How i manage the adult potential organ donor: Donation after neurological death (Part 1)

Neurocritical Care

Volumn 12, Issue 1, 2010, Pages 103-110

  Frontera, Jennifer A ^a   Kalb, Thomas ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Brain death; Donation after neurological death; End of life; Hormonal therapy; Organ donation; Organ sparing therapy

Indexed keywords

ACETYLSALICYLIC ACID; ANTIBIOTIC AGENT; CILOSTAZOL; CLOPIDOGREL; DESMOPRESSIN; HEPARIN; HYPERTENSIVE FACTOR; INOTROPIC AGENT; INSULIN; LEVOTHYROXINE; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; NORADRENALIN; PROTAMINE; THYROXINE; VASOPRESSIN;

ANTIBIOTIC THERAPY; ARTIFICIAL VENTILATION; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TIME; BLOOD PRESSURE; BRAIN DEATH; BRAIN HEMORRHAGE; BRONCHOSCOPY; COMPUTER ASSISTED TOMOGRAPHY; DRUG DOSE REDUCTION; FEMORAL ARTERY; FLUID THERAPY; HEADACHE; HEART EJECTION FRACTION; HEMODYNAMIC MONITORING; HORMONAL THERAPY; HOSPITAL MANAGEMENT; HUMAN; HYPERTENSION; HYPONATREMIA; HYPOPITUITARISM; INTENSIVE CARE; INTENSIVE CARE UNIT; LUNG TRANSPLANTATION; MEDICAL PRACTICE; NOTE; ORGAN DONOR; OVARY CYST; PERIPHERAL VASCULAR DISEASE; PHYSIOTHERAPY; PRIORITY JOURNAL; RESUSCITATION; SIDE EFFECT; STENT; TACHYCARDIA; THROMBOCYTE TRANSFUSION; THROMBOSIS; TRANSTHORACIC ECHOCARDIOGRAPHY; URINE VOLUME; VASOCONSTRICTION; WEAKNESS;

BRAIN DEATH; COMBINED MODALITY THERAPY; COMMUNICATION; HORMONE REPLACEMENT THERAPY; HUMANS; HYPERTENSION; INTENSIVE CARE; INTERPROFESSIONAL RELATIONS; LIFE SUPPORT CARE; MIDDLE AGED; STROKE; TISSUE AND ORGAN HARVESTING; TISSUE AND ORGAN PROCUREMENT;

EID: 76649129851     PISSN: 15416933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12028-009-9292-y     Document Type: Note

References (43)

