Design, synthesis and evaluation of carbamate-modified (-)-N1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1721-1723

  Takahashi, Jun ^a   Hijikuro, Ichiro ^c   Kihara, Takeshi ^a   Murugesh, Modachur G ^c   Fuse, Shinichiro ^b   Tsumura, Yoshinori ^a   Akaike, Akinori ^a   Niidome, Tetsuhiro ^a   Takahashi, Takashi ^b   Sugimoto, Hachiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c ChemGenesis Incorporated   (Japan)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Carbamate

Indexed keywords

CARBAMIC ACID DERIVATIVE; CHOLINESTERASE INHIBITOR; CYCLOHEXYLMETHYLCARBAMATE DERIVATIVE; N1 PHENETHYLNORESEROLINE; N1 PHENETHYLNORPHYSOSTIGMINE; N1 PHENETHYLNORPHYSOSTIGMINE DERIVATIVE; N1-PHENETHYLNORPHENSERINE; PHYSOSTIGMINE; UNCLASSIFIED DRUG;

ARTICLE; CHOLINESTERASE INHIBITION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CARBAMATES; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; NEUROPROTECTIVE AGENTS; PHYSOSTIGMINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76649143375     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.035     Document Type: Article

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