Serotonin transporter promoter polymorphism and dopaminergic sensitivity in alcoholics

Journal of Neural Transmission

Volumn 117, Issue 1, 2010, Pages 133-138

  Budde, Henning ^a   Sander, Thomas ^b   Wernicke, Catrin ^c   Müller, Anett ^d   Gallinat, Jürgen ^c   Schmidt, Lutz G ^e   Smolka, Michael N ^d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Alcohol; Apomorphine; Dopamine; Growth hormone; Serotonin transporter

Indexed keywords

ALCOHOL; APOMORPHINE; GROWTH HORMONE; SEROTONIN TRANSPORTER;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ALLELE; ARTICLE; DOPAMINERGIC ACTIVITY; DOPAMINERGIC SYSTEM; FEMALE; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; GENOTYPE; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMISSION; PRIORITY JOURNAL; PROMOTER REGION; SEROTONINERGIC SYSTEM; SMOKING;

ALCOHOLISM; ANALYSIS OF VARIANCE; APOMORPHINE; DOPAMINE; DOPAMINE AGONISTS; FEMALE; GENOTYPE; GROWTH HORMONE; HUMANS; INDEL MUTATION; MALE; MIDDLE AGED; NEUROSECRETORY SYSTEMS; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SMOKING;

EID: 76949108031     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-009-0331-9     Document Type: Article

References (30)

