The mitochondrial DNA variant 16189T>C is associated with coronary artery disease and myocardial infarction in Saudi Arabs

Genetic Testing and Molecular Biomarkers

Volumn 14, Issue 1, 2010, Pages 43-47

  Abu Amero, Khaled K ^a   Al Boudari, Olyan M ^b   Mousa, Ahmed ^a   Gonzalez, Ana M ^c   Larruga, Jose M ^c   Cabrera, Vicente M ^c   Dzimiri, Nduna ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^c UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGE DISTRIBUTION; ANGIOCARDIOGRAPHY; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; GENETIC ASSOCIATION; HAPLOTYPE; HEART INFARCTION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; SAUDI ARABIA;

ADULT; ARABS; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; DNA, MITOCHONDRIAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SAUDI ARABIA;

EID: 76949094230     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2009.0095     Document Type: Article

References (33)

1. Abu-Amero K, Larruga JM, Cabrera VM, Gonzalez AM (2008a) Mitochondrial DNA structure in the Arabian Peninsula. BMC Evol Biol 8:45-54.
2. Abu-Amero KK, Gonzalez AM, Larruga JM, et al. (2007) Eurasian and African mitochondrial DNA influences in the Saudi Arabian population. BMC Evol Biol 7:32-46.
3. Abu-Amero KK, Hellani A, Bohlega S (2008b) Absence of mtDNA mutations in leukocytes of CADASIL patients. BMC Res Notes 1:16-19.
4. Abu-Amero KK, Larruga JM, Gonzalez AM, Bosley TM (2008c) The role of mitochondrial haplogroups in non-arteritic anterior ischemic optic neuropathy. Ophthalmic Genet 29:111-116.
5. Abu-Amero KK, Morales J, Bosley TM, et al. (2008d) The role of mitochondrial haplogroups in glaucoma: a study in an Arab population. Mol Vis 14:518-522.
6. Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined-a consensus document of the Joint European Society of Cardiology=American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36:959-969. (Pubitemid 30681627)
7. Bai RK, Leal SM, Covarrubias D, et al. (2007) Mitochondrial genetic background modifies breast cancer risk. Cancer Res 67:4687-4694.
8. Botto N, Berti S, Manfredi S, et al. (2005) Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease. Mutat Res 570:81-88.
9. Corral-Debrinski M, Shoffner JM, Lott MT, Wallace DC (1992) Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease. Mutat Res 275:169-180.
10. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 26 Suppl 1:S5-S20.
11. Fuku N, Park KS, Yamada Y, et al. (2007) Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet 80:407-415.
12. Gerbitz KD, van den Ouweland JM, Maassen JA, Jaksch M (1995) Mitochondrial diabetes mellitus: a review. Biochim Biophys Acta 1271:253-260.
13. Gutierrez J, Ballinger SW, Darley-Usmar VM, Landar A (2006) Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ Res 99:924-932.
14. Herrnstadt C, Howell N (2004) An evolutionary perspective on pathogenic mtDNA mutations: haplogroup associations of clinical disorders. Mitochondrion 4:791-798.
15. Katagiri H, Asano T, Ishihara H, et al. (1994) Mitochondrial diabetes mellitus: prevalence and clinical characterization of diabetes due to mitochondrial tRNA(Leu(UUR)) gene mutation in Japanese patients. Diabetologia 37:504-510.
16. Kofler B, Mueller EE, Eder W, et al. (2009) Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study. BMC Med Genet 10:35-41.
17. Lee YY, Park KS, Pak YK, Lee HK (2005) The role of mitochondrial DNA in the development of type 2 diabetes caused by fetal malnutrition. J Nutr Biochem 16:195-204.
18. Li XY, Su M, Huang HH, et al. (2007) mtDNA evidence: genetic background associated with related populations at high risk for esophageal cancer between Chaoshan and Taihang Mountain areas in China. Genomics 90:474-481.
19. Livesey KJ, Wimhurst VL, Carter K, et al. (2004) The 16189 variant of mitochondrial DNA occurs more frequently in C282Y homozygotes with haemochromatosis than those without iron loading. J Med Genet 41:6-10.
20. Lusis AJ, Fogelman AM, Fonarow GC (2004a) Genetic basis of atherosclerosis: part I: new genes and pathways. Circulation 110:1868-1873.
21. Lusis AJ, Fogelman AM, Fonarow GC (2004b) Genetic basis of atherosclerosis: part II: clinical implications. Circulation 110: 2066-2071.
22. Maca-Meyer N, Gonzalez AM, Larruga JM, et al. (2001) Major genomic mitochondrial lineages delineate early human expansions. BMC Genet 2:13-20.
23. Park KS, Chan JC, Chuang LM, et al. (2008) A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians. Diabetologia 51:602-608.
24. Poulton J, Bednarz AL, Scott-Brown M, et al. (2002) The presence of a common mitochondrial DNA variant is associated with fasting insulin levels in Europeans in Auckland. Diabet Med 19:969-971.
25. Poulton J, Das S (2004) Correction: no evidence of an association between the T16189C mtDNA variant and late onset dementia (Gibson et al.). J Med Genet 41:957; author reply 957-958.
26. Poulton J, Luan J, Macaulay V, et al. (2002) Type 2 diabetes is associated with a common mitochondrial variant: evidence from a population-based case-control study. Hum Mol Genet 11:1581-1583.
27. Takagi K, Yamada Y, Gong JS, et al. (2004) Association of a 5178C-A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals. Atherosclerosis 175:281-286.
28. Tang DL, Zhou X, Li X, et al. (2006) Variation of mitochondrial gene and the association with type 2 diabetes mellitus in a Chinese population. Diabetes Res Clin Pract 73:77-82.
29. Tang DL, Zhou X, Zhou KY, et al. (2005) [Association of mitochondrial DNA variation with type 2 diabetes mellitus] (Chi). Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22:636-640.
30. Torroni A, Achilli A, Macaulay V, et al. (2006) Harvesting the fruit of the human mtDNA tree. Trends Genet 22:339-345.
31. Wallace DC, Shoffner JM, Trounce I, et al. (1995) Mitochondrial DNA mutations in human degenerative diseases and aging. Biochim Biophys Acta 1271:141-151.
32. Wang L, Bamlet WR, de Andrade M, et al. (2007) Mitochondrial genetic polymorphisms and pancreatic cancer risk. Cancer Epidemiol Biomarkers Prev 16:1455-1459.
33. Xu L, Hu Y, Chen B, et al. (2006) Mitochondrial polymorphisms as risk factors for endometrial cancer in southwest China. Int J Gynecol Cancer 16:1661-1667.