A review of the characteristics and treatment of methicillinresistant staphylococcus aureus (MRSA) in the horse and a case series of MRSA infection in four horses

Equine Veterinary Education

Volumn 22, Issue 2, 2010, Pages 91-102

  Maddox, T W ^a   Scantlebury, C E ^b   Clegg, P D ^c   Dawson, S ^a   Pinchbeck, G L ^b   Williams, N J ^a  

^a National Centre for Zoonosis Research   (United Kingdom)

^b Department of Animal and Population Health   (Canada)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Horse; Infection; MRSA; Prevalence; Treatment

Indexed keywords

ANIMALIA; BACTERIA (MICROORGANISMS); EQUIDAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 77049117532     PISSN: 09577734     EISSN: 20423292     Source Type: Journal    
DOI: 10.1111/j.2042-3292.2009.00026.x     Document Type: Review

References (105)

1. Anderson, M.E.C., Lefebvre, S.L. and Weese, J.S. (2008) Evaluation of prevalence and risk factors for methicillin-resistant Staphylococcus aureus colonization in veterinary personnel attending an international equine veterinary conference. Vet. Microbiol. 129, 410-417.
2. Anderson, M.E.C., Lefebvre, S.L., Rankin, S.C., Aceto, H., Morley, P.S., Caron, J.P., Welsh, R.D., Holbrook, T.C., Moore, B., Taylor, D.J. and Weese, J.S. (2009) Retrospective multicentre study of methicillin-resistant Staphylococcus aureus infections in 115 horses. Equine vet. J. 41, 401-405.
3. Anon (2008) Biosecurity Standard Operation Procedures (SOP) James L. Voss Veterinary Teaching Hospital, (online) http://csuvets.colostate.edu/biosecurity, Colorado State University.
4. Anzai, T., Kamada, M., Kanemaru, T., Sugita, S., Shimizu, A. and Higuchi, T. (1996) Isolation of Methicillin-Resistant Staphylococcus aureus (MRSA) from Mares with Metritis and its Zooepidemiology. J. equine vet. Sci. 7, 7-11.
5. Ayliffe, G.A.J., Buckles, A., Casewell, M.W., Cookson, B.D., Cox, R.A., Duckworth, G.J., French, G.L., Griffiths-Jones, A., Heathcock, R., Humphreys, H., Keane, C.T., Marples, R.R., Shanson, D.C., Slack, R., Tebbs, E. and British Soc Antimicrobial Chemotherapy Hosp, I. (1998) Revised guidelines for the control of methicillin-resistant Staphylococcus aureus infection in hospitals. J. Hosp. Infect. 39, 253-290.
6. Baptiste, K.E., Williams, K., Willams, N.J., Wattret, A., Clegg, P.D., Dawson, S., Corkill, J., O'Neill, T. and Hart, C.A. (2005) Methicillin resistant Staphylococci in companion animals. Emerg. Infect. Dis. 11, 1942-1944.
7. Bhattacharyya, M. and Bradley, H. (2008) A case report of the use of nanocrystalline silver dressing in the management of acute surgical site wound infected with MRSA to prevent cutaneous necrosis following revision surgery. Int. J. Low Extrem. Wounds 7, 45-48.
8. Blumberg, H.M., Rimland, D., Carroll, D.J., Terry, P. and Wachsmuth, I.K. (1991) Rapid development of ciprofloxacin resistance in methicillin-susceptible and methicillin-resistant Staphylococcusaureus. J. Infect. Dis. 163, 1279-1285.
9. Booth, T.M., Butson, R.J., Clegg, P.D., Schramme, M.C. and Smith, R.K. (2001) Treatment of sepsis in the small tarsal joints of 11 horses with gentamicin-impregnated polymethylmethacrylate beads. Vet. Rec. 148,376-380.
10. Bootsma, M.C.J., Diekmann, O. and Bonten, M.J.M. (2006) Controlling methicillin-resistant Staphylococcus aureus: Quantifying the effects of interventions and rapid diagnostic testing. In: Proceedings of the National Academy of Sciences of the United States of America 103, 5620-5625.
11. Boubaker, I.B.B., Ben Abbes, R., Ben Abdallah, H., Mamlouk, K., Mahjoubi, F., Kammoun, A., Hammami, A. and Ben Redjeb, S. (2004) Evaluation of a cefoxitin disk diffusion test for the routine detection of methicillin-resistant Staphylococcus aureus. Clin. Microbiol. Infect. 10,762-765.
