pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery

Journal of Controlled Release

Volumn 68, Issue 1, 2000, Pages 23-30

  Risbud, Makarand V ^a   Hardikar, Anandwardhan A ^b   Bhat, Sujata V ^a   Bhonde, Ramesh R ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^b National Centre of Cell Sciences   (India)

Author keywords

Chitosan; Controlled release; Drug delivery; Hydrogel; Polyvinyl pyrrolidone

Indexed keywords

ANTIBIOTIC AGENT; CHITOSAN; POVIDONE;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRON MICROSCOPY; HYDROGEL; NONHUMAN; PRIORITY JOURNAL;

ANTI-INFECTIVE AGENTS; CHITIN; CHITOSAN; DRUG DELIVERY SYSTEMS; FREEZE DRYING; HYDROGELS; HYDROGEN-ION CONCENTRATION; PHARMACEUTIC AIDS; POVIDONE;

EID: 0034738827     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00208-X     Document Type: Article

References (24)

1. Dumitriu S., Dumitriu M. Polymeric drug carriers. Dumitriu S. Polymeric Biomaterials. 1994;447-448 Marcel Dekker, New York.
2. Junginger H.E. Drug Targetting and Delivery: Concepts in Dosage From Design. 1992;Ellis Horwood, Chichester.
3. Jarvinen K., Akerman S., Svarfvar B., Tarvainen T., Viinikka P., Paronen P. Drug release from pH and ionic strength responsive poly (acrylic acid) grafted poly(vinylidenefluoride) membrane bags in vitro. Pharm. Res. 15:(5):1998;802-805.
4. Needleman I.G., Smales F.C., Martin G.P. An investigation of bioadhesion for periodontal and oral mucosal drug delivery. J. Clin. Periodontol. 24:(6):1997;394-400.
5. Deshpande A.A., Shah N.H., Rhodes C.T., Malick W. Development of a novel controlled-release system for gastric retention. Pharm. Res. 14:(6):1997;815-819.
6. Hari R.P., Chandy T., P Sharma C. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. J. Microencapsul. 13:(3):1996;319-329.
7. Cascone M.G., Sim B., Downes S. Blends of synthetic and natural polymers as drug delivery systems for growth hormone. Biomaterials. 16:(7):1995;569-574.
8. Brondsted H., Kopecek J. Hydrogels for site-specific drug delivery to the colon: in vitro and in vivo degradation. Pharm. Res. 9:(6):1992;1540-1545.
9. Ratner B.D. Biomedical applications of hydrogels: review and critical appraisal. Williams D.F. Biocompatibility of Clinical Implant Materials II. 1981;146 CRC Press, Boca Raton, FL.
10. Chiba N., Lahaie R., Fedorak R.N., Bailey R., Veldhuyzen van Zanten S.J., Bernucci B. Helicobacter pylori and peptic ulcer disease. Current evidence for management strategies. Can. Fam. Physician. 44:(7):1998;1481-1488.
11. L Sidebotham R., Baron J.H. Hypothesis: Helicobacter, urease, mucus and gastric ulcer. Lancet. 335:(1):1990;193-195.
12. Goodman L.G., Lisowski J.M. Helicobacter pylori and the upper GI tract: A bug for all lesions. Hosp. Formul. 26:(10):1991;792-800.
13. A Siegel R., Falamarzian M., Firestone B.A., Moxley B.C. pH controlled release from hydrophobic/polyelectrolyte copolymer hydrogel. J. Control. Release. 8:1988;179-182.
14. Muzzarelli R., Jeuniaux C., Gooday G. Chitin in Nature and Technology. 1986;Plenum Press, New York.
15. Muzzarelli R., Baldassarre V., Conti F., Ferrara P., Biagini G., Gazzanelli G., Vasi V. Biological activity of chitosan: ultrastructural study. Biomaterials. 9:(3):1988;247-252.
16. Inouye K., Machida Y., Sannan T., Nagi T. Buoyant sustained release tablets based on chitosan. Drug Design Deliv. 2:(3):1988;165-175.
17. Chandy T., Sharma C.P. Chitosan beads and granules for oral sustained delivery of nifedipine: in vitro studies. Biomaterials. 13:(13):1992;949-952.
18. Chandy T., Sharma C.P. Chitosan matrix for oral sustained delivery of ampicillin. Biomaterials. 14:(12):1993;939-944.
19. Yao K.D., Peng T., Feng H.B., He Y.Y. Swelling kinetics and release characteristic of crosslinked chitosan: Polyether polymer network (semi-IPN) hydrogels. J. Polym Sci. A: Polym. Chem. 32:1994;1213-1223.
20. Shalaby W.S., Peck G.E., Park K. Release of dextomethophan hydrobromide from freeze-dried enzyme degradable hydrogels. J. Control. Release. 16:1991;355-364.
21. Patel V.R., M Amiji M. Preparation and characterisation of freeze-dried chitosan poly(ethylene oxide) hydrogels for site specific antibiotic delivery in the stomach. Pharm. Res. 13:(4):1996;588-593.
22. Bellamy L.J. The Infrared Spectra of Complex Molecules. 1980;Chapman and Hall, London.
23. Remunan-Lopez C., Lorenzo-Lamosa M.L., Vila-Jato J.L., Alonso M.J. Development of new chitosan-cellulose multicore microcapsules for controlled drug delivery. Eur. J. Pharm. Biopharm. 45:(1):1998;49-56.
24. Lhommeau C., Toillon S., Pith T., Kessler L., Jesser C., Pinget M. Polyamide 4,6 membranes for the encapsulation of Langerhans islets: preparation, physico-chemical properties and biocompatibility studies. J. Mater. Sci. Mater. Med. 8:1997;163-174.