메뉴 건너뛰기




Volumn 123, Issue 5, 2010, Pages 682-689

Osteoblastic molecular scaffold Gab1 is required for maintaining bone homeostasis

Author keywords

AKT; Apoptosis; Bone mass; ERK; Gab1; Osteoblast

Indexed keywords

INSULIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN KINASE B; SCAFFOLD PROTEIN; SCAFFOLD PROTEIN GAB1; SOMATOMEDIN C; UNCLASSIFIED DRUG;

EID: 77149124277     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.058396     Document Type: Article
Times cited : (16)

References (53)
  • 1
    • 18844411108 scopus 로고    scopus 로고
    • Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
    • Bard-Chapeau, E. A., Hevener, A. L., Long, S., Zhang, E. E., Olefsky, J. M. and Feng, G. S. (2005). Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nat. Med. 11, 567-571.
    • (2005) Nat. Med , vol.11 , pp. 567-571
    • Bard-Chapeau, E.A.1    Hevener, A.L.2    Long, S.3    Zhang, E.E.4    Olefsky, J.M.5    Feng, G.S.6
  • 3
    • 33644876366 scopus 로고    scopus 로고
    • Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling
    • Boyce, B. F., Xing, L. and Chen, D. (2005). Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling. Cell Metab. 2, 344-345.
    • (2005) Cell Metab , vol.2 , pp. 344-345
    • Boyce, B.F.1    Xing, L.2    Chen, D.3
  • 4
    • 0037078320 scopus 로고    scopus 로고
    • Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation
    • Cai, T., Nishida, K., Hirano, T. and Khavari, P. A. (2002). Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation. J. Cell Biol. 159, 103-112.
    • (2002) J. Cell Biol , vol.159 , pp. 103-112
    • Cai, T.1    Nishida, K.2    Hirano, T.3    Khavari, P.A.4
  • 5
    • 0020699974 scopus 로고
    • Effect of hormones and growth factors on alkaline phosphatase activity and collagen synthesis in cultured rat calvariae
    • Canalis, E. (1983). Effect of hormones and growth factors on alkaline phosphatase activity and collagen synthesis in cultured rat calvariae. Metabolism 32, 14-20.
    • (1983) Metabolism , vol.32 , pp. 14-20
    • Canalis, E.1
  • 6
    • 0034607968 scopus 로고    scopus 로고
    • Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor
    • Cunnick, J. M., Dorsey, J. F., Munoz-Antonia, T., Mei, L. and Wu, J. (2000). Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor. J. Biol. Chem. 275, 13842-13848.
    • (2000) J. Biol. Chem , vol.275 , pp. 13842-13848
    • Cunnick, J.M.1    Dorsey, J.F.2    Munoz-Antonia, T.3    Mei, L.4    Wu, J.5
  • 7
    • 3142707223 scopus 로고    scopus 로고
    • Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    • Fujita, T., Azuma, Y., Fukuyama, R., Hattori, Y., Yoshida, C., Koida, M., Ogita, K. and Komori, T. (2004). Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J. Cell Biol. 166, 85-95.
    • (2004) J. Cell Biol , vol.166 , pp. 85-95
    • Fujita, T.1    Azuma, Y.2    Fukuyama, R.3    Hattori, Y.4    Yoshida, C.5    Koida, M.6    Ogita, K.7    Komori, T.8
  • 8
    • 34548479484 scopus 로고    scopus 로고
    • Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action
    • Fulzele, K., DiGirolamo, D. J., Liu, Z., Xu, J., Messina, J. L. and Clemens, T. L. (2007). Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action. J. Biol. Chem. 282, 25649-25658.
    • (2007) J. Biol. Chem , vol.282 , pp. 25649-25658
    • Fulzele, K.1    DiGirolamo, D.J.2    Liu, Z.3    Xu, J.4    Messina, J.L.5    Clemens, T.L.6
  • 9
    • 33847375078 scopus 로고    scopus 로고
    • Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development
    • Ge, C., Xiao, G., Jiang, D. and Franceschi, R. T. (2007). Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J. Cell Biol. 176, 709-718.
    • (2007) J. Cell Biol , vol.176 , pp. 709-718
    • Ge, C.1    Xiao, G.2    Jiang, D.3    Franceschi, R.T.4
  • 10