12. Brown, D.F.J. and Reynolds, P.E. (1980) Intrinsic Resistance to Beta-Lactam Antibiotics in Staphylococcus-Aureus. Febs Letters 122, 275-278.
13. Burton, S., Reid-Smith, R., McClure, J.T. and Weese, J.S. (2008) Staphylococcus aureus colonization in healthy horses in Atlantic Canada. Can. vet. J. 49, 797-799.
14. Busscher, J.F., van Duijkeren, E. and van Oldruitenborgh-Oosterbaan, M.M.S. (2006) The prevalence of methicillin-resistant staphylococci in healthy horses in the Netherlands. Vet. Microbiol. 113, 131-136.
15. Butson, R.J., Schramme, M.C., Garlick, M.H. and Davies, J.V. (1996) Treatment of intrasynovial infection with gentamicin-impregnated polymethylmethacrylate beads. Vet. Rec. 138, 460-464.
16. Cavassini, M., Wenger, A., Jaton, K., Blanc, D.S. and Bille, J. (1999) Evaluation of MRSA-screen, a simple anti-PBP 2a slide latex agglutination kit, for rapid detection of methicillin resistance in Staphylococcus aureus. J. clin. Microbiol. 37, 1591-1594.
17. Chambers, H.F. (2001) The changing epidemiology of Staphylococcus aureus? Emerg. Infect. Dis. 7, 178-182.
18. Coia, J.E., Duckworth, G.J., Edwards, D.I., Farrington, M., Fry, C., Humphreys, H., Mallaghan, C., Tucker, D.R. and Joint Working Party British Soc, A. (2006) Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. J. Hosp. Infect. 63, S1-S44.
19. Cotter, L., Lynch, M., Cryan, B., Greer, P. and Fanning, S. (1997) Investigation of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak in an Irish hospital: Triplex PCR and DNA amplification fingerprinting. J. Hosp. Infect. 36, 37-47.
20. Cuny, C., Strommenger, B., Witte, W. and Stanek, C. (2008) Clusters of infections in horses with MRSA ST1, ST254, and ST398 in a veterinary hospital. Microbial Drug Resistance 14, 307-310.
21. Cuny, C., Kuemmerle, J., Stanek, C., Willey, B.M., Strommenger, B. and Witte, W. (2006) Emergence of MRSA infections in horses in a veterinary hospital: strain characterisation and comparison with MRSA from humans. Euro Surveillance 11, 44-47.
22. Daum, R.S., Ito, T., Hiramatsu, K., Hussain, F., Mongkolrattanothai, K., Jamklang, M. and Boyle-Wang, S. (2002) A novel methicillinresistance cassette in community-acquired Methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds. J. Infect. Dis. 186, 1344-1347.
23. Deurenberg, R.H. and Stobberingh, E.E. (2008) The evolution of Staphylococcus aureus. Infect. Genet. Evol. 8, 747-763.
24. Devriese, L.A. and Hommez, J. (1975) Epidemiology of methicillin-resistant Staphylococcus-aureus in dairy herds. Res. vet. Sci. 19, 23-27.
25. Devriese, L.A., Vandamme, L.R. and Fameree, L. (1972) Methicillin (cloxacillin)-resistant Staphylococcus-aureus strains isolated from bovine mastitis cases. Zentralblatt Fur Veterinarmedizin Riehe B 19, 598.
26. Edwards-Jones, V. (2006) Antimicrobial and barrier effects of silver against methicillin-resistant Staphylococcus aureus. J. Wound. Care 15,285-290.
27. Enright, M.C., Day, N.P.J., Davies, C.E., Peacock, S.J. and Spratt, B.G. (2000) Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J. clin. Microbiol. 38, 1008-1015.
28. Evans, R.S., Wallace, C.J., Lloyd, J.F., Taylor, C.W., Abouzelof, R.H., Sumner, S., Johnson, K.V., Wuthrich, A., Harbarth, S., Samore, M.H. and Program, C.D.C.P.E. (2008) Rapid identification of hospitalized patients at high risk for MRSA carriage. J. Am. Med. Inf. Ass. 15, 506-512.