1. D Novitzky A Horak DK Cooper AG Rose 1989 Electrocardiographic and histopathologic changes developing during experimental brain death in the baboon Transplant Proc 21 1 Pt 3 2567 2569 1:STN:280:DyaL1M3gsVGjug%3D%3D 2705268
2. DK Cooper D Novitzky WN Wicomb 1989 The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart Ann R Coll Surg Engl 71 4 261 266 1:STN:280:DyaL1Mznt1Krsw%3D%3D 2774455
3. B Shivalkar J Van Loon W Wieland, et al. 1993 Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function Circulation 87 1 230 239 1:STN:280:DyaK3s7itFGjtg%3D%3D 8419012
4. D Novitzky DK Cooper JD Rosendale HM Kauffman 2006 Hormonal therapy of the brain-dead organ donor: experimental and clinical studies Transplantation 82 11 1396 1401 10.1097/01.tp.0000237195.12342.f1 1:CAS:528:DC%2BD28XhtlSrsL7N 17164704 (Pubitemid 44967616)
5. WN Wicomb DK Cooper RP Lanza D Novitzky S Isaacs 1986 The effects of brain death and 24 hours' storage by hypothermic perfusion on donor heart function in the pig J Thorac Cardiovasc Surg 91 6 896 909 1:STN:280: DyaL283ivFWrtQ%3D%3D 3520162
6. DR Wheeldon CD Potter A Oduro J Wallwork SR Large 1995 Transforming the "unacceptable" donor: outcomes from the adoption of a standardized donor management technique J Heart Lung Transplant 14 4 734 742 1:STN:280:DyaK28%2FgtVKjsw%3D%3D 7578183
7. B Riou S Dreux S Roche, et al. 1995 Circulating cardiac troponin T in potential heart transplant donors Circulation 92 3 409 414 1:CAS:528: DyaK2MXntlCit7Y%3D 7634456
8. JM Chen S Cullinane TB Spanier, et al. 1999 Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors Circulation 100 19 Suppl II244 II246 1:STN:280:DC%2BD3c%2FjslSnuw%3D%3D 10567311
9. KE Wood BN Becker JG McCartney AM D'Alessandro DB Coursin 2004 Care of the potential organ donor N Engl J Med 351 26 2730 2739 10.1056/NEJMra013103 1:CAS:528:DC%2BD2MXhtFWitQ%3D%3D 15616207 (Pubitemid 39665326)
10. SD Shemie H Ross J Pagliarello, et al. 2006 Organ donor management in Canada: recommendations of the forum on Medical Management to Optimize Donor Organ Potential CMAJ 174 6 S13 S32 16534070
11. D Novitzky DK Cooper 1988 Results of hormonal therapy in human brain-dead potential organ donors Transplant Proc 20 5 Suppl 7 59 62 1:STN:280: DyaL1M%2FksFagtA%3D%3D 3055561
12. D Novitzky DK Cooper PA Human B Reichart N Zuhdi 1988 Triiodothyronine therapy for heart donor and recipient J Heart Transplant 7 5 370 376 1:STN:280:DyaL1M%2FmvVansA%3D%3D 3058907 (Pubitemid 18242758)
13. D Novitzky DK Cooper B Reichart 1987 Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors Transplantation 43 6 852 854 1:STN:280:DyaL2s3jsFKlsQ%3D%3D 3296351
14. A Salim P Vassiliu GC Velmahos, et al. 2001 The role of thyroid hormone administration in potential organ donors Arch Surg 136 12 1377 1380 10.1001/archsurg.136.12.1377 1:CAS:528:DC%2BD38XisV2lsA%3D%3D 11735863
15. V Jeevanandam 1997 Triiodothyronine: spectrum of use in heart transplantation Thyroid 7 1 139 145 10.1089/thy.1997.7.139 1:STN:280: DyaK2s3ktFaisw%3D%3D 9086582
16. JD Rosendale HM Kauffman MA McBride, et al. 2003 Aggressive pharmacologic donor management results in more transplanted organs Transplantation 75 4 482 487 10.1097/01.TP.0000045683.85282.93 12605114 (Pubitemid 36241143)
17. FW Selck P Deb EB Grossman 2008 Deceased organ donor characteristics and clinical interventions associated with organ yield Am J Transplant 8 5 965 974 10.1111/j.1600-6143.2008.02205.x 1:STN:280:DC%2BD1c3lsFGntQ%3D%3D 18341685
18. JD Rosendale HM Kauffman MA McBride, et al. 2003 Hormonal resuscitation yields more transplanted hearts, with improved early function Transplantation 75 8 1336 1341 10.1097/01.TP.0000062839.58826.6D 12717226 (Pubitemid 36513044)
19. PE Marik M Baram B Vahid 2008 Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares Chest 134 1 172 178 10.1378/chest.07-2331 18628220 (Pubitemid 352008780)
20. L Mascia K Bosma D Pasero, et al. 2006 Ventilatory and hemodynamic management of potential organ donors: an observational survey Crit Care Med 34 2 321 327 10.1097/01.CCM.0000196828.87358.6E 16424709 quiz 328 (Pubitemid 43145607)
21. AE Frost 1997 Donor criteria and evaluation Clin Chest Med 18 2 231 237 10.1016/S0272-5231(05)70374-9 1:STN:280:DyaK2szjtFCrtw%3D%3D 9187817 (Pubitemid 27247132)
22. AJ Fisher JH Dark PA Corris 1998 Improving donor lung evaluation: a new approach to increase organ supply for lung transplantation Thorax 53 10 818 820 10.1136/thx.53.10.818 1:STN:280:DyaK1M3gvFCntw%3D%3D 10193365
23. AJ Fisher SC Donnelly G Pritchard JH Dark PA Corris 2004 Objective assessment of criteria for selection of donor lungs suitable for transplantation Thorax 59 5 434 437 10.1136/thx.2003.007542 1:STN:280:DC%2BD2c3jvVOltA%3D%3D 15115876 (Pubitemid 38624751)
