A new paradigm in respiratory hygiene: Modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance

BMC Pulmonary Medicine

Volumn 7, Issue , 2007, Pages

  Zayas, Gustavo ^a,b   Valle, Juan C ^b   Alonso, Mauricio ^b   Alfaro, Henry ^b   Vega, Daniel ^b   Bonilla, Gloria ^b   Reyes, Miguel ^b   King, Malcolm ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Hospital Nacional Dr Jose Antonio Saldaña Neumologia y Medicina Familiar   (El Salvador)

Author keywords

[No Author keywords available]

Indexed keywords

EXPECTORANT AGENT;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BULLFROG; CONCENTRATION RESPONSE; CONTROLLED STUDY; COUGHING; DOG; EX VIVO STUDY; FEMALE; HYGIENE; IN VIVO STUDY; LUNG CLEARANCE; MALE; MUCOCILIARY CLEARANCE; MUCUS SECRETION; NONHUMAN; RESPIRATORY CARE; RESPIRATORY FUNCTION; TRACHEA MUCOSA; ANIMAL; CHEMISTRY; EUKARYOTIC FLAGELLUM; FROGS AND TOADS; MUCUS; PALATE; PHYSIOLOGY; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT MUCOSA; TRACHEA; VISCOSITY;

AEROSOLS; ANIMALS; ANURA; CILIA; COUGH; DOGS; FEMALE; HYGIENE; MALE; MUCOCILIARY CLEARANCE; MUCUS; PALATE; RESPIRATORY MUCOSA; RESPIRATORY TRACT DISEASES; TRACHEA; VISCOSITY;

EID: 34748868483     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-7-11     Document Type: Article

References (15)

1. Silberberg A Meyer FA Structure and function of mucus Mucus in Health and Disease II Plenum Press. New York and London Chantler EN, Elder JB, Ebstein M 1982:53-74
2. Basbaum CB Finkbeiner WE Mucus-producing cells of the airways Lung Cell Biology New York, Basel: Marcel Dekker Massaro D 1989:37-79
3. King M Rubin BK Rheology of airway mucus: Relationship with clearance function Airway Secretion: Physiological Bases for the Control of Mucus Hypersecretion (Lung Biology in Health and Disease Series) New York: Marcel Dekker Takishima T, Shimura S 1994 Chapter 7 283-314
4. Zayas JG Rubin BK York E Lien D King M Bronchial mucus properties in lung cancer. Relationship with site of lesion Can Respir J 1999, 6:246-252 10393286
5. Lopez-Vidriero MT Biochemical basis of physical properties of respiratory tract secretions Eur J Respir Dis 1987, 71:130-135 3622663
6. King M Rubin BK Pharmacological approaches to discovery and development of new mucolytic agents Advanced Drug Delivery Reviews 2002, 54:1475-1490 10.1016/S0169-409X(02)00156-4 12458156
7. King M Magnetic microrheometer Methods in Bronchial Mucology New York: Raven Press Braga PC, Allegra L 1988:73-83
8. King M Role of mucus viscoelasticity in cough clearance Biorheology 1987, 24:589-597 3502760
9. Zayas G Dimitry J Zayas A O'Brien D King M A new paradigm in respiratory hygiene: Increasing the cohesivity of airway secretions to improve cough interaction and reduce aerosol dispersion BMC Pulm Med 2005, 5:11 1208914 16138926
10. King M Festa E The evolution of the frog palate model for mucociliary clearance Cilia, Mucus and Mucociliary Interactions New York: Marcel Dekker Baum G 1998:191-201
11. Rubin BK Ramirez O King M Mucus-depleted frog palate as a model for the study of mucociliary clearance J Appl Physiol 1990, 69:424-429 2228850
12. Jeanneret-Grosjean A King M Michoud MC Lioté H Amyot R Sampling technique and rheology of human bronchial mucus Am Rev Respir Dis 1988, 137:707-710 3345048
13. Rubin BK Ramirez O Zayas JG Finegan B King M Collection and analysis of respiratory mucus from individuals without lung disease Am Rev Respir Dis 1990, 141:1040-1043 2327638
14. King M Zahm JM Pierrot D Vaquez-Girod S Puchelle E The role of mucus gel viscosity, spinnability, and adhesive properties in clearance by simulated cough Biorheology 1989, 26:737-745 2611367
15. Zayas G O'Brien DW Tai S Ding J Lim L King M Adaptation of an Amphibian Mucociliary Clearance Model to Evaluate Early Effects of Tobacco Smoke Exposure Respir Res 2004, 5:9. (Epub 20 Aug 04) 517705 15357881 10.1186/ 1465-9921-5-9