    • 20244373613 scopus 로고    scopus 로고
    • Glass, D. A., 2nd, Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A. et al. (2005). Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8, 751-764.
    • Glass, D. A., 2nd, Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A. et al. (2005). Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev. Cell 8, 751-764.
  • 11
    • 0037333264 scopus 로고    scopus 로고
    • The "Gab" in signal transduction
    • Gu, H. and Neel, B. G. (2003). The "Gab" in signal transduction. Trends Cell Biol. 13, 122-130.
    • (2003) Trends Cell Biol , vol.13 , pp. 122-130
    • Gu, H.1    Neel, B.G.2
  • 13
    • 0032578611 scopus 로고    scopus 로고
    • Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines
    • Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Riggs, B. L. and Khosla, S. (1998). Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines. Biochem. Biophys. Res. Commun. 250, 776-781.
    • (1998) Biochem. Biophys. Res. Commun , vol.250 , pp. 776-781
    • Hofbauer, L.C.1    Dunstan, C.R.2    Spelsberg, T.C.3    Riggs, B.L.4    Khosla, S.5
  • 14
    • 0030028790 scopus 로고    scopus 로고
    • A Grb2-associated docking protein in EGF- and insulin-receptor signalling
    • Holgado-Madruga, M., Emlet, D. R., Moscatello, D. K., Godwin, A. K. and Wong, A. J. (1996). A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379, 560-564.
    • (1996) Nature , vol.379 , pp. 560-564
    • Holgado-Madruga, M.1    Emlet, D.R.2    Moscatello, D.K.3    Godwin, A.K.4    Wong, A.J.5
  • 15
    • 0030812590 scopus 로고    scopus 로고
    • Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
    • Holgado-Madruga, M., Moscatello, D. K., Emlet, D. R., Dieterich, R. and Wong, A. J. (1997). Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc. Natl. Acad. Sci. USA 94, 12419-12424.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 12419-12424
    • Holgado-Madruga, M.1    Moscatello, D.K.2    Emlet, D.R.3    Dieterich, R.4    Wong, A.J.5
  • 17
    • 0035853673 scopus 로고    scopus 로고
    • The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase
    • Ingham, R. J., Santos, L., Dang-Lawson, M., Holgado-Madruga, M., Dudek, P., Maroun, C. R., Wong, A. J., Matsuuchi, L. and Gold, M. R. (2001). The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase. J. Biol. Chem. 276, 12257-12265.
    • (2001) J. Biol. Chem , vol.276 , pp. 12257-12265
    • Ingham, R.J.1    Santos, L.2    Dang-Lawson, M.3    Holgado-Madruga, M.4    Dudek, P.5    Maroun, C.R.6    Wong, A.J.7    Matsuuchi, L.8    Gold, M.R.9
  • 18
    • 0033624921 scopus 로고    scopus 로고
    • Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokineinduced extracellular signal-regulated kinase mitogen-activated protein kinase activation
    • Itoh, M., Yoshida, Y., Nishida, K., Narimatsu, M., Hibi, M. and Hirano, T. (2000). Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokineinduced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol. Cell. Biol. 20, 3695-3704.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 3695-3704
    • Itoh, M.1    Yoshida, Y.2    Nishida, K.3    Narimatsu, M.4    Hibi, M.5    Hirano, T.6
  • 19
    • 33847315581 scopus 로고    scopus 로고
    • Gab2 plays distinct roles in bone homeostasis at different time points
    • Itoh, S., Yoshitake, F., Narita, H., Ishihara, K. and Ebisu, S. (2007). Gab2 plays distinct roles in bone homeostasis at different time points. J. Bone Miner. Metab. 25, 81-85.
    • (2007) J. Bone Miner. Metab , vol.25 , pp. 81-85
    • Itoh, S.1    Yoshitake, F.2    Narita, H.3    Ishihara, K.4    Ebisu, S.5
  • 20
    • 0033835880 scopus 로고    scopus 로고
    • Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1
    • Jochum, W., David, J. P., Elliott, C., Wutz, A., Plenk, H., Jr, Matsuo, K. and Wagner, E. F. (2000). Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat. Med. 6, 980-984.