29. Fascia, D.T.M., Singanayagam, A. and Keating, J.F. (2009) Methicillin-resistant Staphylococcus aureus in orthopaedic trauma: Identification of risk factors as a strategy for control of infection. J. Bone Joint Surg.- Br. Vol. 91B, 249-252.
30. Frénay, H., Bunschoten, A., Schouls, L., van Leeuwen, W., Vandenbroucke-Grauls, C., Verhoef, J. and Mooi, F.R. (1996) Molecular typing of methicillin-resistant Staphylococcus aureus on the basis of protein A gene polymorphism. Eur. J. Clin. Microbiol. Infect. Dis. 15, 60-64.
31. Gemmell, C.G., Edwards, D.I., Fraise, A.P., Gould, F.K., Ridgway, G.L., Warren, R.E. and Joint Working Party British, S. (2006) Guidelines for the prophylaxis and treatment of methicillin-resistant staphylococcus aureus (MRSA) infections in the UK. J. Antimicrob. Chemother. 57, 589-608.
32. Gould, I.M. (2005) Control of methicillin-resistant Staphylococcus aureus in the UK. Eur. J. Clin. Microbiol. Infect. Dis. 24, 789-793.
33. Hallin, M., Deplano, A., Denis, O., De Mendonca, R., De Ryck, R. and Struelens, M.J. (2007) Validation of pulsed-field gel electrophoresis and spa typing for long-term, nationwide epidemiological surveillance studies of Staphylococcus aureus infections. J. clin. Microbiol. 45, 127-133.
34. Hanselman, B.A., Kruth, S.A., Rousseau, J., Low, D.E., Willey, B.M., McGeer, A. and Weese, J.S. (2006) Methicillin-resistant Staphylococcus aureus colonization in veterinary personnel. Emerg. Infect. Dis. 12, 1933-1938.
35. Hanssen, A.M. and Sollid, J.U.E. (2006) SCCmec in staphylococci: genes on the move. Fems Immunol. Med. Microbiol. 46, 8-20.
36. Hartmann, F.A., Trostle, S.S. and Klohnen, A.A.O. (1997) Isolation of methicillin-resistant Staphylococcus aureus from a postoperative wound infection in a horse. J. Am. vet. med. Ass. 211, 590-592.
37. Henry, S.L. and Galloway, K.P. (1995) Local antibacterial therapy for the management of orthopaedic infections. Pharmacokinetic considerations. Clin. Pharmacokinet. 29, 36-45.
38. Hermans, K., Lipinska, U., Denis, O., Deplano, A., Struelens, M.J., Nemati, M., Pasmans, F., Butaye, P., Martens, A., Deprez, P. and Haesebrouck, F. (2008) MRSA clone ST398-SCCmec IV as a cause of infections in an equine clinic. Vlaams Diergeneeskundig Tijdschrift 77, 429-433.
39. Herold, B.C., Immergluck, L.C., Maranan, M.C., Lauderdale, D.S., Gaskin, R.E., Boyle-Vavra, S., Leitch, C.D. and Daum, R.S. (1998) Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. J. Am. Med. Ass. 279, 593-598.
40. Hiramatsu, K. (1995) Molecular Evolution of MRSA. Microbiol. Immunol. 39,531-543.
41. Holcombe, S.J., Schneider, R.K., Bramlage, L.R. and Embertson, R.M. (1997) Use of antibiotic-impregnated polymethyl methacrylate in horses with open or infected fractures or joints: 19 cases (1987-1995). J. Am. vet. med. Ass. 211, 889-893.
42. Hollis, A.R. and Wilkins, P.A. (2009) Current controversies in equine antimicrobial therapy. Equine vet. Educ. 21, 216-224.
43. Jevons, M.P., Rolinson, G.N. and Knox, R. (1961) Celbenin-resistant staphylococci. Br. Med. J. 1, 124.
44. Kim, J., Jeong, J.H., Cha, H.Y., Jin, J.S., Lee, J.C., Lee, Y.C., Seol, S.Y. and Cho, D.T. (2007) Detection of diverse SCCmec variants in methicillin-resistant Staphylococcus aureus and comparison of SCCmec typing methods. Clin. Microbiol. Infect. 13, 1128-1130.
45. Kim, M.J., Yun, H.J., Kang, J.W., Kim, S., Kwak, J.H. and Choi, E.C. (2003) In vitro development of resistance to a novel fluoroquinolone, DW286, in methicillin-resistant Staphylococcus aureus clinical isolates. J. Antimicrob. Chemother. 51, 1011-1016.
