Improved production of mycelial biomass and ganoderic acid by submerged culture of Ganoderma lucidum SB97 using complex media

Enzyme and Microbial Technology

Volumn 42, Issue 4, 2008, Pages 325-331

  Xu, Peng ^a   Ding, Zhong Yang ^b   Qian, Zhu ^c   Zhao, Chang Xin ^a   Zhang, Ke Chang ^b  

^a DALIAN POLYTECHNIC UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Beijing Engineering Laboratory for Geriatric Nutrition Food Research   (China)

Author keywords

Catabolite repression; Complex media; Ganoderic acid; Ganoderma lucidum; Response surface methodology

Indexed keywords

CATABOLITE REPRESSION; COMPLEX MEDIA; GANODERIC ACID (GA); GANODERMA LUCIDUM; RESPONSE SURFACE METHODOLOGY;

BIOMASS; GLUCOSE; GROWTH KINETICS; METABOLISM; OPTIMIZATION; PLANTS (BOTANY);

HYDROCARBONS;

GANODERIC ACID; GLUCOSE; NATURAL PRODUCT; NITROGEN; PEPTONE; UNCLASSIFIED DRUG;

ARTICLE; BIOMASS; BIOREACTOR; CARBON SOURCE; CELL METABOLISM; FUNGUS CULTURE; GANODERMA LUCIDUM; MYCELIUM; NONHUMAN; SOYBEAN;

FUNGI; GANODERMA LUCIDUM; GLYCINE MAX; ZEA MAYS;

EID: 39149097549     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2007.10.016     Document Type: Article

References (23)

1. Fang Q.H., and Zhong J.J. Effect of initial pH on production of ganoderic acid and polysaccharide by submerged fermentation of Ganoderma lucidum. Process Biochem 37 (2002) 769-774
2. Yang H.L., Wu T.X., and Zhang K.C. Enhancement of mycelial growth and polysaccharide production in Ganoderma lucidum (the Chinese medicinal fungus 'Lingzhi') by the addition of ethanol. Biotechnol Lett 26 (2004) 841-844
3. Campos Z.F., Hanssen H.P., and Konig W.A. Secondary metabolites from Ganoderma lucidum and Spongiporus leucomallellus. Phytochemistry 67 (2006) 202-211
4. Lin S.B., Li C.H., Lee S.S., and Kan L.S. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci 72 (2003) 2381-2390
5. Patocka J. Anti-inflammatory triterpenoids from mysterious mushroom Ganoderma lucidum and their potential possibility in modern medicine. Acta Med (Hradec Kralove) 42 (1999) 123-125
6. El-Mekkawy S., Meselhy M.R., Nakamura N., Tezuka Y., Hattori M., Kakiuchi N., et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49 (1998) 1651-1657
7. Min B.S., Nakamura N., Miyashiro H., Bae K.W., and Hattori M. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull (Tokyo) 46 (1998) 1607-1612
8. Hikino H., Ishiyama M., Suzuki Y., and Konno C. Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies. Planta Med 55 (1989) 423-428
9. Berger A., Rein D., Kratky E., Monnard I., Hajjaj H., Meirim I., et al. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. Lipids Health Dis 3 (2004) 2
10. Hajjaj H., Mace C., Roberts M., Niederberger P., and Fay L.B. Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors. Appl Environ Microbiol 71 (2005) 3653-3658
11. Kohda H., Tokumoto W., Sakamoto K., Fujii M., Hirai Y., Yamasaki K., et al. The biologically active constituents of Ganoderma lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes. Chem Pharm Bull (Tokyo) 33 (1985) 1367-1374
12. Tang Y.J., and Zhong J.J. Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid. Enzyme Microb Technol 31 (2002) 20-28
13. Chang M.Y., Tsai G.J., and Houng J.Y. Optimization of the medium composition for the submerged culture of Ganoderma lucidum by Taguchi array design and steepest ascent method. Enzyme Microb Technol 38 (2006) 407-414
14. Tang Y.J., and Zhong J.J. Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid. Enzyme Microb Technol 32 (2003) 478-484
15. Yang F.C., and Liau C.B. The influence of environmental conditions on polysaccharide formation by Ganoderma lucidum in submerged cultures. Process Biochem 33 (1998)
16. Blanch H.W., and Clark D.S. Biochemical engineering (1997), Marcel Dekker Inc., New York p. 183-185
17. Hsieh C., Tseng M.H., and Liu C.J. Production of polysaccharides from Ganoderma lucidum (CCRC 36041) under limitations of nutrients. Enzyme Microb Technol 38 (2006) 109-117
18. Miller G.L. Use of dinitrosalicylic acid reagent for determination of reducing sugars. Anal Chem 31 (1959) 426-428
19. Shih I.L., Pan K., and Hsieh C. Influence of nutritional components and oxygen supply on the mycelial growth and bioactive production in submerged culture of Antrodia cinnamomea. Process Biochem 41 (2006) 1129-1135
20. Parra R., Aldred D., and Magan N. Medium optimization for the production of the secondary metabolite squalestatin S1 by a Phoma sp. combining orthogonal design and response surface methodology. Enzyme Microb Technol 37 (2005) 704-711
21. Wu J., Ding Z.Y., and Zhang K.C. Improvement of exopolysaccharide production by macro-fungus Auricularia auricula in submerged culture. Enzyme Microb Technol 39 (2006) 743-749
22. Mao X.B., Eksriwong T., Chauvatcharin S., and Zhong J.J. Optimization of carbon source and carbon/nitrogen ration for cordycepin production by submerged cultivation of medicinal mushroom Cordyceps militaris. Process Biochem 40 (2005) 1667-1672
23. Fang Q.H., and Zhong J.J. Submerged fermentation of higher fungus Ganoderma lucidum for production of valuable bioactive metabolites-ganoderic acid and polysaccharide. Biochem Eng J 10 (2002) 61-65