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Volumn 43, Issue 1, 2010, Pages 27-34

Mucus and Mucins

Author keywords

Cough; Mucins; Mucus; Phlegm; Rheology; Sputum; Tenacity

Indexed keywords

BRONCHODILATING AGENT; DORNASE ALFA; EXPECTORANT AGENT; MACROLIDE; MUCIN; MUCIN 2; MUCIN 5B; MUCIN 7; MUCOLYTIC AGENT; THYMOSIN BETA4;

EID: 76749085784     PISSN: 00306665     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otc.2009.11.002     Document Type: Review
Times cited : (24)

References (37)
  • 1
    • 60249095813 scopus 로고    scopus 로고
    • Mucus, mucins, and sputum
    • Voynow J.A., and Rubin B.K. Mucus, mucins, and sputum. Chest 135 (2009) 505-512
    • (2009) Chest , vol.135 , pp. 505-512
    • Voynow, J.A.1    Rubin, B.K.2
  • 2
    • 69249094267 scopus 로고    scopus 로고
    • Disrupted ciliated epithelium shows slower ciliary beat frequency and increased dyskinesia
    • Thomas B., Rutman A., and O'Callaghan C. Disrupted ciliated epithelium shows slower ciliary beat frequency and increased dyskinesia. Eur Respir J 34 (2009) 401-404
    • (2009) Eur Respir J , vol.34 , pp. 401-404
    • Thomas, B.1    Rutman, A.2    O'Callaghan, C.3
  • 3
    • 66849097677 scopus 로고    scopus 로고
    • Mucus, phlegm, and sputum in cystic fibrosis
    • Rubin B.K. Mucus, phlegm, and sputum in cystic fibrosis. Respir Care 54 (2009) 726-732
    • (2009) Respir Care , vol.54 , pp. 726-732
    • Rubin, B.K.1
  • 4
    • 43549093774 scopus 로고    scopus 로고
    • Structure and function of the polymeric mucins in airways mucus
    • Thornton D.J., Rousseau K., and McGuckin M.A. Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 70 (2008) 459-486
    • (2008) Annu Rev Physiol , vol.70 , pp. 459-486
    • Thornton, D.J.1    Rousseau, K.2    McGuckin, M.A.3
  • 5
    • 0032110419 scopus 로고    scopus 로고
    • MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways
    • Sharma P., Dudus L., Nielsen P.A., et al. MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways. Am J Respir Cell Mol Biol 19 (1998) 30-37
    • (1998) Am J Respir Cell Mol Biol , vol.19 , pp. 30-37
    • Sharma, P.1    Dudus, L.2    Nielsen, P.A.3
  • 6
    • 0029611346 scopus 로고
    • Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus
    • Sheehan J.K., Richardson P.S., Fung D.C., et al. Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Biol 13 (1995) 748-756
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 748-756
    • Sheehan, J.K.1    Richardson, P.S.2    Fung, D.C.3
  • 7
    • 34548201282 scopus 로고    scopus 로고
    • MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells
    • Davies J.R., Kirkham S., Svitacheva N., et al. MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells. Int J Biochem Cell Biol 39 (2007) 1943-1954
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1943-1954
    • Davies, J.R.1    Kirkham, S.2    Svitacheva, N.3
  • 8
    • 0032530370 scopus 로고    scopus 로고
    • Coordinated clearance of periciliary liquid and mucus from airway surfaces
    • Matsui H., Randell S.H., Peretti S.W., et al. Coordinated clearance of periciliary liquid and mucus from airway surfaces. J Clin Invest 102 (1998) 1125-1131
    • (1998) J Clin Invest , vol.102 , pp. 1125-1131
    • Matsui, H.1    Randell, S.H.2    Peretti, S.W.3
  • 11
    • 0024761768 scopus 로고
    • The mechanism of mucus clearance in cough
    • Basser P.J., McMahon T.A., and Griffith P. The mechanism of mucus clearance in cough. J Biomech Eng 111 (1989) 288-297
    • (1989) J Biomech Eng , vol.111 , pp. 288-297
    • Basser, P.J.1    McMahon, T.A.2    Griffith, P.3
  • 12
    • 33644914472 scopus 로고    scopus 로고
    • Clearance of viscoelastic mucus simulant with airflow in a rectangular channel, an experimental study
    • Hassan A.A., Evrensel C.A., and Krumpe P.E. Clearance of viscoelastic mucus simulant with airflow in a rectangular channel, an experimental study. Technol Health Care 14 (2006) 1-11
    • (2006) Technol Health Care , vol.14 , pp. 1-11
    • Hassan, A.A.1    Evrensel, C.A.2    Krumpe, P.E.3
  • 13
    • 0030470371 scopus 로고    scopus 로고
    • Ring distraction technique for measuring surface tension of sputum: relationship to sputum clearability
    • Albers G.M., Tomkiewicz R.P., May M.K., et al. Ring distraction technique for measuring surface tension of sputum: relationship to sputum clearability. J Appl Phys 81 (1996) 2690-2695