46. Kuhl, S.A., Pattee, P.A. and Baldwin, J.N. (1978) Chromosomal map location of methicillin resistance determinant in StaphylococcusAureus. J. Bacteriol. 135, 460-465.
47. Leaper, D.J. (2006) Silver dressings: their role in wound management. Int. Wound. J. 3, 282-294.
48. Leonard, F.C., Abbott, Y., Rossney, A., Quinn, P.J., O'Mahony, R. and Markey, B.K. (2006) Methicillin-resistant Staphylococcus aureus isolated from a veterinary surgeon and five dogs in one practice. Vet. Rec. 158, 155-159.
49. Lepelletier, D., Corvec, S., Caillon, J., Reynaud, A., Roze, J.C. and Gras-Leguen, C. (2009) Eradication of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit: Which measures for which success? Am. J. Infect. Control 37, 195-200.
50. Loeffler, A., Baines, S.J., Toleman, M.S., Felmingham, D., Milsom, S.K., Edwards, E.A. and Lloyd, D.H. (2008) In vitro activity of fusidic acid and mupirocin against coagulase-positive staphylococci from pets. J. Antimicrob. Chemother. 62, 1301-1304.
51. Loeffler, A., Boag, A.K., Sung, J., Lindsay, J.A., Guardabassi, L., Dalsgaard, A., Smith, H., Stevens, K.B. and Lloyd, D.H. (2005) Prevalence of methicillin-resistant Staphylococcus aureus among staff and pets in a small animal referral hospital in the UK. J. Antimicrob. Chemother. 56, 692-697.
52. Loeffler, A., Kearns, A.M., Ellington, M.J., Smith, L.J., Unt, V.E., Lindsay, J.A., Pfeiffer, D.U. and Lloyd, D.H. (2009) First isolation of MRSA ST398 from UK animals: a new challenge for infection control teams? J. Hosp. Infect. 72, 269-271.
53. Loh, J.V., Percival, S.L., Woods, E.J., Williams, N.J. and Cochrane, C.A. (2009) Silver resistance in MRSA isolated from wound and nasal sources in humans and animals. Int. Wound J. 6, 32-38.
54. Loveday, H.P., Pellowe, C.M., Jones, S. and Pratt, R.J. (2006) A systematic review of the evidence for interventions for the prevention and control of meticillin-resistant Staphylococcus aureus (1996-2004): report to the Joint MRSA Working Party (Subgroup A). J. Hosp. Infect. 63, S45-S70.
55. Maddox, T.W., Clegg, P., Wedley, A., Pinchbeck, G.L., Ryvar, R., Hutchinson, G., Dawson, S. and Willams, N.J. (2009) Prevalence and antimicrobial resistance of meticilin-resistant Staphylococi obtained from horses in Great Britain. In: Methicillin-resistant Staphylococci in Animals: Veterinary and Public Health Implications, Conference Proceedings, American Society for Microbiology, London. pp 30-31.
56. Mahamat, A., MacKenzie, F.M., Brooker, K., Monnet, D.L., Daures, J.P. and Gould, I.M. (2007) Impact of infection control interventions and antibiotic use on hospital MRSA: a multivariate interrupted time- series analysis. Int. J. Antimicrobial Agents 30, 169-176.
57. Maiden, M.C.J., Bygraves, J.A., Feil, E., Morelli, G., Russell, J.E., Urwin, R., Zhang, Q., Zhou, J.J., Zurth, K., Caugant, D.A., Feavers, I.M., Achtman, M. and Spratt, B.G. (1998) Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms. In: Proceedings of the National Academy of Sciences of the United States of America 95, 3140-3145.
58. Marchevsky, A.M. and Read, R.A. (1999) Bacterial septic arthritis in 19 dogs. Aust. vet. J. 77, 233-237.
59. McConeghy, K.W., Mikolich, D.J. and LaPlante, K.L. (2009) Agents for the decolonization of methicillin-resistant Staphylococcus aureus. Pharmacotherap. 29, 263-280.
60. Moodley, A., Stegger, M., Bagcigil, A.F., Baptiste, K.E., Loeffler, A., Lloyd, D.H., Williams, N.J., Leonard, N., Abbott, Y., Skov, R. and Guardabassi, L. (2006) Spa typing of methicillin-resistant Staphylococcus aureus isolated from domestic animals and veterinary staff in the UK and Ireland. J. Antimicrob. Chemother. 58, 1118-1123.
