A modeling study of T-type Ca2+ Channel gating and modulation by L-cysteine in rat nociceptors

Biophysical Journal

Volumn 98, Issue 2, 2010, Pages 197-206

  Nelson, Michael T ^a   Milescu, Lorin S ^b   Todorovic, Slobodan M ^a   Scroggs, Reese S ^c  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RATTUS;

EID: 77049083143     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.10.007     Document Type: Article

References (21)

1. Todorovic, S. M., and V. Jevtovic-Todorovic. 2007. Regulation of T-type calcium channels in the peripheral pain pathway. Channels (Austin). 1:238-245.
2. 2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J. Neurosci. 25:8766-8775.
3. Todorovic, S. M., V. Jevtovic-Todorovic,., C. F. Zorumski. 2001. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron. 31:75-85.
4. Nelson, M. T., J. Woo,., S. M. Todorovic. 2007. Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J. Neurosci. 27:8250-8260.
5. 2+ channels in the rat and mouse thalamus. J. Physiol. 574:415-430.
6. Jagodic, M. M., S. Pathirathna,., S. M. Todorovic. 2008. Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J. Neurophysiol. 99:3151-3156.
7. Lee, J. H., J. C. Gomora,., E. Perez-Reyes. 1999. Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H. Biophys. J. 77:3034-3042.
8. Milescu, L. S., G. Akk, and F. Sachs. 2005. Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophys. J. 88:2494-2515.
9. Celentano, J. J., and A. G. Hawkes. 2004. Use of the covariance matrix in directly fitting kinetic parameters: application to GABAA receptors. Biophys. J. 87:276-294.
10. Moffatt, L. 2007. Estimation of ion channel kinetics from fluctuations of macroscopic currents. Biophys. J. 93:74-91.
11. Burgess, D. E., O. Crawford,., J. Satin. 2002. Mechanism of inactivation gating of human T-type (low-voltage activated) calcium channels. Biophys. J. 82:1894-1906.
12. Serrano, J. R., E. Perez-Reyes, and S. W. Jones. 1999. State-dependent inactivation of the a1G T-type calcium channel. J. Gen. Physiol. 114:185-201.
13. Satin, J., and L. L. Cribbs. 2000. Identification of a T-type Ca(2+) channel isoform in murine atrial myocytes (AT-1 cells). Circ. Res. 86:636-642.
14. Chen, C. F., and P. Hess. 1990. Mechanism of gating of T-type calcium channels. J. Gen. Physiol. 96:603-630.
15. 2+ channels. Cell Calcium. 40:97-114.
16. 2+ channels in guinea-pig heart cells. J. Physiol. 456:247-265.
17. Droogmans, G., and B. Nilius. 1989. Kinetic properties of the cardiac T-type calcium channel in the guinea-pig. J. Physiol. 419:627-650.
18. Durante, P., C. G. Cardenas,., R. S. Scroggs. 2004. Low-threshold L-type calcium channels in rat dopamine neurons. J. Neurophysiol. 91: 1450-1454.
19. Carbone, E., and H. D. Lux. 1987. Single low-voltage-activated calcium channels in chick and rat sensory neurones. J. Physiol. 386:571-601.
20. +) in rat nociceptors. Biophys. J. 83:5-21.
21. + channel: model fitting to whole-cell current traces. Biophys. J. 77:204-216.