The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique: Evidence for saturable insulin transport in humans

Journal of Clinical Investigation

Volumn 97, Issue 2, 1996, Pages 501-507

  Prigeon, Ronald L ^a,b   Roder, Michael E ^a   Porte Jr , Daniel ^a   Kahn, Steven E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Biological transport; Glucose tolerance test; Kinetics; Models, biological; Receptors, insulin

Indexed keywords

CELL SURFACE RECEPTOR; GLUCOSE; INSULIN; INSULIN RECEPTOR;

ADULT; ARTICLE; BODY MASS; BOLUS INJECTION; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTRAVENOUS DRUG ADMINISTRATION; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; METABOLIC PARAMETERS; OBESITY; PRIORITY JOURNAL;

ADULT; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; MALE; OBESITY;

EID: 0030068333     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118441     Document Type: Article

References (25)

1. Finegood, D. T , I. M. Hramiak, and J. Dupre 1990. A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes. J Clin. Endocrinol. & Metab. 70: 1538-1549
2. Welch, S , S. S. P. Gebhart, R. N. Bergman, and L. S. Phillips. 1990. Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J. Clin. Endocrinol & Metab 71:1508-1518.
3. Saad, M. F., R. L. Anderson, A. Laws, R. M. Watanabe, W. W. Kades, Y. D. I. Chen, R. E Sands. D. Pei, P. J. Savage, and R. N. Bergman. 1994. A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Diabetes. 43:1114-1421
4. King, G. L., and S. M. Johnson 1985. Receptor-mediated transport of insulin across endothelial cells. Science (Wash. DC). 277:1583-1586.
5. Kahn, S. E , R. L. Prigeon, D K. McCulloch, E. J Boyko, R. N. Bergman, M. W. Schwartz, J L. Neifing, W. K. Ward, J. C. Beard, J. P. Palmer, and D. Porte, Jr. 1993. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes. 42:1663-1672.
6. Olefsky, J. M., O. G. Kolterman, and J. A. Scarlett. 1982. Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Phvsiol 243:E15-E30.
7. Bergman, R N., Y. Z. Ider, C. R. Bowden, and C. Cobelli. 1979. Quantitative estimation of insulin sensitivity. Am. J. Physiol. 236:E667-E677.
8. McGuire, E. A. H., J. H. Helderman, J. E. Tobin, R. Andres, and M. Herman. 1976. Effects of arterial versus venous sampling on glucose kinetics in man. J. Appl. Physiol 41:563-573.
9. Marquardt, D 1963. An algorithm for least squares estimation of nonlinear parameters. J Soc. Indust. Appl Math 11:431-441.
10. Kahn, S. E., L. J. Klaff, M. W. Schwartz, J. C. Beard, R. N. Bergman, G. J. Taborsky, Jr , and D. Porte. Jr. 1990. Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose. J Clin. Endocrinol. Metab 71:994-1002.
11. Carson, E. R., C. Cobelli, and L. Finkelstein. 1983. Parameter estimation, practical (a posteriori) identifiability, and enhanced experimental design In The Mathematical Modeling of Metabolic and Endocrine Systems. John Wiley & Sons, New York. 179-216.
12. Dennis, J. E., D. M. Gay, and R. E. Welsch. 1981. An adaptive nonlinear least-squares algorithm. ACM Transactions on Mathematical Software. 7:348-368.
13. Morgan, D. R., and A. Lazarow. 1963. Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic, and diabetic rats. Diabetes 12:115-126.
14. Carmer, S. G., and M. R. Swanson. 1973. An evaluation of ten pairwise multiple comparison procedures by Monte Carlo methods. J. Am Stat. Assoc. 68:66-74.
15. Bergman, R. N., D. T. Finegood, and M. Ader. 1985. Assessment of insulin sensitivity in vivo. Endocr Rev. 6:45-86.
16. Jansson, P.-A. E , J. P. Fowelin, H. P. Von Schenck, U. P. Smith, and P. N. Lonnroth. 1993. Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid. Importance of the endothelial barrier for insulin. Diabetes. 42.1469-1473.
17. Poulin, R. A., G M. Steil, D. M. Moore, M. Ader, and R. N. Bergman. 1994 Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes. 43:180-190
18. Yang, Y. J., I D. Hope, M Ader. and R. N. Bergman. 1989. Insulin transport across capillaries is rate limiting for insulin action in dogs. J. Clin. Invest. 84.1620-1628.
19. Abbate, S L., W. Y. Fujimoto, J. D. Brunzell, and S. E. Kahn. 1993. Effect ot heparin on insulin-glucose interactions measured by the minimal model technique: Implications for reproducibility using this method. Metab. Clin Exp. 42:353-357.
20. Ferrari, P., Y. Alleman, S. Shaw, W. Riesen, and P. Weidmann. 1991. Reproducibility of insulin sensitivity measured by the minimal model method. Diabetologia. 34:527-530
21. Steil, G. M . J. Murray, R. N. Bergman. and T. A. Buchanan. 1994. Repeatability of insulin sensitivity and glucose effectiveness from the minimal model. Implications for study design. Diabetes. 43:1365-1371.
22. Prigeon, R. L., S. E. Kahn, and D. Porte, Jr. 1994. Reliability of error estimates from the minimal model: implications for measurements in physiological studies. Am. J. Physiol. 266:E279-E286.
23. Bar, R S., J. C. Hoak, and M. L. Peacock. 1978. Insulin receptors in human endothelial cells: Identification and characterization. J. Clin. Endocrinol. Metab. 47:699-702.
24. Dernovsek, K D., R. S. Bar, B. H. Ginsberg, and M. N. Lioubin. 1984. Rapid transport of biologically intact insulin through cultured endothelial cells. J. Clin. Endocrinol. Metab. 58:761-763.
25. Holmang, A., K Mimura, P. Bjorntorp, and P. Lonnroth. 1995. Measurement by microdialysis of muscle insulin concentration in the rat. Diabetes. 44:91a. (Abstr.)