Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study

Atherosclerosis

Volumn 209, Issue 1, 2010, Pages 215-219

  Seet, Raymond C S ^a   Kasiman, Katherine ^b   Gruber, Jan ^b   Tang, Soon Yew ^b   Wong, Meng Cheong ^c   Chang, Hui Meng ^d   Chan, Yiong Huak ^b   Halliwell, Barry ^b   Chen, Christopher P ^b  

^a Dept Medicine Endocrinol Diabet   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^d NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

Author keywords

Infarction; Prognosis; Stroke; Uric acid

Indexed keywords

URIC ACID;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; ASIAN; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FOLLOW UP; HEART DEATH; HEART INFARCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANKIN SCALE; RECURRENT DISEASE; TRANSIENT ISCHEMIC ATTACK; URIC ACID BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; SINGAPORE; STROKE; URIC ACID;

EID: 77049114008     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.08.012     Document Type: Article

References (21)

1. Becker B.F. Towards the physiological function of uric acid. Free Radic Biol Med 14 6 (1993) 615-631
2. Wu X M.D., Lee C.C., and Caskey C.T. Two independent mutational events in the loss of urate oxidase during hominoid evolution. J Mol Evol 34 (1992) 78-84
3. Cherubini A., Ruggiero C., Polidori M.C., and Mecocci P. Potential markers of oxidative stress in stroke. Free Radic Biol Med 39 (2005) 841-852
4. Weir C.J., Muir S.W., Walters M.R., and Lees K.R. Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Stroke 34 (2003) 1951-1956
5. Chamorro A., Obach V., Cervera A., et al. Prognostic significance of uric acid serum concentration in patients with acute ischemic stroke. Stroke 33 (2002) 1048-1052
6. Bonita R., and Beaglehole R. Recovery of motor function after stroke. Stroke 19 (1988) 1497-1500
7. Singapore Ministry of Health. Health facts Singapore (2005)
8. Bamford J., Sandercock P., Dennis M., Burn J., and Warlow C. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 337 (1991) 1521-1526
9. Venketasubramanian N., Tan L.C., Sahadevan S., et al. Prevalence of stroke among Chinese, Malay, and Indian Singaporeans: a community-based tri-racial cross-sectional survey. Stroke 36 (2005) 551-556
10. Venketasubramanian N., and Yin A. Hospital costs for stroke care in Singapore. Cerebrovasc Dis 10 (2000) 320-326
11. Rinaldi P., Polidori M.C., Metastasio A., et al. Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging 24 (2003) 915-919
12. de Lau L.M., Koudstaal P.J., Hofman A., and Breteler M.M. Serum uric acid levels and the risk of Parkinson disease. Ann Neurol 58 (2005) 797-800
13. Amaro S.S.D., Obach V., Cervera A., Planas A.M., and Chamorro A. A pilot study of dual treatment with recombinant tissue plasminogen activator and uric acid in acute ischemic stroke. Stroke 38 (2007) 2173-2175
14. Lehto S.N.L., Ronnemaa T., and Laakso M. Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke 29 (1998) 635-639
15. Ginsberg M.H., Kozin F., O'Malley M., and McCarty D.J. Release of platelet constituents by monosodium urate crystals. J Clin Invest 60 (1977) 999-1007
16. Mazzali M., Kanellis J., Han L., et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol 282 (2002) F991-F997
17. De Scheerder I.K., van de Kraay A.M., Lamers J.M., et al. Myocardial malondialdehyde and uric acid release after short-lasting coronary occlusions during coronary angioplasty: potential mechanisms for free radical generation. Am J Cardiol 68 4 (1991) 392-395
18. Abuja P.M. Ascorbate prevents prooxidant effects of urate in oxidation of human low density lipoprotein. FEBS Lett 446 (1999) 305-308
19. Johnson R.J., Kang D.H., Feig D., et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?. Hypertension 41 (2003) 1183-1190
20. Ames B.N., Cathcart R., Schwiers E., and Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci USA 78 (1981) 6858-6862
21. Nieto F.J., Iribarren C., Gross M.D., Comstock G.W., and Cutler R.G. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?. Atherosclerosis 148 (2000) 131-139