Impact of azithromycin resistance mutations on the virulence and fitness of Chlamydia caviae in Guinea Pigs

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 3, 2010, Pages 1094-1101

  Binet, Rachel ^a   Bowlin, Anne K ^b   Maurelli, Anthony T ^a   Rank, Roger G ^b  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; RIBOSOME RNA;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; ATTENUATION; BACTERIAL GROWTH; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CELL DIVISION; CHLAMYDIA; CHLAMYDIA CAVIAE; CHLAMYDIASIS; ESCHERICHIA COLI; EXPERIMENTAL MODEL; EYE INFECTION; FEMALE; GENE SEQUENCE; GUINEA PIG; HOST; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SURVIVAL; WILD TYPE;

ANIMALS; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CELLS, CULTURED; CHLAMYDIA; CHLAMYDIA INFECTIONS; CONJUNCTIVITIS, INCLUSION; CULTURE MEDIA; DRUG RESISTANCE, BACTERIAL; FIBROBLASTS; GUINEA PIGS; MICE; MICROBIAL SENSITIVITY TESTS; MUTATION; VIRULENCE;

EID: 77149137975     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01321-09     Document Type: Article

References (36)

1. Abdelrahman, Y. M., and R. J. Belland. 2005. The chlamydial developmental cycle. FEMS Microbiol. Rev. 29:949-959.
2. Andersson, D. I., and B. R. Levin. 1999. The biological cost of antibiotic resistance. Curr. Opin. Microbiol. 2:489-493.
3. Banks, J., B. Eddie, J. Schachter, and K. F. Meyer. 1970. Plaque formation by Chlamydia in L cells. Infect. Immun. 1:259-262.
4. Binet, R., and A. T. Maurelli. 2005. Fitness cost due to mutations in the 16S rRNA associated with spectinomycin resistance in Chlamydia psittaci 6BC. Antimicrob. Agents Chemother. 49:4455-4464.
5. Binet, R., and A. T. Maurelli. 2005. Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp. Antimicrob. Agents Chemother. 49:2865-2873.
6. Binet, R., and A. T. Maurelli. 2007. Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2. Antimicrob. Agents Chemother. 51:4267-4275.
7. Binet, R., and A. T. Maurelli. 2009. Transformation and isolation of allelic exchange mutants of Chlamydia psittaci using recombinant DNA introduced by electroporation. Proc. Natl. Acad. Sci. U. S. A. 106:292-297.
8. Bottger, E. C., B. Springer, M. Pletschette, and P. Sander. 1998. Fitness of antibiotic-resistant microorganisms and compensatory mutations. Nat. Med. 4:1343-1344.
9. Brunham, R. C., and M. L. Rekart. 2008. The arrested immunity hypothesis and the epidemiology of chlamydia control. Sex. Transm. Dis. 35:53-54.
10. Doucet-Populaire, F., K. Buriankova, J. Weiser, and J. L. Pernodet. 2002. Natural and acquired macrolide resistance in mycobacteria. Curr. Drug Targets Infect. Disord. 2:355-370.
11. Dugan, J., D. D. Rockey, L. Jones, and A. A. Andersen. 2004. Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene. Antimicrob. Agents Chemother. 48:3989-3995.
12. Emerson, P. M., M. Burton, A. W. Solomon, R. Bailey, and D. Mabey. 2006. The SAFE strategy for trachoma control: Using operational research for policy, planning and implementation. Bull. World Health Organ. 84:613-619.
13. Gagneux, S., C. D. Long, P. M. Small, T. Van, G. K. Schoolnik, and B. J. Bohannan. 2006. The competitive cost of antibiotic resistance in Mycobacterium tuberculosis. Science 312:1944-1946.
14. Hong, K. C., J. Schachter, J. Moncada, Z. Zhou, J. House, and T. M. Lietman. 2009. Lack of macrolide resistance in Chlamydia trachomatis after mass azithromycin distributions for trachoma. Emerg. Infect. Dis. 15:1088-1090.
15. Horner, P. 2006. The case for further treatment studies of uncomplicated genital Chlamydia trachomatis infection. Sex. Transm. Infect. 82:340-343.
16. Jain, R., and L. H. Danziger. 2004. The macrolide antibiotics: a pharmaco-kinetic and pharmacodynamic overview. Curr. Pharm. Des. 10:3045-3053.
