A simulation model of insulin saturation and glucose balance for glycemic control in ICU patients

Computer Methods and Programs in Biomedicine

Volumn 97, Issue 3, 2010, Pages 211-222

  Pielmeier, Ulrike ^a   Andreassen, Steen ^a   Nielsen, Birgitte S ^b   Chase, J Geoffrey ^c   Haure, Pernille ^b  

^a AALBORG UNIVERSITY   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Critical care; Glucose control; Hyperglycemia; Metabolic modelling

Indexed keywords

BEFORE AND AFTER; BLOOD GLUCOSE EXCURSION; BLOOD GLUCOSE MEASUREMENTS; BLOOD SUGARS; CRITICAL CARE; CRITICALLY-ILL PATIENTS; GLUCOSE CONTROL; GLYCEMIC CONTROL; INSULIN ACTION; INSULIN SENSITIVITY; INSULIN THERAPY; INTENSIVE-CARE PATIENTS; METABOLIC MODELS; NON-LINEARITY; SIMULATION MODEL;

BLOOD; GLUCOSE; INTENSIVE CARE UNITS; LINEARIZATION; METABOLISM; MODEL STRUCTURES; SUGAR (SUCROSE);

INSULIN;

GLUCOSE; INSULIN;

ACCURACY; ARTICLE; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLYCEMIC CONTROL; HORMONE ACTION; INSULIN METABOLISM; INSULIN SENSITIVITY; INTESTINE ABSORPTION; MATHEMATICAL MODEL; NONLINEAR SYSTEM; PREDICTION; PROCESS MODEL;

BLOOD GLUCOSE; HUMANS; INSULIN; INTENSIVE CARE UNITS; MODELS, BIOLOGICAL;

EID: 76749103284     PISSN: 01692607     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmpb.2009.06.004     Document Type: Article

References (33)

