The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 298, Issue 2, 2010, Pages

  Milona, Alexandra ^a   Owen, Bryn M ^a   Van Mil, Saskia ^b   Dormann, Dirk ^a   Mataki, Chikage ^c   Boudjelal, Mohamed ^d   Cairns, William ^d   Schoonjans, Kristina ^c   Milligan, Stuart ^e   Parker, Malcolm ^a   White, Roger ^a   Williamson, Catherine ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c EPFL   (Switzerland)

^d GLAXOSMITHKLINE   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Bile acids; Cell cycle; Cholestasis; Liver regeneration

Indexed keywords

BILE ACID; CELL PROTEIN; CHOLIC ACID; CYCLIN D1; PROTEIN FXR; PROTEIN P27; PROTEIN P53; PROTEIN PXR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID BLOOD LEVEL; BODY WEIGHT; CELL CYCLE PROGRESSION; CELL HYPERPLASIA; CONTROLLED STUDY; DIET; FEMALE; HEPATOMEGALY; HYPERTROPHY; LIVER CELL; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; POLYPLOIDY; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT GAIN;

ANIMALS; CHOLATES; CYCLIN D1; ENERGY METABOLISM; FEMALE; HEPATOCYTES; LIVER; LIVER REGENERATION; MICE; MICE, MUTANT STRAINS; OVARIECTOMY; POLYPLOIDY; PREGNANCY; PREGNANCY, ANIMAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; S PHASE;

EID: 76749124020     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00336.2009     Document Type: Article

References (28)

1. Alfert M, Geschwind II. The development of polysomaty in rat liver. Exp Cell Res 15: 230-232, 1958.
2. Augustine RA, Ladyman SR, Grattan DR. From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy. J Physiol 586: 387-397, 2008.
3. Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol 7: R100, 2006.
4. Castano G, Lucangioli S, Sookoian S, Mesquida M, Lemberg A, Di Scala M, Franchi P, Carducci C, Tripodi V. Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy. Clin Sci (Lond) 110: 459-465, 2006.
5. Celton-Morizur S, Merlen G, Couton D, Margall-Ducos G, Desdouets C. The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents. J Clin Invest 119: 1880-1887, 2009.
6. Cohen PE, Milligan SR. Silastic implants for delivery of oestradiol to mice. J Reprod Fertil 99: 219-223, 1993.
7. Cramer SD, Wong L, Kensinger RS, Ogren L, Talamantes F. Regulation of the hepatic growth hormone receptor and serum growth hormone-binding protein during pregnancy in the mouse: effects of litter size. Endocrinology 131: 2914-2920, 1992.
8. Dai G, He L, Bu P, Wan YJ. Pregnane X receptor is essential for normal progression of liver regeneration. Hepatology 47: 1277-1287, 2008.
9. El Khattabi I, Remacle C, Reusens B. The regulation of IGFs and IGFBPs by prolactin in primary culture of fetal rat hepatocytes is influenced by maternal malnutrition. Am J Physiol Endocrinol Metab 291: E835-E842, 2006.
10. Freemark M, Kirk K, Pihoker C, Robertson MC, Shiu RP, Driscoll P. Pregnancy lactogens in the rat conceptus and fetus: circulating levels, distribution of binding, and expression of receptor messenger ribonucleic acid. Endocrinology 133: 1830-1842, 1993.
11. Germain AM, Carvajal JA, Glasinovic JC, Kato CS, Williamson C. Intrahepatic cholestasis of pregnancy: an intriguing pregnancy-specific disorder. J Soc Gynecol Investig 9: 10-14, 2002.
12. Hay JE. Liver disease in pregnancy. Hepatology 47: 1067-1076, 2008.
13. Hollister A, Okubara P, Watson JG, Chaykin S. Reproduction in mice: liver enlargement in mice during pregnancy and lactation. Life Sci 40: 11-18, 1987.
14. Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, Dong B, Huang X, Moore DD. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 312: 233-236, 2006.
15. Kim I, Morimura K, Shah Y, Yang Q, Ward JM, Gonzalez FJ. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 28: 940-946, 2007.
16. Milligan SR, Cohen PE. Silastic implants for delivering physiological concentrations of progesterone to mice. Reprod Fertil Dev 6: 235-239, 1994.
17. Milligan SR, Cohen PE, Finn CA. The minimum requirements for oestradiol to induce uterine sensitivity for implantation and decidualization in mice. Hum Reprod 10: 1502-1506, 1995.
18. Milligan SR, Finn CA. Minimal progesterone support required for the maintenance of pregnancy in mice. Hum Reprod 12: 602-607, 1997.
19. Ochs H, Dusterberg B, Schulte-Hermann R. Induction of monooxygenases and growth in rat liver by progesterone. Arch Toxicol 59: 146-149, 1986.
20. Paschkis KE, Cantarow A. Pregnancy, tumor growth, and liver regeneration. Cancer Res 18: 1060-1066, 1958.
21. Soares MJ. The prolactin and growth hormone families: pregnancy-specific hormones/cytokines at the maternal-fetal interface. Reprod Biol Endocrinol 2: 51, 2004.
22. Sookoian S, Castano G, Burgueno A, Gianotti TF, Pirola CJ. Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy. J Hepatol 48: 125-132, 2008.
23. Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98: 3369-3374, 2001.
24. Tarla MR, Ramalho FS, Ramalho LN, Silva Tde C, Brandao DF, Ferreira J, Silva Ode C, Zucoloto S. A molecular view of liver regeneration. Acta Cir Bras 21, Suppl 1: 58-62, 2006.
25. Toyoda H, Bregerie O, Vallet A, Nalpas B, Pivert G, Brechot C, Desdouets C. Changes to hepatocyte ploidy and binuclearity profiles during human chronic viral hepatitis. Gut 54: 297-302, 2005.
26. Yamamoto Y, Moore R, Hess HA, Guo GL, Gonzalez FJ, Korach KS, Maronpot RR, Negishi M. Estrogen receptor alpha mediates 17alphaethynylestradiol causing hepatotoxicity. J Biol Chem 281: 16625-16631, 2006.
27. Yang F, Huang X, Yi T, Yen Y, Moore DD, Huang W. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 67: 863-867, 2007.
28. Zhang Y, Xu P, Park K, Choi Y, Moore DD, Wang L. Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology 48: 289-298, 2008.