Screening of plant extracts from the Brazilian Cerrado for their in vitro trypanocidal activity

Pharmaceutical Biology

Volumn 47, Issue 8, 2009, Pages 744-749

  Cunha, Wilson R ^a   Dos Santos, Fernanda M ^a   De Andrade Peixoto, Juliana ^a   Veneziani, Rodrigo C S ^a   Crotti, Antonio E M ^a   Silva, Márcio L A ^a   Da Silva Filho, Ademar A ^a   Albuquerque, Sérgio ^b   Turatti, Isabel C C ^b   Bastos, Jairo K ^b  

^a UNIVERSIDADE DE FRANCA   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aspidosperma; Miconia; Myrcia; Solanum; Tibouchina; Trypanocidal activity

Indexed keywords

AEGIPHILA SELLOWIANA EXTRACT; ALKALOID; ALPHA AMYRIN; ANTITRYPANOSOMAL AGENT; ASPIDOSPERMA MACROCARPUM EXTRACT; BETA AMYRIN; BETA FRIEDELANOL; BYRSONIMA INTERMEDIA EXTRACT; CAMPESTEROL; CYPERUS ROTUNDUS EXTRACT; FRIEDELIN; HEXANE; LEANDRA LACUNOSA EXTRACT; LUPEOL; MICONIA LIGUSTROIDES EXTRACT; MICONIA SELLOWIANA EXTRACT; MYRCIA VARIABILIS EXTRACT; OLEANOLIC ACID; PLANT EXTRACT; SITOSTEROL; SOLAMARGINE; SOLANUM LYCOCARPUM EXTRACT; SOLASONINE; STIGMASTEROL; TIBOUCHINA STENOCARPA EXTRACT; TRITERPENE; UNCLASSIFIED DRUG; URSOLIC ACID;

AEGIPHILA SELLOWIANA; ASPIDOSPERMA; ASPIDOSPERMA MACROCARPUM; BYRSONIMA INTERMEDIA; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; GAS CHROMATOGRAPHY; IC 50; IN VITRO STUDY; LEANDRA LACUNOSA; MALPIGHIACEAE; MASS SPECTROMETRY; MELASTOMATACEAE; MICONIA LIGUSTROIDES; MICONIA SELLOWIANA; MOUSE; MYRCIA VARIABILIS; MYRTACEAE; NONHUMAN; PHYTOCHEMISTRY; PLANT GROWTH; SCRUB; SOLANUM; SOLANUM LYCOCARPUM; TIBOUCHINA STENOCARPA; VERBENACEAE;

AEGIPHILA; APOCYNACEAE; ASPIDOSPERMA; BYRSONIMA INTERMEDIA; CYPERACEAE; CYPERUS ROTUNDUS; LEANDRA; MALPIGHIACEAE; MELASTOMATACEAE; MICONIA; MYRCIA; MYRTACEAE; SOLANACEAE; SOLANUM; SOLANUM LYCOCARPUM; TIBOUCHINA; VERBENACEAE;

EID: 77149134995     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200902951361     Document Type: Conference Paper

References (30)

