. V. Risbud, A. A. Hardikar, S. V. Bhat and R. R. Bhonde, J. Control. Rel. 68, 23 (2000).
11. H. J. Kao, H. R. Lin, Y. L. Lo and S. P. Yu, J. Pharm. Pharmacol. 58, 179 (2006).
12. C. M. Lehr, J. A. Bouwstra, E. H. Schacht and H. E. Junginger, Int. J. Pharm. 78, 43 (1992).
13. S. Rossi, F. Ferrari, M. C. Bonferoni and C. Caramella, Eur. J. Pharm. Sci. 12, 479 (2001).
14. M. J. Alonso and A. Sanchez, J. Pharm. Pharmacol. 55, 1451 (2003).
15. P. Artursson, T. Lindmark, S. S. Davis and L. Illum, Pharm. Res. 11, 1358 (1994).
16. S. Chopra, S. Mahdi, J. Kaur, Z. Iqbal, S. Talegaonkar and F. J. Ahmad, J. Pharm. Pharmacol. 58, 1021 (2006).
17. V. Dodane, M. A. Khan and J. R. Mervin, Int. J. Pharm. 182, 21 (1999).
18. H. R. Lin, S. P. Yu, C. J. Kuo, H. J. Kao, Y. L. Lo and Y. J. Lin, J. Biomater. Sci. Polymer Edn 18, 205 (2007).
19. J. S. Ahn, H. K. Choi and C. S. Cho, Biomaterials 22, 923 (2001).
20. F. Tian, Y. Liu, K. Hu and B. Zhao, Carbohydr. Polym. 57, 31 (2004).
21. G. A. F. Roberts and J. G. Domszy, Int. J. Biol. Macromol. 4, 374 (1982).
22. K. Tôei and T. Kohara, Anal. Chim. Acta 83, 59 (1976).
23. J. M. Fang, R. C. Sun, D. Salisbury, P. Fowler and J. Tomkinson, Polym. Degrad. Stabil. 66, 423 (1999).
24. S. Ding, Pharm. Sci. Technol. Today 1, 328 (1998).
25. Y. Hu, X. Jiang, Y. Ding, H. Ge, Y. Yuan and C. Yang, Biomaterials 23, 3193 (2002).
26. J. Ferguson, S. Al-Alawi and R. Granmayeh, Eur. Polym. J. 19, 475 (1983).
27. N. A. Peppas, Pharm. Acta Helv. 60, 110 (1985).
28. J. S. Ahn, H. K. Choi, M. K. Chun, J. M. Ryu, J. H. Jung, Y. U. Kim and C. S. Cho, Biomaterials 23, 1411 (2002).
29. H. R. Lin and K. C. Sung, J. Control. Rel. 69, 379 (2000).
30. H. R. Lin, K. C. Sung and W. J. Vong, Biomacromolecules 5, 2358 (2004).