Safety evaluation of food contact paper and board using chemical tests and in vitro bioassays: Role of known and unknown substances

Food Additives and Contaminants - Part A

Volumn 27, Issue 3, 2010, Pages 406-415

  Honkalampi Hamalainen U ^a   Bradley, E L ^b   Castle, L ^b   Severin, I ^c   Dahbi, L ^c   Dahlman, O ^d   Lhuguenot, J C ^c   Andersson, M A ^e   Hakulinen, P ^f   Hoornstra, D ^e   Maki Paakkanen J ^e   Salkinoja Salonen, M ^e   Turco, L ^g   Stammati, A ^g   Zucco, F ^h   Weber, A ⁱ   von Wright, A ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b CENTRAL SCIENCE LABORATORY   (United Kingdom)

^c UNIVERSITÉ DE BOURGOGNE   (France)

^d INNVENTIA AB   (Sweden)

^e UNIVERSITY OF HELSINKI   (Finland)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^g ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^h CNR   (Italy)

ⁱ KCL   (Finland)

Author keywords

Bioassay; Cytotoxicity; Food contact materials; Mutagenic compounds; Packaging; Toxicology

Indexed keywords

2,4 DIAMINOTOLUENE; ACRYLAMIDE; BENZO[A]PYRENE; DIISOPROPYLNAPHTHALENE; NAPHTHALENE DERIVATIVE; PHTHALIC ACID; RESIN; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOASSAY; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; FOOD ANALYSIS; FOOD CONTAMINATION; FOOD INTAKE; FOOD PACKAGING; FOOD PROCESSING; FOOD SAFETY; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; MUTAGENIC ACTIVITY; NONHUMAN; OUTCOME ASSESSMENT; PAPER; PRIORITY JOURNAL; SPRUCE; TARGET CELL; TOXICITY TESTING; XENOBIOTIC METABOLISM;

EID: 76649129366     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440040903401358     Document Type: Article

References (32)