17. Kari, L., W. M. Whitmire, J. H. Carlson, D. D. Crane, N. Reveneau, D. E. Nelson, D. C. Mabey, R. L. Bailey, M. J. Holland, G. McClarty, and H. D. Caldwell. 2008. Pathogenic diversity among Chlamydia trachomatis ocular strains in nonhuman primates is affected by subtle genomic variations. J. Infect. Dis. 197:449-456.
18. Lenart, J., A. A. Andersen, and D. D. Rockey. 2001. Growth and development of tetracycline-resistant Chlamydia suis. Antimicrob. Agents Chemother. 45: 2198-2203.
19. Lenski, R. E. 1998. Bacterial evolution and the cost of antibiotic resistance. Int. Microbiol. 1:265-270.
20. Maisnier-Patin, S., and D. I. Andersson. 2004. Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution. Res. Microbiol. 155:360-369.
21. Misyurina, O. Y., E. V. Chipitsyna, Y. P. Finashutina, V. N. Lazarev, T. A. Akopian, A. M. Savicheva, and V. M. Govorun. 2004. Mutations in a 23S rRNA gene of Chlamydia trachomatis associated with resistance to macrolides. Antimicrob. Agents Chemother. 48:1347-1349.
22. Murray, E. S. 1964. Guinea pig inclusion conjunctivitis virus. I. Isolation and identification as a member of the pstittacosis-lymphogranuloma- trachoma group. J. Infect. Dis. 114:1-12.
23. O'Neill, A. J., T. Huovinen, C. W. Fishwick, and I. Chopra. 2006. Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of rifampin resistance genotypes in relation to clinical prevalence. Antimicrob. Agents Chemother. 50:298-309.
24. Owen, W. M., C. P. Sturgess, D. A. Harbour, K. Egan, and T. J. Gruffydd-Jones. 2003. Efficacy of azithromycin for the treatment of feline chlamydophilosis. J. Feline Med. Surg. 5:305-311.
25. Ramsey, K. H., I. M. Sigar, J. H. Schripsema, C. J. Denman, A. K. Bowlin, G. A. Myers, and R. G. Rank. 2009. Strain and virulence diversity in the mouse pathogen Chlamydia muridarum. Infect. Immun. 77:3284-3293.
26. Rank, R. G., A. K. Bowlin, R. L. Reed, and T. Darville. 2003. Characterization of chlamydial genital infection resulting from sexual transmission from male to female guinea pigs and determination of infectious dose. Infect. Immun. 71:6148-6154.
27. Rank, R. G., C. Dascher, A. K. Bowlin, and P. M. Bavoil. 1995. Systemic immunization with Hsp60 alters the development of chlamydial ocular disease. Invest. Ophthalmol. Vis. Sci. 36:1344-1351.
28. Roan, N. R., and M. N. Starnbach. 2008. Immune-mediated control of Chlamydia infection. Cell. Microbiol. 10:9-19.
29. Roblin, P. M., and M. R. Hammerschlag. 1998. Microbiologic efficacy of azithromycin and susceptibilities to azithromycin of isolates of Chlamydia pneumoniae from adults and children with community-acquired pneumonia. Antimicrob. Agents Chemother. 42:194-196.
30. Sander, P., B. Springer, T. Prammananan, A. Sturmfels, M. Kappler, M. Pletschette, and E. C. Bottger. 2002. Fitness cost of chromosomal drug resistance-conferring mutations. Antimicrob. Agents Chemother. 46:1204-1211.
31. Senn, L., M. R. Hammerschlag, and G. Greub. 2005. Therapeutic approaches to Chlamydia infections. Expert Opin. Pharmacother. 6:2281-2290.
32. Srivastava, P., H. C. Jha, S. Salhan, and A. Mittal. 2009. Azithromycin treatment modulates cytokine production in Chlamydia trachomatis infected women. Basic Clin. Pharmacol. Toxicol. 104:478-482.
33. Stephens, R. S. 2003. The cellular paradigm of chlamydial pathogenesis. Trends Microbiol. 11:44-51.
34. Stephens, R. S., G. Myers, M. Eppinger, and P. M. Bavoil. 2009. Divergence without difference: phylogenetics and taxonomy of Chlamydia resolved. FEMS Immunol. Med. Microbiol. 55:115-119.
35. Vester, B., and S. Douthwaite. 2001. Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob. Agents Chemother. 45:1-12.
36. Wang, S. A., J. R. Papp, W. E. Stamm, R. W. Peeling, D. H. Martin, and K. K. Holmes. 2005. Evaluation of antimicrobial resistance and treatment failures for Chlamydia trachomatis: a meeting report. J. Infect. Dis. 191:917-923.