24. RC Geiger CD Kaufman AP Lam GR Budinger DA Dean 2009 Tubulin acetylation and histone deacetylase 6 activity in the lung under cyclic load Am J Respir Cell Mol Biol 40 1 76 82 10.1165/rcmb.2007-0307OC 1:CAS:528: DC%2BD1MXis1CjtQ%3D%3D 18635817
25. M Kotani T Kotani Z Li R Silbajoris CA Piantadosi YC Huang 2004 Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch Eur Respir J 24 2 238 246 10.1183/09031936.04.00128703 1:CAS:528: DC%2BD2cXntFOhu7s%3D 15332391 (Pubitemid 39139790)
26. AJ Fisher SC Donnelly N Hirani, et al. 1999 Enhanced pulmonary inflammation in organ donors following fatal non-traumatic brain injury Lancet 353 9162 1412 1413 10.1016/S0140-6736(99)00494-8 1:STN:280:DyaK1M3ktFOlug%3D%3D 10227229 (Pubitemid 29192420)
27. H Kaneda TK Waddell M de Perrot, et al. 2006 Pre-implantation multiple cytokine mRNA expression analysis of donor lung grafts predicts survival after lung transplantation in humans Am J Transplant 6 3 544 551 10.1111/j.1600-6143. 2005.01204.x 1:CAS:528:DC%2BD28Xit12gt7o%3D 16468964 (Pubitemid 43382141)
28. VM Ranieri PM Suter C Tortorella, et al. 1999 Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial JAMA 282 1 54 61 10.1001/jama.282.1.54 1:STN:280:DyaK1MzjtFOqug%3D%3D 10404912 (Pubitemid 29318933)
29. L Tremblay F Valenza SP Ribeiro J Li AS Slutsky 1997 Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model J Clin Invest 99 5 944 952 10.1172/JCI119259 1:CAS:528:DyaK2sXhs1Kqtbg%3D 9062352
30. L Mascia E Zavala K Bosma, et al. 2007 High tidal volume is associated with the development of acute lung injury after severe brain injury: an international observational study Crit Care Med 35 8 1815 1820 10.1097/01.CCM.0000275269.77467.DF 17568331 (Pubitemid 47220353)
31. MJ Schultz JJ Haitsma AS Slutsky O Gajic 2007 What tidal volumes should be used in patients without acute lung injury? Anesthesiology 106 6 1226 1231 10.1097/01.anes.0000267607.25011.e8 17525599 (Pubitemid 46828177)
32. RG Brower PN Lanken N MacIntyre, et al. 2004 Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome N Engl J Med 351 4 327 336 10.1056/NEJMoa032193 15269312 (Pubitemid 38944401)
33. RG Brower A Morris N MacIntyre, et al. 2003 Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure Crit Care Med 31 11 2592 2597 10.1097/01.CCM.0000090001.91640.45 14605529 (Pubitemid 37452838)
34. C Guerin S Gaillard S Lemasson, et al. 2004 Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial JAMA 292 19 2379 2387 10.1001/jama.292.19.2379 1:CAS:528: DC%2BD2cXhtVSktLrO 15547166 (Pubitemid 39491923)
35. MO Meade DJ Cook GH Guyatt, et al. 2008 Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial JAMA 299 6 637 645 10.1001/jama.299.6.637 1:CAS:528: DC%2BD1cXhvFensLk%3D 18270352 (Pubitemid 351252725)
36. RW Taylor JL Zimmerman RP Dellinger, et al. 2004 Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial JAMA 291 13 1603 1609 10.1001/jama.291.13.1603 1:CAS:528:DC%2BD2cXjtVehsbw%3D 15069048 (Pubitemid 38552433)
37. AP Wheeler GR Bernard BT Thompson, et al. 2006 Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury N Engl J Med 354 21 2213 2224 10.1056/NEJMoa061895 16714768 (Pubitemid 43788136)
38. H Yamamoto H Teramoto K Uetani K Igawa E Shimizu 2002 Cyclic stretch upregulates interleukin-8 and transforming growth factor-beta1 production through a protein kinase C-dependent pathway in alveolar epithelial cells Respirology 7 2 103 109 10.1046/j.1440-1843.2002.00377.x 11985731 (Pubitemid 34662940)
39. V Bhandari 2008 Molecular mechanisms of hyperoxia-induced acute lung injury Front Biosci 13 6653 6661 10.2741/3179 1:CAS:528:DC%2BD1cXnsVOitLk%3D 18508685
40. DM Follette SM Rudich WD Babcock 1998 Improved oxygenation and increased lung donor recovery with high-dose steroid administration after brain death J Heart Lung Transplant 17 4 423 429 1:STN:280:DyaK1c3kvVSjsA%3D%3D 9588588
41. DB McElhinney JH Khan WD Babcock TS Hall 2001 Thoracic organ donor characteristics associated with successful lung procurement Clin Transplant 15 1 68 71 10.1034/j.1399-0012.2001.150112.x 1:STN:280:DC%2BD3M7lsFartQ%3D%3D 11168319 (Pubitemid 32094338)
42. E Gabbay TJ Williams AP Griffiths, et al. 1999 Maximizing the utilization of donor organs offered for lung transplantation Am J Respir Crit Care Med 160 1 265 271 1:STN:280:DyaK1Mzit1arsw%3D%3D 10390410
43. B Cantin BW Kwok MC Chan, et al. 2003 The impact of brain death on survival after heart transplantation: time is of the essence Transplantation 76 9 1275 1279 10.1097/01.TP.0000093445.50624.5A 14627902 (Pubitemid 37430710)