1. KD Alex EA Pehek 2007 Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission Pharmacol Ther 113 296 320 10.1016/j.pharmthera. 2006.08.004 1:CAS:528:DC%2BD2sXhtVCgt7Y%3D 17049611 (Pubitemid 46149046)
2. G Aymard I Berlin B de Brettes B Diquet 2003 Pharmacokinetic- pharmacodynamic study of apomorphine's effect on growth hormone secretion in healthy subjects Fundam Clin Pharmacol 17 473 481 10.1046/j.1472-8206.2003. 00152.x 1:CAS:528:DC%2BD3sXlvFCntL8%3D 12914551 (Pubitemid 36920650)
3. O Blomqvist M Ericson JA Engel B Soderpalm 1997 Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine Eur J Pharmacol 334 149 156 10.1016/S0014-2999(97)01220-X 1:CAS:528: DyaK2sXlsleqsLk%3D 9369343 (Pubitemid 27451983)
4. I Boileau JM Assaad RO Pihl C Benkelfat M Leyton M Diksic RE Tremblay A Dagher 2003 Alcohol promotes dopamine release in the human nucleus accumbens Synapse 49 226 231 10.1002/syn.10226 1:CAS:528:DC%2BD3sXmt1Ghur4%3D 12827641 (Pubitemid 36927963)
5. H Budde US Zimmermann B Steffin H Rommelspacher LG Schmidt MN Smolka 2007 Apomorphine-induced growth hormone response is attenuated by ethanol but not dextromethorphan Alcohol Clin Exp Res 31 100 103 10.1111/j.1530-0277.2006.00267. x 1:CAS:528:DC%2BD2sXhvVOmtrw%3D 17207107 (Pubitemid 46025371)
6. A Dagher C Bleicher JA Aston RN Gunn PB Clarke P Cumming 2001 Reduced dopamine D1 receptor binding in the ventral striatum of cigarette smokers Synapse 42 48 53 10.1002/syn.1098 1:CAS:528:DC%2BD3MXmtlCqs7o%3D 11668590 (Pubitemid 32786423)
7. M Dettling A Heinz P Dufeu H Rommelspacher KJ Graf LG Schmidt 1995 Dopaminergic responsivity in alcoholism: trait, state, or residual marker? Am J Psychiatry 152 1317 1321 1:STN:280:DyaK2Mzot1agsg%3D%3D 7653687
8. G Di Chiara A Imperato 1988 Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats Proc Natl Acad Sci U S A 85 5274 5278 10.1073/pnas.85.14.5274 1:CAS:528:DyaL1cXltVCls74%3D 2899326 (Pubitemid 18192948)
9. C Fehr I Yakushev N Hohmann HG Buchholz C Landvogt H Deckers A Eberhardt M Klager MN Smolka A Scheurich T Dielentheis LG Schmidt F Rosch P Bartenstein G Grunder M Schreckenberger 2008 Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse Am J Psychiatry 165 507 514 10.1176/appi.ajp.2007.07020352 18316420 (Pubitemid 351694294)
10. BD Greenberg TJ Tolliver SJ Huang Q Li D Bengel DL Murphy 1999 Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets Am J Med Genet 88 83 87 10.1002/(SICI)1096- 8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0 1:STN:280: DyaK1M7lvValsg%3D%3D 10050973 (Pubitemid 29075327)
11. A Heils A Teufel S Petri G Stober P Riederer D Bengel KP Lesch 1996 Allelic variation of human serotonin transporter gene expression J Neurochem 66 2621 2624 1:CAS:528:DyaK28XjtFCrsrk%3D 8632190
12. A Heinz D Goldman 2000 Genotype effects on neurodegeneration and neuroadaptation in monoaminergic neurotransmitter systems Neurochem Int 37 425 432 10.1016/S0197-0186(00)00057-7 1:CAS:528:DC%2BD3cXmvFShsLY%3D 10871694 (Pubitemid 30386980)
13. A Heinz M Dettling S Kuhn P Dufeu KJ Graf I Kurten H Rommelspacher IG Schmidt 1995 Blunted growth hormone response is associated with early relapse in alcohol-dependent patients Alcohol Clin Exp Res 19 62 65 1:STN:280: DyaK2M3ovFKjsA%3D%3D 7771665
14. A Heinz DW Jones C Mazzanti D Goldman P Ragan D Hommer M Linnoila DR Weinberger 2000 A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity Biol Psychiatry 47 643 649 10.1016/S0006-3223(99)00171-7 1:CAS:528:DC%2BD3cXitVSku7Y%3D 10745057 (Pubitemid 30169258)
15. A Heinz T Siessmeier J Wrase HG Buchholz G Grunder Y Kumakura P Cumming M Schreckenberger MN Smolka F Rosch K Mann P Bartenstein 2005 Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients Am J Psychiatry 162 1515 1520 10.1176/appi.ajp.162.8.1515 16055774 (Pubitemid 41105567)
16. MA Javors C Seneviratne JD Roache N Ait-Daoud SE Bergeson MC Walss-Bass FZ Akhtar BA Johnson 2005 Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholics Prog Neuropsychopharmacol Biol Psychiatry 29 7 13 10.1016/j.pnpbp.2004.08.004 1:CAS:528:DC%2BD2cXhtFahsLvL 15610939 (Pubitemid 40018200)
17. BA Johnson 2004 Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment CNS Drugs 18 1105 1118 10.2165/00023210-200418150-00005 1:CAS:528:DC%2BD2MXmvVSlsg%3D%3D 15581381 (Pubitemid 40007493)
18. G Koob 2000 Drug addiction Neurobiol Dis 7 543 545 10.1006/nbdi.2000.0351 1:STN:280:DC%2BD3M%2Fkt1Oqsg%3D%3D 11042073 (Pubitemid 30816211)
19. D LeMarquand RO Pihl C Benkelfat 1994 Serotonin and alcohol intake, abuse, and dependence: clinical evidence Biol Psychiatry 36 326 337 10.1016/0006-3223(94)90630-0 1:STN:280:DyaK2M%2Fos1Wgsw%3D%3D 7993959 (Pubitemid 24288762)
20. KP Lesch D Bengel A Heils SZ Sabol BD Greenberg S Petri J Benjamin CR Muller DH Hamer DL Murphy 1996 Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1527 1531 10.1126/science.274.5292.1527 1:CAS:528:DyaK28Xnt1ansL8%3D 8929413 (Pubitemid 26403928)
21. KY Little DP McLaughlin L Zhang CS Livermore GW Dalack PR McFinton ZS DelProposto E Hill BJ Cassin SJ Watson EH Cook 1998 Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels Am J Psychiatry 155 207 213 1:STN:280:DyaK1c7isFCntg%3D%3D 9464199
22. SA Miller DD Dykes HF Polesky 1988 A simple salting out procedure for extracting DNA from human nucleated cells Nucleic Acids Res 16 1215 10.1093/nar/16.3.1215 1:CAS:528:DyaL1cXhsVKlsrs%3D 3344216
23. M Reimold MN Smolka G Schumann A Zimmer J Wrase K Mann XZ Hu D Goldman G Reischl C Solbach HJ Machulla R Bares A Heinz 2007 Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype J Neural Transm 114 635 639 10.1007/s00702-006-0609-0 1:CAS:528:DC%2BD2sXksF2ksLo%3D 17225932 (Pubitemid 46664049)
24. LG Schmidt M Smolka 2001 Relapse prevention in alcoholics by cigarette smoking? Involvement of nicotinic-dopaminergic mechanisms Alcohol 24 111 115 10.1016/S0741-8329(01)00129-X 1:CAS:528:DC%2BD3MXmtV2ltb8%3D 11522432 (Pubitemid 32755916)
25. LG Schmidt S Kuhn M Smolka K Schmidt H Rommelspacher 2002 Lisuride, a dopamine D2 receptor agonist, and anticraving drug expectancy as modifiers of relapse in alcohol dependence Prog Neuropsychopharmacol Biol Psychiatry 26 209 217 10.1016/S0278-5846(01)00214-7 1:CAS:528:DC%2BD38XlvFOrtg%3D%3D 11817496 (Pubitemid 34038046)
26. MA Schuckit C Mazzanti TL Smith U Ahmed M Radel N Iwata D Goldman 1999 Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABA alpha 6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study Biol Psychiatry 45 647 651 10.1016/S0006-3223(98)00248-0 1:STN:280: DyaK1M7ovVSntw%3D%3D 10088053 (Pubitemid 29147375)
27. MH Skowronek M Laucht E Hohm K Becker MH Schmidt 2006 Interaction between the dopamine D4 receptor and the serotonin transporter promoter polymorphisms in alcohol and tobacco use among 15-year-olds Neurogenetics 7 239 246 10.1007/s10048-006-0050-4 1:CAS:528:DC%2BD28XhtVyqtrjF 16819620 (Pubitemid 44584077)
28. MN Smolka H Budde AC Karow LG Schmidt 2004 Neuroendocrinological and neuropsychological correlates of dopaminergic function in nicotine dependence Psychopharmacology (Berl) 175 374 381 10.1007/s00213-004-1824-8 1:CAS:528:DC%2BD2cXotVOhtr4%3D (Pubitemid 39361926)
29. I Sora FS Hall AM Andrews M Itokawa XF Li HB Wei C Wichems KP Lesch DL Murphy GR Uhl 2001 Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference Proc Natl Acad Sci USA 98 5300 5305 10.1073/pnas.091039298 1:CAS:528:DC%2BD3MXjt1Ontr0%3D 11320258 (Pubitemid 32397123)
30. ND Volkow GJ Wang L Maynard JS Fowler B Jayne F Telang J Logan YS Ding SJ Gatley R Hitzemann C Wong N Pappas 2002 Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study Psychiatry Res 116 163 172 10.1016/S0925-4927(02)00087-2 1:CAS:528:DC%2BD3sXhsV2is7w%3D 12477600 (Pubitemid 35441320)