61. Moreno, F., Crisp, C., Jorgensen, J.H. and Patterson, J.E. (1995) Methicillin-resistant Staphylococcus-aureus as a community organism. Clin. Infect. Dis. 21, 1308-1312.
62. Morris, D.O., Rook, K.A., Shofer, F.S. and Rankin, S.C. (2006) Screening of Staphylococcus aureus, Staphylococcus intermedius, and Staphylococcus schleiferi isolates obtained from small companion animals for antimicrobial resistance: a retrospective review of 749 isolates (2003-04). Vet. Dermatol. 17, 332-337.
63. Murakami, K., Minamide, W., Wada, K., Nakamura, E., Teraoka, H. and Watanabe, S. (1991) Identification of Methicillin-resistant strains of Staphylococci by Polymerase Chain-Reaction. J. clin. Microbiol. 29, 2240-2244.
64. Naimi, T.S., LeDell, K.H., Como-Sabetti, K., Borchardt, S.M., Boxrud, D.J., Etienne, J., Johnson, S.K., Vandenesch, F., Fridkin, S., O'Boyle, C., Danila, R.N. and Lynfield, R. (2003) Comparison of community-and health care-associated methicillin-resistant Staphylococcus aureus infection. J. Am. Med. Ass. 290, 2976-2984.
65. Nuttall, T.J. (2006) Methicilllin resistant Staphylococcus aureus (MRSA): control in veterinary practice. In: 1st International Conference on MRSA in Animals, University of Liverpool, Liverpool, UK. pp 13-16.
66. O'Mahony, R., Abbott, Y., Leonard, F.C., Markey, B.K., Quinn, P.J., Pollock, P.J., Fanning, S. and Rossney, A.S. (2005) Methicillin-resistant Staphylococcus aureus (MRSA) isolated from animals and veterinary personnel in Ireland. Vet. Microbiol. 109, 285-296.
67. Owen, M.R., Moores, A.P. and Coe, R.J. (2004) Management of MRSA septic arthritis in a dog using a gentamicin-impregnated collagen sponge. J. small anim. Pract. 45, 609-612.
68. Patel, M., Weinheimer, J.D., Waites, K.B. and Baddley, J.W. (2007) Active surveillance to determine the impact of methicillin-resistant Staphylococcus aureus colonization on patients in intensive care units of a Veterans Affairs Medical Center. In: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy, Univ Chicago Press, Chicago. pp 503-509.
69. Peyrou, M., Bousquet-Melou, A., Laroute, V., Vrins, A. and Doucet, M.Y. (2006) Enrofloxacin and marbofloxacin in horses: comparison of pharmacokinetic parameters, use of urinary and metabolite data to estimate first-pass effect and absorbed fraction. J. vet. Pharmacol. Therap. 29, 337-344.
70. Post, E.M., Singer, E.R., Clegg, P.D., Smith, R.K. and Cripps, P.J. (2003) Retrospective study of 24 cases of septic calcaneal bursitis in the horse. Equine vet. J. 35, 662-668.
71. Prevost, G., Pottecher, B., Dahlet, M., Bientz, M., Mantz, J.M. and Piemont, Y. (1991) Pulsed field gel electrophoresis as a new epidemiological tool for monitoring methicillin-resistant Staphylococcus aureus in an intensive care unit. J. Hosp. Infect. 17, 255-269.
72. Pyorala, S. and Taponen, S. (2009) Coagulase-negative staphylococciemerging mastitis pathogens. Vet. Microbiol. 134, 3-8.
73. Rankin, S., Roberts, S., O'Shea, K., Maloney, D., Lorenzo, M. and Benson, C.E. (2005) Panton valentine leukocidin (PVL) toxin positive MRSA strains isolated from companion animals. Vet. Microbiol. 108, 145-148.
74. Robinson, D.A. and Enright, M.C. (2004) Multilocus sequence typing and the evolution of methicillin-resistant Staphylococcus aureus. Clin. Microbiol. Infect. 10, 92-97.
75. Ryffel, C., Tesch, W., Birchmachin, I., Reynolds, P.E., Barberismaino, L., Kayser, F.H. and Bergerbachi, B. (1990) Sequence comparison of meca genes Isolated from methicillin-resistant Staphylococcusaureus and Staphylococcus-epidermidis. Gene 94, 137-138.