1. Araújo ARB, Teixeira MIJG, Rodrigues RR (1999): Florística e fltossociologia de um trecho de cerrado no município de Franca. Naturalia 24: 153-170.
2. Boza SS, Cassels BK (1996): Plant metabolites active against Trypanosoma cruzi. Planta Med 62: 98-105.
3. Brener Z (1962): Therapeutic activity and criterion of cure on mice experimentally infected with Trypanossoma cruzi. Rev Inst Med Trop São Paulo 4: 389-396.
4. Brener Z, Andrade Z (1997): Trypanosoma cruzi e a doença de Chagas. Rio de Janeiro, Guanabara-Koogan, pp. 1-41.
5. Butler MS (2004): The role of natural product chemistry in drug discovery. J Nat Prod 67: 2141-2153.
6. Chataing B, Concepción JL, Lobatón R, Usubillaga A (1998): Inhibition of Trypanosoma cruzi growth in vitro by Solanum alkaloids: A comparison with ketoconazole. Planta Med 64: 31-36.
7. Coll JC, Bowden BF (1986): The application of vacuum liquid chromatography to the separation of terpene mixtures. J Nat Prod 49: 934-936.
8. Cordell GA (2000): Biodiversity and drug discovery - a symbiotic relationship. Phytochemistry 55: 463-480.
9. Crevelin EJ, Turatti ICC, Crotti AEM, Veneziani, RCS, Lopes JLC, Lopes NP, Cunha WR (2006): Identification of biologically activity triterpenes and sterols present in hexane extracts from Miconia species using high-resolution gas chromatography. Biomed Chromatogr 20: 827-830.
10. Cunha WR, Crevelin E J, Arantes GM, Crotti AEM, Silva MLA, Furtado NAJC, Albuquerque S, Ferreira DSA (2006): A study of the trypanocidal activity of triterpene acids isolated from Miconia species. Phytother Res 20: 474-478.
11. Cunha WR, Martins C, Ferreira DS, Crotti AEM, Lopes NP, Albuquerque S (2003): In vitro trypanocidal activity of triterpenes from Miconia species. Planta Med 69: 470-472.
12. Cunha WR, Silva MLA, Dos Santos FM, Montenegro IM, Oliveira ARA, Tavares HR, Leme dos Santos HS, Da Silva Bizário JC (2008): In vitro inhibition of tumor cell growth by Miconia fallax. Pharm Biol 46: 292-294.
13. Da Silva Filho AA, Albuquerque S, Silva MLA, Tomazela DM, Eberlin MN, Bastos JK (2004): Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity. J Nat Prod 67: 42-45.
14. Da Silva Filho AA, Sousa JPB, Soares S, Furtado NAJC, Silva MLA, Cunha WR, Gregório LE, Nanayakkara NPD, Bastos JK (2008): Antimicrobial activity of the extract and isolated compounds from Bacharis dracunculifolia DC (Asteraceae). Z Naturforsch C 63: 40-46.
15. Fournet A, Angelo A, Munoz V, Roblot F, Hocquemiller R, Cave A (1992): Biological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis. J Ethnopharmacol 37: 159-164.
16. Gaertner M, Muller L, Roos JF, Cani G, Santos AR, Niero R, Calixto JB, Yunes RA, Delle Monache F, Cechinel-Filho V (1999): Analgesic triterpenes from Sebastiana schottiana roots. Phytomedicine 6: 41-44.
17. Grael CFF, Vichnewski W, De Souza GEP, Lopes JLC, Albuquerque S, Cunha WR (2000): A study of the trypanocidal and analgesic properties from Lychnophora granmogolense (Duarte) Semir & Leitão Filho. Phytother Res 14: 203-206.
18. Lee KH (2004): Current developments in the discovery and design of new drugs candidates from plant natural product leads. J Nat Prod 67: 273-283.
19. 13CNMR spectra of pentaciclic triterpenoids - a compilation and some salient features. Phytochemistry 37: 1517-1575.
20. Molinar-Toribio E, González J, Ortega-Barria E, Capson TL, Coley PD, Kursar TA, McPhail K, Cubilla-Rios L (2006): Antiprotozoal activity against Plasmodium falciparum and Trypanosoma cruzi of xanthones isolated from Chrysochlamys tenuis. Pharm Biol 44: 550-553.
21. Myers N, Mittermeier RA, Fonseca GAB, Kent J (2000): Biodiversity hotspots for conservation priorities. Nature 403: 853-858.
22. Newman DJ, Cragg GM, Snader KM (2003): Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 66: 1022-1037.
23. Nussenzweig V, Sonntaeg R (1953): Ação da violeta genciana sobre o T. cruzi in vitro: Sua importância na esterilizaç ão do sangue destinado a transfusão. Rev Paul Med 42: 85-86.
24. Otuki MF, Ferreira J, Lima FV, Meyre-Silva C, Malheiros A, Muller LA, Cani GS, Sabtos ARS, Yunes RA, Calixto JB (2005): Antinociceptive properties of mixture of α-amyrin and β-amyrin trterpenes: Evidence for participation of protein kinase C and protein kinase A pathways. J Pharmacol Exp Ther 313: 310-318.
25. Resende FA, Barcala CAMA, Faria MCS, Kato FH, Cunha WR, Tavares DC (2006): Antimutagenicity of ursolic and oleanoic acid against doxorubicin-induced clastogenesis in Balb/c mice. Life Sci 79: 1268-1273.
26. Schwarz A, Pinto E, Haraguchi M, De Oliveira CA, Bernardi MM, Spinosa HS (2007): Phytochemical study of Solanum lycocarpum (St. Hil) unripe fruit and its effects on rat gestation. Phytother Res 21: 1025-1028.
27. Spessoto MA, Ferreira DS, Crotti AEM, Silva MLA, Cunha WR (2003): Evaluation of the analgesic activity of extracts of Miconia rubiginosa (Melastomataceae) Phytomedicine 10: 606-609.
28. Vasconcelos MAL, Royo VA, Ferreira DS, Crotti AEM, Silva MLA, Carvalho JCT, Bastos JK, Cunha WR (2006): In vivo analgesic and anti-inflammatory activities of ursolic acid and oleanoic acid from Miconia albicans (Melastomataceae). Z Naturforsch 61c: 477-486.
29. World Health Organization (2000): Special Programme for Research and Training in Tropical Disease (TDR). Natural products for parasitic diseases. TDR News 62: 4.
30. World Health Organization (2001): Chagas' disease intervention development and implemention research: transfer to the WHO regional office for the Americas. TDR News 66: 17.