Discovery of novel poly(ADP-ribose) glycohydrolase inhibitors by a quantitative assay system using dot-blot with anti-poly(ADP-ribose)

Biochemical and Biophysical Research Communications

Volumn 392, Issue 4, 2010, Pages 485-489

  Okita, Naoyuki ^a   Ashizawa, Daisuke ^a   Ohta, Ryo ^a   Abe, Hideaki ^a   Tanuma, Sei ichi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Dot blot assay; High throughput screening; PARG; Poly(ADP ribose); Poly(ADP ribosyl)ation

Indexed keywords

ADENOSINE DIPHOSPHATE (HYDROXYMETHYL) PYRROLIDINEDIOL; MONOCLONAL ANTIBODY; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLY(ADENOSINE DIPHOSPHATE RIBOSE) GLYCOHYDROLASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE) GLYCOHYDROLASE INHIBITOR; POLY(ETHENOADENOSINE DIPHOSPHATE RIBOSE); PYROXYLIN; UNCLASSIFIED DRUG; XANTHENE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ARTICLE; DNA REPAIR; DNA REPLICATION; DOT HYBRIDIZATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; HYDROLYSIS; IC 50; MEMBRANE BINDING; MICHAELIS CONSTANT; PRIORITY JOURNAL; QUANTITATIVE ASSAY;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; HUMANS; INHIBITORY CONCENTRATION 50; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS;

EID: 76749103351     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.01.044     Document Type: Article

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