76. Saroglou, G., Cromer, M. and Bisno, A.L. (1980) Methicillin-resistant Staphylococcus-aureus interstate spread of nosocomial infections with emergence of gentamicin-methicillin resistant strains. Infect. Control Hosp. Epidemiol. 1, 81-89.
77. Scantlebury, C.E., Clegg, P.D., Pinchbeck, G.L., Dawson, S., Hart, C.A. and Willams, N.J. (2007) Nasal carriage of methicillin-resistant Staphylococcus aureus Amongst Veterinary Personnel at BEVA Congress 2006. In: 46th British Equine Veterinary AssociationCongress, Conference Proceedings, Equine Veterinary Journal, Newmarket. p 425.
78. Schneider, R.K., Bramlage, L.R., Moore, R.M., Mecklenburg, L.M., Kohn, C.W. and Gabel, A.A. (1992) A retrospective study of 192 horses affected with septic arthritis tenosynovitis. Equine vet. J. 24, 436-442.
79. Schwartz, M., Boettcher, I.C., Kramer, S. and Tipold, A. (2009) Two dogs with iatrogenic discospondylitis caused by meticillin-resistant Staphylococcus aureus. J. small anim. Pract. 50, 201-205.
80. Seguin, J.C., Walker, R.D., Caron, J.P., Kloos, W.E., George, C.G., Hollis, R.J., Jones, R.N. and Pfaller, M.A. (1999) Methicillin-resistant Staphylococcus aureus outbreak in a veterinary teaching hospital: Potential human-to-animal transmission. J. clin. Microbiol. 37, 1459-1463.
81. Skinner, S., Inglis, B., Matthews, P.R. and Stewart, P.R. (1988) Mercury and tetracycline resistance genes and flanking repeats associated with methicillin resistance on the chromosome of Staphylococcus aureus. Molecular Microbiol. 2, 289-292.
82. Smith, L.J., Marr, C.M., Payne, R.J., Stoneham, S.J. and Reid, S.W.J. (2004) What is the likelihood that Thoroughbred foals treated for septic arthritis will race? Equine vet. J. 36, 452-456.
83. Steinman, A., Britzi, M., Levi, O., Lavy, E., Lichter, A. and Soback, S. (2006) Lack of effect of diet on the pharmacokinetics of enrofloxacin in horses. J. vet. Pharmacol. Therap. 29, 67-70.
84. Stewart, P.R., Dubin, D.T., Chikramane, S.G., Inglis, B., Matthews, P.R. and Poston, S.M. (1994) Is257 and small plasmid insertions in the mec region of the chromosome of Staphylococcus-aureus. Plasmid 31, 12-20.
85. Strohal, R., Schelling, M., Takacs, M., Jurecka, W., Gruber, U. and Offner, F. (2005) Nanocrystalline silver dressings as an efficient anti-MRSA barrier: a new solution to an increasing problem. J. Hosp. Infect. 60, 226-230.
86. Strommenger, B., Kehrenberg, C., Kettlitz, C., Cuny, C., Verspohl, J., Witte, W. and Schwarz, S. (2006) Molecular characterization of methicillin-resistant Staphylococcus aureus strains from pet animals and their relationship to human isolates. J. Antimicrob. Chemother. 57,461-465.
87. Tacconelli, E., De Angelis, G., Cataldo, M.A., Pozzi, E. and Cauda, R. (2008) Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation?A systematic review and meta-analysis. J. Antimicrob. Chem. 61, 26-38.
88. Thompson, D.S., Workman, R. and Strutt, M. (2009) Decline in the rates of meticillin-resistant Staphylococcus aureus acquisition and bacteraemia in a general intensive care unit between 1996 and 2008. J. Hosp. Infect. 71, 314-319.
89. Trostle, S.S., Peavey, C.L., King, D.S. and Hartmann, F.A. (2001) Treatment of methicillin-resistant Staphylococcus epidermidis infection following repair of an ulnar fracture and humeroradial joint luxation in a horse. J. Am. vet. med. Ass. 218, 554-559.
90. van Belkum, A., Melles, D.C., Peeters, J.K., van Leeuwen, W.B., van Duijkeren, E., Huijsdens, X.W., Spalburg, E., de Neeling, A.J., Verbrugh, H.A. and Dutch Working Party, S. (2008) Methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398 in pigs and humans. Emerg. Infect. Dis. 14, 479-483.
