Synthetic β-(1→6)-linked N-acetylated and nonacetylated oligoglucosamines used to produce conjugate vaccines for bacterial pathogens

Infection and Immunity

Volumn 78, Issue 2, 2010, Pages 764-772

  Gening, Marina L ^a   Maira Litrán, Tomás ^b   Kropec, Andrea ^c   Skurnik, David ^b   Grout, Martha ^b   Tsvetkov, Yury E ^a   Nifantiev, Nikolay E ^a   Pier, Gerald B ^b  

^a N D ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 BETA (1-6) DEXTRO GLUCOSAMINE TETANUS TOXOID CONJUGATE; 5 BETA (1-6) DEXTRO N ACETYLGLUCOSAMINE TETANUS TOXOID CONJUGATE; 9 BETA (1-6) DEXTRO GLUCOSAMINE TETANUS TOXOID CONJUGATE; 9 BETA (1-6) DEXTRO N ACETYLGLUCOSAMINE TETANUS TOXOID CONJUGATE; BETA (1-6) POLY N ACETYL DEXTRO GLUCOSAMINE; ESCHERICHIA COLI VACCINE; OLIGOSACCHARIDE; STAPHYLOCOCCUS VACCINE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL PERITONITIS; BLOOD SAMPLING; CONJUGATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VIVO STUDY; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; RABBIT; STAPHYLOCOCCAL SKIN INFECTION; STAPHYLOCOCCUS AUREUS;

ACETYLATION; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL CAPSULES; BETA-GLUCANS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI INFECTIONS; HUMANS; MICE; PERITONITIS; RABBITS; STAPHYLOCOCCAL SKIN INFECTIONS; VACCINES, CONJUGATE;

EID: 76749149152     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01093-09     Document Type: Article

References (43)