1. Andersson MA, Mikkola R, Helin J, Andersson MC, Salkinoja-Salonen M. 1998. A novel sensitive bioassay for detection of Bacillus cereus emetic toxin and related depsipeptide ionophores. Appl Environ Microbiol. 64:1338-1343.
2. Barlow SM. 2009. Risk assessment of food contact materials: Past experience and future challenges. Proceedings of the 4th International Symposium on Food Packaging, Prague, November 2008. Food Addit Contam. 26:1526-1533.
3. Bebiolka H, Dunkel K. 1997. Übergang von di-iso-propyl-naphthalin aus karton-verpackungen auf lebensmittel (Passage of diisopropylnaphthalene from cardboard packing to food). Lebensmittelchemie 51:53-61.
4. Bradley EL, Honkalampi-Hamalainen U, Weber A, Andersson MA, Bertaud F, Castle L, Dahlman O, Hakulinen P, Hoornstra D, Lhuguenot J-C, et al. 2008. The BIOSAFEPAPER project for in vitro toxicity assessments: Preparation, detailed chemical characterisation and testing of extracts from paper and board samples. Food Chem Toxicol. 46:2498-2509.
5. Bradley EL, Honkalampi-Hamalainen U, Andersson MA, Bertaud F, Castle L, Dahlman O, Hakulinen P, Hoornstra D, Lhuguenot J-C, Maki-Paakkanen J, et al. 2009. Test procedures for obtaining representative extracts suitable for reliable in vitro toxicity assessment of paper and board intended for food contact. Food Addit Contam. In press.
6. Chhabra RS. 2000. NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9). Administered in feed to F344/N rats and B6C3F mice. Toxicity Report Series 61:1-53.
7. COE 2002. Council of Europe Resolution A.P 2002.1 on paper and board materials and articles intended to come into contact with foodstuffs.
8. EN 648:2003. Paper and board intended to come into contact with foodstuffs. Determination of the fastness of fluorescent whitened paper and board. European Standard EN 648:2003.
9. FSA 2002. Paper and board packaging: not likely to be a source of acrylamide in food. Food Survey Information Sheet 27/02. London: Food Standards Agency.
10. Heudorf U, Mersch-Sunderman V, Angerer J. 2007. Phthalates: Toxicology and exposure. Int J Hyg Environ Health 210:623-634.
11. Hoke H, Zellerhoff R. 1998. Metabolism and toxicity of diisopropylnahthalene as compared to naphthalene and monoalkyl naphthalenes: a minireview. Toxicology 126:1-7.
12. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CWW, Fong HHS, Farnsworth NR, Kinghorn AD, Mehta RG, et al. 1997. Cancer chemopre-ventive action of resveratrol, a natural product derived from grapes. Science 275:218-220.
13. Kleinsasser NH, Kastenbauer ER, Weissacher H, Muenzenrieder RK, Harreus UA. 2000. Phthalates demonstrate genotoxicity on human mucosa of the upper aerodigestive tract. Environ Mol Mutagen. 35:9-12.
14. Kleinsassner NH, Wallner BC, Kastenbauer ER, Weissacher H, Harreus UA. 2001. Genotoxicity of di-butyl-phthalate and di-isobutyl-phthalate in human lymphocytes and mucosal cells. Teratogen Carcinogen Mutagen. 21:189-196.
15. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, et al. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127:1-14.
16. Lever JE. 1979. Inducers of mammalian cell differentiation stimulate dome formation in a differentiated kidney epithelial cell line (MDCK). Proc Natl Acad Sci USA 76:1323-1327.
17. MAFF 1995. Fluorescent whitening agents. Food Surveillance Information Sheet 47. London: Ministry of Agriculture Fisheries and Food.
18. MAFF 1999. Diisopropylnaphthalenes in food packaging made from recycled paper and board. Food Surveillance Information Sheet 169. London: Ministry of Agriculture Fisheries and Food.
19. Maron DM, Ames BN. 1983. Revised methods for the Salmonella mutagenicity test. Mutat Res. 113:173-215.
20. Ozaki A, Yamaguchi Y, Fujita T, Kuroda K, Endo G. 2005. Safety assessment of paper and board food packaging: Chemical analysis and genotoxicity of possible contaminants in packaging? Food Addit Contam. 22:1053-1060.
21. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. 1995. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implication for protection against coronary heart disease. Clin Chim Acta 235:207-219.
22. RKS 1998. DIPN (diisopropylnaphthalene) technical information (data sheet) July 1998. RKS GmbH, Duisburg, DE.
23. Roberts JC (editor). 1991. Paper Chemistry. Blackie, Glasgow. ISBN 0-2 16-92909-1.
24. Schweikl H, Schmalz G, Rackenbrandt K. 1998. The mutagenic activity of unpolymerized resin monomers in Salmonella typhimurium and V79 cells. Mutat Res. 415:119-130.
25. Severin I, Dahbi L, Lhuguenot J-C, Andersson MA, Hoornstra D, Salkinoja-Salonen M, Turco L, Zucco F, Stammati A, Dahlman O, et al. 2005. Safety assessment of food-contact paper and board using a battery of short-term toxicity tests: European Union BIOSAFEPAPER project. Food Addit Contam. 22:1032-1041.
26. Simat JT. 2008. Use of biotests in the analysis of migrants from coatings and plastic laminates. Paper presented at the 4th International Symposium on Food Packaging. November 19-21, Prague (Czech Republic).
27. Sturaro A, Parvoli G, Rella R, Bardati S, Doretti L. 1994. Food contamination by diisopropylnaphthalenes from cardboard packages. Int J Food Sci Technol. 29:593-603.
28. Valimaa A-L, Honkalampi-Hamalainen U, Pietarinen S, Willfor S, Holmbom B, von Wright A. 2007. Antimicrobial and cytotoxic knotwood extracts and related pure compounds and their effects on food-associated microorganisms. Int J Food Microbiol. 115:235-243.
29. von Wright A. 2007. Safety assessment of paper and board used in food packaging. In: Barnes KA, Sinclair R, Watson D, editors. Chemical migration and food contact materials. Cambridge, UK: Woodhead Publishing. p. 333-345, ISBN-13: 978-1-84569-029-8.
30. Yoshikawa K, Tanaka A, Yamaha T, Kurata H. 1983. Mutagenicity study of nine monoalkyl phthalates and a dialkylpthalate using Salmonella typhimurium and Escherichia coli. Food Chem Toxicol. 21:221-223.
31. Zeiger E, Haworth S, Mortelmans K, Speck W. 1985. Mutagenicity testing of di(2-ethylhexyl)phthalate and related chemicals in Salmonella. Environ Mutagen. 7:213-232.
32. Zhang K, Noonan GO, Begley TH. 2008. Determination of 2,6-diisopropylnaphthalene (DiPN) and n-dibutylphtha-late (DBP) in food and paper packaging materials from US marketplaces. Food Addit Contam A 25:1416-1423.