    • (1996) J Appl Phys , vol.81 , pp. 2690-2695
    • Albers, G.M.1    Tomkiewicz, R.P.2    May, M.K.3
  • 14
    • 0009574140 scopus 로고    scopus 로고
    • Surface properties of respiratory secretions: relationship to mucus transport
    • Baum G. (Ed), Marcel Dekker, Inc, New York chapter 32
    • Rubin B.K. Surface properties of respiratory secretions: relationship to mucus transport. In: Baum G. (Ed). Cilia, mucus, and mucociliary interactions (1998), Marcel Dekker, Inc, New York 317-324 chapter 32
    • (1998) Cilia, mucus, and mucociliary interactions , pp. 317-324
    • Rubin, B.K.1
  • 15
    • 44649197130 scopus 로고    scopus 로고
    • Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis
    • Clunes M.T., and Boucher R.C. Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis. Curr Opin Pharmacol 8 (2008) 292-299
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 292-299
    • Clunes, M.T.1    Boucher, R.C.2
  • 16
    • 8544250584 scopus 로고    scopus 로고
    • Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium
    • Burgel P.R., and Nadel J.A. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax 59 (2004) 992-996
    • (2004) Thorax , vol.59 , pp. 992-996
    • Burgel, P.R.1    Nadel, J.A.2
  • 17
    • 0037484498 scopus 로고    scopus 로고
    • Hyperosmolar solutions stimulate mucus secretion in the ferret trachea
    • Kishioka C., Okamoto K., Kim J.-S., and Rubin B.K. Hyperosmolar solutions stimulate mucus secretion in the ferret trachea. Chest 124 (2003) 306-313
    • (2003) Chest , vol.124 , pp. 306-313
    • Kishioka, C.1    Okamoto, K.2    Kim, J.-S.3    Rubin, B.K.4
  • 18
    • 0023507163 scopus 로고
    • Ciliary beat frequency and mucociliary clearance. What is the relationship?
    • Katz I., Zwas T., Baum G.L., et al. Ciliary beat frequency and mucociliary clearance. What is the relationship?. Chest 92 (1987) 491-493
    • (1987) Chest , vol.92 , pp. 491-493
    • Katz, I.1    Zwas, T.2    Baum, G.L.3
  • 19
    • 33144473276 scopus 로고    scopus 로고
    • Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis
    • Bush A., Payne D., Pike S., et al. Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis. Chest 129 (2006) 118-123
    • (2006) Chest , vol.129 , pp. 118-123
    • Bush, A.1    Payne, D.2    Pike, S.3
  • 20
    • 34047185781 scopus 로고    scopus 로고
    • Mucus structure and properties in cystic fibrosis
    • Rubin B.K. Mucus structure and properties in cystic fibrosis. Paediatr Respir Rev 8 (2007) 4-7
    • (2007) Paediatr Respir Rev , vol.8 , pp. 4-7
    • Rubin, B.K.1
  • 21
    • 38449111865 scopus 로고    scopus 로고
    • Designing clinical trials to evaluate mucus clearance therapy
    • Rubin B.K. Designing clinical trials to evaluate mucus clearance therapy. Respir Care 52 (2007) 1348-1361
    • (2007) Respir Care , vol.52 , pp. 1348-1361
    • Rubin, B.K.1
  • 22
    • 76749156682 scopus 로고    scopus 로고
    • Interactions of airflow oscillation, tracheal inclination, and elasticity significantly improve mucus clearance during simulated cough
    • PMID:19762551, in press
    • Ragavan AJ, Evrensel CA, Krumpe P. Interactions of airflow oscillation, tracheal inclination, and elasticity significantly improve mucus clearance during simulated cough. Chest, in press. PMID:19762551.
    • Chest
    • Ragavan, A.J.1    Evrensel, C.A.2    Krumpe, P.3
  • 23
    • 0021943287 scopus 로고
    • Influence of surfactant on mucociliary transport
    • Allegra L., Bossi R., and Braga P. Influence of surfactant on mucociliary transport. Eur J Respir Dis Suppl 142 (1985) 71-76
    • (1985) Eur J Respir Dis Suppl , vol.142 , pp. 71-76
    • Allegra, L.1    Bossi, R.2    Braga, P.3
  • 24
    • 0030611938 scopus 로고    scopus 로고
    • Effects of aerosolized surfactant in patients with stable chronic bronchitis. A prospective randomized controlled trial
    • Anzueto A., Jubran A., Ohar J.A., et al. Effects of aerosolized surfactant in patients with stable chronic bronchitis. A prospective randomized controlled trial. JAMA 278 (1997) 1426-1431
    • (1997) JAMA , vol.278 , pp. 1426-1431
    • Anzueto, A.1    Jubran, A.2    Ohar, J.A.3
  • 25
    • 40049101993 scopus 로고    scopus 로고
    • Nasal and sinus involvement in chronic obstructive pulmonary disease
    • Kim J.-S., and Rubin B.K. Nasal and sinus involvement in chronic obstructive pulmonary disease. Curr Opin Pulm Med 14 (2008) 101-104
