Role of the basolateral amygdala in the reinstatement and extinction of fear responses to a previously extinguished conditioned stimulus

Learning and Memory

Volumn 17, Issue 2, 2010, Pages 86-96

  Laurent, Vincent ^a   Westbrook, R Frederick ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BASOLATERAL MEMBRANE; BEHAVIOR; CONDITIONED REFLEX; CONTROLLED STUDY; EXPOSURE; FEAR; HISTOLOGY; LEARNING; NONHUMAN; PRIORITY JOURNAL; RAT; SHOCK; STIMULUS;

AMYGDALA; ANIMALS; CONDITIONING, CLASSICAL; ELECTROSHOCK; EXTINCTION, PSYCHOLOGICAL; FEAR; FREEZING REACTION, CATALEPTIC; GABA AGONISTS; MALE; MUSCIMOL; RATS; RATS, WISTAR;

EID: 76649120545     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.1655010     Document Type: Article

References (39)

1. Blanchard RJ, Blanchard DC. 1969. Crouching as an index of fear. J Comp Physiol Psychol 67: 370-375.
2. Bouton ME, Bolles RC. 1979. Role of conditioned contextual stimuli in reinstatement of extinguished fear. J Exp Psychol Anim Behav Process 5: 368-378.
3. Bouton ME, Rosengard C, Achenbach GG, Peck CA, Brooks DC. 1993. Effects of contextual conditioning and unconditional stimulus presentation on performance in appetitive conditioning. Q J Exp Psychol B 46: 63-95.
4. Bouton ME, Westbrook RF, Corcoran KA, Maren S. 2006. Contextual and temporal modulation of extinction: Behavioral and biological mechanisms. Biol Psychiatry 60: 352-360.
5. Burgos-Robles A, Vidal-Gonzalez I, Santini E, Quirk GJ. 2007. Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron 53: 871-880.
6. Harris JA, Jones ML, Bailey GK, Westbrook RF. 2000. Contextual control over conditioned responding in an extinction paradigm. J Exp Psychol Anim Behav Process 26: 174-185.
7. Helmstetter FJ, Bellgowan PS. 1994. Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats. Behav Neurosci 108: 1005-1009.
8. Herry C, Trifilieff P, Micheau J, Luthi A, Mons N. 2006. Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdala. Eur J Neurosci 24: 261-269.
9. Hugues S, Chessel A, Lena I, Marsault R, Garcia R. 2006. Prefrontal infusion of PD098059 immediately after fear extinction training blocks extinction-associated prefrontal synaptic plasticity and decreases prefrontal ERK2 phosphorylation. Synapse 60: 280-287.
10. Kim JH, Richardson R. 2008. The effect of temporary amygdala inactivation on extinction and reextinction of fear in the developing rat: Unlearning as a potential mechanism for extinction early in development. J Neurosci 28: 1282-1290.
11. Kim J, Lee S, Park H, Song B, Hong I, Geum D, Shin K, Choi S. 2007. Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction. Biochem Biophys Res Commun 355: 188-193.
12. Laurent V, Westbrook RF. 2008. Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear. Learn Mem 15: 657-666.
13. Laurent V,Westbrook RF. 2009a. Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction. Learn Mem 16: 520-529.
14. Laurent V, Westbrook RF. 2009b. Infusion of the NMDA receptor antagonist, DL-APV, into the basolateral amygdala disrupts learning to fear a novel and a familiar context as well as relearning to fear an extinguished context. Learn Mem 16: 96-105.
15. Laurent V, Marchand AR, Westbrook RF. 2008. The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear. Learn Mem 15: 304-314.
16. LeDoux J. 2003. The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 23: 727-738.
17. Lee H, Kim JJ. 1998. Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. J Neurosci 18: 8444-8454.
18. Lee HJ, Choi JS, Brown TH, Kim JJ. 2001. Amygdalar nmda receptors are critical for the expression of multiple conditioned fear responses. J Neurosci 21: 4116-4124.
19. Leung HT, Westbrook RF. 2008. Spontaneous recovery of extinguished fear responses deepens their extinction: A role for error-correction mechanisms. J Exp Psychol Anim Behav Process 34: 461-474.
20. Lin CH, Yeh SH, Lu HY, Gean PW. 2003. The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory. J Neurosci 23: 8310-8317.
21. Maren S. 2001. Neurobiology of Pavlovian fear conditioning. Annu Rev Neurosci 24: 897-931.
22. Maren S, Yap SA, Goosens KA. 2001. The amygdala is essential for the development of neuronal plasticity in the medial geniculate nucleus during auditory fear conditioning in rats. J Neurosci 21: RC135-1-6.
23. McDonald AJ. 1998. Cortical pathways to the mammalian amygdala. Prog Neurobiol 55: 257-332.
24. Milad MR, Quirk GJ. 2002. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420: 70-74.
25. Muller J, Corodimas KP, Fridel Z, LeDoux JE. 1997. Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli. Behav Neurosci 111: 683-691.
26. Myers KM, Davis M. 2007. Mechanisms of fear extinction. Mol Psychiatry 12: 120-150.
27. Pare D, Smith Y. 1993. The intercalated cell masses project to the central and medial nuclei of the amygdala in cats. Neuroscience 57: 1077-1090.
28. Paxinos G,Watson C. 2007. The rat brain in stereotaxic coordinates. Academic, Sydney, Australia.
29. Quirk GJ, Mueller D. 2008. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology 33: 56-72.
30. Quirk GJ, Russo GK, Barron JL, Lebron K. 2000. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J Neurosci 20: 6225-6231.
31. Rodrigues SM, Schafe GE, LeDoux JE. 2004. Molecular mechanisms underlying emotional learning and memory in the lateral amygdala. Neuron 44: 75-91.
32. Royer S, Martina M, Pare D. 1999. An inhibitory interface gates impulse traffic between the input and output stations of the amygdala. J Neurosci 19: 10575-10583.
33. Sah P, Faber ES, Lopez De Armentia M, Power J. 2003. The amygdaloid complex: Anatomy and physiology. Physiol Rev 83: 803-834.
34. Santini E, Ge H, Ren K, Pena de Ortiz S, Quirk GJ. 2004. Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex. J Neurosci 24: 5704-5710.
35. Sierra-Mercado Jr., D, Corcoran KA, Lebron-Milad K, Quirk GJ. 2006. Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction. Eur J Neurosci 24: 1751-1758.
36. Sotres-Bayon F, Bush DE, LeDoux JE. 2007. Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology 32: 1929-1940.
37. Sotres-Bayon F, Diaz-Mataix L, Bush DE, LeDoux JE. 2009. Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution. Cereb Cortex 19: 474-482.
38. Westbrook RF, Iordanova M, McNally G, Richardson R, Harris JA. 2002. Reinstatement of fear to an extinguished conditioned stimulus: Two roles for context. J Exp Psychol Anim Behav Process 28: 97-110.
39. Wilensky AE, Schafe GE, Kristensen MP, LeDoux JE. 2006. Rethinking the fear circuit: The central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. J Neurosci 26: 12387-12396.