In vitro inhibition of tumor cell growth by miconia fallax

Pharmaceutical Biology

Volumn 46, Issue 4, 2008, Pages 292-294

  Cunha, W R ^a   Silva, M L A ^a   Santos, F M Dos ^a   Montenegro, I M ^b   Oliveira, A R A ^b   Tavares, H R ^b   Santos, H S Leme Dos ^b   Bizário, J C Da Silva ^b  

^a UNIVERSIDADE DE FRANCA   (Brazil)

^b UNIVERSITY OF RIBEIRÃO PRETO   (Brazil)

Author keywords

Anticancer activity; Miconia; Oleanolic acid; Ursolic acid

Indexed keywords

ALCOHOL; MICONIA FALLAX EXTRACT; OLEANOLIC ACID; PLANT EXTRACT; TRITERPENOID; UNCLASSIFIED DRUG; URSOLIC ACID;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOASSAY; CANCER INHIBITION; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; FEMALE; FRACTIONATION; HUMAN; HUMAN CELL; MEDICINAL PLANT; MICONIA FALLAX;

FALLAX; MELASTOMATACEAE; MICONIA;

EID: 41349104922     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200701741245     Document Type: Article

References (24)

1. 2+ release mediates ursolic acid-induced apoptosis in human leukemic HL-60 cells. Int J Cancer 73: 725-728.
2. Chan WR, Sheppard V, Kathleen AM, Tinto WF, Reynolds WF (1992): Triterpenes from Miconia stenostachya. J Nat Prod 55: 963-966.
3. Cragg GM, Newnman DJ (2005): Plants as source of anticancer agents. J Ethnopharmacol 100: 72-79.
4. Cunha WR, Crevelin EJ, Arantes GM, Crotti AEM, Silva MLA, Furtado NAJC, Albuquerque S, Ferreira DS (2006): A study of the trypanocidal activity of triterpene acids isolated from Miconia species. Phytother Res 20: 474-478.
5. Cunha WR, Martins C, Ferreira DS, Crotti AEM, Lopes NP, Albuquerque S (2003): In vitro trypanocidal activity of triterpenes from Miconia species. Planta Med 69: 470-472.
6. Goldin A, Venditt JM, Macdonald JS, Muggia FM, Henney JE, Devita VT (1981): Currents results of the screening program at the division of cancer treatment, National Cancer Institute. Eur J Cancer 17: 129-142.
7. Gunatilaka AAL, Berger JM, Evans R, Miller JS, Wisse JH, Neddermann KM, Bursuker I, Kingston DGI (2001): Isolation, synthesis and structure-activity relationships of bioative benzoquinones from Miconia lepidota from the Suriname rainforest. J. Nat Prod 64: 2-5.
8. Hsu HY, Yang JJ, Lin CC (1997): Effects of oleanoic acid and ursolic acid on inhibiting tumor growth and enhancing the recovery of heamatopoietic system postirradiation in mice. Cancer Lett 111: 7-13.
9. Judd WS, Skean JD Jr (1991): Taxonomic studies in Miconieae (Melastomataceae). Bull Florida Mus Nat Hist 36: 25-84.
10. Kim SH, Ahn B-Z, Ryu SY (1998): Antitumor effects of ursolic acid isolated from Oldenlandia diffuse. Phytother Res 12: 553-556.
11. Li J, Guo WJ, Yang QY (2002): Effects of ursolic acid and oleanoic acid on human colon carcinoma cell line HCT15. World J Gastroenterol 8: 493-495.
12. Liu J (1995): Pharmacology of oleanoic acid and ursolic acid. J Ethnopharmacol 49: 57-68.
13. Liu J (2005): Oleanoic acid and ursolic acid: Research perspectives. J Ethnopharmacol 100: 92-94.
14. Lowry JB (1968): The distribuition and potential taxonomic value of alkylated ellagic acids. Phytochemistry 7: 1803-1813.
15. Macari PAT, Emerenciano VP, Ferreira ZMGS (1990): Identificaç ão dos triterpenos de Miconia albicans Triana através de análise por microcomputador. Quím Nova 13: 260-262.
16. Martins AB, Semir J, Goldenberg R, Martins E (1996): O gênero Miconia Ruiz & Pav. (Melastomataceae) no estado de São Paulo. Acta Bot Bras 10: 267-316.
17. Novotý L, Vachálková A, Biggs D (2001): Ursolic acid: An antitumorigenic and chemopreventive activity. Neoplasma 48: 241-246.
18. Pater MM, Pater A (1985): Human papillomavirus types 16 and 18 sequences in carcinoma cell lines of the cervix. Virology 145: 313-318.
19. Pezzuto JM (1997): Plant-derived anticancer agents. Biochem Pharmacol 53: 121-133.
20. Renner SS (1993): Phylogeny and classification of the Melastomataceae and Memecylaceae. Nord J Bot 13: 519-540.
21. Resende FA, Barcala CAMA, Faria MCS, Kato FH, Cunha WR, Tavares DC (2006): Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in Balb/c mice. Life Sci 79: 1268-1273.
22. Spessoto MA, Ferreira DS, Crotti AEM, Silva MLA, Cunha WR (2003): Evaluation of the analgesic activity of extracts of Miconia rubiginosa (Melastomataceae). Phytomedicine 10: 606-609.
23. Urech K, Scher JM, Hostanska K, Becker H (2005): Apoptosis inducing activity if viscin, a lipophilic extract from Viscum album L. J Pharm Pharmacol 57: 101-109.
24. Vasconcelos MA, Royo VA, Ferreira DS, Crotti AEM, Silva MLA, Carvalho JCT, Bastos JK, Cunha, WR (2006): In vivo analgesic and anti-inflammatory activities of ursolic acid and oleanolic acid from Miconia albicans (Melastomataceae). Z Naturforsh C 61: 477-482.