91. Van den Eede, A., Martens, A., Lipinska, U., Struelens, M., Deplano, A., Denis, O., Haesebrouck, F., Gasthuys, F. and Hermans, K. (2009) High occurrence of methicillin-resistant Staphylococcus aureus ST398 in equine nasal samples. Vet. Microbiol. 133, 138-144.
92. van Duijkeren, E., Moleman, M., Sloet van Oldruitenborgh-Oosterbaan, M., Multem, J., Troelstra, A., Fluit, A.C., van Wamel, W.J.B., Houwers, D.J., de Neeling, A.J. and Wagenaar, J.A. (2009) Methicillin-resistant Staphylococcus aureus in horses and horse personnel: An investigation of several outbreaks. Vet. Microbiol. doi:10.1016/ j.vetmic.2009.08.09.
93. Vengust, M., Anderson, M.E.C., Rousseau, J. and Weese, J.S. (2006) Methicillin-resistant staphylococcal colonization in clinically normal dogs and horses in the community. Letters Appl. Microbiol. 43, 602-606.
94. Walther, B., Wieler, L.H., Friedrich, A.W., Hanssen, A.M., Kohn, B., Brurmberg, L. and Luebke-Becker, A. (2008) Methicillin-resistant Staphylococcus aureus (MRSA) isolated from small and exotic animals at a university hospital during routine microbiological examinations. Vet. Microbiol. 127, 171-178.
95. Walther, B., Monecke, S., Ruscher, C., Friedrich, A.W., Ehricht, R., Slickers, P., Soba, A., Wleklinski, C.G., Wieler, L.H. and Lubke-Becker, A. (2009) Comparative molecular analysis substantiates zoonotic potential of equine methicillin-resistant Staphylococcus aureus. J. clin. Microbiol. 47,704-710.
96. Weese, J.S. (2004) Methicillin-resistant Staphylococcus aureus in horses and horse personnel. Vet. Clin. N. Am.: Equine Pract. 20, 601-613.
97. Weese, J.S. (2007) MRSA infection in horses. Vet. Rec. 161, 359-360.
98. Weese, J.S. and Lefebvre, S.L. (2007) Risk factors for methicillin-resistant Staphylococcus aureus colonization in horses admitted to a veterinary teaching hospital. Can. vet. J. 48, 921-926.
99. Weese, J.S. and Rousseau, J. (2005) Attempted eradication of methicillin-resistant Staphylococcus aureus colonisation in horses on two farms. Equine vet. J. 37, 510-514.
100. Weese, J. and van Duijkeren, E. (2009) Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine. Vet. Microbiol. doi:10.1016/j.vetmic.2009. 01.039.
101. Weese, J.S., Archambault, M., Willey, B.M., Hearn, P., Kreiswirth, B.N., Said-Salim, B., McGeer, A., Likhoshvay, Y., Prescott, J.F. and Low, D.E. (2005a) Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000-2002. Emerg. Infect. Dis. 11, 430-435.
102. Weese, J.S., Rousseau, J., Traub-Dargatz, J.L., Willey, B.M., McGeer, A.J. and Low, D.E. (2005b) Community-associated methicillin-resistant Staphylococcus aureus in horses and humans who work with horses. J. Am. vet. med. Ass. 226, 580-583.
103. Weese, J.S., Dick, H., Willey, B.M., McGeer, A., Kreiswirth, B.N., Innis, B. and Low, D.E. (2006a) Suspected transmission of methicillin-resistant Staphylococcus aureus between domestic pets and humans in veterinary clinics and in the household. Vet. Microbiol. 115, 148-155.
104. Weese, J.S., Rousseau, J., Willey, B.M., Archambault, M., McGeer, A. and Low, D.E. (2006b) Methicillin-resistant Staphylococcus aureus in horses at a veterinary teaching hospital: frequency, characterization, and association with clinical disease. J. vet. intern. Med. 20, 182-186.
105. Weese, J.S., Caldwell, F., Willey, B.M., Kreiswirth, B.N., McGeer, A., Rousseau, J. and Low, D.E. (2006c) An outbreak of methicillin-resistant Staphylococcus aureus skin infections resulting from horse to human transmission in a veterinary hospital. Vet. Microbiol. 114, 160-164.