Noninvasive functional liver blood flow measurement: Comparison between bolus dose and steady-state clearance of sorbitol in a small-rodent model

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 298, Issue 2, 2010, Pages

  Van Der Hoven, Ben ^a   Van Pelt, Hans ^b   Swart, Eleonore L ^c   Bonthuis, Fred ^a   Tilanus, Huug W ^a   Bakker, Jan ^a   Gommers, Diederik ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Microcirculation; Rats; Sepsis

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE; SORBITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; ARTIFICIAL VENTILATION; BLOOD FLOWMETRY; BODY WEIGHT; CONTROLLED STUDY; CORRELATION ANALYSIS; DOPPLER FLOWMETER; DRUG CLEARANCE; ESCHERICHIA COLI; HEMODYNAMICS; LIVER BLOOD FLOW; LIVER CLEARANCE; LIVER FUNCTION; MALE; NONHUMAN; PLASMA CLEARANCE; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; RAT; SEPSIS; STEADY STATE;

ANIMALS; DISEASE MODELS, ANIMAL; INJECTIONS, INTRAVENOUS; LIPOPOLYSACCHARIDES; LIVER; LIVER CIRCULATION; MALE; METABOLIC CLEARANCE RATE; MICROCIRCULATION; RATS; RATS, WISTAR; SEPSIS; SORBITOL; ULTRASONOGRAPHY, DOPPLER;

EID: 76749156301     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90688.2008     Document Type: Article

References (23)

1. Ballare M, Avagnina P, Torchio M, Cavanna A, Aurucci PE, Niro AG, Molino G. D-sorbitol plasma disappearance rate: an index to evaluate changes in liver circulation. Ric Clin Lab 18: 305-311, 1988.
2. Barstow L, Small RE. Liver function assessment by drug metabolism. Pharmacotherapy 10: 280-288, 1990.
3. Bergmeyer H, Gruber W, Guttmann I. D-Sorbitol. In: Methods of Enzymatic Analysis, edited by Bergmeyer H. New York: Verlag Chemie, 1975, p. 1323-1330.
4. Blakley RL. The metabolism and antiketogenic effects of sorbitol. Sorbitol dehydrogenase. Biochem J 49: 257-271, 1951.
5. Cavanna A, Molino G, Ballare M, Torchio M, Fracchia M, Avagnina P, Bircher J. Non-invasive evaluation of portal-systemic shunting in man by D-sorbitol bioavailability. J Hepatol 5: 154-161, 1987.
6. Cherrick GR, Stein SW, Leevy CM, Davidson CS. Indocyanine green: observations on its physical properties, plasma decay, and hepatic extraction. J Clin Invest 39: 592-600, 1960.
7. Hwang TL, Yang JT, Lau YT. Arginine-nitric oxide pathway in plasma membrane of rat hepatocytes during early and late sepsis. Crit Care Med 27: 137-141, 1999.
8. Ince C. The microcirculation is the motor of sepsis. Crit Care, 9 Suppl 4: S13-S19, 2005.
9. Keiding S. Galactose clearance measurements and liver blood flow. Gastroenterology 94: 477-481, 1988.
10. Keiding S, Engsted E, Ott P. Sorbitol as a test substance for measurement of liver plasma flow in humans. Hepatology 28: 50-56, 1998.
11. Koppel C, Pohle S, Muller C. Rapid determination of functional liver plasma flow in ICU patients by a modified hepatic D-sorbitol plasma clearance method. Eur J Drug Metab Pharmacokinet 18: 327-331, 1993.
12. Kortgen A, Paxian M, Werth M, Recknagel P, Rauchfuss F, Lupp A, Krenn CG, Muller D, Claus RA, Reinhart K, Settmacher U, Bauer M. Prospective assessment of hepatic function and mechanisms of dysfunction in the critically ill. Shock 32: 358-365, 2009.
13. Molino G, Avagnina P, Ballare M, Torchio M, Niro AG, Aurucci PE, Grosso M, Fava C. Combined evaluation of total and functional liver plasma flows and intrahepatic shunting. Dig Dis Sci 36: 1189-1196, 1991.
14. Molino G, Avagnina P, Belforte G, Bircher J. Assessment of the hepatic circulation in humans: new concepts based on evidence derived from a D-sorbitol clearance method. J Lab Clin Med 131: 393-405, 1998.
15. Molino G, Avagnina P, Cavanna A, Ballare M, Torchio M, Bona B, Belforte G. Sorbitol clearance: a parameter reflecting liver plasma flow in the rat. Res Commun Chem Pathol Pharmacol 52: 119-132, 1986.
16. Molino G, Cavanna A, Avagnina P, Ballar ÇM, Torchio M. Hepatic clearance of D-sorbitol. Noninvasive test for evaluating functional liver plasma flow. Dig Dis Sci 32: 753-758, 1987.
17. Oda M, Yokomori H, Han JY. Regulatory mechanisms of hepatic microcirculatory hemodynamics: hepatic arterial system. Clin Hemorheol Microcirc 34: 11-26, 2006.
18. Porta F, Takala J, Weikert C, Bracht H, Kolarova A, Lauterburg BH, Borotto E, Jakob SM. Effects of prolonged endotoxaemia on liver, skeletal muscle and kidney mitochondrial function (Abstract). Crit Care 10: R118, 2006.
19. Porta F, Takala J, Weikert C, Bracht H, Kolarova A, Lauterburg BH, Borotto E, Jakob SM. Systemic and renal actions of dopexamine and dobutamine during endotoxin-shock in the rat. J Crit Care 6: 61-70, 1991.
20. Sestoft L. An evaluation of biochemical aspects of intravenous fructose, sorbitol and xylitol administration in man. Acta Anaesthesiol Scand 29: 19-29, 1985.
21. Torchio M, Battista S, Bar F, Molino G. Prediction by mathematical simulation of different pathophysiological effects on D-sorbitol bioavailability. Comput Biol Med 28: 91-104, 1998.
22. van Lambalgen AA, van den Bos GC, Thijs LG. Changes in regional plasma extravasation in rats following endotoxin infusion. Microvasc Res 34: 116-132, 1987.
23. Zeeh J, Lange H, Bosch J, Pohl S, Loesgen H, Eggers R, Navasa M, Chesta J, Bircher J. Steady-state extrarenal sorbitol clearance as a measure of hepatic plasma flow. Gastroenterology 95: 749-759, 1988.