The importance of gut microbiota in mediating the effect of NOD2 defects in inflammatory bowel disease

Gut

Volumn 59, Issue 2, 2010, Pages 153-154

  Rogler, Gerhard ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; GAMMA INTERFERON; LEUCINE RICH REPEAT KINASE 2; MURAMYL DIPEPTIDE; OXYGEN RADICAL; PATTERN RECOGNITION RECEPTOR; PEPTIDOGLYCAN; TUMOR NECROSIS FACTOR RECEPTOR 2;

ALLOGENIC BONE MARROW TRANSPLANTATION; BACTERIAL TRANSLOCATION; BINDING SITE; CD4+ T LYMPHOCYTE; CELL MEMBRANE PERMEABILITY; CROHN DISEASE; CYTOKINE RELEASE; DISEASE ASSOCIATION; ENTERITIS; ESCHERICHIA COLI; GENE MUTATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GRAFT VERSUS HOST REACTION; HETEROZYGOTE; HUMAN; INNATE IMMUNITY; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; LYMPHOCYTE FUNCTION; MACROPHAGE; MORTALITY; MUCOSA INFLAMMATION; NONHUMAN; NOTE; PANETH CELL; PATHOGENESIS; PEYER PATCH; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; STEM CELL TRANSPLANTATION; T LYMPHOCYTE ACTIVATION;

GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINES; NOD2 SIGNALING ADAPTOR PROTEIN;

EID: 77149120449     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gut.2009.193185     Document Type: Note

References (16)

1. Barreau F, Madre C, Meinzer U, et al. Nod2 regulates the host response towards microflora by modulating T-cell function and epithelial permeability in mouse Peyer's patches. Gut 2009.
2. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
3. Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-6.
4. Hampe J, Cuthbert A, Croucher PJ, et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 2001;357:1925-8.
5. Sugimura M, Kinouchi Y, Takahashi S, et al. CARD15/ NOD2 mutational analysis in Japanese patients with Crohn's disease. Clin Genet 2003;63:160-2.
6. Leong RW, Armuzzi A, Ahmad T, et al. NOD2/ CARD15 gene polymorphisms and Crohn's disease in the Chinese population. Aliment Pharmacol Ther 2003;17:1465-70.
7. Girardin SE, Boneca IG, Viala J, et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003;278:8869-72.
8. Inohara N, Ogura Y, Fontalba A, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 2003;278:5509-12.
9. Berrebi D, Maudinas R, Hugot JP, et al. Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon. Gut 2003;52:840-6.
10. Gutierrez O, Pipaon C, Inohara N, et al. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation. J Biol Chem 2002;277:41701-5.
11. Ogura Y, Lala S, Xin W, et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 2003;52:1591-7.
12. Eckmann L. Innate immunity and mucosal bacterial interactions in the intestine. Curr Opin Gastroenterol 2004;20:82-8.
13. Chamaillard M, Girardin SE, Viala J, et al. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol 2003;5:581-92.
14. Holler E, Rogler G, Brenmoehl J, et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 2006;107:4189-93.
15. Holler E, Rogler G, Herfarth H, et al. Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 2004;104:889-94.
16. Landfried K, Bataille F, Rogler G, et al. Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease. Clin Exp Immunol 2009;159:87-92.