1. Ahmed, A., J. Li, Y. Shiloach, J. B. Robbins, and S. C. Szu. 2006. Safety and immunogenicity of Escherichia coli O157 O-specific polysaccharide conjugate vaccine in 2-5-year-old children. J. Infect. Dis. 193:515-521.
2. Anisimov, A. P., L. E. Lindler, and G. B. Pier. 2004. Intraspecific diversity of Yersinia pestis. Clin. Microbiol. Rev. 17:434-464.
3. Baba, T., T. Bae, O. Schneewind, F. Takeuchi, and K. Hiramatsu. 2008. Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands. J. Bacteriol. 190:300-310.
4. Baker, C. J., M. A. Rench, L. C. Paoletti, and M. S. Edwards. 2007. Dose-response to type V group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine in healthy adults. Vaccine 25:55-63.
5. Bernatoniene, J., and A. Finn. 2005. Advances in pneumococcal vaccines: advantages for infants and children. Drugs 65:229-255.
6. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
7. Cerca, N., T. Maira-Litran, K. K. Jefferson, M. Grout, D. A. Goldmann, and G. B. Pier. 2007. Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide. Proc. Natl. Acad. Sci. U. S. A. 104:7528-7533.
8. Choi, A. H. K., L. Slamti, F. Y. Avci, G. B. Pier, and T. Maira-Litrán. 2009. The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-β-1-6-N- acetylglucosamine, which is critical for biofilm formation. J. Bacteriol. 191:5953-5963.
9. Diep, B. A., H. F. Chambers, C. J. Graber, J. D. Szumowski, L. G. Miller, L. L. Han, J. H. Chen, F. Lin, J. Lin, T. H. Phan, H. A. Carleton, L. K. McDougal, F. C. Tenover, D. E. Cohen, K. H. Mayer, G. F. Sensabaugh, and F. Perdreau-Remington. 2008. Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann. Intern. Med. 148:249-257.
10. Erickson, D. L., C. O. Jarrett, J. A. Callison, E. R. Fischer, and B. J. Hinnebusch. 2008. Loss of a biofilm-inhibiting glycosyl hydrolase during the emergence of Yersinia pestis. J. Bacteriol. 190:8163-8170.
11. Gening, M. L., Y. E. Tsvetkov, G. B. Pier, and N. E. Nifantiev. 2007. Synthesis of β-(1→6)-linked glucosamine oligosaccharides corresponding to fragments of the bacterial surface polysaccharide poly-N-acetylglucosamine. Carbohydr. Res. 342:567-575.
12. Hinnebusch, B. J., and D. L. Erickson. 2008. Yersinia pestis biofilm in the flea vector and its role in the transmission of plague. Curr. Top. Microbiol. Immunol. 322:229-248.
13. Itoh, Y., J. D. Rice, C. Goller, A. Pannuri, J. Taylor, J. Meisner, T. J. Beveridge, J. F. Preston III, and T. Romeo. 2008. Roles of pgaABCD genes in synthesis, modification, and export of the Escherichia coli biofilm adhesin poly-β-1,6-N-acetyl-D- glucosamine. J. Bacteriol. 190:3670-3680.
14. Kaiser, A. B., D. S. Kernodle, and R. A. Parker. 1992. Low-inoculum model of surgical wound infection. J. Infect. Dis. 166:393-399.
15. Kaplan, J. B., K. Velliyagounder, C. Ragunath, H. Rohde, D. Mack, J. K. Knobloch, and N. Ramasubbu. 2004. Genes involved in the synthesis and degradation of matrix polysaccharide in Actinobacillus actinomycetemcomitans and Actinobacillus pleuropneumoniae biofilms. J. Bacteriol. 186:8213-8220.
16. Kelly-Quintos, C., L. A. Cavacini, M. R. Posner, D. Goldmann, and G. B. Pier. 2006. Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosamine. Infect. Immun. 74:2742-2750.
17. Kelly-Quintos, C., A. Kropec, S. Briggs, C. Ordonez, D. A. Goldmann, and G. B. Pier. 2005. The role of epitope specificity in the human opsonic antibody response to the staphylococcal surface polysaccharide poly N-acetyl glucosamine. J. Infect. Dis. 192:2012-2019.
18. Kreiswirth, B. N., S. Lofdahl, M. J. Betley, M. O'Reilly, P. M. Schlievert, M. S. Bergdoll, and R. P. Novick. 1983. The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature 305:709-712.
19. Kropec, A., T. Maira-Litran, K. K. Jefferson, M. Grout, S. E. Cramton, F. Gotz, D. A. Goldmann, and G. B. Pier. 2005. Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection. Infect. Immun. 73:6868-6876.
20. Lin, F. Y., V. A. Ho, H. B. Khiem, D. D. Trach, P. V. Bay, T. C. Thanh, Z. Kossaczka, D. A. Bryla, J. Shiloach, J. B. Robbins, R. Schneerson, and S. C. Szu. 2001. The efficacy of a Salmonella typhi Vi conjugate vaccine in two-to-five-year-old children. N. Engl. J. Med. 344:1263-1269.
21. Mack, D., W. Fischer, A. Krokotsch, K. Leopold, R. Hartmann, H. Egge, and R. Laufs. 1996. The intercellular adhesin involved in biofilm accumulation of Staphylococcus epidermidis is a linear beta-1,6-linked glucosaminoglycan: purification and structural analysis. J. Bacteriol. 178:175-183.
22. Maira-Litran, T., A. Kropec, C. Abeygunawardana, J. Joyce, G. Mark III, D. A. Goldmann, and G. B. Pier. 2002. Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharide. Infect. Immun. 70:4433-4440.