    • (2008) Curr Opin Pulm Med , vol.14 , pp. 101-104
    • Kim, J.-S.1    Rubin, B.K.2
  • 27
    • 0001825429 scopus 로고    scopus 로고
    • Mucoactive agents: old and new
    • Wilmott R.W. (Ed), Birkhäuser Publishing, Ltd, Basel (Switzerland) chapter 7
    • Rubin B.K., Tomkiewicz R.P., and King M. Mucoactive agents: old and new. In: Wilmott R.W. (Ed). The pediatric lung (1997), Birkhäuser Publishing, Ltd, Basel (Switzerland) 155-179 chapter 7
    • (1997) The pediatric lung , pp. 155-179
    • Rubin, B.K.1    Tomkiewicz, R.P.2    King, M.3
  • 28
    • 3042709453 scopus 로고    scopus 로고
    • MUC5AC and MUC5B mucins are decreased in cystic fibrosis airway secretions
    • Henke M.O., Renner A., Huber R.M., et al. MUC5AC and MUC5B mucins are decreased in cystic fibrosis airway secretions. Am J Respir Cell Mol Biol 31 (2004) 86-91
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 86-91
    • Henke, M.O.1    Renner, A.2    Huber, R.M.3
  • 29
    • 0032896384 scopus 로고    scopus 로고
    • Who will benefit from DNase?
    • Rubin B.K. Who will benefit from DNase?. Pediatr Pulmonol 27 (1999) 3-4
    • (1999) Pediatr Pulmonol , vol.27 , pp. 3-4
    • Rubin, B.K.1
  • 30
    • 35349014567 scopus 로고    scopus 로고
    • The role of DNA and actin polymers on the polymer structure and rheology of cystic fibrosis sputum and depolymerization by gelsolin or thymosin beta 4
    • Kater A., Henke M.O., and Rubin B.K. The role of DNA and actin polymers on the polymer structure and rheology of cystic fibrosis sputum and depolymerization by gelsolin or thymosin beta 4. Ann N Y Acad Sci 1112 (2007) 140-153
    • (2007) Ann N Y Acad Sci , vol.1112 , pp. 140-153
    • Kater, A.1    Henke, M.O.2    Rubin, B.K.3
  • 31
    • 34548593997 scopus 로고    scopus 로고
    • Mucolytics, expectorants, and mucokinetic medications
    • Rubin B.K. Mucolytics, expectorants, and mucokinetic medications. Respir Care 52 (2007) 859-865
    • (2007) Respir Care , vol.52 , pp. 859-865
    • Rubin, B.K.1
  • 32
    • 30944452384 scopus 로고    scopus 로고
    • Mucus clearance and lung function in cystic fibrosis with hypertonic saline
    • Donaldson S.H., Bennett W.D., Zeman K.L., et al. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med 354 (2006) 241-250
    • (2006) N Engl J Med , vol.354 , pp. 241-250
    • Donaldson, S.H.1    Bennett, W.D.2    Zeman, K.L.3
  • 33
    • 14844292681 scopus 로고    scopus 로고
    • Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputum
    • Daviskas E., Anderson S.D., Gomes K., et al. Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputum. Respirology 10 (2005) 46-56
    • (2005) Respirology , vol.10 , pp. 46-56
    • Daviskas, E.1    Anderson, S.D.2    Gomes, K.3
  • 34
    • 34047180932 scopus 로고    scopus 로고
    • MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during a pulmonary exacerbation
    • Henke M.O., Gerrit J., Germann M., et al. MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during a pulmonary exacerbation. Am J Respir Crit Care Med 175 (2007) 816-821
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 816-821
    • Henke, M.O.1    Gerrit, J.2    Germann, M.3
  • 35
    • 34748868483 scopus 로고    scopus 로고
    • A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance
    • Zayas G., Valle J.C., Alonso M., et al. A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance. BMC Pulm Med 13 7 (2007) 11
    • (2007) BMC Pulm Med , vol.13 , Issue.7 , pp. 11
    • Zayas, G.1    Valle, J.C.2    Alonso, M.3
  • 36
    • 34447565004 scopus 로고    scopus 로고
    • Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by P. aeruginosa flagellin
    • Shinkai M., López-Boado Y., and Rubin B.K. Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by P. aeruginosa flagellin. J Antimicrob Chemother 59 (2007) 1096-1101
    • (2007) J Antimicrob Chemother , vol.59 , pp. 1096-1101
    • Shinkai, M.1    López-Boado, Y.2    Rubin, B.K.3
  • 37
    • 0035036322 scopus 로고    scopus 로고
    • Regulation of secretion from mucous and serous cells in the excised ferret trachea
    • Kishioka C., Okamoto K., Kim J.S., et al. Regulation of secretion from mucous and serous cells in the excised ferret trachea. Respir Physiol 126 (2001) 163-171
    • (2001) Respir Physiol , vol.126 , pp. 163-171
    • Kishioka, C.1    Okamoto, K.2    Kim, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.