    • (2000) Nat. Med , vol.6 , pp. 980-984
    • Jochum, W.1    David, J.P.2    Elliott, C.3    Wutz, A.4    Plenk Jr, H.5    Matsuo, K.6    Wagner, E.F.7
  • 21
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty, G. and Wagner, E. F. (2002). Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2, 389-406.
    • (2002) Dev. Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 23
    • 42049110350 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease
    • Kearns, A. E., Khosla, S. and Kostenuik, P. J. (2008). Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr. Rev. 29, 155-192.
    • (2008) Endocr. Rev , vol.29 , pp. 155-192
    • Kearns, A.E.1    Khosla, S.2    Kostenuik, P.J.3
  • 24
    • 0039021687 scopus 로고    scopus 로고
    • Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells
    • Korhonen, J. M., Said, F. A., Wong, A. J. and Kaplan, D. R. (1999). Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells. J. Biol. Chem. 274, 37307-37314.
    • (1999) J. Biol. Chem , vol.274 , pp. 37307-37314
    • Korhonen, J.M.1    Said, F.A.2    Wong, A.J.3    Kaplan, D.R.4
  • 25
    • 53049095095 scopus 로고    scopus 로고
    • Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway
    • Koyama, T., Nakaoka, Y., Fujio, Y., Hirota, H., Nishida, K., Sugiyama, S., Okamoto, K., Yamauchi-Takihara, K., Yoshimura, M., Mochizuki, S. et al. (2008). Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathway. J. Biol. Chem. 283, 24234-24244.
    • (2008) J. Biol. Chem , vol.283 , pp. 24234-24244
    • Koyama, T.1    Nakaoka, Y.2    Fujio, Y.3    Hirota, H.4    Nishida, K.5    Sugiyama, S.6    Okamoto, K.7    Yamauchi-Takihara, K.8    Yoshimura, M.9    Mochizuki, S.10
  • 26
    • 0021967944 scopus 로고
    • Characterization of the effect of insulin on collagen synthesis in fetal rat bone
    • Kream, B. E., Smith, M. D., Canalis, E. and Raisz, L. G. (1985). Characterization of the effect of insulin on collagen synthesis in fetal rat bone. Endocrinology 116, 296-302.
    • (1985) Endocrinology , vol.116 , pp. 296-302
    • Kream, B.E.1    Smith, M.D.2    Canalis, E.3    Raisz, L.G.4
  • 27
    • 42449100788 scopus 로고    scopus 로고
    • Bim, Bak, and Bax regulate osteoblast survival
    • Liang, M., Russell, G. and Hulley, P. A. (2008). Bim, Bak, and Bax regulate osteoblast survival. J. Bone Miner. Res. 23, 610-620.
    • (2008) J. Bone Miner. Res , vol.23 , pp. 610-620
    • Liang, M.1    Russell, G.2    Hulley, P.A.3
  • 30
    • 43049131846 scopus 로고    scopus 로고
    • Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression
    • Mak, K. K., Bi, Y., Wan, C., Chuang, P. T., Clemens, T., Young, M. and Yang, Y. (2008). Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev. Cell 14, 674-688.
    • (2008) Dev. Cell , vol.14 , pp. 674-688
    • Mak, K.K.1    Bi, Y.2    Wan, C.3    Chuang, P.T.4    Clemens, T.5    Young, M.6    Yang, Y.7
  • 33
    • 0347660479 scopus 로고    scopus 로고
    • The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors
    • Nishida, K. and Hirano, T. (2003). The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors. Cancer Sci. 94, 1029-1033.
    • (2003) Cancer Sci , vol.94 , pp. 1029-1033
    • Nishida, K.1    Hirano, T.2
  • 36
    • 33745501153 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development
    • Okamoto, M., Murai, J., Yoshikawa, H. and Tsumaki, N. (2006). Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development. J. Bone Miner. Res. 21, 1022-1033.
    • (2006) J. Bone Miner. Res , vol.21 , pp. 1022-1033
    • Okamoto, M.1    Murai, J.2    Yoshikawa, H.3    Tsumaki, N.4
  • 37
    • 0023488581 scopus 로고
    • Bone histomorphometry: Standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee
    • Parfitt, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. A., Malluche, H., Meunier, P. J., Ott, S. M. and Recker, R. R. (1987). Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2, 595-610.
    • (1987) J. Bone Miner. Res , vol.2 , pp. 595-610
    • Parfitt, A.M.1    Drezner, M.K.2    Glorieux, F.H.3    Kanis, J.A.4    Malluche, H.5    Meunier, P.J.6    Ott, S.M.7    Recker, R.R.8
  • 38
    • 0020730536 scopus 로고
    • Multiple hormonal mechanisms for the control of collagen synthesis in an osteoblast-like cell line, MMB-1
    • Rosen, D. M. and Luben, R. A. (1983). Multiple hormonal mechanisms for the control of collagen synthesis in an osteoblast-like cell line, MMB-1. Endocrinology 112, 992-999.
    • (1983) Endocrinology , vol.112 , pp. 992-999
    • Rosen, D.M.1    Luben, R.A.2
  • 40
    • 0035489468 scopus 로고    scopus 로고
    • PKB/AKT: Functional insights from genetic models
    • Scheid, M. P. and Woodgett, J. R. (2001). PKB/AKT: functional insights from genetic models. Nat. Rev. Mol. Cell. Biol. 2, 760-768.
    • (2001) Nat. Rev. Mol. Cell. Biol , vol.2 , pp. 760-768
    • Scheid, M.P.1    Woodgett, J.R.2
  • 41
    • 0027321842 scopus 로고
    • Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype
    • Stein, G. S. and Lian, J. B. (1993). Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr. Rev. 14, 424-442.
    • (1993) Endocr. Rev , vol.14 , pp. 424-442
    • Stein, G.S.1    Lian, J.B.2
  • 42
  • 44
  • 48
    • 0040784413 scopus 로고    scopus 로고
    • Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts
    • Winnay, J. N., Bruning, J. C., Burks, D. J. and Kahn, C. R. (2000). Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts. J. Biol. Chem. 275, 10545-10550.
    • (2000) J. Biol. Chem , vol.275 , pp. 10545-10550
    • Winnay, J.N.1    Bruning, J.C.2    Burks, D.J.3    Kahn, C.R.4
  • 49
    • 0037435036 scopus 로고    scopus 로고
    • Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2
    • Yamasaki, S., Nishida, K., Yoshida, Y., Itoh, M., Hibi, M. and Hirano, T. (2003). Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. Oncogene 22, 1546-1556.
    • (2003) Oncogene , vol.22 , pp. 1546-1556
    • Yamasaki, S.1    Nishida, K.2    Yoshida, Y.3    Itoh, M.4    Hibi, M.5    Hirano, T.6
  • 50
    • 58049197169 scopus 로고    scopus 로고
    • PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress
    • Yang, G., Sun, Q., Teng, Y., Li, F., Weng, T. and Yang, X. (2008). PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Development 135, 3587-3597.
    • (2008) Development , vol.135 , pp. 3587-3597
    • Yang, G.1    Sun, Q.2    Teng, Y.3    Li, F.4    Weng, T.5    Yang, X.6
  • 52
    • 51549112478 scopus 로고    scopus 로고
    • Collagen1alpha1 promoter drives the expression of Cre recombinase in osteoblasts of transgenic mice
    • Zha, L., Hou, N., Wang, J., Yang, G., Gao, Y., Chen, L. and Yang, X. (2008). Collagen1alpha1 promoter drives the expression of Cre recombinase in osteoblasts of transgenic mice. J. Genet. Genomics 35, 525-530.
    • (2008) J. Genet. Genomics , vol.35 , pp. 525-530
    • Zha, L.1    Hou, N.2    Wang, J.3    Yang, G.4    Gao, Y.5    Chen, L.6    Yang, X.7
  • 53
    • 0347721834 scopus 로고    scopus 로고
    • Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    • Zhang, M., Xuan, S., Bouxsein, M. L., von Stechow, D., Akeno, N., Faugere, M. C., Malluche, H., Zhao, G., Rosen, C. J., Efstratiadis, A. et al. (2002). Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J. Biol. Chem. 277, 44005-44012
    • (2002) J. Biol. Chem , vol.277 , pp. 44005-44012
    • Zhang, M.1    Xuan, S.2    Bouxsein, M.L.3    von Stechow, D.4    Akeno, N.5    Faugere, M.C.6    Malluche, H.7    Zhao, G.8    Rosen, C.J.9    Efstratiadis, A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.