23. Maira-Litran, T., A. Kropec, D. A. Goldmann, and G. B. Pier. 2005. Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated staphylococcal poly-N-acetyl-β-(1-6)-glucosamine. Infect. Immun. 73:6752-6762.
24. Matthysse, A. G., R. Deora, M. Mishra, and A. G. Torres. 2008. Polysaccharides cellulose, poly-β-1,6-N-acetyl-D-glucosamine, and colanic acid are required for optimal binding of Escherichia coli O157:H7 strains to alfalfa sprouts and K-12 strains to plastic but not for binding to epithelial cells. Appl. Environ. Microbiol. 74:2384-2390.
25. McKenney, D., J. Hubner, E. Muller, Y. Wang, D. A. Goldmann, and G. B. Pier. 1998. The ica locus of Staphylococcus epidermidis encodes production of the capsular polysaccharide/adhesin. Infect. Immun. 66:4711-4720.
26. McKenney, D., K. L. Pouliot, Y. Wang, V. Murthy, M. Ulrich, G. Doring, J. C. Lee, D. A. Goldmann, and G. B. Pier. 1999. Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen. Science 284:1523-1527.
27. Miller, L. G., F. Perdreau-Remington, G. Rieg, S. Mehdi, J. Perlroth, A. S. Bayer, A. W. Tang, T. O. Phung, and B. Spellberg. 2005. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N. Engl. J. Med. 352:1445-1453.
28. Overheim, K. A., R. W. Depaolo, K. L. Debord, E. M. Morrin, D. M. Anderson, N. M. Green, R. R. Brubaker, B. Jabri, and O. Schneewind. 2005. LcrV plague vaccine with altered immunomodulatory properties. Infect. Immun. 73:5152-5159.
29. Parise, G., M. Mishra, Y. Itoh, T. Romeo, and R. Deora. 2006. Role of a putative polysaccharide locus in Bordetella biofilm development. J. Bacteriol. 189:750-760.
30. Phalipon, A., C. Costachel, C. Grandjean, A. Thuizat, C. Guerreiro, M. Tanguy, F. Nato, B. Vulliez-Le Normand, F. Belot, K. Wright, V. Marcel-Peyre, P. J. Sansonetti, and L. A. Mulard. 2006. Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine. J. Immunol. 176:1686-1694.
31. Phalipon, A., M. Tanguy, C. Grandjean, C. Guerreiro, F. Belot, D. Cohen, P. J. Sansonetti, and L. A. Mulard. 2009. A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection. J. Immunol. 182:2241-2247.
32. Pozsgay, V. 2008. Recent developments in synthetic oligosaccharide-based bacterial vaccines. Curr. Top. Med. Chem. 8:126-140.
33. Pozsgay, V., J. Kubler-Kielb, R. Schneerson, and J. B. Robbins. 2007. Effect of the nonreducing end of Shigella dysenteriae type 1 O-specific oligosaccharides on their immunogenicity as conjugates in mice. Proc. Natl. Acad. Sci. U. S. A. 104:14478-14482.
34. Quenee, L. E., C. A. Cornelius, N. A. Ciletti, D. Elli, and O. Schneewind. 2008. Yersinia pestis caf1 variants and the limits of plague vaccine protection. Infect. Immun. 76:2025-2036.
35. Roush, S. W., and T. V. Murphy. 2007. Historical comparisons of morbidity and mortality for vaccine-preventable diseases in the United States. JAMA 298:2155-2163.
36. Sloan, G. P., C. F. Love, N. Sukumar, M. Mishra, and R. Deora. 2007. The Bordetella Bps polysaccharide is critical for biofilm development in the mouse respiratory tract. J. Bacteriol. 189:8270-8276.
37. Smith, R. L., and E. Gilkerson. 1979. Quantitation of glycosaminoglycan hexosamine using 3-methyl-2-benzothiazolone hydrazone hydrochloride. Anal. Biochem. 98:478-480.
38. Swingler, G., D. Fransman, and G. Hussey. 2003. Conjugate vaccines for preventing Haemophilus influenzae type b infections. Cochrane Database Syst. Rev. 2003:CD001729.
39. Theilacker, C., F. Coleman, S. Mueschenborn, M. Grout, and G. B. Pier. 2003. Construction and characterization of a Pseudomonas aeruginosa mucoid exopolysaccharide/alginate conjugate vaccine. Infect. Immun. 71:3875-3884.
40. Trotter, C. L., J. McVernon, M. E. Ramsay, C. G. Whitney, E. K. Mulholland, D. Goldblatt, J. Hombach, and M. P. Kieny. 2008. Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae. Vaccine 26: 4434-4445.
41. Verez-Bencomo, V., V. Fernandez-Santana, E. Hardy, M. E. Toledo, M. C. Rodriguez, L. Heynngnezz, A. Rodriguez, A. Baly, L. Herrera, M. Izquierdo, A. Villar, Y. Valdes, K. Cosme, M. L. Deler, M. Montane, E. Garcia, A. Ramos, A. Aguilar, E. Medina, G. Torano, I. Sosa, I. Hernandez, R. Martinez, A. Muzachio, A. Carmenates, L. Costa, F. Cardoso, C. Campa, M. Diaz, and R. Roy. 2004. A synthetic conjugate polysaccharide vaccine against Haemophilus influenzae type b. Science 305:522-525.
42. Wang, X., J. F. Preston III, and T. Romeo. 2004. The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation. J. Bacteriol. 186:2724-2734.
43. Watts, A., D. Ke, Q. Wang, A. Pillay, A. Nicholson-Weller, and J. C. Lee. 2005. Staphylococcus aureus strains that express serotype 5 or serotype 8 capsular polysaccharides differ in virulence. Infect. Immun. 73:3502-3511.