1. Krinsley J.S. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin. Proc. 79 (2004) 992-1000
2. Van den Berghe G., Wouters P., Weekers F., Verwaest C., Bruyninckx F., Schetz M., Vlasselaers D., Ferdinande P., Lauwers P., and Bouillon R. Intensive insulin treatment in critically ill patients. N. Engl. J. Med. 345 (2001) 1359-1367
3. Chase J.G., Shaw G.M., Le Compte A.J., Lonergan T.R., Willacy M.B., Wong X.W., Lin J., Lotz T., Lee D.S., and Hann C.E. Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change. Crit. Care 12 2 (2008) R49
4. Wiener R.S., Wiener D.C., and Larson R.J. Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA 300 (2008) 933-944
5. Griesdale D.E.G., de Souza R.J., van Dam R.M., Heyland D.K., Cook D.J., Malhotra A., Dhaliwal R., Henderson W.R., Chittock D.R., Finfer S., and Talmor D. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 180 8 (2009) 821-827
6. The NICE-SUGAR Study Investigators: S. Finfer, D.R. Chittock, et al., Intensive versus conventional glucose control in critically ill patients, N. Engl. J. Med. 360 (13) (2009) 1283-1297.
7. Chase J.G., Shaw G.M., Wong X.W., Lotz T., Lin J., and Hann C.E. Model-based glycaemic control in critical care-a review of the state of the possible. Biomed. Signal Process. Control 1 (2006) 3-21
8. Prigeon R.L., Røder M.E., Porte D., and Kahn Jr. S.E. The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique. Evidence for saturable insulin transport in humans. J. Clin. Invest. 97 2 (1996) 501-507
9. Katz H., Butler P., Homan M., Zerman A., Caumo A., Cobelli C., and Rizza R. Hepatic and extrahepatic insulin action in humans: measurement in the absence of non-steadystate error. Am. J. Physiol. 264 (1993) 561-566
10. Rizza R.A., Mandarino L.J., and Gerich J.E. Dose-response characteristics for effect of insulin on production and utilization of glucose in man. Am. J. Physiol. 240 (1981) E630-E639
11. Natali A., Gastaldelli A., Camastra S., Sironi A.M., Toschi E., Masoni A., Ferrannini E., and Mari A. Dose-response characteristics of insulin action on glucose metabolism: a non-steadystate approach. Am. J. Physiol. Endocrinol. Metab. 278 5 (2000) E794-E801
12. Langouche L., Van der Perre S., Wouters P.J., d'Hoore A., Hansen T.K., and Van den Berghe G. Effect of intensive insulin therapy on insulin sensitivity in the critically ill. J. Clin. Endocrinol. Metab. 92 10 (2007) 3890-3897
13. Van den Berghe G., Wilmer A., Milants I., Wouters P.J., Bouckaert B., Bruyninckx F., Bouillon R., and Schetz M. Intensive insulin therapy in mixed medical/surgical intensive care units. Diabetes 5 (2006) 3151-3159
14. Lonergan T., Le Compte A., Willacy M., Chase J.G., Shaw G.M., Wong X.W., Lotz T., Lin J., and Hann C.E. A simple insulin-nutrition protocol for tight glycemic control in critical illness: development and protocol comparison. Diabetes Technol. Ther. 8 2 (2006) 191-206
15. Blaha J., Kopecky P., Matias M., Hovorka R., Kunstyr J., Kotulak T., Lips M., Rubes D., Stritesky M., Lindner J., Semrad M., and Haluzik M. Comparison of three protocols for tight glycemic control in cardiac surgery patients. Diabetes Care (2009) (February 5 Epub ahead of print)
16. Arleth T., Andreassen S., Federici M.O., and Benedetti M.M. A model of the endogenous glucose balance incorporating the characteristics of glucose transporters. Comput. Methods Prog. Biomed. 62 (2000) 219-234
17. Chapman M.J., Nguyen N.Q., and Fraser R.J. Gastrointestinal motility and prokinetics in the critically ill. Curr. Opin. Crit. Care 13 (2007) 187-194
18. Eaton R.P., Allen R.C., and Schade D.S. Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion. J. Clin. Endocrinol. Metab. 56 6 (1983) 1294-1300
19. Van Cauter E., Mestrez F., Sturis J., and Polonsky K.S. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41 (1992) 368-377
20. Sjöstrand M., Gudbjörnsdottir S., Strindberg L., and Lönnroth P. Delayed transcapillary delivery of insulin to muscle interstitial fluid after oral glucose load in obese subjects. Diabetes 54 1 (2005) 152-157
21. Buse J.B., Polonsky K.S., and Burant C.F. Type 2 Diabetes Mellitus. In: Kronenberg H., Shlomo M., Polonsky K., and Larsen P.R. (Eds). Williams Textbook of Endocrinology. 11th ed. (2007), Saunders Elsevier
22. Polonsky K.S., Given B.D., and Van Cauter E. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J. Clin. Invest. 81 (1988) 442-448
23. Andreassen S., Pielmeier U., and Chase J.G. Receptor-based models of insulin saturation dynamics. Sixth IASTED International Conference on Biomedical Engineering. Innsbruck, Austria (2008)
24. Nguyen N.Q., Ng M.P., Chapman M., Fraser R.J., and Holloway R.H. The impact of admission diagnosis on gastric emptying in critically ill patients. Critical Care 11 (2007) R16
25. Chapman M., Fraser R., and Bryant L.K. The relationship between glucose absorption and gastric emptying in critical illness. Gastroenterology 130 (2006) 603
26. Rave K., Nosek L., Posner J., Heise T., Roggen K., and Van Hoogdalem E.J. Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes-results of a hyperglycaemic glucose clamp study. Nephrol. Dial. Transplant. 21 (2006) 2166-2171
27. Jin R., Grunkemeier G.L., Brown J.R., and Furnary A.P. Estimated glomerular filtration rate and renal function. Ann. Thorac. Surg. 86 (2008) 1-3
28. Greger R. Cellular membrane transport mechanisms. In: Greger R., and Windhorst U. (Eds). Comprehensive Human Physiology, vol. 2 (1996), Springer-Verlag, Berlin Heidelberg
29. Radiometer Medical ApS MHRA Blood Gas Analyser Survey 2004, Information supplied by the manufacturer, ABL 700 Series, http://www.surrey.ac.uk/MHRA/Pages/GuildfordEvaluations/CurrentReports/BloodGas/Bloodgaspdfs/RadiometerABL700series.pdf (accessed 27.08.2008).
30. Laakso M., Edelman S.V., Brechtel G., and Baron A.D. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J. Clin. Invest. 85 6 (1990) 1844-1852
31. Barrett E.J., Eggleston E.M., Inyard A.C., Wang H., Li G., Chai W., and Liu Z. The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia 52 5 (2009) 752-764
32. van Echten G., Eckel J., and Reinauer H. Down-regulation of insulin receptors in the heart: studies on primary cultured adult cardiac myocytes. Biochim. Biophys. Acta 886 (1986) 468-473
33. Fülöp T., Nagy J.T., Worum I., Fóris G., Mudri K., Varga P., and Udvardy Jr. M. Glucose intolerance and insulin resistance with aging-studies on insulin receptors and post-receptor events. Arch. Gerontol. Geriatr. 6 (1987) 107-115